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The map label for this gene is adiA [H]

Identifier: 187929650

GI number: 187929650

Start: 2687339

End: 2689618

Strand: Reverse

Name: adiA [H]

Synonym: Rpic_2578

Alternate gene names: 187929650

Gene position: 2689618-2687339 (Counterclockwise)

Preceding gene: 187929651

Following gene: 187929646

Centisome position: 68.22

GC content: 62.02

Gene sequence:

>2280_bases
ATGAAATTCCGCTTTCCCGTCATCATCATTGACGAGGACTTCCGCTCCGAGAACATCTCCGGGTCGGGCATTCGCGCGCT
GGCCCAGGCCATCGAGCAGGAAGGGATGGAGGTGACCGGCCTCACCAGCTATGGTGACTTGACCTCGTTCGCGCAACAGT
CCAGCCGCGCGTCCACCTTCATCGTCTCGATCGACGACGACGAGTTCATCAATCCGGACAACGACAAGCCGGAACCGGAA
GCCGTCGAAAACCTGCGCGCCTTCGTGGCAGAAGTGCGTCGCCGCAACGCCGACATCCCCATCTTCCTGTACGGCGAAAC
GCGCACCTCGCGCCATCTGCCGAACGACGTGCTGCGCGAGCTGCACGGCTTCATCCACATGTTCGAGGACACGCCCGAGT
TCGTGGCCCGACACATCATTCGTGAAGCGCGCAATTACCTGGATTCGCTGCCGCCGCCGTTCTTCAAGGCGCTGATCGAC
TACGCGCAGGACAGCTCGTATTCGTGGCATTGCCCGGGGCACTCGGGCGGCGTGGCGTTCCTGAAGAGCCCGGTGGGGCA
GGTGTTCCATCAGTTCTTTGGCGAGAACATGCTGCGCGCCGACGTCTGCAACGCCGTGGAAGAACTGGGCCAACTGCTGG
ATCACACGGGTCCCGTGGCCGCGTCTGAGCGCAACGCTGCGCGCATCTTCGGTTCGGACCACATGTTCTTCGTGACCAAC
GGCACGTCGACGTCGAACAAGATGGTGTGGCACGCCAACGTGGCGCCCGGTGACATCGTGGTGGTGGACCGCAACTGCCA
CAAGTCGAATCTGCACGCGATCATGATGACGGGCGCGATCCCCGTGTTCCTGATGCCGACGCGCAACCACTTCGGCATCA
TCGGCCCGATCCCGAAGAGCGAGTTCGAGCCGGAAACGATCGCCAGGAAGATCGCCGACCATCCGTTTGCCAGCAAGGCC
AAGAACAAGAAGCCGCGCATCCTGACCATCACGCAGGGTACGTACGACGGCGTGCTGTACAACGCCGAGATGATCAAGAA
CATGCTGTCGACCGAAATCGACACACTGCACTTTGACGAAGCGTGGCTGCCGCACGCGTCGTTCCACCCGTTCTACGAGA
ACATGCACGCGATCGGCCACGGCCGTCCGCGCAGCAAGGATGCGCTGGTCTATGCCACGCAGAGCACGCACAAGCTGCTG
GCTGGCTTGTCACAGGCCTCGCAGATCCTCGTGCAGGATTCCGAGACGCGCAAGCTCGATACGTATCGCTTCAACGAGGC
GTATCTGATGCACACGTCGACGAGCCCGCAGTACTCGATCATTGCGTCGTGCGACGTCGCGGCCGCGATGATGGAAGCGC
CGGGCGGCACCGCGCTGGTGGAAGAGAGCATTGCCGAAGCGCTGGACTTCCGCCGCGCCATGCGCAAGGTTGAGCACGAA
TACCTGGGCACAAATGGTGGCAACGGCCGCGGCGACGACTGGTGGTTCAAGGTCTGGGGCCCGAACGATCTGTCGGACGA
AGGCATCGAAGAGCGCGAAGCGTGGATGCTCAAGGCCAACGAGCGCTGGCACGGCTTCGGCAACCTGGCCGAAGACTTCA
ACCTGCTCGATCCGATCAAGGCCACCATCATCACCCCGGGCCTGGATGTGGACGGCAAGTTCAGCGATTCCGGCATCCCG
GCCGCCATCGTCACGCGCTACCTGGCCGAGCACGGCATCATCGTCGAGAAGACGGGTCTGTACTCGTTCTTCATCATGTT
CACGATCGGCATCACCAAGGGCCGCTGGAACTCGCTGGTGACGGAGTTGCAGCAGTTCAAGGACGATTACGACAACAACC
AGCCGCTGTGGCGCGTGTTGCCGGAATTCGTGCGCCAGTATCCGCAGTACGAGCGCATCGGCCTGCGCGAACTGTGCGAC
AGCATCCACAGCGTCTATCAGGCCAACGACGTGGCCCGCGTGACGACCGAGATGTACCTGTCGGACATGGAGCCGGCGAT
GATCCCGTCGGACGCTTGGGCCAAGATGGCGCACCGCGAGACCGAGCGTGTAGCGATCGACGATCTGGAAGGCCGCATCA
CCGGCATCCTGCTGACACCGTATCCGCCGGGCATTCCGCTGCTGATCCCGGGCGAGCGCTTCAATAAAACGATCGTGCAG
TACCTGCAGTTCGCTCGCGAGTTCAACAAGCTGTTCCCGGGCTTCGAGACGGATATTCACGGGCTGGTCGAGGAAGAGGT
CGACGGCAGGATGGAGTACTTCGTCGATTGCGTGCGCTGA

