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The map label for this gene is dinB [H]

Identifier: 187929043

GI number: 187929043

Start: 2073640

End: 2074713

Strand: Reverse

Name: dinB [H]

Synonym: Rpic_1963

Alternate gene names: 187929043

Gene position: 2074713-2073640 (Counterclockwise)

Preceding gene: 187929044

Following gene: 187929042

Centisome position: 52.62

GC content: 64.53

Gene sequence:

>1074_bases
GTGCGAAAGATCATCCACTGCGACTGCGACTGTTTTTACGCTGCCATCGAAATGCGCGACGATCCGCGCCTCGTTGGCAA
GCCGCTGGCTGTCGGTGGACGGCCGGAGCGGCGCGGCGTGGTCGCGACTTGCAACTACGAAGCGCGCAAGTTCGGCATTC
ATTCGGCGATGCCCATGGCGCAGGCCGTCAAGCGCTGCCCGGACTTGCTGATCGTGCCGCCGTCCATGGAGAAGTACCGC
CAGGTTGCGCGCCAGATCTTCGCCATCTATCACAGCTACACGCCGCTGGTGGAGCCGCTCTCGCTGGACGAGGCATATCT
GGATGTGACCGACAGCCCGATGCTCGCCGGCAGCGGCACCCGCATCGCAGAAGACATCCGCCGCCGCGTGCGCGAAGAGA
TCGGCATTACCGTATCGGCGGGCGTTGCGCCCAACAAGTTCATCGCCAAGATTGCCAGCGACTGGAACAAGCCCGATGGC
CTGTTCGTCGTGCGGCCGGAGCAGATCGACGCGTTTGTTGCGGAGTTGCCGGTGGACCGCCTGTTCGGGGTGGGCAAGGT
GACCGCTGCGAAGCTGCGTCGCCTGGGCGCAGAAACCTGTGGTGACTTGCGCGCCTGGGGCACCGACCGCTTGCAGCAGC
ATTTCGGCGTGTTCGGTTTCCGGCTCCACGACCTTTGCCGAGGCATCGACCATCGGCAGGTGCAACCTTCGCAGATCCGC
AAGTCGGTCAGTGTGGAAGAAACGTACGCCACCGATCTGCGCACGCTCGACGACTGCCAGCGTGAGCTGATCATCCTCGT
CGAGCAGCTTGCCGCCCGCGTCGAGCGTGCGCGCGCAGGCAACATGATCCACAAAACCTACGTCAAGCTGCGTTTTGCCG
ATTTTCGTGGCACGACGGTGGAGTGCATCTCGCCCCAGGTGTCCTTGCCGGTGTTCTCCAAGTTGCTGGCGCAGGGGTTT
GAGCGCCGCGGCATTCCCGTGCGGTTGCTCGGCGTGGGCGTGCGCTTGTACGAGTCCGACGCGCACGCGCGCCAGCAACC
GCTGTTTGCCGAAGACCCGGCCGCCACCAGCTGA

Upstream 100 bases:

>100_bases
TTGCGTGCGCAGCCGGCGGAAGCTGATACGCTTGCGGTCCTCCTGAACGAGCAAGCCCGACACCGACGCAGCTTCCTGCA
GCCGGTTCTGGCCTTGTGCC

Downstream 100 bases:

>100_bases
GGTTGCCCCCTCGACCCGGCAATCGGGTGCGAATTGTCCTATTTTCCTGTCTGCACGACGGCGATAGAAGGGCGGAATGT
CGCCTGCGGGTAAAATGCTC

Product: DNA polymerase IV

Products: NA

Alternate protein names: Pol IV [H]

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MRKIIHCDCDCFYAAIEMRDDPRLVGKPLAVGGRPERRGVVATCNYEARKFGIHSAMPMAQAVKRCPDLLIVPPSMEKYR
QVARQIFAIYHSYTPLVEPLSLDEAYLDVTDSPMLAGSGTRIAEDIRRRVREEIGITVSAGVAPNKFIAKIASDWNKPDG
LFVVRPEQIDAFVAELPVDRLFGVGKVTAAKLRRLGAETCGDLRAWGTDRLQQHFGVFGFRLHDLCRGIDHRQVQPSQIR
KSVSVEETYATDLRTLDDCQRELIILVEQLAARVERARAGNMIHKTYVKLRFADFRGTTVECISPQVSLPVFSKLLAQGF
ERRGIPVRLLGVGVRLYESDAHARQQPLFAEDPAATS

Sequences:

