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The map label for this gene is maeB [H]

Identifier: 187929342

GI number: 187929342

Start: 2380405

End: 2382726

Strand: Reverse

Name: maeB [H]

Synonym: Rpic_2263

Alternate gene names: 187929342

Gene position: 2382726-2380405 (Counterclockwise)

Preceding gene: 187929343

Following gene: 187929335

Centisome position: 60.44

GC content: 65.03

Gene sequence:

>2322_bases
ATGAACGACAAGCTTCACGACGCCTCGCCGGATTCCCAAGACCAAGGCGCCGAGGCCGAACTGCGCCGCGCAGCGTTTGA
ATATCACCGCGCCCCCACGCGCGGCAAGATTGAGGTTCGCCCGACCAAGGCGCTGATCAACCAGCGTGATCTTTCGCTGG
CGTATTCGCCGGGCGTGGCATATCCGTGTACCGCGATCGAGCAAGACCCGTCGCTGGCGGCGGAGTACACGTCGCGCGGC
AACCTGGTCGGCGTGATCACCAACGGCACCGCGGTGCTGGGTCTGGGCGACATCGGCCCGCTGGCCAGCAAGCCCGTCAT
GGAAGGCAAGGGCTGCCTGTTCAAGAAGTTTGCCGGCGTGGACGTGTTCGATATCGAACTGGCCGAGCGCGATCCGGACA
AGCTCGTTGACATCATCGCCTCGCTGGAGCCGACGCTGGGCGGGATCAACCTCGAAGACATCAAGGCGCCGGAGTGCTTC
TACATCGAGCAGAAGCTGCGTGACCGCCTGAATATTCCCGTTTTCCACGATGACCAGCACGGCACGGCGATCATCTCGTC
GGCTGCCCTGCTCAACGGCCTGAAGGTCGTCGGCAAGGACATCGGCAATGTGAAGGTGGCCGTGTCGGGTGCGGGCGCCG
CGGCCATCGCCTGCCTGGACGTGATGGTCGGCCTGGGCGTCAAGCGCGAGAACGTCTACGTAGTCGACTCCAAGGGCGTG
ATCTACGCCGGCCGCGACGCCAAGATGGAGCCGAACAAGGCGCGCTATGCGCAAGACACGTCGGCCCGTACGCTGGCCGA
CATCGTGCGCGATGCAGACGTGTTCTTGGGTTGCTCGGCCGCCGGCGTGCTGACCGCCGACATGGTCAAGACCATGGCGC
CGAAGCCGATCATCCTGGCGCTGGCCAATCCCGAGCCGGAAATCCGCCCGGAAGTGGCCAAAGCCGCGCGCCCGGACTGC
ATCATCGCTACGGGCCGCTCGGACTACCCGAACCAGGTCAACAACGTGCTGTGCTTCCCGTATATCTTCCGCGGTGCGCT
CGATTGCGGCGCCACCAAGATCACGGAAGAGATGAAGCTGGCATGCGTGAAGGCCATTGCCGAGCTGGCAGAAGCCGAAA
CGAACGATGCCGTGGCGCAGGCTTATGCCGGCCAGGACCTGACCTTCGGCCCGGATTACATCATCCCGAAGCCGTTCGAT
TCGCGCCTGATCGAGAAGATCGCGCCGGCCGTCGCCAAGGCCGCGGAAGAGTCTGGCGTGGCCACGCGCCCGATCAAGGA
TCTGGACGCCTATCGCGCCCAGCTGAGCGACTTCGTGTACCACACGGGCCTGACCATGCGCCCGGTGTTCTCGGCCGCCA
AGGCCAACCCGAAGCGCGTCGTCTACGCCGAAGGTGAAGAAGAGCGCGTGCTGCGCGCGGTGCAGACGGTGGTGGACGAA
GGCCTGGCCAAGCCGATCCTGATCGGCCGTCCGCACGTGATCGAAATGCGCATCCAGAAGGCCGGCCTGCGCCTGAAGCC
GGGGGTGCATTTCGAGCTGGTCGATCCGGAAGACGACCGCCGCTATCACCAGTACCACACCGCTTACCACGAGCTGATGG
GCCGCAACGGCGTGACGCCGGACATGGCGAAGTCGGCGCTGCGCCGTTCGAACACGCTGATCGGTGCACTGCTGGTGCGC
CTGGGTGATGCCGATGCGCTGCTGTGCGGCACGGTTGGCCGCTTCGACGCCCACCTGGAACACGTGCGTGACGTGATCGG
CCTGGCCCCGAATGCCAAGGTGTTCGCCGCCATGAACGGCCTGATGCTGGAGAAGCACACGCTGTTCATCACCGATACGT
TCGTCAACGAGCTGCCGAGCGCAGAAGAGCTGGCCGACATCACCAAGCTGGCGGCAGAAGAAGTGCGCCGTTTCGGCCAG
GAGCCGAAGGTGGCGATGCTGTCGCACTCGATGTTCGGCTCGTCGAAAAACGCATCGGCCCGCCGCATGCGCGCTGCGTA
TGACCTGCTGAAGGTGGAAGCGCCCGACCTGCAGGTGGAAGGCGAGATCCAGGGTGACGCGGCACTGTCGGAAGACATCC
GCCATCATTTCCTGCCGAAGAGCGCGTTCTCGGGTAGCGCAAACCTGCTGGTGATGCCGTCGCTCGACGCCGCCAACATC
GCGTTCAACCTGCTCAAGATCACGGGCGGGCAGGGCGTGACGGTGGGCCCGATCCTGCTGGGCGCGGCCAAGCCGGTGCA
CATCCTGAACCCGTCGGCCACGTCGCGCCGCATCGTCAACATGACGGCGCTGGCGGTGGCAGACGTGTCGGCTACGCGTT
GA