Upstream 100 bases:

>100_bases
CACGGTGTGACGCTGCCCAAGACCTAGTTTTTGTAGTCCGTTTCCGCGCGTTCAGGCGTATCCGGAGCGGTGCCTTTAGC
TGCATCCATAAGGAACCACG

Downstream 100 bases:

>100_bases
GTTTCAGTCGCACAAACAAAAACGCCGCGCTGAGTTGATCAGCGCGGCGTTTTTGTTTGAAGCGGCTGCGAATTACTCAG
CCAGCGCAGCCCGTGCAAAC

Product: Lysine decarboxylase

Products: NA

Alternate protein names: ADC [H]

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MKFRFPVIIIDEDFRSENISGSGIRALAQAIEQEGMEVTGLTSYGDLTSFAQQSSRASTFIVSIDDDEFINPDNDKPEPE
AVENLRAFVAEVRRRNADIPIFLYGETRTSRHLPNDVLRELHGFIHMFEDTPEFVARHIIREARNYLDSLPPPFFKALID
YAQDSSYSWHCPGHSGGVAFLKSPVGQVFHQFFGENMLRADVCNAVEELGQLLDHTGPVAASERNAARIFGSDHMFFVTN
GTSTSNKMVWHANVAPGDIVVVDRNCHKSNLHAIMMTGAIPVFLMPTRNHFGIIGPIPKSEFEPETIARKIADHPFASKA
KNKKPRILTITQGTYDGVLYNAEMIKNMLSTEIDTLHFDEAWLPHASFHPFYENMHAIGHGRPRSKDALVYATQSTHKLL
AGLSQASQILVQDSETRKLDTYRFNEAYLMHTSTSPQYSIIASCDVAAAMMEAPGGTALVEESIAEALDFRRAMRKVEHE
YLGTNGGNGRGDDWWFKVWGPNDLSDEGIEEREAWMLKANERWHGFGNLAEDFNLLDPIKATIITPGLDVDGKFSDSGIP
AAIVTRYLAEHGIIVEKTGLYSFFIMFTIGITKGRWNSLVTELQQFKDDYDNNQPLWRVLPEFVRQYPQYERIGLRELCD
SIHSVYQANDVARVTTEMYLSDMEPAMIPSDAWAKMAHRETERVAIDDLEGRITGILLTPYPPGIPLLIPGERFNKTIVQ
YLQFAREFNKLFPGFETDIHGLVEEEVDGRMEYFVDCVR

Sequences:

