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The map label for this gene is exaA [H]

Identifier: 187929571

GI number: 187929571

Start: 2606822

End: 2608576

Strand: Reverse

Name: exaA [H]

Synonym: Rpic_2494

Alternate gene names: 187929571

Gene position: 2608576-2606822 (Counterclockwise)

Preceding gene: 187929572

Following gene: 187929570

Centisome position: 66.16

GC content: 62.68

Gene sequence:

>1755_bases
ATGAGGACACTACGAGTGATTGCACTTGCGGCTGCCATGGCGGCTGCAAGTGTTGCCGTGCACGCGGCAACGCCCCCCGT
TACCGATGCCATGATCGAGAACGATGCGAAATCGTCGAACGACGTGCTGACCTGGGGCATGGGTACGCAAGGGCAGCGCT
TCTCGACGCTCACCAAGATCAACACGAAGAATGTCAGCCAGCTTGTACCGGCATGGTCGTTCTCGTTTGGCGGTGAGAAG
CAGCGCGGTCAGGAATCCCAGCCGCTGATCTACAACGGCAAGATGTTCGTCACGGCGTCGTACTCGCGCATCTATGCGAT
CGACCTGAAGACCGGCAAGAAGCTGTGGAAGTACGAGCAGCGTCTGCCGGAGGGCATCATGCCCTGCTGCGACGTCGTCA
ACCGCGGCGCCGCGCTGTACGACAACCTGGTCATCTTCTCCACGCTGGATGCGCAGCTGATCGCGCTCAATCAGGACACC
GGCAAGATCGTCTGGAAAGACAAGATCGAGGACTACGCCGCCGGCTATTCAACGACCGCCGCACCGCTGATCGTGAAGGG
CATGGTGCTGACGGGCGTGTCGGGTGGCGAGTTTGGCGTGGTCGGCCGTGTGGAAGCGCGCGATGCCAAGACCGGCCAGT
TGATCTGGTCGCGTCCGACGGTCGAAGGCCACATGGGCTACAAGTACGACAAGGATGGCAACAAGACCGAGAACGGCATG
ACGGGCACGCTCAACGCGAGCTGGCCCGGCGAGACGTGGAAGACCGGTGGCGCATCGACGTGGCTGGGCGGCACCTACGA
CCCGCAGACCAACCTGGTCTACTTCGGCACCGGCAACCCGGGACCGTGGAACAGCCATCTGCGCAAGGGCGACAACCTGT
ATTCGTCTTCCACGCTGGCCATCGACCCGGACACCGGCAAGATCGTCTGGCACTACCAGAACACCCCGAACGACGGCTGG
GATTTCGACGGCGTGAACGAGTTCGTGACGTTCGACATGGACGGCAAGCGCGTCGGCGGCAAGGCTGACCGCAACGGCTT
CTTCTACGTGAACGATGCGAAAACCGGCAAGCTGCTCAACGCGTTCCCGTTCGTGAAGGTCAACTGGGCCACCAGCATCG
ACCTCAAGACCGGCCGCCCGAACTACGCACCCGACCACCGTCCGGGCGATCCGGCCCAGGCCGCGGGTGAAGAGAAGAAG
GGCAAGTCGGTGTTTGCCGAGCCCGGCTTCCTGGGCGGCAAGAACCAGATGCCGATGGCATACAGCCCGCAAACCGGGCT
GTTCTACGTGCCCGCCAACGAGTGGGGCATGGACATCTGGAACGAACCCGTGAGCTACAAGAAGGGCGCCGCCTACCTGG
GAGCTGGCTTTACCATCAAGCCGCTCAATGAGGATTACATCGGCGCACTGCGCGCGATCAATCCGAAGACGGGCAAGATG
GAATGGCAGATCAAGAACAACGCGCCGCTGTGGGGCGGTGTGATGACGACTGCCGGTGGCCTGGTGTTCTGGGGCACGCC
CGAGGGCTATCTGAAGGCGGCCGATGCCAAGACCGGCAAGGAGCTGTGGCAATTCCAGACTGGCAGCGGCATCGTCGCGC
CGCCCGTCACCTGGGAAGACAACGGCGAGCAGTTCGTGGCCGTGGTGTCGGGCTGGGGTGGTGCAGTGCCGCTGTGGGGC
GGTGAAGTGGCCAAGCGCGTGAACTTCCTGGAGCAGGGCGGTTCGGTTTGGGTGTTCAAGCTGCACAAGAACTGA

Upstream 100 bases:

>100_bases
TTCACGGCGTTTTTCGATGGCACGGGATTTGCCCTGAGTCCGACCGGTGTGACATCACACTGCCGGACCTGGACCATAAA
GAGAGGTAGAGGAGACAAGA

Downstream 100 bases:

>100_bases
CGTGCGTGGTTGAGCGCTGTGCGCCTTTGCGGCGCACAGCCTCTCGCACAGCTTCAAGGAGTTTCAGATCGTGATCATGC
GCAATGGAGTGTTCTCGCTG

Product: PQQ-dependent dehydrogenase

Products: NA

Alternate protein names: QEDH [H]

