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The map label for this gene is pepA [H]

Identifier: 187929750

GI number: 187929750

Start: 2790904

End: 2792412

Strand: Reverse

Name: pepA [H]

Synonym: Rpic_2679

Alternate gene names: 187929750

Gene position: 2792412-2790904 (Counterclockwise)

Preceding gene: 187929754

Following gene: 187929749

Centisome position: 70.83

GC content: 66.07

Gene sequence:

>1509_bases
ATGGAATTTAGCACAAAAGCCCTGGACTGGGCCAAAGCGGGCGCCCTGGCTGCCAAGAGCGATTGCCTCGTGATCGGTCT
GTTCGAGTCGCAGACCTTGGCTGGCGCCGCAAAGGCGCTGGACGTGGCCACCAAGGGCCTGGTCGCCCGCCTCGTCAAGC
TGGGCGACTTCGAAGGCAAGCGCGGCACGTCGCTGCTGCTGCACGAAGTGGCCGGCGTGGGCGCTGCCCGCGTGCTGCTG
GTCGGCCTGGGCAAGGAAGCCGACTTTACCGACCGCGCTTACGCTGAAGCCGTGCGCACCGCACTGCGCGCGCTGGCCAG
CACCAAGGCCGCCAGCGTGACATGGACGCTCACCGAGCACACCGCGCGCGACAAGGACACCGCCTGGGCCGTGTTGACCG
CCGTCACGCTTATCCGCGAAGCCAGCTACCGCTTTATCGAGCGCCATCCGGAACTCAAGAGCAAGCGCGACAAGAACGGT
ACCGGTTTGCGCAAGCTCGTGCTGGCCGTGCCGGCTGCCGACGCCAAGACAGCCAGCGTGGCTGCCGCCCGCGGCACCGC
CATCGCCAACGGCATGGACCTCACGCGTGATCTGGGCAACCTGCCGTCCAACATCTGCACGCCGACGTACCTGGCCAACA
CCGCACGCCAGATCGCCAAGGATTTCAAGCTCAAGGTTGAAGTGCTTGGCCGCAAGCAGATCGAAGCCCTAAAGATGGGC
GCCTTCCTGGCCGTGACCAAGGGCAGCGTCGAGCCGCCGGCGTTCATCGTGCTGCGCTACGAGGGAGGTCCGGCCAAGCA
GGCCCCGGTGGTGCTGGTCGGCAAGGGCATCACGTTTGATACGGGTGGCATCTCGCTCAAGCCGGGCGAGGGCATGGACG
AGATGAAGTACGACATGTGCGGCGCCGCTTCGGTGCTGGGCACGTTGCGTGCCGTGGCCGAAATGGGCCTCAAGCAGAAC
GTCATTGCCGTGGTGCCGACCTGCGAGAACATGCCCAGCGGCATCGCCACCAAGCCGGGTGACGTGGTGACCAGCATGTC
GGGCCAGACCATCGAGATCTTGAACACCGACGCCGAAGGCCGCCTGATCCTCTGCGATGCGCTCACCTATGTGGAGCGCT
TCAAGCCGGCCGTGGTGATCGACGTGGCCACGCTCACGGGCGCCTGCATCATTGCCCTGGGCCACATCAACACCGGCATG
TACGCCCGCAGCGATGCACTGGCCGATGCGTTGGTAGCGGCGGGCAAGCAGTCGCTCGATACCGCGTGGCGCATGCCGCT
GGACGAGGAGTACCAGGAACAGCTCAAATCCAACTTTGCGGACATGGGCAACATCGGCGGCCGCCCGGCCGGCAGCGTGA
CGGCAGCCTGCTTCCTGGCGCGCTTTACTGAAAAGTACGACTGGGCCCACCTCGACATCGCCGGTACGGCCTGGAAGAGC
GGTGCAGCCAAGGGCGCCACGGGCCGCCCGGTGCCGTTGCTGACGCGCTTCCTGATGGACCGCGGTTGA

Upstream 100 bases:

>100_bases
GTTGGGACGATGCGTGCCCCATCCAGGTTCCATCGGAGCCCCCGCGCAAAATGGCGGATAATGTGGGCTTTCGTTGACTC
GCCTCATAGAGAGAAGCGCG

Downstream 100 bases:

>100_bases
TCAGCCGGAGGCACTGCACCGTATGACCCGCGTCGATTTCCACAGCAACGTGCCTGGCAAACTGGCGTATGCCTGCCGGC
TCGTGCGCAAGGCCTACGGC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MEFSTKALDWAKAGALAAKSDCLVIGLFESQTLAGAAKALDVATKGLVARLVKLGDFEGKRGTSLLLHEVAGVGAARVLL
VGLGKEADFTDRAYAEAVRTALRALASTKAASVTWTLTEHTARDKDTAWAVLTAVTLIREASYRFIERHPELKSKRDKNG
TGLRKLVLAVPAADAKTASVAAARGTAIANGMDLTRDLGNLPSNICTPTYLANTARQIAKDFKLKVEVLGRKQIEALKMG
AFLAVTKGSVEPPAFIVLRYEGGPAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAASVLGTLRAVAEMGLKQN
VIAVVPTCENMPSGIATKPGDVVTSMSGQTIEILNTDAEGRLILCDALTYVERFKPAVVIDVATLTGACIIALGHINTGM
YARSDALADALVAAGKQSLDTAWRMPLDEEYQEQLKSNFADMGNIGGRPAGSVTAACFLARFTEKYDWAHLDIAGTAWKS
GAAKGATGRPVPLLTRFLMDRG

Sequences:

>Translated_502_residues
MEFSTKALDWAKAGALAAKSDCLVIGLFESQTLAGAAKALDVATKGLVARLVKLGDFEGKRGTSLLLHEVAGVGAARVLL
VGLGKEADFTDRAYAEAVRTALRALASTKAASVTWTLTEHTARDKDTAWAVLTAVTLIREASYRFIERHPELKSKRDKNG
TGLRKLVLAVPAADAKTASVAAARGTAIANGMDLTRDLGNLPSNICTPTYLANTARQIAKDFKLKVEVLGRKQIEALKMG
AFLAVTKGSVEPPAFIVLRYEGGPAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAASVLGTLRAVAEMGLKQN
VIAVVPTCENMPSGIATKPGDVVTSMSGQTIEILNTDAEGRLILCDALTYVERFKPAVVIDVATLTGACIIALGHINTGM
YARSDALADALVAAGKQSLDTAWRMPLDEEYQEQLKSNFADMGNIGGRPAGSVTAACFLARFTEKYDWAHLDIAGTAWKS
GAAKGATGRPVPLLTRFLMDRG
>Mature_502_residues
MEFSTKALDWAKAGALAAKSDCLVIGLFESQTLAGAAKALDVATKGLVARLVKLGDFEGKRGTSLLLHEVAGVGAARVLL
VGLGKEADFTDRAYAEAVRTALRALASTKAASVTWTLTEHTARDKDTAWAVLTAVTLIREASYRFIERHPELKSKRDKNG
TGLRKLVLAVPAADAKTASVAAARGTAIANGMDLTRDLGNLPSNICTPTYLANTARQIAKDFKLKVEVLGRKQIEALKMG
AFLAVTKGSVEPPAFIVLRYEGGPAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAASVLGTLRAVAEMGLKQN
VIAVVPTCENMPSGIATKPGDVVTSMSGQTIEILNTDAEGRLILCDALTYVERFKPAVVIDVATLTGACIIALGHINTGM
YARSDALADALVAAGKQSLDTAWRMPLDEEYQEQLKSNFADMGNIGGRPAGSVTAACFLARFTEKYDWAHLDIAGTAWKS
GAAKGATGRPVPLLTRFLMDRG

