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The map label for this gene is pcaI [H]

Identifier: 187929538

GI number: 187929538

Start: 2569159

End: 2569854

Strand: Reverse

Name: pcaI [H]

Synonym: Rpic_2459

Alternate gene names: 187929538

Gene position: 2569854-2569159 (Counterclockwise)

Preceding gene: 187929545

Following gene: 187929537

Centisome position: 65.18

GC content: 64.66

Gene sequence:

>696_bases
ATGCACGTGATCAACAAGCTTTGTCCGTCTGTGGAGGCCGCCCTGGCCGATATCCCGGACGGTGCCACCATCATGATCGG
CGGGTTCGGTACCGCCGGCATGCCCTCGGAACTCATCGACGGGCTGATCGCGCATGGCGCGCGTGAGCTGACCATCATCA
ATAACAACGCCGGCAATGGCGAGACGGGCCTGGCCGCACTGCTCAAGGCGCGCCGCGTACGCAAGATCGTCTGCTCGTTC
CCGCGCCAGGCCGATTCGTATGTGTTCGATGCGCTCTACCGTGCCGGCGAGATCGAACTGGAACTGGTGCCGCAAGGCAA
CCTGGCCGAGCGCATCCGCGCCGCAGGTGCCGGCATTGGCGGTTTTTTCTGCCCGACCGCCTACGGTACGCAATTGGCCG
AAGGCAAGGAAACGCGCATCATCGACGGCAAGCCCTACGTGTTCGAGCTGCCGCTGACTGCCGACTACGCTCTCATCAAG
GCCCTGCGCGCTGATCGCTGGGGCAACCTCGTCTATCGCAAGACCGCGCGCAACTTCGGGCCGGTGATGGCGATGGCGGC
CAAGTGCACCATCGCGCAAGTCAGCGAGACGGTGGAGCTAGGCGAGCTGGACCCAGAGCACATCGTCACGCCGGGCATTT
TTGTGAAGCGCGTCGTCCAGCTCGCCGCCGCCCAACCCGCCAAGGAGGCCGCATGA

Upstream 100 bases:

>100_bases
AGACTCGCAGGCCGCTCGGTTGCGGCTCGGCCATGTCCGGCCCCTCGCGATGCTCCGACCCGCGCCAGCCATCGAGAATG
TGCGGCGCCCTTGCCGGAGA

Downstream 100 bases:

>100_bases
GCGCCGAAACTACCGCCAAGATCCAGCGCTGGACGCGCGATCAGATCGCTACGCGTGTGGCGCGCGATATTCCCGATGGT
TCGGTCGTCAACCTGGGCAT

Product: 3-oxoacid CoA-transferase subunit A

Products: NA

Alternate protein names: Beta-ketoadipate:succinyl-CoA transferase subunit A [H]

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MHVINKLCPSVEAALADIPDGATIMIGGFGTAGMPSELIDGLIAHGARELTIINNNAGNGETGLAALLKARRVRKIVCSF
PRQADSYVFDALYRAGEIELELVPQGNLAERIRAAGAGIGGFFCPTAYGTQLAEGKETRIIDGKPYVFELPLTADYALIK
ALRADRWGNLVYRKTARNFGPVMAMAAKCTIAQVSETVELGELDPEHIVTPGIFVKRVVQLAAAQPAKEAA

Sequences:

>Translated_231_residues
MHVINKLCPSVEAALADIPDGATIMIGGFGTAGMPSELIDGLIAHGARELTIINNNAGNGETGLAALLKARRVRKIVCSF
PRQADSYVFDALYRAGEIELELVPQGNLAERIRAAGAGIGGFFCPTAYGTQLAEGKETRIIDGKPYVFELPLTADYALIK
ALRADRWGNLVYRKTARNFGPVMAMAAKCTIAQVSETVELGELDPEHIVTPGIFVKRVVQLAAAQPAKEAA
>Mature_231_residues
MHVINKLCPSVEAALADIPDGATIMIGGFGTAGMPSELIDGLIAHGARELTIINNNAGNGETGLAALLKARRVRKIVCSF
PRQADSYVFDALYRAGEIELELVPQGNLAERIRAAGAGIGGFFCPTAYGTQLAEGKETRIIDGKPYVFELPLTADYALIK
ALRADRWGNLVYRKTARNFGPVMAMAAKCTIAQVSETVELGELDPEHIVTPGIFVKRVVQLAAAQPAKEAA

Specific function: SHORT-CHAIN FATTY ACIDS METABOLISM. [C]

COG id: COG1788

COG function: function code I; Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-oxoacid CoA-transferase subunit A family [H]

Homologues:

Organism=Homo sapiens, GI4557817, Length=225, Percent_Identity=42.2222222222222, Blast_Score=192, Evalue=2e-49,
Organism=Homo sapiens, GI11545841, Length=224, Percent_Identity=43.75, Blast_Score=176, Evalue=2e-44,
Organism=Escherichia coli, GI1788551, Length=204, Percent_Identity=45.5882352941176, Blast_Score=183, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17531517, Length=234, Percent_Identity=42.7350427350427, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI21358325, Length=233, Percent_Identity=40.7725321888412, Blast_Score=176, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24655794, Length=233, Percent_Identity=40.7725321888412, Blast_Score=176, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012792
- InterPro:   IPR004165
- InterPro:   IPR004163 [H]

Pfam domain/function: PF01144 CoA_trans [H]

EC number: =2.8.3.6 [H]

Molecular weight: Translated: 24607; Mature: 24607

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS01273 COA_TRANSF_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHVINKLCPSVEAALADIPDGATIMIGGFGTAGMPSELIDGLIAHGARELTIINNNAGNG
CCCHHHHCCHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCC
ETGLAALLKARRVRKIVCSFPRQADSYVFDALYRAGEIELELVPQGNLAERIRAAGAGIG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCC
GFFCPTAYGTQLAEGKETRIIDGKPYVFELPLTADYALIKALRADRWGNLVYRKTARNFG
CHHCCHHHCCHHCCCCCCEEECCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
PVMAMAAKCTIAQVSETVELGELDPEHIVTPGIFVKRVVQLAAAQPAKEAA
HHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure
MHVINKLCPSVEAALADIPDGATIMIGGFGTAGMPSELIDGLIAHGARELTIINNNAGNG
CCCHHHHCCHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEECCCCCC
ETGLAALLKARRVRKIVCSFPRQADSYVFDALYRAGEIELELVPQGNLAERIRAAGAGIG
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHCCCCC
GFFCPTAYGTQLAEGKETRIIDGKPYVFELPLTADYALIKALRADRWGNLVYRKTARNFG
CHHCCHHHCCHHCCCCCCEEECCCCEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHH
PVMAMAAKCTIAQVSETVELGELDPEHIVTPGIFVKRVVQLAAAQPAKEAA
HHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1624453; 6780551 [H]