>Translated_759_residues
MKFRFPVIIIDEDFRSENISGSGIRALAQAIEQEGMEVTGLTSYGDLTSFAQQSSRASTFIVSIDDDEFINPDNDKPEPE
AVENLRAFVAEVRRRNADIPIFLYGETRTSRHLPNDVLRELHGFIHMFEDTPEFVARHIIREARNYLDSLPPPFFKALID
YAQDSSYSWHCPGHSGGVAFLKSPVGQVFHQFFGENMLRADVCNAVEELGQLLDHTGPVAASERNAARIFGSDHMFFVTN
GTSTSNKMVWHANVAPGDIVVVDRNCHKSNLHAIMMTGAIPVFLMPTRNHFGIIGPIPKSEFEPETIARKIADHPFASKA
KNKKPRILTITQGTYDGVLYNAEMIKNMLSTEIDTLHFDEAWLPHASFHPFYENMHAIGHGRPRSKDALVYATQSTHKLL
AGLSQASQILVQDSETRKLDTYRFNEAYLMHTSTSPQYSIIASCDVAAAMMEAPGGTALVEESIAEALDFRRAMRKVEHE
YLGTNGGNGRGDDWWFKVWGPNDLSDEGIEEREAWMLKANERWHGFGNLAEDFNLLDPIKATIITPGLDVDGKFSDSGIP
AAIVTRYLAEHGIIVEKTGLYSFFIMFTIGITKGRWNSLVTELQQFKDDYDNNQPLWRVLPEFVRQYPQYERIGLRELCD
SIHSVYQANDVARVTTEMYLSDMEPAMIPSDAWAKMAHRETERVAIDDLEGRITGILLTPYPPGIPLLIPGERFNKTIVQ
YLQFAREFNKLFPGFETDIHGLVEEEVDGRMEYFVDCVR
>Mature_759_residues
MKFRFPVIIIDEDFRSENISGSGIRALAQAIEQEGMEVTGLTSYGDLTSFAQQSSRASTFIVSIDDDEFINPDNDKPEPE
AVENLRAFVAEVRRRNADIPIFLYGETRTSRHLPNDVLRELHGFIHMFEDTPEFVARHIIREARNYLDSLPPPFFKALID
YAQDSSYSWHCPGHSGGVAFLKSPVGQVFHQFFGENMLRADVCNAVEELGQLLDHTGPVAASERNAARIFGSDHMFFVTN
GTSTSNKMVWHANVAPGDIVVVDRNCHKSNLHAIMMTGAIPVFLMPTRNHFGIIGPIPKSEFEPETIARKIADHPFASKA
KNKKPRILTITQGTYDGVLYNAEMIKNMLSTEIDTLHFDEAWLPHASFHPFYENMHAIGHGRPRSKDALVYATQSTHKLL
AGLSQASQILVQDSETRKLDTYRFNEAYLMHTSTSPQYSIIASCDVAAAMMEAPGGTALVEESIAEALDFRRAMRKVEHE
YLGTNGGNGRGDDWWFKVWGPNDLSDEGIEEREAWMLKANERWHGFGNLAEDFNLLDPIKATIITPGLDVDGKFSDSGIP
AAIVTRYLAEHGIIVEKTGLYSFFIMFTIGITKGRWNSLVTELQQFKDDYDNNQPLWRVLPEFVRQYPQYERIGLRELCD
SIHSVYQANDVARVTTEMYLSDMEPAMIPSDAWAKMAHRETERVAIDDLEGRITGILLTPYPPGIPLLIPGERFNKTIVQ
YLQFAREFNKLFPGFETDIHGLVEEEVDGRMEYFVDCVR

Specific function: ADC can be found in two forms:biodegradative and biosynthetic. The biodegradative form may play a role in regulating pH by consuming proteins [H]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI221142684, Length=775, Percent_Identity=37.4193548387097, Blast_Score=536, Evalue=1e-153,
Organism=Escherichia coli, GI1790573, Length=731, Percent_Identity=38.1668946648427, Blast_Score=517, Evalue=1e-148,
Organism=Escherichia coli, GI1786384, Length=727, Percent_Identity=36.5887207702889, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1786909, Length=673, Percent_Identity=33.2838038632987, Blast_Score=376, Evalue=1e-105,
Organism=Escherichia coli, GI87082193, Length=720, Percent_Identity=32.9166666666667, Blast_Score=366, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.19 [H]