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MRTLRVIALAAAMAAASVAVHAATPPVTDAMIENDAKSSNDVLTWGMGTQGQRFSTLTKINTKNVSQLVPAWSFSFGGEK
QRGQESQPLIYNGKMFVTASYSRIYAIDLKTGKKLWKYEQRLPEGIMPCCDVVNRGAALYDNLVIFSTLDAQLIALNQDT
GKIVWKDKIEDYAAGYSTTAAPLIVKGMVLTGVSGGEFGVVGRVEARDAKTGQLIWSRPTVEGHMGYKYDKDGNKTENGM
TGTLNASWPGETWKTGGASTWLGGTYDPQTNLVYFGTGNPGPWNSHLRKGDNLYSSSTLAIDPDTGKIVWHYQNTPNDGW
DFDGVNEFVTFDMDGKRVGGKADRNGFFYVNDAKTGKLLNAFPFVKVNWATSIDLKTGRPNYAPDHRPGDPAQAAGEEKK
GKSVFAEPGFLGGKNQMPMAYSPQTGLFYVPANEWGMDIWNEPVSYKKGAAYLGAGFTIKPLNEDYIGALRAINPKTGKM
EWQIKNNAPLWGGVMTTAGGLVFWGTPEGYLKAADAKTGKELWQFQTGSGIVAPPVTWEDNGEQFVAVVSGWGGAVPLWG
GEVAKRVNFLEQGGSVWVFKLHKN

Sequences:

>Translated_584_residues
MRTLRVIALAAAMAAASVAVHAATPPVTDAMIENDAKSSNDVLTWGMGTQGQRFSTLTKINTKNVSQLVPAWSFSFGGEK
QRGQESQPLIYNGKMFVTASYSRIYAIDLKTGKKLWKYEQRLPEGIMPCCDVVNRGAALYDNLVIFSTLDAQLIALNQDT
GKIVWKDKIEDYAAGYSTTAAPLIVKGMVLTGVSGGEFGVVGRVEARDAKTGQLIWSRPTVEGHMGYKYDKDGNKTENGM
TGTLNASWPGETWKTGGASTWLGGTYDPQTNLVYFGTGNPGPWNSHLRKGDNLYSSSTLAIDPDTGKIVWHYQNTPNDGW
DFDGVNEFVTFDMDGKRVGGKADRNGFFYVNDAKTGKLLNAFPFVKVNWATSIDLKTGRPNYAPDHRPGDPAQAAGEEKK
GKSVFAEPGFLGGKNQMPMAYSPQTGLFYVPANEWGMDIWNEPVSYKKGAAYLGAGFTIKPLNEDYIGALRAINPKTGKM
EWQIKNNAPLWGGVMTTAGGLVFWGTPEGYLKAADAKTGKELWQFQTGSGIVAPPVTWEDNGEQFVAVVSGWGGAVPLWG
GEVAKRVNFLEQGGSVWVFKLHKN
>Mature_584_residues
MRTLRVIALAAAMAAASVAVHAATPPVTDAMIENDAKSSNDVLTWGMGTQGQRFSTLTKINTKNVSQLVPAWSFSFGGEK
QRGQESQPLIYNGKMFVTASYSRIYAIDLKTGKKLWKYEQRLPEGIMPCCDVVNRGAALYDNLVIFSTLDAQLIALNQDT
GKIVWKDKIEDYAAGYSTTAAPLIVKGMVLTGVSGGEFGVVGRVEARDAKTGQLIWSRPTVEGHMGYKYDKDGNKTENGM
TGTLNASWPGETWKTGGASTWLGGTYDPQTNLVYFGTGNPGPWNSHLRKGDNLYSSSTLAIDPDTGKIVWHYQNTPNDGW
DFDGVNEFVTFDMDGKRVGGKADRNGFFYVNDAKTGKLLNAFPFVKVNWATSIDLKTGRPNYAPDHRPGDPAQAAGEEKK
GKSVFAEPGFLGGKNQMPMAYSPQTGLFYVPANEWGMDIWNEPVSYKKGAAYLGAGFTIKPLNEDYIGALRAINPKTGKM
EWQIKNNAPLWGGVMTTAGGLVFWGTPEGYLKAADAKTGKELWQFQTGSGIVAPPVTWEDNGEQFVAVVSGWGGAVPLWG
GEVAKRVNFLEQGGSVWVFKLHKN

Specific function: Catalyzes the oxidation of primary alcohols except for methanol that is a very poor substrate [H]

COG id: COG4993

COG function: function code G; Glucose dehydrogenase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial PQQ dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1786316, Length=361, Percent_Identity=25.7617728531856, Blast_Score=104, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019556
- InterPro:   IPR019551
- InterPro:   IPR018391
- InterPro:   IPR017512
- InterPro:   IPR002372
- InterPro:   IPR011047
- InterPro:   IPR001479 [H]

Pfam domain/function: PF01011 PQQ; PF10535 PQQ_C; PF10527 PQQ_N [H]

EC number: =1.1.2.8 [H]

