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The map label for this gene is cyoB [H]

Identifier: 187928957

GI number: 187928957

Start: 1976153

End: 1978156

Strand: Reverse

Name: cyoB [H]

Synonym: Rpic_1876

Alternate gene names: 187928957

Gene position: 1978156-1976153 (Counterclockwise)

Preceding gene: 187928958

Following gene: 187928956

Centisome position: 50.17

GC content: 60.73

Gene sequence:

>2004_bases
ATGCCCGAGCGTTCTGAACTCGCCAACATGATTTTTGGCCGCCTGACGTGGGAGGCCATTCCGTATCACGAGCCGATCCT
GCTCGCCACCTTCGCGGTCGTCGCGCTGGTCGGCCTCGTGCTGGTCGGTGCGCTGACGTACTTCCGCCTCTGGGGCTACC
TCTGGCGTGAATGGTTCACCAGCATCGACCACAAGAAGATCGGCATCATGTACGTCGTGCTGGGCATCGTGATGCTGCTG
CGCGGCTTTGCCGATGCCGTCATGATGCGGATACAGCAGGCGGTGGCCTTCGGCGACAACCTGGGCTACCTGCCGCCGCA
CCACTACGACCAGATATTCACCGCGCACGGTGTGATCATGATCTTCTTCGTCGCCATGCCGCTGGTGACCGGGCTCATGA
ACTTTGTCATGCCGCTGCAGATCGGCGCGCGCGACGTGGCCTTCCCGTTCCTCAACAACTTCAGTTTCTGGATGACCACC
GGCGGCGCCATCCTGGTGATGATGTCGCTGTTCGTGGGCGAGTTCGCACGTACCGGATGGCTGGCGTATCCGCCGCTGTC
GGGCATCCTTGCAAGCCCAGATGTGGGCGTCGACTACTACATATGGGCATTGCAGATAGCGGGGGTTGGTACCGTGCTAT
CGGGCATCAACTTGCTGGTCACCATCGTCAAGATGCGCGCGCCCGGCATGACGTTGATGCGCATGCCGATCTTCACCTGG
ACGGCGCTGTGCACGAACACGCTGATCGTTGCCGCCTTTCCGGTGTTGACGGCCGCAGTGACGCTGCTTGCCCTGGACCG
TTACCTTGGCACCCATTTCTTTACGGTCGAGCAGGGCGGTAGCGCGATGATGTATGTGAACCTGATCTGGATCTGGGGCC
ACCCCGAGGTCTACATCCTGGTGCTGCCCGCGTTCGGCATCTTCTCGGAAGTGGTGGCCACGTATTCACGCAAGCGCCTG
TTCGGCTACGCATCGATGGTGTACGCCACGGTCGTGATTACCGTGCTGTCGTACCTCGTCTGGCTCCACCACTTCTTCAC
CATGGGCTCCGGCGCCAGCGTCAACTCGTTCTTCGGGATCACGACGATGATCATCTCGATCCCGACAGGCGCCAAGATCT
TCAATTGGCTGTTCACGATGTACCACGGCAAGATCCGCTTCGAGCCGCCCATGCTGTGGACGATCGGGTTCATGGTGACG
TTTGTCATTGGCGGCATGACAGGCGTGTTGTTGGCGGTGCCGCCGGCGGATTTCTCGCTGCACAACAGCCTGTTCCTGAT
CGCGCATTTTCATAACGTGATCATCGGCGGCGTGTTGTTTGGCCTCATGGCCGGCATTACGTACTGGTTCCCCAAGGCGT
TTGGCTACCGCCTCGTGTCGTCGTGGGGCAAGGCGTCGTTCTGGTTCTGGTTTGTCGGCTTCTACATCGCGTTCATGCCG
TTGTACTGGCTGGGCATGCTTGGGGTCACACGCCGCATGAACCATTTCGACGATCCGTCCTTGCAGATCTGGTTCCAGAT
TGCCGCATTGGGCGCCTTGCTGATCGCCATCGGCATTGCCTGCTTCCTGATCCAGCTGGTGGTCAGCTTCCTCCGTCGGG
AAGAACTGCGCGACACGACCGGCGACCCGTGGAACGGCCGCACGTTGGAATGGTCCACTTCGTCGCCGCCGCCGCAGTAC
AACTTCGCAATGACGCCGCTCGTACATGACGCCGACGCCTGGTGGCAGATGAAGCAGTACGGCTACCGGCGGCCGCAGGA
AGGCTTCAAGCCGATTCACATGCCCAAGGGCACCGCTGCCGGCATCGTGCTGGCGGGGCTCTCGACGCTGTGCGGCTTTG
CGCTGATCTGGCATATCTGGTGGCTGGCCATCGTGTCGTTCGCGGCCACGATCCTCTCGGCGATCATTCATACCTTCAAC
TACAAGCGCGACTACTACATTCCGGCGGAAGAGGTGATCCGCACCGAAGCATCGCGCACGCAACTGATGGCAGGCCATGG
CTGA

Upstream 100 bases:

>100_bases
GGGCCTTGCCCGTTCGGCTTTTCAGCTCTTTCCGCCCCGTTGATGTTGTTCGCCAACATTGATCGGCCAGAATTGGTCAA
TACAGGCACAGGTGACATCC

Downstream 100 bases:

>100_bases
AACGACCGCATCCCTGCATGTGACCGGCCCCACGGGTACTACCACGGCGGATGACGTACCGCCGGGCGGCTACCAGTTCC
ACGTCACCGAAGAACCGCAC

Product: cytochrome o ubiquinol oxidase subunit I

Products: NA

Alternate protein names: Cytochrome o subunit 1; Cytochrome o ubiquinol oxidase subunit 1; Oxidase BO(3) subunit 1; Ubiquinol oxidase chain A; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 667; Mature: 666

Protein sequence:

>667_residues
MPERSELANMIFGRLTWEAIPYHEPILLATFAVVALVGLVLVGALTYFRLWGYLWREWFTSIDHKKIGIMYVVLGIVMLL
RGFADAVMMRIQQAVAFGDNLGYLPPHHYDQIFTAHGVIMIFFVAMPLVTGLMNFVMPLQIGARDVAFPFLNNFSFWMTT
GGAILVMMSLFVGEFARTGWLAYPPLSGILASPDVGVDYYIWALQIAGVGTVLSGINLLVTIVKMRAPGMTLMRMPIFTW
TALCTNTLIVAAFPVLTAAVTLLALDRYLGTHFFTVEQGGSAMMYVNLIWIWGHPEVYILVLPAFGIFSEVVATYSRKRL
FGYASMVYATVVITVLSYLVWLHHFFTMGSGASVNSFFGITTMIISIPTGAKIFNWLFTMYHGKIRFEPPMLWTIGFMVT
FVIGGMTGVLLAVPPADFSLHNSLFLIAHFHNVIIGGVLFGLMAGITYWFPKAFGYRLVSSWGKASFWFWFVGFYIAFMP
LYWLGMLGVTRRMNHFDDPSLQIWFQIAALGALLIAIGIACFLIQLVVSFLRREELRDTTGDPWNGRTLEWSTSSPPPQY
NFAMTPLVHDADAWWQMKQYGYRRPQEGFKPIHMPKGTAAGIVLAGLSTLCGFALIWHIWWLAIVSFAATILSAIIHTFN
YKRDYYIPAEEVIRTEASRTQLMAGHG

Sequences:

>Translated_667_residues
MPERSELANMIFGRLTWEAIPYHEPILLATFAVVALVGLVLVGALTYFRLWGYLWREWFTSIDHKKIGIMYVVLGIVMLL
RGFADAVMMRIQQAVAFGDNLGYLPPHHYDQIFTAHGVIMIFFVAMPLVTGLMNFVMPLQIGARDVAFPFLNNFSFWMTT
GGAILVMMSLFVGEFARTGWLAYPPLSGILASPDVGVDYYIWALQIAGVGTVLSGINLLVTIVKMRAPGMTLMRMPIFTW
TALCTNTLIVAAFPVLTAAVTLLALDRYLGTHFFTVEQGGSAMMYVNLIWIWGHPEVYILVLPAFGIFSEVVATYSRKRL
FGYASMVYATVVITVLSYLVWLHHFFTMGSGASVNSFFGITTMIISIPTGAKIFNWLFTMYHGKIRFEPPMLWTIGFMVT
FVIGGMTGVLLAVPPADFSLHNSLFLIAHFHNVIIGGVLFGLMAGITYWFPKAFGYRLVSSWGKASFWFWFVGFYIAFMP
LYWLGMLGVTRRMNHFDDPSLQIWFQIAALGALLIAIGIACFLIQLVVSFLRREELRDTTGDPWNGRTLEWSTSSPPPQY
NFAMTPLVHDADAWWQMKQYGYRRPQEGFKPIHMPKGTAAGIVLAGLSTLCGFALIWHIWWLAIVSFAATILSAIIHTFN
YKRDYYIPAEEVIRTEASRTQLMAGHG
>Mature_666_residues
PERSELANMIFGRLTWEAIPYHEPILLATFAVVALVGLVLVGALTYFRLWGYLWREWFTSIDHKKIGIMYVVLGIVMLLR
GFADAVMMRIQQAVAFGDNLGYLPPHHYDQIFTAHGVIMIFFVAMPLVTGLMNFVMPLQIGARDVAFPFLNNFSFWMTTG
GAILVMMSLFVGEFARTGWLAYPPLSGILASPDVGVDYYIWALQIAGVGTVLSGINLLVTIVKMRAPGMTLMRMPIFTWT
ALCTNTLIVAAFPVLTAAVTLLALDRYLGTHFFTVEQGGSAMMYVNLIWIWGHPEVYILVLPAFGIFSEVVATYSRKRLF
GYASMVYATVVITVLSYLVWLHHFFTMGSGASVNSFFGITTMIISIPTGAKIFNWLFTMYHGKIRFEPPMLWTIGFMVTF
VIGGMTGVLLAVPPADFSLHNSLFLIAHFHNVIIGGVLFGLMAGITYWFPKAFGYRLVSSWGKASFWFWFVGFYIAFMPL
YWLGMLGVTRRMNHFDDPSLQIWFQIAALGALLIAIGIACFLIQLVVSFLRREELRDTTGDPWNGRTLEWSTSSPPPQYN
FAMTPLVHDADAWWQMKQYGYRRPQEGFKPIHMPKGTAAGIVLAGLSTLCGFALIWHIWWLAIVSFAATILSAIIHTFNY
KRDYYIPAEEVIRTEASRTQLMAGHG

Specific function: Cytochrome o terminal oxidase complex is the component of the aerobic respiratory chain that predominates when cells are grown at high aeration. This ubiquinol oxidase shows proton pump activity across the membrane in addition to the electron transfer [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=509, Percent_Identity=37.721021611002, Blast_Score=337, Evalue=2e-92,
Organism=Escherichia coli, GI1786634, Length=651, Percent_Identity=66.8202764976959, Blast_Score=919, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=500, Percent_Identity=37.6, Blast_Score=345, Evalue=2e-95,
Organism=Saccharomyces cerevisiae, GI6226524, Length=325, Percent_Identity=42.4615384615385, Blast_Score=251, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6226523, Length=249, Percent_Identity=36.144578313253, Blast_Score=143, Evalue=9e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 75015; Mature: 74884

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHCCCC
>Mature Secondary Structure 
PERSELANMIFGRLTWEAIPYHEPILLATFAVVALVGLVLVGALTYFRLWGYLWREWFT
CCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SIDHKKIGIMYVVLGIVMLLRGFADAVMMRIQQAVAFGDNLGYLPPHHYDQIFTAHGVIM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
IFFVAMPLVTGLMNFVMPLQIGARDVAFPFLNNFSFWMTTGGAILVMMSLFVGEFARTGW
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEECCHHHHHHHHHHHHHHHHCCC
LAYPPLSGILASPDVGVDYYIWALQIAGVGTVLSGINLLVTIVKMRAPGMTLMRMPIFTW
EECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TALCTNTLIVAAFPVLTAAVTLLALDRYLGTHFFTVEQGGSAMMYVNLIWIWGHPEVYIL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCEEEEEEEEEEECCCCEEEE
VLPAFGIFSEVVATYSRKRLFGYASMVYATVVITVLSYLVWLHHFFTMGSGASVNSFFGI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
TTMIISIPTGAKIFNWLFTMYHGKIRFEPPMLWTIGFMVTFVIGGMTGVLLAVPPADFSL
HHHEEECCCCHHHHHHHHHHHCCEEEECCCHHHHHHHHHHHHHHHHHCEEEEECCCCCCC
HNSLFLIAHFHNVIIGGVLFGLMAGITYWFPKAFGYRLVSSWGKASFWFWFVGFYIAFMP
CCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
LYWLGMLGVTRRMNHFDDPSLQIWFQIAALGALLIAIGIACFLIQLVVSFLRREELRDTT
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GDPWNGRTLEWSTSSPPPQYNFAMTPLVHDADAWWQMKQYGYRRPQEGFKPIHMPKGTAA
CCCCCCCEEEECCCCCCCCCCEEECCCEECCHHHHHHHHHCCCCCCCCCCCCCCCCCCHH
GIVLAGLSTLCGFALIWHIWWLAIVSFAATILSAIIHTFNYKRDYYIPAEEVIRTEASRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
QLMAGHG
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]