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The map label for this gene is sdhB [H]

Identifier: 187929227

GI number: 187929227

Start: 2260273

End: 2260974

Strand: Reverse

Name: sdhB [H]

Synonym: Rpic_2148

Alternate gene names: 187929227

Gene position: 2260974-2260273 (Counterclockwise)

Preceding gene: 187929228

Following gene: 187929226

Centisome position: 57.35

GC content: 61.4

Gene sequence:

>702_bases
ATGAAGCGTATTTTTGAAGTCTATCGCTACGATCCGGACAAGGACGCAGCGCCCCGCATGCAGACCTACGAGGTTGAACT
TGACGGTCACGAGCGCATGCTGCTCGACGCGCTGGTCAAGCTGAAGAAGCTCGACGAGTCGATCGCGTTCCGTCGTTCGT
GCCGCGAAGGCGTGTGCGGCTCCGACGCCATGAACATCAACGGCAAGAATGGTCTGGCGTGCCTGACCAACATGCGTGAG
CTGCCCGAGAAGATCGTGCTGCGCCCGCTGCCGGGGCTGCCGGTGGTGCGCGACCTGATCGTCGACATGACGCAGTTCTT
CAACCAGTACCACTCGATCAAGCCGTACCTGATCAACGACGAGCCGCCGCCCGAGAAGGAGCGTCTGCAGTCGCCGGAAG
AGCGCGAAGAGCTTGACGGCCTGTACGAGTGCATTCTGTGCGCGAGCTGCTCGACGTCGTGCCCGTCGTTCTGGTGGAAC
CCGGACAAGTTCGTCGGCCCGGCCGGTCTGCTGCAGGCATATCGTTTCATCGCCGACAGCCGCGACCAGGCCACCAGCGA
ACGTCTGGACAATCTGGAAGATCCGTACCGCCTGTTCCGCTGCCACACCATCATGAATTGCGTCGATGTGTGCCCGAAGG
GGCTGAACCCGACCAAGGCCATCGGCAAGATCAAGGAATTGATGGTGCGCCGCGCGGTGTAA

Upstream 100 bases:

>100_bases
AACCGCCTGGACTACAAGCCCGTGCAGTTGAAGCCGCTGTCGGTGGAATCGGTGCCGCCCAAGGCGCGTACGTTCTAACG
GATAAGAAGGACCCGCAAAA

Downstream 100 bases:

>100_bases
GGCGCGAGTCAGGGCACTTTGGCATTGTGTGTCGCCGGAGCGGTTTCTCCGGCGACACATTTCTAGAAAGTATGGTTGCT
GTGAACACTCCGACGTTCTC

Product: succinate dehydrogenase iron-sulfur subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 233; Mature: 233

Protein sequence:

>233_residues
MKRIFEVYRYDPDKDAAPRMQTYEVELDGHERMLLDALVKLKKLDESIAFRRSCREGVCGSDAMNINGKNGLACLTNMRE
LPEKIVLRPLPGLPVVRDLIVDMTQFFNQYHSIKPYLINDEPPPEKERLQSPEEREELDGLYECILCASCSTSCPSFWWN
PDKFVGPAGLLQAYRFIADSRDQATSERLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTKAIGKIKELMVRRAV

Sequences:

>Translated_233_residues
MKRIFEVYRYDPDKDAAPRMQTYEVELDGHERMLLDALVKLKKLDESIAFRRSCREGVCGSDAMNINGKNGLACLTNMRE
LPEKIVLRPLPGLPVVRDLIVDMTQFFNQYHSIKPYLINDEPPPEKERLQSPEEREELDGLYECILCASCSTSCPSFWWN
PDKFVGPAGLLQAYRFIADSRDQATSERLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTKAIGKIKELMVRRAV
>Mature_233_residues
MKRIFEVYRYDPDKDAAPRMQTYEVELDGHERMLLDALVKLKKLDESIAFRRSCREGVCGSDAMNINGKNGLACLTNMRE
LPEKIVLRPLPGLPVVRDLIVDMTQFFNQYHSIKPYLINDEPPPEKERLQSPEEREELDGLYECILCASCSTSCPSFWWN
PDKFVGPAGLLQAYRFIADSRDQATSERLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTKAIGKIKELMVRRAV

Specific function: Two distinct, membrane-bound, FAD-containing enzymes are responsible for the catalysis of fumarate and succinate interconversion; the fumarate reductase is used in anaerobic growth, and the succinate dehydrogenase is used in aerobic growth [H]

COG id: COG0479

COG function: function code C; Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 4Fe-4S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI115387094, Length=233, Percent_Identity=57.0815450643777, Blast_Score=274, Evalue=5e-74,
Organism=Escherichia coli, GI1786943, Length=236, Percent_Identity=66.5254237288136, Blast_Score=336, Evalue=9e-94,
Organism=Escherichia coli, GI1790596, Length=226, Percent_Identity=37.1681415929204, Blast_Score=153, Evalue=8e-39,
Organism=Caenorhabditis elegans, GI17533915, Length=232, Percent_Identity=52.1551724137931, Blast_Score=256, Evalue=6e-69,
Organism=Saccharomyces cerevisiae, GI6322987, Length=228, Percent_Identity=53.5087719298246, Blast_Score=252, Evalue=3e-68,
Organism=Drosophila melanogaster, GI24643156, Length=232, Percent_Identity=54.3103448275862, Blast_Score=264, Evalue=3e-71,
Organism=Drosophila melanogaster, GI17137106, Length=231, Percent_Identity=54.5454545454545, Blast_Score=264, Evalue=4e-71,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR012285
- InterPro:   IPR009051
- InterPro:   IPR004489 [H]

Pfam domain/function: NA

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 26791; Mature: 26791

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS51085 2FE2S_FER_2 ; PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRIFEVYRYDPDKDAAPRMQTYEVELDGHERMLLDALVKLKKLDESIAFRRSCREGVCG
CHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SDAMNINGKNGLACLTNMRELPEKIVLRPLPGLPVVRDLIVDMTQFFNQYHSIKPYLIND
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECC
EPPPEKERLQSPEEREELDGLYECILCASCSTSCPSFWWNPDKFVGPAGLLQAYRFIADS
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCHHHHHHHHHHHHCC
RDQATSERLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTKAIGKIKELMVRRAV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKRIFEVYRYDPDKDAAPRMQTYEVELDGHERMLLDALVKLKKLDESIAFRRSCREGVCG
CHHHHHHHHCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
SDAMNINGKNGLACLTNMRELPEKIVLRPLPGLPVVRDLIVDMTQFFNQYHSIKPYLIND
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECC
EPPPEKERLQSPEEREELDGLYECILCASCSTSCPSFWWNPDKFVGPAGLLQAYRFIADS
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCHHHHHHHHHHHHCC
RDQATSERLDNLEDPYRLFRCHTIMNCVDVCPKGLNPTKAIGKIKELMVRRAV
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6388571; 8905232; 9278503; 6376123; 9298646 [H]