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The map label for this gene is nuoH

Identifier: 187929286

GI number: 187929286

Start: 2316501

End: 2317565

Strand: Reverse

Name: nuoH

Synonym: Rpic_2207

Alternate gene names: 187929286

Gene position: 2317565-2316501 (Counterclockwise)

Preceding gene: 187929287

Following gene: 187929285

Centisome position: 58.78

GC content: 60.19

Gene sequence:

>1065_bases
ATGATCGAGTCGATTACTTCTTTCGGTACCGCCACCTTCGGTGGCTGGTGGCCGCTGGTCTGGACGCTGGTCCGTGCGGT
CTGCATCATTCTGCCGCTGCTGCTGTGCGTGGCTTACCTGATCCTGTGGGAGCGCAAGCTCATCGGCTGGATGCACGTGC
GTCTGGGCCCGAACCGCGTGGGCCCGATGGGCCTGCTGCAGCCGATTGCCGACGTGCTCAAGCTGCTGCTCAAGGAAGTC
ATGGTGCCGAGCGCGGTCAGCCGTGGCATGTACATCATCGCGCCGCTGATGGTGCTGATGCCCGCCGTGGCGATCTGGGC
GGTGATTCCGTTCCAGGCCGAGGCGATGGTGTCGAACATCAACGCTGGCCTGCTGTACGTGATGGCGATCAGCTCGGTGG
GCGTATACGGCGTGATTCTGGCGGGCTGGGCTTCGAACTCGAAGTACGCGTTCCTGGGTGCGATGCGTGCTTCGGCACAA
ATGATTTCGTACGAAATCGCCATGGGCTTCGCGCTCGTGACCGTGCTGATGGTAACGGGCAGCCTGAACCTGTCGGACAT
CGTCAACTCGCAGAACCGCGGTTTCTTTGCAGGTCACGGTATCAACATCCTGTCGTGGAACTGGCTGCCGCTGCTGCCGA
TGTTCGGCGTCTACTTCATCTCGGGTGTAGCTGAAACGAACCGCCATCCGTTTGACGTGGTGGAAGGTGAATCCGAAATC
GTGGCCGGCCACATGATCGAATACTCGGGCATGGCGTTCGCGCTGTTCTTCCTGGCCGAGTACATCAACATGATCGTGAT
CTCGGCGCTGACGGCGACGCTGTTCCTGGGCGGCTGGGCTTCGCCGATCGACGCACCGGTCCTCAACTGGATTCCGGGCT
TCTTCTGGCTGCTGATCAAGGTTTTCCTGCTGCTGTCGGTCTTCATCTGGCTGCGTGCATCGTTCCCGCGTTATCGCTAT
GACCAGATCATGCGTCTGGGCTGGAAGATCTTCATTCCGCTCACTGTGGGCTGGCTTGTCGTCGTCGCCATCTGGTTGGT
GTCGCCGTGGAACATCTGGAAGTAA

Upstream 100 bases:

>100_bases
CCGCTACCGAGGCGTCGGCTCAGCTGGGTGCCATGTTCGGGGCGGTAAGCGTTGAGAAGGTTGAATCGTCCGCGCTGGCG
GCTACGGTGTAAGGGTCAAC

Downstream 100 bases:

>100_bases
CGGGACAATAGGAAGGCACCATGTTGCTTGCCATCAAGGAATTCTTTAACAGCCTGCTCCTGAAGGAACTCTTCAAGGGG
CTGGCTCTGACCGGGCGCTA

Product: NADH dehydrogenase subunit H

Products: NA

Alternate protein names: NADH dehydrogenase I subunit H; NDH-1 subunit H

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MIESITSFGTATFGGWWPLVWTLVRAVCIILPLLLCVAYLILWERKLIGWMHVRLGPNRVGPMGLLQPIADVLKLLLKEV
MVPSAVSRGMYIIAPLMVLMPAVAIWAVIPFQAEAMVSNINAGLLYVMAISSVGVYGVILAGWASNSKYAFLGAMRASAQ
MISYEIAMGFALVTVLMVTGSLNLSDIVNSQNRGFFAGHGINILSWNWLPLLPMFGVYFISGVAETNRHPFDVVEGESEI
VAGHMIEYSGMAFALFFLAEYINMIVISALTATLFLGGWASPIDAPVLNWIPGFFWLLIKVFLLLSVFIWLRASFPRYRY
DQIMRLGWKIFIPLTVGWLVVVAIWLVSPWNIWK

Sequences:

