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The map label for this gene is folP [H]

Identifier: 187929107

GI number: 187929107

Start: 2134901

End: 2135698

Strand: Reverse

Name: folP [H]

Synonym: Rpic_2028

Alternate gene names: 187929107

Gene position: 2135698-2134901 (Counterclockwise)

Preceding gene: 187929108

Following gene: 187929106

Centisome position: 54.17

GC content: 64.41

Gene sequence:

>798_bases
ATGGGCATTCTCAACGTCACGCCCGATTCGTTCTCCGATGGCGGGCGGCACGCCACGCGTGATGCAGCGTTGCGCCACGC
CGAGCAGCTGATCACCGAAGGCGTCGACATGATCGACATCGGTGGAGAGTCGAGCCGGCCGGGCGCCGAGCCGTTGAGCC
TGCAAGCCGAGTTGGACCGGGTGATGCCCATCGTCGAGGCGCTACGCGAATGCGGCAAGCCGCTGTCGATCGATACCTAC
AAGCCCGAGGTGATGCGGGCCACGCTGGATGCGGGCGCCGATTTGATCAACGATATCTGGGGTTTTCGCCGGCCTGGCGC
GATCGAGGCGGTGGCAAAGGGCAACGCGGGCCTGTGTGTCATGCATATGCAGCGCGATCCCGAAACGATGCAGGAAGCGC
CCAGCTATGTAGACCTGATGGGCGAGGTGGAGGCCTTCCTGTGCACGCAGACGGAGGCGCTGATGGCTGCCGGCGTGGCG
GCCGAGCGTGTCTCCCTTGATCCGGGGTTTGGTTTTGGCAAGACGCCGGATCACAACCTCACCATGCTCAATCGCTTGGC
GGAGTTTCAGCGCATCGGTTTGCCGCTGCTCGCCGGTTTGTCGCGCAAATCGACGCTGGGCGCGGTGTTGGGCGGCAAAC
CGCCAGCCGAACGTGTGACCGTCAGTGTGGCGGCAGCGCTACTGGCGGCGGAGCGGGGCGCGTTCATCGTGCGTGTGCAC
GACGTGCAGCCGACCTTGGAGGCAATTCAACTCTGGTGGGCCATGCGTCATGAACGCGTAAATCCGCCAATGGCCTGA

Upstream 100 bases:

>100_bases
ACAGCATTTCCATCGATCTATCTTGTCCGCTTCCATTCCCACCACAACGCACTTCCAGTGCGGACGCTTCCGTTACCCAC
GCGATCGCCGTCCGCTTGTC

Downstream 100 bases:

>100_bases
TAGCCGCCCAAGCCTCACGCGGCTGGGGGTCAAGCGAACAGAGGATTGCCCGGCGATGGCCAGCGCCTTACAAACAAAGA
AAGAAACATTTCTCCAGGAG

Product: dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MGILNVTPDSFSDGGRHATRDAALRHAEQLITEGVDMIDIGGESSRPGAEPLSLQAELDRVMPIVEALRECGKPLSIDTY
KPEVMRATLDAGADLINDIWGFRRPGAIEAVAKGNAGLCVMHMQRDPETMQEAPSYVDLMGEVEAFLCTQTEALMAAGVA
AERVSLDPGFGFGKTPDHNLTMLNRLAEFQRIGLPLLAGLSRKSTLGAVLGGKPPAERVTVSVAAALLAAERGAFIVRVH
DVQPTLEAIQLWWAMRHERVNPPMA

Sequences:

>Translated_265_residues
MGILNVTPDSFSDGGRHATRDAALRHAEQLITEGVDMIDIGGESSRPGAEPLSLQAELDRVMPIVEALRECGKPLSIDTY
KPEVMRATLDAGADLINDIWGFRRPGAIEAVAKGNAGLCVMHMQRDPETMQEAPSYVDLMGEVEAFLCTQTEALMAAGVA
AERVSLDPGFGFGKTPDHNLTMLNRLAEFQRIGLPLLAGLSRKSTLGAVLGGKPPAERVTVSVAAALLAAERGAFIVRVH
DVQPTLEAIQLWWAMRHERVNPPMA
>Mature_264_residues
GILNVTPDSFSDGGRHATRDAALRHAEQLITEGVDMIDIGGESSRPGAEPLSLQAELDRVMPIVEALRECGKPLSIDTYK
PEVMRATLDAGADLINDIWGFRRPGAIEAVAKGNAGLCVMHMQRDPETMQEAPSYVDLMGEVEAFLCTQTEALMAAGVAA
ERVSLDPGFGFGKTPDHNLTMLNRLAEFQRIGLPLLAGLSRKSTLGAVLGGKPPAERVTVSVAAALLAAERGAFIVRVHD
VQPTLEAIQLWWAMRHERVNPPMA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=262, Percent_Identity=49.618320610687, Blast_Score=257, Evalue=6e-70,
Organism=Saccharomyces cerevisiae, GI6324073, Length=309, Percent_Identity=28.1553398058252, Blast_Score=99, Evalue=9e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 28514; Mature: 28383

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS50972 PTERIN_BINDING ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGILNVTPDSFSDGGRHATRDAALRHAEQLITEGVDMIDIGGESSRPGAEPLSLQAELDR
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHH
VMPIVEALRECGKPLSIDTYKPEVMRATLDAGADLINDIWGFRRPGAIEAVAKGNAGLCV
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEECCCCCEEE
MHMQRDPETMQEAPSYVDLMGEVEAFLCTQTEALMAAGVAAERVSLDPGFGFGKTPDHNL
EEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHH
TMLNRLAEFQRIGLPLLAGLSRKSTLGAVLGGKPPAERVTVSVAAALLAAERGAFIVRVH
HHHHHHHHHHHCCHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEEE
DVQPTLEAIQLWWAMRHERVNPPMA
CCCHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
GILNVTPDSFSDGGRHATRDAALRHAEQLITEGVDMIDIGGESSRPGAEPLSLQAELDR
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCHHHHHHHH
VMPIVEALRECGKPLSIDTYKPEVMRATLDAGADLINDIWGFRRPGAIEAVAKGNAGLCV
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHEECCCCCEEE
MHMQRDPETMQEAPSYVDLMGEVEAFLCTQTEALMAAGVAAERVSLDPGFGFGKTPDHNL
EEECCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCHH
TMLNRLAEFQRIGLPLLAGLSRKSTLGAVLGGKPPAERVTVSVAAALLAAERGAFIVRVH
HHHHHHHHHHHCCHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEEEEEE
DVQPTLEAIQLWWAMRHERVNPPMA
CCCHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]