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The map label for this gene is cueR [H]

Identifier: 187929088

GI number: 187929088

Start: 2116144

End: 2116602

Strand: Direct

Name: cueR [H]

Synonym: Rpic_2009

Alternate gene names: 187929088

Gene position: 2116144-2116602 (Clockwise)

Preceding gene: 187929085

Following gene: 187929089

Centisome position: 53.67

GC content: 66.45

Gene sequence:

>459_bases
ATGAAGATTGGTGAACTGGCGCGCCTGAGCGGCGTGGCCGCCTCGCGCATCCGGTTCTATGAAGCCAGCGGCCTGTTGCA
GCCGGCTGAGCGGCAGTCCAATGGCTATCGGGAGTACGCGCCGGAATCCGTCACGCGGCTGCAGATCATCCTGCGCGCGC
AAAGCGCGGGGTTCTCGCTGGAAGAGATTCGCGCCCTCTTGCCCGGACACCAGGGCGCGTGGCCACGCGAAGAACTTCTG
CAGGCGCTGCACAGCAAGGTCGCGGAAATCGGCGTGCTTGAGCAGCGCCTGGCGCAAAACAAGCGCGACTTGCTTGCGCT
CATCCGCGAAGTCGACCACGAGCCCGACGGCGAAGACTGCACCGACCGCGCCCGCCGCATGTTCGACAAGATGAACCTCC
GGCCGCTCGCGCAACCTGCCGCCGAACCGCAGATGCGCCACGCACGAAAGCGCGGCTGA

Upstream 100 bases:

>100_bases
GAAGAGCTTCATGGTGGCATCCGCGTGGGATTTGACATTTGACGAGACCTCAACCCTAAGCTTAAAGTCAACTTGAATGT
CAAGTCTGCGGAGCACGCAC

Downstream 100 bases:

>100_bases
GGCCGCAGCCTATTCCGAGACACGCGCAAACGTGTCGGCGTTGGTCATCACCGGGTGCCTTCGCCGCTTGTGGCCCGGTC
CGACAGAACGTGCCAGACGG

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 152; Mature: 152

Protein sequence:

>152_residues
MKIGELARLSGVAASRIRFYEASGLLQPAERQSNGYREYAPESVTRLQIILRAQSAGFSLEEIRALLPGHQGAWPREELL
QALHSKVAEIGVLEQRLAQNKRDLLALIREVDHEPDGEDCTDRARRMFDKMNLRPLAQPAAEPQMRHARKRG

Sequences:

>Translated_152_residues
MKIGELARLSGVAASRIRFYEASGLLQPAERQSNGYREYAPESVTRLQIILRAQSAGFSLEEIRALLPGHQGAWPREELL
QALHSKVAEIGVLEQRLAQNKRDLLALIREVDHEPDGEDCTDRARRMFDKMNLRPLAQPAAEPQMRHARKRG
>Mature_152_residues
MKIGELARLSGVAASRIRFYEASGLLQPAERQSNGYREYAPESVTRLQIILRAQSAGFSLEEIRALLPGHQGAWPREELL
QALHSKVAEIGVLEQRLAQNKRDLLALIREVDHEPDGEDCTDRARRMFDKMNLRPLAQPAAEPQMRHARKRG

Specific function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=125, Percent_Identity=33.6, Blast_Score=62, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 17206; Mature: 17206

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGELARLSGVAASRIRFYEASGLLQPAERQSNGYREYAPESVTRLQIILRAQSAGFSL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHCHHHHHHHHHHHHHHCCCCCH
EEIRALLPGHQGAWPREELLQALHSKVAEIGVLEQRLAQNKRDLLALIREVDHEPDGEDC
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
TDRARRMFDKMNLRPLAQPAAEPQMRHARKRG
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCC
>Mature Secondary Structure
MKIGELARLSGVAASRIRFYEASGLLQPAERQSNGYREYAPESVTRLQIILRAQSAGFSL
CCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCHHHCHHHHHHHHHHHHHHCCCCCH
EEIRALLPGHQGAWPREELLQALHSKVAEIGVLEQRLAQNKRDLLALIREVDHEPDGEDC
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
TDRARRMFDKMNLRPLAQPAAEPQMRHARKRG
HHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]