>Translated_354_residues
MIESITSFGTATFGGWWPLVWTLVRAVCIILPLLLCVAYLILWERKLIGWMHVRLGPNRVGPMGLLQPIADVLKLLLKEV
MVPSAVSRGMYIIAPLMVLMPAVAIWAVIPFQAEAMVSNINAGLLYVMAISSVGVYGVILAGWASNSKYAFLGAMRASAQ
MISYEIAMGFALVTVLMVTGSLNLSDIVNSQNRGFFAGHGINILSWNWLPLLPMFGVYFISGVAETNRHPFDVVEGESEI
VAGHMIEYSGMAFALFFLAEYINMIVISALTATLFLGGWASPIDAPVLNWIPGFFWLLIKVFLLLSVFIWLRASFPRYRY
DQIMRLGWKIFIPLTVGWLVVVAIWLVSPWNIWK
>Mature_354_residues
MIESITSFGTATFGGWWPLVWTLVRAVCIILPLLLCVAYLILWERKLIGWMHVRLGPNRVGPMGLLQPIADVLKLLLKEV
MVPSAVSRGMYIIAPLMVLMPAVAIWAVIPFQAEAMVSNINAGLLYVMAISSVGVYGVILAGWASNSKYAFLGAMRASAQ
MISYEIAMGFALVTVLMVTGSLNLSDIVNSQNRGFFAGHGINILSWNWLPLLPMFGVYFISGVAETNRHPFDVVEGESEI
VAGHMIEYSGMAFALFFLAEYINMIVISALTATLFLGGWASPIDAPVLNWIPGFFWLLIKVFLLLSVFIWLRASFPRYRY
DQIMRLGWKIFIPLTVGWLVVVAIWLVSPWNIWK

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1005

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 1 (chain H)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 1 family

Homologues:

Organism=Homo sapiens, GI251831107, Length=313, Percent_Identity=44.408945686901, Blast_Score=252, Evalue=3e-67,
Organism=Escherichia coli, GI1788618, Length=322, Percent_Identity=42.5465838509317, Blast_Score=263, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOH_RALPJ (B2U7Q4)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001899773.1
- GeneID:   6288404
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_2207
- HOGENOM:   HBG727670
- OMA:   FMVEYGS
- ProtClustDB:   PRK06076
- HAMAP:   MF_01350
- InterPro:   IPR023020
- InterPro:   IPR001694
- InterPro:   IPR018086
- PANTHER:   PTHR11432

Pfam domain/function: PF00146 NADHdh

EC number: =1.6.99.5

Molecular weight: Translated: 39443; Mature: 39443

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS00667 COMPLEX1_ND1_1; PS00668 COMPLEX1_ND1_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x171bcecc)-; HASH(0x16a98b60)-; HASH(0x16a90f78)-; HASH(0x16d10ee4)-; HASH(0x1671f6f0)-; HASH(0x16aeb444)-; HASH(0x16654f70)-; HASH(0x16c9c398)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIESITSFGTATFGGWWPLVWTLVRAVCIILPLLLCVAYLILWERKLIGWMHVRLGPNRV
CCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
GPMGLLQPIADVLKLLLKEVMVPSAVSRGMYIIAPLMVLMPAVAIWAVIPFQAEAMVSNI
CCHHHHHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
NAGLLYVMAISSVGVYGVILAGWASNSKYAFLGAMRASAQMISYEIAMGFALVTVLMVTG
CCHHHHHHHHHHCCHHHHHHEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SLNLSDIVNSQNRGFFAGHGINILSWNWLPLLPMFGVYFISGVAETNRHPFDVVEGESEI
CCCHHHHHCCCCCCEEEECCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHH
VAGHMIEYSGMAFALFFLAEYINMIVISALTATLFLGGWASPIDAPVLNWIPGFFWLLIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
VFLLLSVFIWLRASFPRYRYDQIMRLGWKIFIPLTVGWLVVVAIWLVSPWNIWK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEHHHHHHHHHHHHHHHCCCCCCCH
>Mature Secondary Structure
MIESITSFGTATFGGWWPLVWTLVRAVCIILPLLLCVAYLILWERKLIGWMHVRLGPNRV
CCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCC
GPMGLLQPIADVLKLLLKEVMVPSAVSRGMYIIAPLMVLMPAVAIWAVIPFQAEAMVSNI
CCHHHHHHHHHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHC
NAGLLYVMAISSVGVYGVILAGWASNSKYAFLGAMRASAQMISYEIAMGFALVTVLMVTG
CCHHHHHHHHHHCCHHHHHHEECCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SLNLSDIVNSQNRGFFAGHGINILSWNWLPLLPMFGVYFISGVAETNRHPFDVVEGESEI
CCCHHHHHCCCCCCEEEECCCEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHH
VAGHMIEYSGMAFALFFLAEYINMIVISALTATLFLGGWASPIDAPVLNWIPGFFWLLIK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
VFLLLSVFIWLRASFPRYRYDQIMRLGWKIFIPLTVGWLVVVAIWLVSPWNIWK
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEHHHHHHHHHHHHHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA