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The map label for this gene is gmk [H]

Identifier: 187929355

GI number: 187929355

Start: 2396450

End: 2397115

Strand: Reverse

Name: gmk [H]

Synonym: Rpic_2276

Alternate gene names: 187929355

Gene position: 2397115-2396450 (Counterclockwise)

Preceding gene: 187929356

Following gene: 187929354

Centisome position: 60.8

GC content: 63.06

Gene sequence:

>666_bases
ATGCCATCCTCTCAAGCGCACTCTGCCGTTGATACGCCCATCGAGAATCATTTTCCCGGCAGCCTGTTCATGGTCGTGGC
ACCGTCCGGCGCCGGCAAGTCGACGCTGGTGAATGCGCTGCTGGCGCAGGATTCGTCGATTCGCCTGTCGGTCTCAGCTA
CGACGCGCAAGCCGCGTCCGGGCGAGCAGCACGGCCGCGAGTACAACTTCATGACCGTCGAGGAGTTCAAGGCTTGTCGT
GATCGCGGCGAGTTTCTCGAATGGGCCGAGGTACACGGCAACTACTACGCCACTTCGCGCGTGTGGATCGAAGAACAGAT
GCGCGCCGGCACCGACGTGCTGCTCGAGATCGACTGGCAGGGCGCTCAACAGGTGCATCAGCGTTTTTCCAATGCCGTCG
AAATCTTCATCCTGCCGCCGTCGCTCCCTGCGCTGGAAGAACGTCTGAAGAAGCGCGGTCAGGACGAGCCGAATGTGATC
GTGCGCCGCCTGCTGGCGGCGGGCTCCGAGATGGCGCACGCGCCCGAGGCCGACTACGTGATCATCAACGAAGTGTTCGA
TACCGCATTGGCCGAACTGCGCACCGTGGTGCAGGCCACGCGCCTGCGCTTCGGTGCCCAGAAGGCGCGCCACGGCGAGT
TGTTCGTCGAGCTGGGCATTCACTGA

Upstream 100 bases:

>100_bases
AAGGAACTGGCCGATGCATCGATGGAACTCAAGCTGCTCATCGAGCAGATGCGCGAGCAGGTCCAGAACCTCGAATAACT
TGAAACGATAGAACCAGAAC

Downstream 100 bases:

>100_bases
GCACGCAGCGCAATCACGTTTTCCAGCGCGATTGCGAAAGTGTGGTAGCGCCTGCGCCCAAGAGCTGTCCGAAGGGAGTG
CTGCGCTGCTGCTAAAATAT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MPSSQAHSAVDTPIENHFPGSLFMVVAPSGAGKSTLVNALLAQDSSIRLSVSATTRKPRPGEQHGREYNFMTVEEFKACR
DRGEFLEWAEVHGNYYATSRVWIEEQMRAGTDVLLEIDWQGAQQVHQRFSNAVEIFILPPSLPALEERLKKRGQDEPNVI
VRRLLAAGSEMAHAPEADYVIINEVFDTALAELRTVVQATRLRFGAQKARHGELFVELGIH

Sequences:

>Translated_221_residues
MPSSQAHSAVDTPIENHFPGSLFMVVAPSGAGKSTLVNALLAQDSSIRLSVSATTRKPRPGEQHGREYNFMTVEEFKACR
DRGEFLEWAEVHGNYYATSRVWIEEQMRAGTDVLLEIDWQGAQQVHQRFSNAVEIFILPPSLPALEERLKKRGQDEPNVI
VRRLLAAGSEMAHAPEADYVIINEVFDTALAELRTVVQATRLRFGAQKARHGELFVELGIH
>Mature_220_residues
PSSQAHSAVDTPIENHFPGSLFMVVAPSGAGKSTLVNALLAQDSSIRLSVSATTRKPRPGEQHGREYNFMTVEEFKACRD
RGEFLEWAEVHGNYYATSRVWIEEQMRAGTDVLLEIDWQGAQQVHQRFSNAVEIFILPPSLPALEERLKKRGQDEPNVIV
RRLLAAGSEMAHAPEADYVIINEVFDTALAELRTVVQATRLRFGAQKARHGELFVELGIH

Specific function: Essential for recycling GMP and indirectly, cGMP [H]

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain [H]

Homologues:

Organism=Homo sapiens, GI226874831, Length=175, Percent_Identity=40.5714285714286, Blast_Score=124, Evalue=4e-29,
Organism=Homo sapiens, GI226874833, Length=175, Percent_Identity=40.5714285714286, Blast_Score=124, Evalue=5e-29,
Organism=Homo sapiens, GI4504221, Length=175, Percent_Identity=40.5714285714286, Blast_Score=124, Evalue=5e-29,
Organism=Homo sapiens, GI4505237, Length=178, Percent_Identity=27.5280898876405, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI262118259, Length=178, Percent_Identity=27.5280898876405, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI38570142, Length=178, Percent_Identity=26.9662921348315, Blast_Score=64, Evalue=9e-11,
Organism=Homo sapiens, GI262118255, Length=178, Percent_Identity=27.5280898876405, Blast_Score=64, Evalue=1e-10,
Organism=Homo sapiens, GI21361598, Length=196, Percent_Identity=24.4897959183673, Blast_Score=64, Evalue=1e-10,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=52.7363184079602, Blast_Score=212, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI193203132, Length=190, Percent_Identity=34.7368421052632, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17508835, Length=181, Percent_Identity=34.8066298342541, Blast_Score=104, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6320662, Length=182, Percent_Identity=40.6593406593407, Blast_Score=139, Evalue=3e-34,
Organism=Drosophila melanogaster, GI21356141, Length=179, Percent_Identity=39.6648044692737, Blast_Score=117, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665 [H]

Pfam domain/function: PF00625 Guanylate_kin [H]

EC number: =2.7.4.8 [H]

Molecular weight: Translated: 24691; Mature: 24560

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00856 GUANYLATE_KINASE_1 ; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSSQAHSAVDTPIENHFPGSLFMVVAPSGAGKSTLVNALLAQDSSIRLSVSATTRKPRP
CCCCCCCHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCC
GEQHGREYNFMTVEEFKACRDRGEFLEWAEVHGNYYATSRVWIEEQMRAGTDVLLEIDWQ
CHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCEEEEEECCC
GAQQVHQRFSNAVEIFILPPSLPALEERLKKRGQDEPNVIVRRLLAAGSEMAHAPEADYV
CHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCEE
IINEVFDTALAELRTVVQATRLRFGAQKARHGELFVELGIH
EHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC
>Mature Secondary Structure 
PSSQAHSAVDTPIENHFPGSLFMVVAPSGAGKSTLVNALLAQDSSIRLSVSATTRKPRP
CCCCCCHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCC
GEQHGREYNFMTVEEFKACRDRGEFLEWAEVHGNYYATSRVWIEEQMRAGTDVLLEIDWQ
CHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHCCCEEEEHHHHHHHHHCCCCEEEEEECCC
GAQQVHQRFSNAVEIFILPPSLPALEERLKKRGQDEPNVIVRRLLAAGSEMAHAPEADYV
CHHHHHHHHCCCEEEEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCHHCCCCCCCEE
IINEVFDTALAELRTVVQATRLRFGAQKARHGELFVELGIH
EHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]