Upstream 100 bases:

>100_bases
TCTCTCTGTTCCCACTGTTTTTTGCCACTTCGTCTCAGGGAGTTTCTGCCTGAGCGCATGTGCGCCTCGTCTGCGGAACT
CCCCATCAGGATGCATTGCT

Downstream 100 bases:

>100_bases
TTGGTTGATCCAACTGTTGGGCCGCTGAAGGTTGGCGGCCCAAAAGAAAACGGCGCCTGGGGAAAGTCCAGGCGCCGTTT
TTCTTTGCTGCCGACTGCTT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 773; Mature: 773

Protein sequence:

>773_residues
MNDKLHDASPDSQDQGAEAELRRAAFEYHRAPTRGKIEVRPTKALINQRDLSLAYSPGVAYPCTAIEQDPSLAAEYTSRG
NLVGVITNGTAVLGLGDIGPLASKPVMEGKGCLFKKFAGVDVFDIELAERDPDKLVDIIASLEPTLGGINLEDIKAPECF
YIEQKLRDRLNIPVFHDDQHGTAIISSAALLNGLKVVGKDIGNVKVAVSGAGAAAIACLDVMVGLGVKRENVYVVDSKGV
IYAGRDAKMEPNKARYAQDTSARTLADIVRDADVFLGCSAAGVLTADMVKTMAPKPIILALANPEPEIRPEVAKAARPDC
IIATGRSDYPNQVNNVLCFPYIFRGALDCGATKITEEMKLACVKAIAELAEAETNDAVAQAYAGQDLTFGPDYIIPKPFD
SRLIEKIAPAVAKAAEESGVATRPIKDLDAYRAQLSDFVYHTGLTMRPVFSAAKANPKRVVYAEGEEERVLRAVQTVVDE
GLAKPILIGRPHVIEMRIQKAGLRLKPGVHFELVDPEDDRRYHQYHTAYHELMGRNGVTPDMAKSALRRSNTLIGALLVR
LGDADALLCGTVGRFDAHLEHVRDVIGLAPNAKVFAAMNGLMLEKHTLFITDTFVNELPSAEELADITKLAAEEVRRFGQ
EPKVAMLSHSMFGSSKNASARRMRAAYDLLKVEAPDLQVEGEIQGDAALSEDIRHHFLPKSAFSGSANLLVMPSLDAANI
AFNLLKITGGQGVTVGPILLGAAKPVHILNPSATSRRIVNMTALAVADVSATR

Sequences:

>Translated_773_residues
MNDKLHDASPDSQDQGAEAELRRAAFEYHRAPTRGKIEVRPTKALINQRDLSLAYSPGVAYPCTAIEQDPSLAAEYTSRG
NLVGVITNGTAVLGLGDIGPLASKPVMEGKGCLFKKFAGVDVFDIELAERDPDKLVDIIASLEPTLGGINLEDIKAPECF
YIEQKLRDRLNIPVFHDDQHGTAIISSAALLNGLKVVGKDIGNVKVAVSGAGAAAIACLDVMVGLGVKRENVYVVDSKGV
IYAGRDAKMEPNKARYAQDTSARTLADIVRDADVFLGCSAAGVLTADMVKTMAPKPIILALANPEPEIRPEVAKAARPDC
IIATGRSDYPNQVNNVLCFPYIFRGALDCGATKITEEMKLACVKAIAELAEAETNDAVAQAYAGQDLTFGPDYIIPKPFD
SRLIEKIAPAVAKAAEESGVATRPIKDLDAYRAQLSDFVYHTGLTMRPVFSAAKANPKRVVYAEGEEERVLRAVQTVVDE
GLAKPILIGRPHVIEMRIQKAGLRLKPGVHFELVDPEDDRRYHQYHTAYHELMGRNGVTPDMAKSALRRSNTLIGALLVR
LGDADALLCGTVGRFDAHLEHVRDVIGLAPNAKVFAAMNGLMLEKHTLFITDTFVNELPSAEELADITKLAAEEVRRFGQ
EPKVAMLSHSMFGSSKNASARRMRAAYDLLKVEAPDLQVEGEIQGDAALSEDIRHHFLPKSAFSGSANLLVMPSLDAANI
AFNLLKITGGQGVTVGPILLGAAKPVHILNPSATSRRIVNMTALAVADVSATR
>Mature_773_residues
MNDKLHDASPDSQDQGAEAELRRAAFEYHRAPTRGKIEVRPTKALINQRDLSLAYSPGVAYPCTAIEQDPSLAAEYTSRG
NLVGVITNGTAVLGLGDIGPLASKPVMEGKGCLFKKFAGVDVFDIELAERDPDKLVDIIASLEPTLGGINLEDIKAPECF
YIEQKLRDRLNIPVFHDDQHGTAIISSAALLNGLKVVGKDIGNVKVAVSGAGAAAIACLDVMVGLGVKRENVYVVDSKGV
IYAGRDAKMEPNKARYAQDTSARTLADIVRDADVFLGCSAAGVLTADMVKTMAPKPIILALANPEPEIRPEVAKAARPDC
IIATGRSDYPNQVNNVLCFPYIFRGALDCGATKITEEMKLACVKAIAELAEAETNDAVAQAYAGQDLTFGPDYIIPKPFD
SRLIEKIAPAVAKAAEESGVATRPIKDLDAYRAQLSDFVYHTGLTMRPVFSAAKANPKRVVYAEGEEERVLRAVQTVVDE
GLAKPILIGRPHVIEMRIQKAGLRLKPGVHFELVDPEDDRRYHQYHTAYHELMGRNGVTPDMAKSALRRSNTLIGALLVR
LGDADALLCGTVGRFDAHLEHVRDVIGLAPNAKVFAAMNGLMLEKHTLFITDTFVNELPSAEELADITKLAAEEVRRFGQ
EPKVAMLSHSMFGSSKNASARRMRAAYDLLKVEAPDLQVEGEIQGDAALSEDIRHHFLPKSAFSGSANLLVMPSLDAANI
AFNLLKITGGQGVTVGPILLGAAKPVHILNPSATSRRIVNMTALAVADVSATR

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=343, Percent_Identity=27.1137026239067, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI62420882, Length=345, Percent_Identity=27.536231884058, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI62420880, Length=345, Percent_Identity=27.536231884058, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI239049447, Length=345, Percent_Identity=27.536231884058, Blast_Score=89, Evalue=2e-17,
Organism=Homo sapiens, GI4505145, Length=359, Percent_Identity=25.9052924791086, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI270265879, Length=318, Percent_Identity=26.4150943396226, Blast_Score=75, Evalue=4e-13,
Organism=Escherichia coli, GI1788806, Length=750, Percent_Identity=63.0666666666667, Blast_Score=971, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=335, Percent_Identity=29.2537313432836, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI1788800, Length=314, Percent_Identity=31.5286624203822, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI87081919, Length=495, Percent_Identity=21.4141414141414, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17537199, Length=359, Percent_Identity=26.1838440111421, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322823, Length=275, Percent_Identity=29.0909090909091, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI21356279, Length=505, Percent_Identity=27.1287128712871, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281362672, Length=482, Percent_Identity=27.1784232365145, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281362674, Length=482, Percent_Identity=27.1784232365145, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24646386, Length=422, Percent_Identity=28.1990521327014, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24646388, Length=422, Percent_Identity=28.1990521327014, Blast_Score=94, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 83184; Mature: 83184

