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The map label for this gene is livM [H]

Identifier: 187929270

GI number: 187929270

Start: 2300311

End: 2301477

Strand: Reverse

Name: livM [H]

Synonym: Rpic_2191

Alternate gene names: 187929270

Gene position: 2301477-2300311 (Counterclockwise)

Preceding gene: 187929271

Following gene: 187929269

Centisome position: 58.38

GC content: 64.44

Gene sequence:

>1167_bases
ATGACGACTCAATTCAAACTCGATATTCCGGCGCGCATGCCGTTGCTGTCGCGGCGCGGGTGGTCCGCGCTGGTGCTGGT
GTCGCTCATCGTGTGTATTGGCGCGCCCGTGTGCGCGTTGCTCGTGCCGGAAGGCAGCCCGCTGCATCTGTCGGCGTATG
CGCTCACGCTCATCGGCAAGATCATGTGCTACGCGCTGGCGGCGCTGGCGCTCGATCTGGTGTGGGGCTACTGCGGCATC
CTCAGCCTCGGCCACGGCGTGTTCTTTGCGCTGGGCGGCTACGCGATGGGCATGTACCTGATGCGTTCCATCGGACGCGA
GGGCGTGTACAAGAGCGATCTGCCCGACTTCATGGTCTTCCTCGACTGGAAAGAGCTGCCCTGGTTCTGGCACGGCACCG
AGCACTTCGCGTGGGCGATGCTGCTGGTGATTCTGGTGCCCGGCGTGCTGGCGTGGCTGTTCGGCTTCTTCGCCTTCCGC
TCACGCGTCAAGGGCGTGTACCTGTCGATCATCACGCAAGCGATGACGTACGCGGCCATGCTGCTGTTCTTCCGCAACGA
GACTGGCTTTGGCGGCAACAATGGCTTTACCGATTTCAAGCGCATCCTCGGATTCCCGATCTCGGCGTTGCCTACGCGCA
CCGTGCTCTTCGTAGCCACGTTCGTCGCGCTGGTGCTGGCGTTCATTGCGTGCCGCGCCATCGTCACGTCCAAGTTCGGC
CGCGTGGTCACGGCCATCCGCGATGCCGAAGCGCGCGTGATGTTCTCCGGCTACAACCCGCTCGGCTACAAGCTGTTCGT
CTGGACGTTCTCGGCGGTGCTGTGCGGCATCGCGGGCGCGCTGTACGTACCGCAGGTCGGCATCATCAACCCGGGCGAGA
TGTCCCCGGGCAATTCCATCGAGATGGCGGTGTGGGTGGCCGTGGGCGGGCGCGGCACGTTGATCGGCCCGATCATCGGC
GCGTTCCTCGTCAACGGGGCCAAGACGTTGCTCACGGCGTGGGTGCCGGAGTACTGGCTGTTCGTGCTCGGTGCGATTTT
TGTGCTGGTGACGCTGTATCTGCCGAACGGCGTGCTGGGGCTGCTGGGCAAGCTGCGGATGAAGCGGCGCACGCCCACGC
AAGCCAAGGCGCATGAAACCGCGACCGTCACCGGAGACCACGCATGA

Upstream 100 bases:

>100_bases
GTGCTGGCGAAGATCATCGTGCTGGTGCTGATCGTGCTGTTCATCCAGAAGCGTCCGCAGGGGCTGTTCGCCCTCAAGGG
CCGCAGCGCCGAGGCCTGAT

Downstream 100 bases:

>100_bases
GCACCTTCACCGAACTCCCCGACCGCGCGGAGACCGGCACCGCCACCGGCATGGGCCATCTGGTCGAGCCGGACACCATC
GACGTCTCGCACGGCGCCAT

Product: urea ABC transporter permease UrtC

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MTTQFKLDIPARMPLLSRRGWSALVLVSLIVCIGAPVCALLVPEGSPLHLSAYALTLIGKIMCYALAALALDLVWGYCGI
LSLGHGVFFALGGYAMGMYLMRSIGREGVYKSDLPDFMVFLDWKELPWFWHGTEHFAWAMLLVILVPGVLAWLFGFFAFR
SRVKGVYLSIITQAMTYAAMLLFFRNETGFGGNNGFTDFKRILGFPISALPTRTVLFVATFVALVLAFIACRAIVTSKFG
RVVTAIRDAEARVMFSGYNPLGYKLFVWTFSAVLCGIAGALYVPQVGIINPGEMSPGNSIEMAVWVAVGGRGTLIGPIIG
AFLVNGAKTLLTAWVPEYWLFVLGAIFVLVTLYLPNGVLGLLGKLRMKRRTPTQAKAHETATVTGDHA

