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The map label for this gene is ilvR [H]

Identifier: 187929746

GI number: 187929746

Start: 2787229

End: 2788173

Strand: Reverse

Name: ilvR [H]

Synonym: Rpic_2675

Alternate gene names: 187929746

Gene position: 2788173-2787229 (Counterclockwise)

Preceding gene: 187929748

Following gene: 187929745

Centisome position: 70.72

GC content: 68.25

Gene sequence:

>945_bases
ATGGATTTGCGCCAGCTTCGCTATTTCGTGACCGTTGCCGAGGAATTACATTTCGGGCGCGCCGCCGAGCGGCTTTCGAT
GACGCAGCCGCCGCTGTCGCAGCAGATTCGCGCGCTCGAAGACGAATTGGGCGTCACGCTGTTCCATCGCACGCAGCGCT
CCGTGGCGCTGACGGCTGTCGGTGCGCGCTGGCTGGTTGAGGTGCGGCGTGTGCTGGCGGAGGCGAATGCACTGCCCGGG
CTCGCGCAGCGGCTGGCGCGCGGCGAGGTCGGCTCGCTGTCGCTGTCCTTCGTCAGCACCGCCGATTACGGCATCCTGCC
CGCCTTGCTGCGGCACTTTCGCGACGCGCGGCCCGATGTGCAGCTTCTGCTGCGCGAGGCCACCAGCGATGTGCAAATCG
AAGCGCTCCTGGCCGGCGATGTGGATGCCGGCGTCGTGATTGCGCATCACGCCGGCTCCGTGCCGGGCGAGCTGGAATAC
CGCCCGATGGTGCGCGAGCGTCTCGTGCTGGCGGTGCCCGCGTCGCGCGCGGCGCAATGGGGCGTGGCGCCGGGCCAGGC
GATTGCGCTGGCAGATGCAGCGGCCGAACCGCTCATCATCTTCCCGCGCCGGTCCGCGCCCGCGCTGTATGACATCATTA
CCGGCTATCATGCCGCGCACGGCGGCCGGCCCGGAGAATCTGGGGCTGCCACGCGCATCGGCCAGGAAGCCATCCAGATG
CAGACCATCGTCAGCCTGGTCTCCGCCGAGATGGGCGTCGCGCTGGTGCCGGCATCGCTATGCAACCTCCAGCGTACCGG
CGTGGTCTATCTCGAACTCGCCGCGCCAAGCCCGATCATCGAGACCGGGCTGGTGTGGCGACGCGATGCCGCTTCGCCGG
TGCTGCCGTGGTTCGTGTCCAGTGCCGAAGCCGTCGCCAAGCTGCAAGAAGACAACCAAACCTGA

Upstream 100 bases:

>100_bases
TTGTAGTCAACGGCTTGGCGCCCAGCATGCGCTTGGAGAAACGACGCGTCAAATATATTATTAAGCGATTATTGAGTCGA
ATAATGTATCAATCGCTGAT

Downstream 100 bases:

>100_bases
AACCCACAGGATTCATGCTCATCCATCCGCAATTCGACCCCGTCGCCCTGCATCTGGGGCCGCTCGCCATCCGCTGGTAC
GGCCTGATGTATCTGGCGGC

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: Isoleucine biosynthesis transcriptional activator [H]

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MDLRQLRYFVTVAEELHFGRAAERLSMTQPPLSQQIRALEDELGVTLFHRTQRSVALTAVGARWLVEVRRVLAEANALPG
LAQRLARGEVGSLSLSFVSTADYGILPALLRHFRDARPDVQLLLREATSDVQIEALLAGDVDAGVVIAHHAGSVPGELEY
RPMVRERLVLAVPASRAAQWGVAPGQAIALADAAAEPLIIFPRRSAPALYDIITGYHAAHGGRPGESGAATRIGQEAIQM
QTIVSLVSAEMGVALVPASLCNLQRTGVVYLELAAPSPIIETGLVWRRDAASPVLPWFVSSAEAVAKLQEDNQT

Sequences:

>Translated_314_residues
MDLRQLRYFVTVAEELHFGRAAERLSMTQPPLSQQIRALEDELGVTLFHRTQRSVALTAVGARWLVEVRRVLAEANALPG
LAQRLARGEVGSLSLSFVSTADYGILPALLRHFRDARPDVQLLLREATSDVQIEALLAGDVDAGVVIAHHAGSVPGELEY
RPMVRERLVLAVPASRAAQWGVAPGQAIALADAAAEPLIIFPRRSAPALYDIITGYHAAHGGRPGESGAATRIGQEAIQM
QTIVSLVSAEMGVALVPASLCNLQRTGVVYLELAAPSPIIETGLVWRRDAASPVLPWFVSSAEAVAKLQEDNQT
>Mature_314_residues
MDLRQLRYFVTVAEELHFGRAAERLSMTQPPLSQQIRALEDELGVTLFHRTQRSVALTAVGARWLVEVRRVLAEANALPG
LAQRLARGEVGSLSLSFVSTADYGILPALLRHFRDARPDVQLLLREATSDVQIEALLAGDVDAGVVIAHHAGSVPGELEY
RPMVRERLVLAVPASRAAQWGVAPGQAIALADAAAEPLIIFPRRSAPALYDIITGYHAAHGGRPGESGAATRIGQEAIQM
QTIVSLVSAEMGVALVPASLCNLQRTGVVYLELAAPSPIIETGLVWRRDAASPVLPWFVSSAEAVAKLQEDNQT

Specific function: Positively regulates the expression of the ilvD gene while negatively autoregulating its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787879, Length=287, Percent_Identity=38.3275261324042, Blast_Score=171, Evalue=4e-44,
Organism=Escherichia coli, GI1788887, Length=302, Percent_Identity=31.1258278145695, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI2367136, Length=278, Percent_Identity=32.3741007194245, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790399, Length=307, Percent_Identity=30.6188925081433, Blast_Score=117, Evalue=8e-28,
Organism=Escherichia coli, GI145693105, Length=171, Percent_Identity=29.2397660818713, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI157672245, Length=313, Percent_Identity=29.7124600638978, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788748, Length=268, Percent_Identity=27.2388059701493, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1790208, Length=180, Percent_Identity=35, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1789173, Length=160, Percent_Identity=34.375, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1787530, Length=204, Percent_Identity=28.4313725490196, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788297, Length=270, Percent_Identity=27.037037037037, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87081904, Length=213, Percent_Identity=29.5774647887324, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787806, Length=306, Percent_Identity=26.4705882352941, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87082132, Length=210, Percent_Identity=30.4761904761905, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787589, Length=133, Percent_Identity=36.8421052631579, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1786713, Length=88, Percent_Identity=42.0454545454545, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1788296, Length=147, Percent_Identity=30.6122448979592, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33748; Mature: 33748

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLRQLRYFVTVAEELHFGRAAERLSMTQPPLSQQIRALEDELGVTLFHRTQRSVALTAV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCEEEEECCCHHEEEHHH
GARWLVEVRRVLAEANALPGLAQRLARGEVGSLSLSFVSTADYGILPALLRHFRDARPDV
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCHH
QLLLREATSDVQIEALLAGDVDAGVVIAHHAGSVPGELEYRPMVRERLVLAVPASRAAQW
HHHHHHCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCHHHHHCEEEEECCHHHHHC
GVAPGQAIALADAAAEPLIIFPRRSAPALYDIITGYHAAHGGRPGESGAATRIGQEAIQM
CCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
QTIVSLVSAEMGVALVPASLCNLQRTGVVYLELAAPSPIIETGLVWRRDAASPVLPWFVS
HHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHCCEEECCCCCCCHHHHHH
SAEAVAKLQEDNQT
HHHHHHHHHHCCCC
>Mature Secondary Structure
MDLRQLRYFVTVAEELHFGRAAERLSMTQPPLSQQIRALEDELGVTLFHRTQRSVALTAV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCEEEEECCCHHEEEHHH
GARWLVEVRRVLAEANALPGLAQRLARGEVGSLSLSFVSTADYGILPALLRHFRDARPDV
HHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHCCCCHH
QLLLREATSDVQIEALLAGDVDAGVVIAHHAGSVPGELEYRPMVRERLVLAVPASRAAQW
HHHHHHCCCCEEEEEEEECCCCCCEEEEECCCCCCCCCCCCHHHHHCEEEEECCHHHHHC
GVAPGQAIALADAAAEPLIIFPRRSAPALYDIITGYHAAHGGRPGESGAATRIGQEAIQM
CCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
QTIVSLVSAEMGVALVPASLCNLQRTGVVYLELAAPSPIIETGLVWRRDAASPVLPWFVS
HHHHHHHHHHCCHHHHHHHHHCCCCCCEEEEEECCCCCHHHHCCEEECCCCCCCHHHHHH
SAEAVAKLQEDNQT
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8113165; 11259647 [H]