Molecular weight: Translated: 63522; Mature: 63522

Theoretical pI: Translated: 8.73; Mature: 8.73

Prosite motif: PS00364 BACTERIAL_PQQ_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTLRVIALAAAMAAASVAVHAATPPVTDAMIENDAKSSNDVLTWGMGTQGQRFSTLTKI
CCHHHHHHHHHHHHHHHEEEEECCCCHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEEEE
NTKNVSQLVPAWSFSFGGEKQRGQESQPLIYNGKMFVTASYSRIYAIDLKTGKKLWKYEQ
CCCCHHHHCCCEECCCCCCHHCCCCCCCEEECCEEEEEEECCEEEEEEECCCHHHHHHHH
RLPEGIMPCCDVVNRGAALYDNLVIFSTLDAQLIALNQDTGKIVWKDKIEDYAAGYSTTA
HCCCCHHHHHHHHHCCHHHHCCEEEEEECCEEEEEEECCCCEEEECCCHHHHHCCCCCCC
APLIVKGMVLTGVSGGEFGVVGRVEARDAKTGQLIWSRPTVEGHMGYKYDKDGNKTENGM
CHHHEEEEEEECCCCCCEEEEEEEECCCCCCCCEEEECCCCCCCCCEEECCCCCCCCCCE
TGTLNASWPGETWKTGGASTWLGGTYDPQTNLVYFGTGNPGPWNSHLRKGDNLYSSSTLA
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHCCCCCCCCCEEE
IDPDTGKIVWHYQNTPNDGWDFDGVNEFVTFDMDGKRVGGKADRNGFFYVNDAKTGKLLN
ECCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCEEE
AFPFVKVNWATSIDLKTGRPNYAPDHRPGDPAQAAGEEKKGKSVFAEPGFLGGKNQMPMA
CCCEEEEEEEEEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCEEECCCCCCCCCCCCCEE
YSPQTGLFYVPANEWGMDIWNEPVSYKKGAAYLGAGFTIKPLNEDYIGALRAINPKTGKM
ECCCCCEEEEECCCCCCHHCCCCCCCCCCCEEEECCCEEEECCHHHHHHEEECCCCCCCE
EWQIKNNAPLWGGVMTTAGGLVFWGTPEGYLKAADAKTGKELWQFQTGSGIVAPPVTWED
EEEECCCCCEECCHHHHCCCEEEECCCCCEEEECCCCCCHHHHEEECCCCEECCCEEECC
NGEQFVAVVSGWGGAVPLWGGEVAKRVNFLEQGGSVWVFKLHKN
CCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECC
>Mature Secondary Structure
MRTLRVIALAAAMAAASVAVHAATPPVTDAMIENDAKSSNDVLTWGMGTQGQRFSTLTKI
CCHHHHHHHHHHHHHHHEEEEECCCCHHHHHHCCCCCCCCCEEEECCCCCCCCEEEEEEE
NTKNVSQLVPAWSFSFGGEKQRGQESQPLIYNGKMFVTASYSRIYAIDLKTGKKLWKYEQ
CCCCHHHHCCCEECCCCCCHHCCCCCCCEEECCEEEEEEECCEEEEEEECCCHHHHHHHH
RLPEGIMPCCDVVNRGAALYDNLVIFSTLDAQLIALNQDTGKIVWKDKIEDYAAGYSTTA
HCCCCHHHHHHHHHCCHHHHCCEEEEEECCEEEEEEECCCCEEEECCCHHHHHCCCCCCC
APLIVKGMVLTGVSGGEFGVVGRVEARDAKTGQLIWSRPTVEGHMGYKYDKDGNKTENGM
CHHHEEEEEEECCCCCCEEEEEEEECCCCCCCCEEEECCCCCCCCCEEECCCCCCCCCCE
TGTLNASWPGETWKTGGASTWLGGTYDPQTNLVYFGTGNPGPWNSHLRKGDNLYSSSTLA
EEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHCCCCCCCCCEEE
IDPDTGKIVWHYQNTPNDGWDFDGVNEFVTFDMDGKRVGGKADRNGFFYVNDAKTGKLLN
ECCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCCCCCEEE
AFPFVKVNWATSIDLKTGRPNYAPDHRPGDPAQAAGEEKKGKSVFAEPGFLGGKNQMPMA
CCCEEEEEEEEEEEEECCCCCCCCCCCCCCHHHHCCCCCCCCEEECCCCCCCCCCCCCEE
YSPQTGLFYVPANEWGMDIWNEPVSYKKGAAYLGAGFTIKPLNEDYIGALRAINPKTGKM
ECCCCCEEEEECCCCCCHHCCCCCCCCCCCEEEECCCEEEECCHHHHHHEEECCCCCCCE
EWQIKNNAPLWGGVMTTAGGLVFWGTPEGYLKAADAKTGKELWQFQTGSGIVAPPVTWED
EEEECCCCCEECCHHHHCCCEEEECCCCCEEEECCCCCCHHHHEEECCCCEECCCEEECC
NGEQFVAVVSGWGGAVPLWGGEVAKRVNFLEQGGSVWVFKLHKN
CCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9826187; 10984043; 10075429; 10736230 [H]