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=328, Percent_Identity=46.6463414634146, Blast_Score=273, Evalue=3e-73,
Organism=Homo sapiens, GI47155554, Length=315, Percent_Identity=35.2380952380952, Blast_Score=135, Evalue=7e-32,
Organism=Escherichia coli, GI1790710, Length=505, Percent_Identity=51.8811881188119, Blast_Score=514, Evalue=1e-147,
Organism=Escherichia coli, GI87082123, Length=320, Percent_Identity=40.3125, Blast_Score=196, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17556903, Length=327, Percent_Identity=34.8623853211009, Blast_Score=160, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17565172, Length=350, Percent_Identity=28, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI20129969, Length=496, Percent_Identity=32.258064516129, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI21355725, Length=512, Percent_Identity=31.8359375, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24662227, Length=324, Percent_Identity=36.7283950617284, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24661038, Length=321, Percent_Identity=37.3831775700935, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI161077148, Length=493, Percent_Identity=32.0486815415822, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI20130057, Length=493, Percent_Identity=32.0486815415822, Blast_Score=202, Evalue=4e-52,
Organism=Drosophila melanogaster, GI21355645, Length=324, Percent_Identity=36.4197530864198, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI24662223, Length=324, Percent_Identity=36.4197530864198, Blast_Score=199, Evalue=5e-51,
Organism=Drosophila melanogaster, GI19922386, Length=491, Percent_Identity=31.7718940936864, Blast_Score=188, Evalue=7e-48,
Organism=Drosophila melanogaster, GI20129963, Length=493, Percent_Identity=30.6288032454361, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI21357381, Length=308, Percent_Identity=34.4155844155844, Blast_Score=143, Evalue=2e-34,
Organism=Drosophila melanogaster, GI221379063, Length=308, Percent_Identity=34.4155844155844, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI221379062, Length=308, Percent_Identity=34.4155844155844, Blast_Score=143, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24646701, Length=325, Percent_Identity=28.6153846153846, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24646703, Length=325, Percent_Identity=28.6153846153846, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21358201, Length=325, Percent_Identity=28.6153846153846, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 52988; Mature: 52988

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFSTKALDWAKAGALAAKSDCLVIGLFESQTLAGAAKALDVATKGLVARLVKLGDFEGK
CCCCCCHHHHHHHCCCEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RGTSLLLHEVAGVGAARVLLVGLGKEADFTDRAYAEAVRTALRALASTKAASVTWTLTEH
CCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
TARDKDTAWAVLTAVTLIREASYRFIERHPELKSKRDKNGTGLRKLVLAVPAADAKTASV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHEEECCCCCCHHHH
AAARGTAIANGMDLTRDLGNLPSNICTPTYLANTARQIAKDFKLKVEVLGRKQIEALKMG
HHHCCCHHCCCCHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHC
AFLAVTKGSVEPPAFIVLRYEGGPAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMC
EEEEEECCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHH
GAASVLGTLRAVAEMGLKQNVIAVVPTCENMPSGIATKPGDVVTSMSGQTIEILNTDAEG
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCC
RLILCDALTYVERFKPAVVIDVATLTGACIIALGHINTGMYARSDALADALVAAGKQSLD
CEEEEHHHHHHHHCCCEEEEEEHHHHCEEEEEEECCCCCCEECHHHHHHHHHHCCCHHHH
TAWRMPLDEEYQEQLKSNFADMGNIGGRPAGSVTAACFLARFTEKYDWAHLDIAGTAWKS
HHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCC
GAAKGATGRPVPLLTRFLMDRG
CCCCCCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MEFSTKALDWAKAGALAAKSDCLVIGLFESQTLAGAAKALDVATKGLVARLVKLGDFEGK
CCCCCCHHHHHHHCCCEECCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
RGTSLLLHEVAGVGAARVLLVGLGKEADFTDRAYAEAVRTALRALASTKAASVTWTLTEH
CCHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECC
TARDKDTAWAVLTAVTLIREASYRFIERHPELKSKRDKNGTGLRKLVLAVPAADAKTASV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCHHHHHHEEECCCCCCHHHH
AAARGTAIANGMDLTRDLGNLPSNICTPTYLANTARQIAKDFKLKVEVLGRKQIEALKMG
HHHCCCHHCCCCHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHC
AFLAVTKGSVEPPAFIVLRYEGGPAKQAPVVLVGKGITFDTGGISLKPGEGMDEMKYDMC
EEEEEECCCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHH
GAASVLGTLRAVAEMGLKQNVIAVVPTCENMPSGIATKPGDVVTSMSGQTIEILNTDAEG
HHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCEECCCCCEEEEEECCCCC
RLILCDALTYVERFKPAVVIDVATLTGACIIALGHINTGMYARSDALADALVAAGKQSLD
CEEEEHHHHHHHHCCCEEEEEEHHHHCEEEEEEECCCCCCEECHHHHHHHHHHCCCHHHH
TAWRMPLDEEYQEQLKSNFADMGNIGGRPAGSVTAACFLARFTEKYDWAHLDIAGTAWKS
HHHCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCC
GAAKGATGRPVPLLTRFLMDRG
CCCCCCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]