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDKLHDASPDSQDQGAEAELRRAAFEYHRAPTRGKIEVRPTKALINQRDLSLAYSPGVA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCCCCEEEECCCCC
YPCTAIEQDPSLAAEYTSRGNLVGVITNGTAVLGLGDIGPLASKPVMEGKGCLFKKFAGV
CCCCCCCCCCCHHHHHCCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCC
DVFDIELAERDPDKLVDIIASLEPTLGGINLEDIKAPECFYIEQKLRDRLNIPVFHDDQH
EEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEHHHHHHHHCCCCEEECCCC
GTAIISSAALLNGLKVVGKDIGNVKVAVSGAGAAAIACLDVMVGLGVKRENVYVVDSKGV
CHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCE
IYAGRDAKMEPNKARYAQDTSARTLADIVRDADVFLGCSAAGVLTADMVKTMAPKPIILA
EEECCCCCCCCCHHHHCCCCHHHHHHHHHHCCHHEEECCCCHHHHHHHHHHCCCCCEEEE
LANPEPEIRPEVAKAARPDCIIATGRSDYPNQVNNVLCFPYIFRGALDCGATKITEEMKL
ECCCCCCCCHHHHHCCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCHHHHHHHHHH
ACVKAIAELAEAETNDAVAQAYAGQDLTFGPDYIIPKPFDSRLIEKIAPAVAKAAEESGV
HHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
ATRPIKDLDAYRAQLSDFVYHTGLTMRPVFSAAKANPKRVVYAEGEEERVLRAVQTVVDE
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHH
GLAKPILIGRPHVIEMRIQKAGLRLKPGVHFELVDPEDDRRYHQYHTAYHELMGRNGVTP
CCCCCEEECCCCEEEEEEHHCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCH
DMAKSALRRSNTLIGALLVRLGDADALLCGTVGRFDAHLEHVRDVIGLAPNAKVFAAMNG
HHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEHHCC
LMLEKHTLFITDTFVNELPSAEELADITKLAAEEVRRFGQEPKVAMLSHSMFGSSKNASA
EEEECEEEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHCCCCCCCHH
RRMRAAYDLLKVEAPDLQVEGEIQGDAALSEDIRHHFLPKSAFSGSANLLVMPSLDAANI
HHHHHHHHHHEECCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHH
AFNLLKITGGQGVTVGPILLGAAKPVHILNPSATSRRIVNMTALAVADVSATR
EEEEEEEECCCCCEEHHEEECCCCCEEEECCCCCCCEEHEEHHHEEECCCCCC
>Mature Secondary Structure
MNDKLHDASPDSQDQGAEAELRRAAFEYHRAPTRGKIEVRPTKALINQRDLSLAYSPGVA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHHHHCCCCCEEEECCCCC
YPCTAIEQDPSLAAEYTSRGNLVGVITNGTAVLGLGDIGPLASKPVMEGKGCLFKKFAGV
CCCCCCCCCCCHHHHHCCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCC
DVFDIELAERDPDKLVDIIASLEPTLGGINLEDIKAPECFYIEQKLRDRLNIPVFHDDQH
EEEEEEECCCCHHHHHHHHHHCCCCCCCCCHHHCCCCCCEEHHHHHHHHCCCCEEECCCC
GTAIISSAALLNGLKVVGKDIGNVKVAVSGAGAAAIACLDVMVGLGVKRENVYVVDSKGV
CHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCCCCEEEEECCCE
IYAGRDAKMEPNKARYAQDTSARTLADIVRDADVFLGCSAAGVLTADMVKTMAPKPIILA
EEECCCCCCCCCHHHHCCCCHHHHHHHHHHCCHHEEECCCCHHHHHHHHHHCCCCCEEEE
LANPEPEIRPEVAKAARPDCIIATGRSDYPNQVNNVLCFPYIFRGALDCGATKITEEMKL
ECCCCCCCCHHHHHCCCCCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCHHHHHHHHHH
ACVKAIAELAEAETNDAVAQAYAGQDLTFGPDYIIPKPFDSRLIEKIAPAVAKAAEESGV
HHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
ATRPIKDLDAYRAQLSDFVYHTGLTMRPVFSAAKANPKRVVYAEGEEERVLRAVQTVVDE
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHH
GLAKPILIGRPHVIEMRIQKAGLRLKPGVHFELVDPEDDRRYHQYHTAYHELMGRNGVTP
CCCCCEEECCCCEEEEEEHHCCCEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCH
DMAKSALRRSNTLIGALLVRLGDADALLCGTVGRFDAHLEHVRDVIGLAPNAKVFAAMNG
HHHHHHHHHCCHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHCCCCCCEEEEHHCC
LMLEKHTLFITDTFVNELPSAEELADITKLAAEEVRRFGQEPKVAMLSHSMFGSSKNASA
EEEECEEEEEEEHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHCCCCCCCHH
RRMRAAYDLLKVEAPDLQVEGEIQGDAALSEDIRHHFLPKSAFSGSANLLVMPSLDAANI
HHHHHHHHHHEECCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCCHHHH
AFNLLKITGGQGVTVGPILLGAAKPVHILNPSATSRRIVNMTALAVADVSATR
EEEEEEEECCCCCEEHHEEECCCCCEEEECCCCCCCEEHEEHHHEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]