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The map label for this gene is mutT [H]

Identifier: 187930144

GI number: 187930144

Start: 3210240

End: 3210689

Strand: Reverse

Name: mutT [H]

Synonym: Rpic_3076

Alternate gene names: 187930144

Gene position: 3210689-3210240 (Counterclockwise)

Preceding gene: 187930145

Following gene: 187930135

Centisome position: 81.44

GC content: 63.78

Gene sequence:

>450_bases
ATGTCGACTGACAACCTGACGCAAGTGCCCCCGACGCACACGCCGGACGGCCGCAAGATCACCGAAGTGGCCGTTGGCGT
GCTCGTGCAGCCCGACGGCAAGTTCTTGCTAGCCCAGCGTCCGGAAGGCAAGCCTTACGCGGGCTACTGGGAATTCCCGG
GCGGCAAGCTTGAAGCGGGCGAATCGGTCGAGGCTGCGCTCATGCGTGAGTTGAAGGAAGAGCTGGACGTCACGCTGCGC
ACCTGCGTTCCCTGGCACACCATCGAGCACGACTACCCGCACGCGTACGTGCGCCTGCACTTCTGCAAGGTCACTGCCTG
GGACGGCACGTTGCGCGCACTGGAAGGCCAGGATTTCGCTTGGCAGACGCTGCCGATCAGCGTCCATCCGGTGCTGCCGG
CAACGTTGCCCGTGTTCGAATGGATGCGCGAGGAAACGACGGTTAGTTGA

Upstream 100 bases:

>100_bases
CGTGGCGACGCGTTGGTATGGGCGCTGGAGCGCGGTTCGCGTTCGGGCCGCGTGGCATGGCAATTCGCCCGCGACTGGGG
TGGCAAGCATGGGCGGCACC

Downstream 100 bases:

>100_bases
GCTTGCCGCTCGTATCGTTGCCCGGTGCGTCGGGCAGGTCGTCTTCTTCGACCACGGGGATGGTGTACTGCTCGGCTGCC
CACGCGCCCAGGTCGATCTG

Product: NUDIX hydrolase

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 149; Mature: 148

Protein sequence:

>149_residues
MSTDNLTQVPPTHTPDGRKITEVAVGVLVQPDGKFLLAQRPEGKPYAGYWEFPGGKLEAGESVEAALMRELKEELDVTLR
TCVPWHTIEHDYPHAYVRLHFCKVTAWDGTLRALEGQDFAWQTLPISVHPVLPATLPVFEWMREETTVS

Sequences:

>Translated_149_residues
MSTDNLTQVPPTHTPDGRKITEVAVGVLVQPDGKFLLAQRPEGKPYAGYWEFPGGKLEAGESVEAALMRELKEELDVTLR
TCVPWHTIEHDYPHAYVRLHFCKVTAWDGTLRALEGQDFAWQTLPISVHPVLPATLPVFEWMREETTVS
>Mature_148_residues
STDNLTQVPPTHTPDGRKITEVAVGVLVQPDGKFLLAQRPEGKPYAGYWEFPGGKLEAGESVEAALMRELKEELDVTLRT
CVPWHTIEHDYPHAYVRLHFCKVTAWDGTLRALEGQDFAWQTLPISVHPVLPATLPVFEWMREETTVS

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788056, Length=123, Percent_Identity=38.2113821138211, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1786288, Length=122, Percent_Identity=31.9672131147541, Blast_Score=69, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 16794; Mature: 16663

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTDNLTQVPPTHTPDGRKITEVAVGVLVQPDGKFLLAQRPEGKPYAGYWEFPGGKLEAG
CCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCEEEEECCCCCCCCCEEECCCCCCCCC
ESVEAALMRELKEELDVTLRTCVPWHTIEHDYPHAYVRLHFCKVTAWDGTLRALEGQDFA
CHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCEEEEEEEEEEEEECCCEEEEECCCCCE
WQTLPISVHPVLPATLPVFEWMREETTVS
EEEECEEECCCCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
STDNLTQVPPTHTPDGRKITEVAVGVLVQPDGKFLLAQRPEGKPYAGYWEFPGGKLEAG
CCCCCCCCCCCCCCCCCEEEEEEEEEEECCCCCEEEEECCCCCCCCCEEECCCCCCCCC
ESVEAALMRELKEELDVTLRTCVPWHTIEHDYPHAYVRLHFCKVTAWDGTLRALEGQDFA
CHHHHHHHHHHHHHHCEEEECCCCCCCCCCCCCEEEEEEEEEEEEECCCEEEEECCCCCE
WQTLPISVHPVLPATLPVFEWMREETTVS
EEEECEEECCCCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe; Mn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8244038 [H]