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The map label for this gene is murC

Identifier: 187930156

GI number: 187930156

Start: 3224110

End: 3225561

Strand: Reverse

Name: murC

Synonym: Rpic_3088

Alternate gene names: 187930156

Gene position: 3225561-3224110 (Counterclockwise)

Preceding gene: 187930157

Following gene: 187930155

Centisome position: 81.81

GC content: 66.46

Gene sequence:

>1452_bases
ATGAAGCACATCGTCAAGAACATCCATTTTGTAGGCATCGGCGGGGCCGGCATGAGCGGCATCGCGGAGGTGCTGCTGAA
TCTGGGCTACCGCGTGACGGGCTCGGATCTGGGCAGCAGCGCGACCACGCAGCGTCTGGCAACGCTGGGCGCCACCATCA
TGCAGGGCCACGCGCCGGAACATGTGATCGGCGCCAATGCCGTGGTGGTCTCCACCGCCGTGCGCGGCGACAACCCGGAA
GTGCTGGCCGCGCGCGCCAAGCGCATCCCCATCGTGCCGCGTGCGGTGATGCTGGCCGAGCTGATGCGCCTGAAGCAGGG
CATCGCGATTGCCGGCACGCACGGCAAGACGACGACGACCAGCCTCGTCGCCTCCGTGCTGGCCGAAGGCGGTCTGGACC
CGACGTTCGTGATCGGTGGCCGTCTCAACTCCGCAGGCGCCAACGCGCGCCTCGGCACGGGCGATTTCATCGTCGCCGAG
GCCGACGAATCCGACGCGTCGTTCCTCAACCTGTTCCCCGTGATCGAGGTCATCACCAATATCGATGCCGATCACATGGA
CACCTACGGGCACGACTTCGCGCGCCTGAAGCAGGCGTTCATCGAGTTCACGCAGCGGCTGCCGTTCTACGGCATTGCCG
TGCTGTGCGTGGACGACCCGAACGTGCGCGAAATCCTGCCGTTCGTCTCCAAGCCGGTCGTGCGCTACGGGTTTGCCGAA
GATGCGCAAGTGCGTGCCGTCAATGCGCGCGCTGTCGATGGCCGCATGGAATTCACCGTGATCCGCCAGCTCAACGGCCA
TGCCGAGCCGCCGCTGTCGATCACGCTCAACCTGCCGGGCCTGCACAACGTGCAGAACGCGCTGGCCGCCATCGCCATCG
CCACCGAACTGGAAGTGCCGGACGAAGCCATCGTCAAGGCGCTGGCCGAGTTCAACGGCGTGGGCCGCCGCTTCCAGCGC
TACGGCGAAGTGCCGACCGCTGACGGCAAAGGCCACTTCACGCTCATCGACGACTACGGCCACCACCCTGTCGAAATGGC
GGCAACGCTGGCTGCTGCGCGCGGTGCGTTCCCCGATCGCCGCCTCGTGCTGTCGTTCCAGCCGCACCGCTTCACGCGCA
CGCGCGATTGTTTCGAAGACTTTGTGAAAGTGCTCGGCACGGTCGACGCGCTGCTGCTGGCCGAGGTGTACGCCGCCGGC
GAGCCACCCATCATCGCCGCTGACGGTCGCGCGCTGACGCGTGCGCTGCGCGTGGCCAACAAGATCGAGCCCGTATTCGT
GGAGCAGATCGAAGACATGCCGCAAGCGATCCTGGATGCGGCGCAGGACGGCGACGTGGTCATCACCATGGGCGCTGGGT
CGATCGGGCAGGTGCCCGGGCAAGTGGTTGCGTTGCAGGCGCAGGCGCGCACTGCAAACGTCGTGGATCTGAACGGAGGC
GCCGCAGCATGA

Upstream 100 bases:

>100_bases
GATATGGCGGCTAAAGCACGTGAGCAGGCACGGCCCGAAGCGGCCGAGCGTGTCGCCGACGTGTGTGTAGCGGTGGCACG
GGCATAGGGAACGAATCGAT

Downstream 100 bases:

>100_bases
CGACCGGTCCGTTTGTTCCCAATCCGACGATTGATCCGAAGTCCCTCGGCAAAGTGGGCGTGCTCATGGGCGGTCGTTCG
GCCGAGCGCGAAATCTCACT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MKHIVKNIHFVGIGGAGMSGIAEVLLNLGYRVTGSDLGSSATTQRLATLGATIMQGHAPEHVIGANAVVVSTAVRGDNPE
VLAARAKRIPIVPRAVMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAEGGLDPTFVIGGRLNSAGANARLGTGDFIVAE
ADESDASFLNLFPVIEVITNIDADHMDTYGHDFARLKQAFIEFTQRLPFYGIAVLCVDDPNVREILPFVSKPVVRYGFAE
DAQVRAVNARAVDGRMEFTVIRQLNGHAEPPLSITLNLPGLHNVQNALAAIAIATELEVPDEAIVKALAEFNGVGRRFQR
YGEVPTADGKGHFTLIDDYGHHPVEMAATLAAARGAFPDRRLVLSFQPHRFTRTRDCFEDFVKVLGTVDALLLAEVYAAG
EPPIIAADGRALTRALRVANKIEPVFVEQIEDMPQAILDAAQDGDVVITMGAGSIGQVPGQVVALQAQARTANVVDLNGG
AAA

Sequences:

>Translated_483_residues
MKHIVKNIHFVGIGGAGMSGIAEVLLNLGYRVTGSDLGSSATTQRLATLGATIMQGHAPEHVIGANAVVVSTAVRGDNPE
VLAARAKRIPIVPRAVMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAEGGLDPTFVIGGRLNSAGANARLGTGDFIVAE
ADESDASFLNLFPVIEVITNIDADHMDTYGHDFARLKQAFIEFTQRLPFYGIAVLCVDDPNVREILPFVSKPVVRYGFAE
DAQVRAVNARAVDGRMEFTVIRQLNGHAEPPLSITLNLPGLHNVQNALAAIAIATELEVPDEAIVKALAEFNGVGRRFQR
YGEVPTADGKGHFTLIDDYGHHPVEMAATLAAARGAFPDRRLVLSFQPHRFTRTRDCFEDFVKVLGTVDALLLAEVYAAG
EPPIIAADGRALTRALRVANKIEPVFVEQIEDMPQAILDAAQDGDVVITMGAGSIGQVPGQVVALQAQARTANVVDLNGG
AAA
>Mature_483_residues
MKHIVKNIHFVGIGGAGMSGIAEVLLNLGYRVTGSDLGSSATTQRLATLGATIMQGHAPEHVIGANAVVVSTAVRGDNPE
VLAARAKRIPIVPRAVMLAELMRLKQGIAIAGTHGKTTTTSLVASVLAEGGLDPTFVIGGRLNSAGANARLGTGDFIVAE
ADESDASFLNLFPVIEVITNIDADHMDTYGHDFARLKQAFIEFTQRLPFYGIAVLCVDDPNVREILPFVSKPVVRYGFAE
DAQVRAVNARAVDGRMEFTVIRQLNGHAEPPLSITLNLPGLHNVQNALAAIAIATELEVPDEAIVKALAEFNGVGRRFQR
YGEVPTADGKGHFTLIDDYGHHPVEMAATLAAARGAFPDRRLVLSFQPHRFTRTRDCFEDFVKVLGTVDALLLAEVYAAG
EPPIIAADGRALTRALRVANKIEPVFVEQIEDMPQAILDAAQDGDVVITMGAGSIGQVPGQVVALQAQARTANVVDLNGG
AAA

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=470, Percent_Identity=53.4042553191489, Blast_Score=446, Evalue=1e-126,
Organism=Escherichia coli, GI1790680, Length=466, Percent_Identity=29.3991416309013, Blast_Score=149, Evalue=3e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_RALPJ (B2UCX6)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001900643.1
- ProteinModelPortal:   B2UCX6
- SMR:   B2UCX6
- GeneID:   6286115
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_3088
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 51204; Mature: 51204

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHIVKNIHFVGIGGAGMSGIAEVLLNLGYRVTGSDLGSSATTQRLATLGATIMQGHAPE
CCCHHCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCC
HVIGANAVVVSTAVRGDNPEVLAARAKRIPIVPRAVMLAELMRLKQGIAIAGTHGKTTTT
CEECCCEEEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHH
SLVASVLAEGGLDPTFVIGGRLNSAGANARLGTGDFIVAEADESDASFLNLFPVIEVITN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHC
IDADHMDTYGHDFARLKQAFIEFTQRLPFYGIAVLCVDDPNVREILPFVSKPVVRYGFAE
CCCHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHCCHHHCCCCC
DAQVRAVNARAVDGRMEFTVIRQLNGHAEPPLSITLNLPGLHNVQNALAAIAIATELEVP
CCEEEEEEEEEECCCEEEEEEEHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
DEAIVKALAEFNGVGRRFQRYGEVPTADGKGHFTLIDDYGHHPVEMAATLAAARGAFPDR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCC
RLVLSFQPHRFTRTRDCFEDFVKVLGTVDALLLAEVYAAGEPPIIAADGRALTRALRVAN
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHH
KIEPVFVEQIEDMPQAILDAAQDGDVVITMGAGSIGQVPGQVVALQAQARTANVVDLNGG
CCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEEECCCCCEEEECCCC
AAA
CCC
>Mature Secondary Structure
MKHIVKNIHFVGIGGAGMSGIAEVLLNLGYRVTGSDLGSSATTQRLATLGATIMQGHAPE
CCCHHCCEEEEEECCCCHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHCCCCCC
HVIGANAVVVSTAVRGDNPEVLAARAKRIPIVPRAVMLAELMRLKQGIAIAGTHGKTTTT
CEECCCEEEEEEEECCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCHHH
SLVASVLAEGGLDPTFVIGGRLNSAGANARLGTGDFIVAEADESDASFLNLFPVIEVITN
HHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHC
IDADHMDTYGHDFARLKQAFIEFTQRLPFYGIAVLCVDDPNVREILPFVSKPVVRYGFAE
CCCHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHCCHHHCCCCC
DAQVRAVNARAVDGRMEFTVIRQLNGHAEPPLSITLNLPGLHNVQNALAAIAIATELEVP
CCEEEEEEEEEECCCEEEEEEEHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCC
DEAIVKALAEFNGVGRRFQRYGEVPTADGKGHFTLIDDYGHHPVEMAATLAAARGAFPDR
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCC
RLVLSFQPHRFTRTRDCFEDFVKVLGTVDALLLAEVYAAGEPPIIAADGRALTRALRVAN
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHH
KIEPVFVEQIEDMPQAILDAAQDGDVVITMGAGSIGQVPGQVVALQAQARTANVVDLNGG
CCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCEEEEEEECCCCCEEEECCCC
AAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA