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The map label for this gene is pyrD [H]

Identifier: 187929008

GI number: 187929008

Start: 2035256

End: 2036353

Strand: Reverse

Name: pyrD [H]

Synonym: Rpic_1928

Alternate gene names: 187929008

Gene position: 2036353-2035256 (Counterclockwise)

Preceding gene: 187929012

Following gene: 187929006

Centisome position: 51.65

GC content: 64.48

Gene sequence:

>1098_bases
ATGCATTGCGGCGTGCCGGCCGTTTACAATGCCGCCTTTCGCGTTCTTCTCTTGATTCCGACCGTGCTCAACGCCCTGTA
CCCGCTTGCCCGCCCGCTGCTGTTTTCGATGGACCCAGAAGACGCACATCACTTCACGCTGAATCAGCTCAAGCGGGCGC
ACGCGATGGGCCTTTCGGGCTGCATCGGTGGCCGCGTAGCCCCGCGGCCGCGCACGGTGATGGGCGTAAAGTTTCCCAAC
CCGGTGGGGCTGGCTGCCGGCCTGGACAAGGATGGCGCGTATATCGATGCGCTCGGCGCGCTCGGCTTCGGCTTTATTGA
AGTTGGCACGGTCACGCCGCGTGCGCAGCCGGGCAACCCGCGCCCGCGCATGTTCCGGCTGCCGGCTGCCAATGCGCTCA
TCAACCGTATGGGATTCAACAACGGCGGTGTCGATGCGTTCATCAATAACGTGAAGGCATCGAAGTGGCGTGAGGCCGGC
GGCGTGCTCGGCCTGAACATCGGCAAGAACGCCGACACCCCGATCGAGCGCGCCGTCGACGATTACCTGCATTGCCTGGA
GCGTGTGTATCCGCATGCAAGCTATGTGACGGTCAACATTTCGTCGCCGAACACGAAGAACCTGCGTCAACTGCAAGGCG
CGAGCGAACTGGACAGTCTGCTCGGGACGCTACGCGGGGCACAGCAGCGCCTGGCAGATCAGCACAAGCGCTACGTACCG
GTGGCACTGAAGATCGCGCCAGACCTGGACGATGACCAGATTGCCAACGTTGCCGACGCGCTCCTGCGCCATAAGATGGA
CGGCGTGATTGCGACCAACACGACGATCAGCCGTGAGGCCGTCGCCGGTCTGGCGCACGCGGAAGAGGCGGGCGGATTGT
CGGGCCAGCCGGTGCGCGAGGGCTCGACGCGGGTGATTCGCGCCTTGCATGGTTTGCTGGGCGATGCTGTGCCCATCATT
GGCGTGGGCGGCATTCTCGCGGGCGAGCACGCGCGCGAGAAGATCGACGCTGGCGCGCAGCTGGTGCAGCTGTATACGGG
ATTGATCTATCGCGGCCCAGGTCTGGTGGCGGAATGCGCGCGCGCACTGGCGCGTTGA

Upstream 100 bases:

>100_bases
ATTGATGGTGCATGTTACCCGTGGAGAGGGCCCGCGATGCCACGCGCCGACGGGTTCTTAGACACATCGTGCGCAGTCAT
GTTCGAAAGCGGTGCGCACG

Downstream 100 bases:

>100_bases
TGCTGGCTGGTCGCGCCTAGCGGCGCAGCAAGAAGATGATGAGCGCGCTGGCGGCCACCACGGCGGCTGCCAGATCGTAC
GGGCCGGCGTAATCGGCCCA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MHCGVPAVYNAAFRVLLLIPTVLNALYPLARPLLFSMDPEDAHHFTLNQLKRAHAMGLSGCIGGRVAPRPRTVMGVKFPN
PVGLAAGLDKDGAYIDALGALGFGFIEVGTVTPRAQPGNPRPRMFRLPAANALINRMGFNNGGVDAFINNVKASKWREAG
GVLGLNIGKNADTPIERAVDDYLHCLERVYPHASYVTVNISSPNTKNLRQLQGASELDSLLGTLRGAQQRLADQHKRYVP
VALKIAPDLDDDQIANVADALLRHKMDGVIATNTTISREAVAGLAHAEEAGGLSGQPVREGSTRVIRALHGLLGDAVPII
GVGGILAGEHAREKIDAGAQLVQLYTGLIYRGPGLVAECARALAR

Sequences:

>Translated_365_residues
MHCGVPAVYNAAFRVLLLIPTVLNALYPLARPLLFSMDPEDAHHFTLNQLKRAHAMGLSGCIGGRVAPRPRTVMGVKFPN
PVGLAAGLDKDGAYIDALGALGFGFIEVGTVTPRAQPGNPRPRMFRLPAANALINRMGFNNGGVDAFINNVKASKWREAG
GVLGLNIGKNADTPIERAVDDYLHCLERVYPHASYVTVNISSPNTKNLRQLQGASELDSLLGTLRGAQQRLADQHKRYVP
VALKIAPDLDDDQIANVADALLRHKMDGVIATNTTISREAVAGLAHAEEAGGLSGQPVREGSTRVIRALHGLLGDAVPII
GVGGILAGEHAREKIDAGAQLVQLYTGLIYRGPGLVAECARALAR
>Mature_365_residues
MHCGVPAVYNAAFRVLLLIPTVLNALYPLARPLLFSMDPEDAHHFTLNQLKRAHAMGLSGCIGGRVAPRPRTVMGVKFPN
PVGLAAGLDKDGAYIDALGALGFGFIEVGTVTPRAQPGNPRPRMFRLPAANALINRMGFNNGGVDAFINNVKASKWREAG
GVLGLNIGKNADTPIERAVDDYLHCLERVYPHASYVTVNISSPNTKNLRQLQGASELDSLLGTLRGAQQRLADQHKRYVP
VALKIAPDLDDDQIANVADALLRHKMDGVIATNTTISREAVAGLAHAEEAGGLSGQPVREGSTRVIRALHGLLGDAVPII
GVGGILAGEHAREKIDAGAQLVQLYTGLIYRGPGLVAECARALAR

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=341, Percent_Identity=43.9882697947214, Blast_Score=246, Evalue=4e-65,
Organism=Escherichia coli, GI1787177, Length=332, Percent_Identity=54.2168674698795, Blast_Score=369, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI17509475, Length=338, Percent_Identity=41.1242603550296, Blast_Score=227, Evalue=9e-60,
Organism=Drosophila melanogaster, GI281361352, Length=296, Percent_Identity=43.9189189189189, Blast_Score=241, Evalue=6e-64,
Organism=Drosophila melanogaster, GI17137316, Length=296, Percent_Identity=43.9189189189189, Blast_Score=241, Evalue=6e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 38788; Mature: 38788

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00911 DHODEHASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHCGVPAVYNAAFRVLLLIPTVLNALYPLARPLLFSMDPEDAHHFTLNQLKRAHAMGLSG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCHH
CIGGRVAPRPRTVMGVKFPNPVGLAAGLDKDGAYIDALGALGFGFIEVGTVTPRAQPGNP
CCCCCCCCCCCEEEEEECCCCCCHHCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCC
RPRMFRLPAANALINRMGFNNGGVDAFINNVKASKWREAGGVLGLNIGKNADTPIERAVD
CCCEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHH
DYLHCLERVYPHASYVTVNISSPNTKNLRQLQGASELDSLLGTLRGAQQRLADQHKRYVP
HHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
VALKIAPDLDDDQIANVADALLRHKMDGVIATNTTISREAVAGLAHAEEAGGLSGQPVRE
EEEEECCCCCHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCC
GSTRVIRALHGLLGDAVPIIGVGGILAGEHAREKIDAGAQLVQLYTGLIYRGPGLVAECA
CHHHHHHHHHHHHHCCHHHHCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RALAR
HHHCC
>Mature Secondary Structure
MHCGVPAVYNAAFRVLLLIPTVLNALYPLARPLLFSMDPEDAHHFTLNQLKRAHAMGLSG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHCCCHH
CIGGRVAPRPRTVMGVKFPNPVGLAAGLDKDGAYIDALGALGFGFIEVGTVTPRAQPGNP
CCCCCCCCCCCEEEEEECCCCCCHHCCCCCCCCHHHHHHHHCCCCEEECCCCCCCCCCCC
RPRMFRLPAANALINRMGFNNGGVDAFINNVKASKWREAGGVLGLNIGKNADTPIERAVD
CCCEEECCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCHHHHHHH
DYLHCLERVYPHASYVTVNISSPNTKNLRQLQGASELDSLLGTLRGAQQRLADQHKRYVP
HHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
VALKIAPDLDDDQIANVADALLRHKMDGVIATNTTISREAVAGLAHAEEAGGLSGQPVRE
EEEEECCCCCHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCC
GSTRVIRALHGLLGDAVPIIGVGGILAGEHAREKIDAGAQLVQLYTGLIYRGPGLVAECA
CHHHHHHHHHHHHHCCHHHHCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
RALAR
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]