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The map label for this gene is pcp1 [H]

Identifier: 187929447

GI number: 187929447

Start: 2462377

End: 2463024

Strand: Reverse

Name: pcp1 [H]

Synonym: Rpic_2368

Alternate gene names: 187929447

Gene position: 2463024-2462377 (Counterclockwise)

Preceding gene: 187929448

Following gene: 187929408

Centisome position: 62.47

GC content: 63.89

Gene sequence:

>648_bases
ATGCCTACCGTCCTCGTCACCGGTTTCGACCCGTTCGAGAACGAACCCATCAATCCGTCGTGGGAAGCCGTGCGCACCCT
CGATGGCCAGGGAATCGCCGGCGCCGAGATCGTCGCGCGACAGTTGCCGACCATCTTCGGCGAATCCAACAAAGTGCTCG
GCAAGTTGCTGCAGACGCTGCAGCCGGAGGTGGTGATTGCCGTGGGGCAGGCTGGCGGCCGAGCCGAGATGGCCATCGAG
CGCATCGCCATCAATGTTGACGACGCACGCATTGCCGACAACGCCGGCAAGCAACCGATCGATATCGCCATCGCAAGTGA
CGGTCCGGCCGCGTATTTTTCAACGCTGCCGATCAAGGCCATCGTGCGCGAACTGCGTGCGGGTGGCGTTCCTGCGTCGG
TCTCGCAGACGGCGGGTACCTTCGTCTGCAACCACGTTTTCTATGGGCTGATGCATGCCATCTCCCGCCACAAGCTGCCC
ACGCGCGGCGGCTTCATCCACATCCCGTATCTGCCGTCGCAGGCCGCCAAGCACCCGGGGCAACCGAGCATGGCGCACGA
CACCATCGTCACCGGTCTGCGCATCGCCATCGAGACAACGCTGCGCACGCTGCACGATGTACGCGAAACCGGCGGCCAGT
TGCACTGA

Upstream 100 bases:

>100_bases
CAAGCGCAGCAAGGCAAACTGACGCCGCAACGCGCTCGGGCATGATGTTCGACGGACGTTTATCATCGTTTTTGTCTTAC
GCAGCAAGCAGGAGAACATC

Downstream 100 bases:

>100_bases
GCCGGCGTGGCGGCACGCGCTCCGGTCAGTCCGTGAAGCGCGTATGCCGTTGCAGTTCGATATGCACCGGCGCGCCCGGC
GCCGCATAGCCTGAAGCGAT

Product: pyrrolidone-carboxylate peptidase

Products: NA

Alternate protein names: 5-oxoprolyl-peptidase 1; Pyroglutamyl-peptidase I 1; PGP-I 1; Pyrase 1 [H]

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MPTVLVTGFDPFENEPINPSWEAVRTLDGQGIAGAEIVARQLPTIFGESNKVLGKLLQTLQPEVVIAVGQAGGRAEMAIE
RIAINVDDARIADNAGKQPIDIAIASDGPAAYFSTLPIKAIVRELRAGGVPASVSQTAGTFVCNHVFYGLMHAISRHKLP
TRGGFIHIPYLPSQAAKHPGQPSMAHDTIVTGLRIAIETTLRTLHDVRETGGQLH

Sequences:

>Translated_215_residues
MPTVLVTGFDPFENEPINPSWEAVRTLDGQGIAGAEIVARQLPTIFGESNKVLGKLLQTLQPEVVIAVGQAGGRAEMAIE
RIAINVDDARIADNAGKQPIDIAIASDGPAAYFSTLPIKAIVRELRAGGVPASVSQTAGTFVCNHVFYGLMHAISRHKLP
TRGGFIHIPYLPSQAAKHPGQPSMAHDTIVTGLRIAIETTLRTLHDVRETGGQLH
>Mature_214_residues
PTVLVTGFDPFENEPINPSWEAVRTLDGQGIAGAEIVARQLPTIFGESNKVLGKLLQTLQPEVVIAVGQAGGRAEMAIER
IAINVDDARIADNAGKQPIDIAIASDGPAAYFSTLPIKAIVRELRAGGVPASVSQTAGTFVCNHVFYGLMHAISRHKLPT
RGGFIHIPYLPSQAAKHPGQPSMAHDTIVTGLRIAIETTLRTLHDVRETGGQLH

Specific function: Removes 5-oxoproline from various penultimate amino acid residues except L-proline [H]

COG id: COG2039

COG function: function code O; Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C15 family [H]

Homologues:

Organism=Homo sapiens, GI8923198, Length=204, Percent_Identity=27.4509803921569, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000816
- InterPro:   IPR016125 [H]

Pfam domain/function: PF01470 Peptidase_C15 [H]

EC number: =3.4.19.3 [H]

Molecular weight: Translated: 22907; Mature: 22775

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS01334 PYRASE_CYS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTVLVTGFDPFENEPINPSWEAVRTLDGQGIAGAEIVARQLPTIFGESNKVLGKLLQTL
CCEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHC
QPEVVIAVGQAGGRAEMAIERIAINVDDARIADNAGKQPIDIAIASDGPAAYFSTLPIKA
CCEEEEEECCCCCHHHHHHHHHEECCCCHHHCCCCCCCCEEEEEECCCCHHHHHHCCHHH
IVRELRAGGVPASVSQTAGTFVCNHVFYGLMHAISRHKLPTRGGFIHIPYLPSQAAKHPG
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCC
QPSMAHDTIVTGLRIAIETTLRTLHDVRETGGQLH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
PTVLVTGFDPFENEPINPSWEAVRTLDGQGIAGAEIVARQLPTIFGESNKVLGKLLQTL
CEEEEECCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHC
QPEVVIAVGQAGGRAEMAIERIAINVDDARIADNAGKQPIDIAIASDGPAAYFSTLPIKA
CCEEEEEECCCCCHHHHHHHHHEECCCCHHHCCCCCCCCEEEEEECCCCHHHHHHCCHHH
IVRELRAGGVPASVSQTAGTFVCNHVFYGLMHAISRHKLPTRGGFIHIPYLPSQAAKHPG
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCC
QPSMAHDTIVTGLRIAIETTLRTLHDVRETGGQLH
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]