>Translated_357_residues
MRKIIHCDCDCFYAAIEMRDDPRLVGKPLAVGGRPERRGVVATCNYEARKFGIHSAMPMAQAVKRCPDLLIVPPSMEKYR
QVARQIFAIYHSYTPLVEPLSLDEAYLDVTDSPMLAGSGTRIAEDIRRRVREEIGITVSAGVAPNKFIAKIASDWNKPDG
LFVVRPEQIDAFVAELPVDRLFGVGKVTAAKLRRLGAETCGDLRAWGTDRLQQHFGVFGFRLHDLCRGIDHRQVQPSQIR
KSVSVEETYATDLRTLDDCQRELIILVEQLAARVERARAGNMIHKTYVKLRFADFRGTTVECISPQVSLPVFSKLLAQGF
ERRGIPVRLLGVGVRLYESDAHARQQPLFAEDPAATS
>Mature_357_residues
MRKIIHCDCDCFYAAIEMRDDPRLVGKPLAVGGRPERRGVVATCNYEARKFGIHSAMPMAQAVKRCPDLLIVPPSMEKYR
QVARQIFAIYHSYTPLVEPLSLDEAYLDVTDSPMLAGSGTRIAEDIRRRVREEIGITVSAGVAPNKFIAKIASDWNKPDG
LFVVRPEQIDAFVAELPVDRLFGVGKVTAAKLRRLGAETCGDLRAWGTDRLQQHFGVFGFRLHDLCRGIDHRQVQPSQIR
KSVSVEETYATDLRTLDDCQRELIILVEQLAARVERARAGNMIHKTYVKLRFADFRGTTVECISPQVSLPVFSKLLAQGF
ERRGIPVRLLGVGVRLYESDAHARQQPLFAEDPAATS

Specific function: Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits

COG id: COG0389

COG function: function code L; Nucleotidyltransferase/DNA polymerase involved in DNA repair

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 umuC domain [H]

Homologues:

Organism=Homo sapiens, GI84043967, Length=327, Percent_Identity=30.5810397553517, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI7706681, Length=328, Percent_Identity=30.4878048780488, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI154350220, Length=285, Percent_Identity=29.8245614035088, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI7705344, Length=107, Percent_Identity=48.5981308411215, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI5729982, Length=185, Percent_Identity=31.8918918918919, Blast_Score=94, Evalue=2e-19,
Organism=Escherichia coli, GI1786425, Length=340, Percent_Identity=45.8823529411765, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI1787432, Length=220, Percent_Identity=28.6363636363636, Blast_Score=82, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17537959, Length=284, Percent_Identity=29.5774647887324, Blast_Score=119, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193205700, Length=110, Percent_Identity=42.7272727272727, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI193205702, Length=240, Percent_Identity=28.75, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI115534089, Length=124, Percent_Identity=35.4838709677419, Blast_Score=78, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6324921, Length=289, Percent_Identity=24.2214532871972, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI19923006, Length=335, Percent_Identity=29.8507462686567, Blast_Score=147, Evalue=8e-36,
Organism=Drosophila melanogaster, GI21355641, Length=284, Percent_Identity=32.7464788732394, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24644984, Length=284, Percent_Identity=32.7464788732394, Blast_Score=137, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24668444, Length=119, Percent_Identity=33.6134453781513, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017962
- InterPro:   IPR017961
- InterPro:   IPR001126
- InterPro:   IPR017963
- InterPro:   IPR022880 [H]

Pfam domain/function: PF00817 IMS [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 39988; Mature: 39988

Theoretical pI: Translated: 8.78; Mature: 8.78

Prosite motif: PS50173 UMUC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKIIHCDCDCFYAAIEMRDDPRLVGKPLAVGGRPERRGVVATCNYEARKFGIHSAMPMA
CCCEEEECCHHEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHCCHHCCHHH
QAVKRCPDLLIVPPSMEKYRQVARQIFAIYHSYTPLVEPLSLDEAYLDVTDSPMLAGSGT
HHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCC
RIAEDIRRRVREEIGITVSAGVAPNKFIAKIASDWNKPDGLFVVRPEQIDAFVAELPVDR
HHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHCCHHH
LFGVGKVTAAKLRRLGAETCGDLRAWGTDRLQQHFGVFGFRLHDLCRGIDHRQVQPSQIR
HHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHH
KSVSVEETYATDLRTLDDCQRELIILVEQLAARVERARAGNMIHKTYVKLRFADFRGTTV
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEEEEEECCCCCEE
ECISPQVSLPVFSKLLAQGFERRGIPVRLLGVGVRLYESDAHARQQPLFAEDPAATS
EECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECEEEEECCCHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MRKIIHCDCDCFYAAIEMRDDPRLVGKPLAVGGRPERRGVVATCNYEARKFGIHSAMPMA
CCCEEEECCHHEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHCCHHCCHHH
QAVKRCPDLLIVPPSMEKYRQVARQIFAIYHSYTPLVEPLSLDEAYLDVTDSPMLAGSGT
HHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCC
RIAEDIRRRVREEIGITVSAGVAPNKFIAKIASDWNKPDGLFVVRPEQIDAFVAELPVDR
HHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHCCHHH
LFGVGKVTAAKLRRLGAETCGDLRAWGTDRLQQHFGVFGFRLHDLCRGIDHRQVQPSQIR
HHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHH
KSVSVEETYATDLRTLDDCQRELIILVEQLAARVERARAGNMIHKTYVKLRFADFRGTTV
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHEEEEEEECCCCCEE
ECISPQVSLPVFSKLLAQGFERRGIPVRLLGVGVRLYESDAHARQQPLFAEDPAATS
EECCCCCCHHHHHHHHHHHHHHCCCCEEEEEECEEEEECCCHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]