Sequences:

>Translated_388_residues
MTTQFKLDIPARMPLLSRRGWSALVLVSLIVCIGAPVCALLVPEGSPLHLSAYALTLIGKIMCYALAALALDLVWGYCGI
LSLGHGVFFALGGYAMGMYLMRSIGREGVYKSDLPDFMVFLDWKELPWFWHGTEHFAWAMLLVILVPGVLAWLFGFFAFR
SRVKGVYLSIITQAMTYAAMLLFFRNETGFGGNNGFTDFKRILGFPISALPTRTVLFVATFVALVLAFIACRAIVTSKFG
RVVTAIRDAEARVMFSGYNPLGYKLFVWTFSAVLCGIAGALYVPQVGIINPGEMSPGNSIEMAVWVAVGGRGTLIGPIIG
AFLVNGAKTLLTAWVPEYWLFVLGAIFVLVTLYLPNGVLGLLGKLRMKRRTPTQAKAHETATVTGDHA
>Mature_387_residues
TTQFKLDIPARMPLLSRRGWSALVLVSLIVCIGAPVCALLVPEGSPLHLSAYALTLIGKIMCYALAALALDLVWGYCGIL
SLGHGVFFALGGYAMGMYLMRSIGREGVYKSDLPDFMVFLDWKELPWFWHGTEHFAWAMLLVILVPGVLAWLFGFFAFRS
RVKGVYLSIITQAMTYAAMLLFFRNETGFGGNNGFTDFKRILGFPISALPTRTVLFVATFVALVLAFIACRAIVTSKFGR
VVTAIRDAEARVMFSGYNPLGYKLFVWTFSAVLCGIAGALYVPQVGIINPGEMSPGNSIEMAVWVAVGGRGTLIGPIIGA
FLVNGAKTLLTAWVPEYWLFVLGAIFVLVTLYLPNGVLGLLGKLRMKRRTPTQAKAHETATVTGDHA

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=335, Percent_Identity=24.1791044776119, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 42316; Mature: 42185

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQFKLDIPARMPLLSRRGWSALVLVSLIVCIGAPVCALLVPEGSPLHLSAYALTLIGK
CCCEEEECCCCCCCHHHCCCHHHHHHHHHHHHHCCCHHEEECCCCCCCCHHHHHHHHHHH
IMCYALAALALDLVWGYCGILSLGHGVFFALGGYAMGMYLMRSIGREGVYKSDLPDFMVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
LDWKELPWFWHGTEHFAWAMLLVILVPGVLAWLFGFFAFRSRVKGVYLSIITQAMTYAAM
EEHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLFFRNETGFGGNNGFTDFKRILGFPISALPTRTVLFVATFVALVLAFIACRAIVTSKFG
HHHHHCCCCCCCCCCHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVVTAIRDAEARVMFSGYNPLGYKLFVWTFSAVLCGIAGALYVPQVGIINPGEMSPGNSI
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
EMAVWVAVGGRGTLIGPIIGAFLVNGAKTLLTAWVPEYWLFVLGAIFVLVTLYLPNGVLG
EEEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LLGKLRMKRRTPTQAKAHETATVTGDHA
HHHHHHHHCCCCCHHHCCCCCEECCCCC
>Mature Secondary Structure 
TTQFKLDIPARMPLLSRRGWSALVLVSLIVCIGAPVCALLVPEGSPLHLSAYALTLIGK
CCEEEECCCCCCCHHHCCCHHHHHHHHHHHHHCCCHHEEECCCCCCCCHHHHHHHHHHH
IMCYALAALALDLVWGYCGILSLGHGVFFALGGYAMGMYLMRSIGREGVYKSDLPDFMVF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEE
LDWKELPWFWHGTEHFAWAMLLVILVPGVLAWLFGFFAFRSRVKGVYLSIITQAMTYAAM
EEHHHCCCEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLFFRNETGFGGNNGFTDFKRILGFPISALPTRTVLFVATFVALVLAFIACRAIVTSKFG
HHHHHCCCCCCCCCCHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RVVTAIRDAEARVMFSGYNPLGYKLFVWTFSAVLCGIAGALYVPQVGIINPGEMSPGNSI
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCE
EMAVWVAVGGRGTLIGPIIGAFLVNGAKTLLTAWVPEYWLFVLGAIFVLVTLYLPNGVLG
EEEEEEEECCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LLGKLRMKRRTPTQAKAHETATVTGDHA
HHHHHHHHCCCCCHHHCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]