Molecular weight: Translated: 85751; Mature: 85751

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFRFPVIIIDEDFRSENISGSGIRALAQAIEQEGMEVTGLTSYGDLTSFAQQSSRASTF
CCEECCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCEEE
IVSIDDDEFINPDNDKPEPEAVENLRAFVAEVRRRNADIPIFLYGETRTSRHLPNDVLRE
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHH
LHGFIHMFEDTPEFVARHIIREARNYLDSLPPPFFKALIDYAQDSSYSWHCPGHSGGVAF
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCCCHHH
LKSPVGQVFHQFFGENMLRADVCNAVEELGQLLDHTGPVAASERNAARIFGSDHMFFVTN
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCEEEEEEC
GTSTSNKMVWHANVAPGDIVVVDRNCHKSNLHAIMMTGAIPVFLMPTRNHFGIIGPIPKS
CCCCCCEEEEEECCCCCCEEEECCCCCCCCCCEEEEECCCEEEEEECCCCCEEECCCCCC
EFEPETIARKIADHPFASKAKNKKPRILTITQGTYDGVLYNAEMIKNMLSTEIDTLHFDE
CCCHHHHHHHHHCCCCHHHCCCCCCCEEEEECCCCCCEEECHHHHHHHHHHHHCEEECCC
AWLPHASFHPFYENMHAIGHGRPRSKDALVYATQSTHKLLAGLSQASQILVQDSETRKLD
CCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECHHHHHHHHHHHHHHEEEECCCCCCCC
TYRFNEAYLMHTSTSPQYSIIASCDVAAAMMEAPGGTALVEESIAEALDFRRAMRKVEHE
CEEECCEEEEEECCCCCEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YLGTNGGNGRGDDWWFKVWGPNDLSDEGIEEREAWMLKANERWHGFGNLAEDFNLLDPIK
HCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHEEEECCCCCCCCCCHHHHCCCCCCCH
ATIITPGLDVDGKFSDSGIPAAIVTRYLAEHGIIVEKTGLYSFFIMFTIGITKGRWNSLV
HEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCHHHHHH
TELQQFKDDYDNNQPLWRVLPEFVRQYPQYERIGLRELCDSIHSVYQANDVARVTTEMYL
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
SDMEPAMIPSDAWAKMAHRETERVAIDDLEGRITGILLTPYPPGIPLLIPGERFNKTIVQ
HCCCCCCCCCHHHHHHHHHHHHHEEHCCCCCEEEEEEECCCCCCCCEEECCHHHHHHHHH
YLQFAREFNKLFPGFETDIHGLVEEEVDGRMEYFVDCVR
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHCC
>Mature Secondary Structure
MKFRFPVIIIDEDFRSENISGSGIRALAQAIEQEGMEVTGLTSYGDLTSFAQQSSRASTF
CCEECCEEEECCCCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCEEE
IVSIDDDEFINPDNDKPEPEAVENLRAFVAEVRRRNADIPIFLYGETRTSRHLPNDVLRE
EEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCHHHHHH
LHGFIHMFEDTPEFVARHIIREARNYLDSLPPPFFKALIDYAQDSSYSWHCPGHSGGVAF
HHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEEECCCCCCCHHH
LKSPVGQVFHQFFGENMLRADVCNAVEELGQLLDHTGPVAASERNAARIFGSDHMFFVTN
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCEEEEEEC
GTSTSNKMVWHANVAPGDIVVVDRNCHKSNLHAIMMTGAIPVFLMPTRNHFGIIGPIPKS
CCCCCCEEEEEECCCCCCEEEECCCCCCCCCCEEEEECCCEEEEEECCCCCEEECCCCCC
EFEPETIARKIADHPFASKAKNKKPRILTITQGTYDGVLYNAEMIKNMLSTEIDTLHFDE
CCCHHHHHHHHHCCCCHHHCCCCCCCEEEEECCCCCCEEECHHHHHHHHHHHHCEEECCC
AWLPHASFHPFYENMHAIGHGRPRSKDALVYATQSTHKLLAGLSQASQILVQDSETRKLD
CCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEECHHHHHHHHHHHHHHEEEECCCCCCCC
TYRFNEAYLMHTSTSPQYSIIASCDVAAAMMEAPGGTALVEESIAEALDFRRAMRKVEHE
CEEECCEEEEEECCCCCEEEEEEHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
YLGTNGGNGRGDDWWFKVWGPNDLSDEGIEEREAWMLKANERWHGFGNLAEDFNLLDPIK
HCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHEEEECCCCCCCCCCHHHHCCCCCCCH
ATIITPGLDVDGKFSDSGIPAAIVTRYLAEHGIIVEKTGLYSFFIMFTIGITKGRWNSLV
HEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCEEEEECCHHHHHHHHHHHCCCCHHHHHH
TELQQFKDDYDNNQPLWRVLPEFVRQYPQYERIGLRELCDSIHSVYQANDVARVTTEMYL
HHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
SDMEPAMIPSDAWAKMAHRETERVAIDDLEGRITGILLTPYPPGIPLLIPGERFNKTIVQ
HCCCCCCCCCHHHHHHHHHHHHHEEHCCCCCEEEEEEECCCCCCCCEEECCHHHHHHHHH
YLQFAREFNKLFPGFETDIHGLVEEEVDGRMEYFVDCVR
HHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8383109; 7610040; 9278503; 2830169; 4204273 [H]