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The map label for this gene is ppiD [H]

Identifier: 187928946

GI number: 187928946

Start: 1962785

End: 1964725

Strand: Reverse

Name: ppiD [H]

Synonym: Rpic_1865

Alternate gene names: 187928946

Gene position: 1964725-1962785 (Counterclockwise)

Preceding gene: 187928947

Following gene: 187928943

Centisome position: 49.83

GC content: 61.57

Gene sequence:

>1941_bases
ATGCTTGATTTCGTACGTACGCATCGGCGCTTGATGTTTCTGGTGCTGCTGATTCTGGTGTTCCCGTCGTTCGTGTTCTT
CGGCGTGCAGAGCTATTCGAGCTTCATGGACAGCTCGCATGACGCCGCCAAGGTCGACGGCAAAGTCATCTCGACCAACG
AAGTCGACGCGCGCGTGCGCGAGCAGACCGAGCGCCTGCGCCAGATGCTTGGCGCGCAATATGATCCGCGCCAGTTCGAA
GGTCCACAGATGCGCCGCGACGTGCTCGACGGCATCATTCAGCAACGCGTGCTGGCCAATGAAGTCGTGCGTGCGAACCT
GACCATCTCGAACGAGAAGATTCGCGACACGATCCTGCAGATTCCGGCCGTGGCGGCGCTGCGCAAGCCGGATGGCTCCT
TCGATCAGGAAGCCTACGTACGGCTGCTGTCTGCGCAGAACATGACGCCCGAGCAGTTGGAAGGCAATCTGCGCTTCGAG
CTCTCGCAGCAGCAGATTCCGCAATCGATCGTGTCGTCGGCGTTTGTGCCGAAGTCGCTGGTGGAGCGCCTCATCCAGGT
ACGCGATCAGCAACGCGAAGTTCAGACACTGCTGTTCAAGCCGGCCGACTACGCTGCAAAGGTCAATGCGGACGACAAGG
CCATCCAGGCTTACTACGACGCGCACCAGCAGGAATTCTCTGTTCCGGAGCAAGTCAAGGCCGAGTATGTCGTGTTCTCG
GGCGAAGAGATGATGAAGCAGATTCCGGTCACGCCCGAGCAGATCAAGGAGTACTACGATCAGAACGCTGCGCGCTTCAA
GACACAGGAAGAACGCCGCGCCGCTCACATCCTGATCAAGCTGCCGGATAACGCCAAGCCTGCCGACAAGGAAGCCGCCA
AGAAGAAGGCCGAAGAAGTCTTGGCCGAGGTGCGCAAGAATCCCGCGAGCTTTGCCGAGCTTGCCAAGAAGTACTCGGGT
GATCCAGGCTCGGCCGCGCAGGGTGGCGAGCTGGGCTTCCTCGGCAAGGGCGCGACTGTGCCGCCGTTCGAGAACGCGCT
GTTTGCGCTCAAGCAGCCGGGCGACATCAGTGACGTGGTCCAAAGCGATTTTGGTTTCCACATCATCAAGCTGGAAGAAG
TGAAGGGCGGCGGCGTGCAGCCCTTGGAAGCCGTGAAGCCTGAGCTTGAACGCGAACTGCGTACGCAACTCGCGAACAAG
AAGTACTCGGAGCTGGCCGATGCGTTCTCCAACACGGTGGAAGATCAGTCCGACAGCCTGAAGCCGGTGGCTGACAAGCT
CAAGCTGCAGATCCAGACGACCGACAACGTAACCCGCACCCCGAGCCCGGCGCAGTCCGGCAGCCCCATCGGCAACGACA
AGGTGCTCAAGGCGCTGTTCGCTGACGACGTGATCAAGAATCACCGCAATACGGCCGCCATCCAAGTGGGCCCGACCACG
CTGGTTGCAGCGCGCGCGGCGGAGTACCGCCCGGCCACGGTGAAGAAGCTGGCCGACGTGCGTGAACAGGTCAAGGCCAA
GGTGATCGCCGAGCAAGCGGCTGCGCTGGCCAAGAAGGCTGGCGAAGAGAAGCTTGCCGCCGTGAAGCAGAGCAACAGCG
CCGATGGCTTCGGTGCTGCACAGACGGTCTCGCGCCAGCAGGCGCAGGGCACGCCGCCGGCTGCACTGACAGCCATCCTG
CGCGCGGATGCGACCAAGCTGCCGACCACCATTGGTGTCGACCTGGGTCCCCAGGGCTACGCGCTGTATCGCATCAACAA
GGTGCTGCCGCCGGCCAATGTGGACGAGACGCGCCGTGCTGCCGATGCACAACAACTGGCTCAGGCCGCTGGTCAGACCG
AGTTCAACGCCTACTATGAAGCACTGAAGGCGCGCTCGAAGGTGAAGATCAACAGCAGCGCGGTCGACAGCAGTAAGCCA
GCCAATACGGCAGAGGACTGA

Upstream 100 bases:

>100_bases
TGCAGGTCATGCCGGGACGCTGTGCCGCGATTGTCCGGAATGTCGGCGGCACCTGATAGAATCGCCGGATTTTCCATCTT
CCATTCACCTCCGGTCCAGC

Downstream 100 bases:

>100_bases
TACGGCGTGCAGAGCACGTAGCCTGACGAAAAAGCCCCCTCAATAACGAGGGGGCTTTTTCTTTGCGTACTTTTTGGCGT
TGCGCTAGTCCAGCGGCTTG

Product: PpiC-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase D; Rotamase D [H]

Number of amino acids: Translated: 646; Mature: 646

Protein sequence:

>646_residues
MLDFVRTHRRLMFLVLLILVFPSFVFFGVQSYSSFMDSSHDAAKVDGKVISTNEVDARVREQTERLRQMLGAQYDPRQFE
GPQMRRDVLDGIIQQRVLANEVVRANLTISNEKIRDTILQIPAVAALRKPDGSFDQEAYVRLLSAQNMTPEQLEGNLRFE
LSQQQIPQSIVSSAFVPKSLVERLIQVRDQQREVQTLLFKPADYAAKVNADDKAIQAYYDAHQQEFSVPEQVKAEYVVFS
GEEMMKQIPVTPEQIKEYYDQNAARFKTQEERRAAHILIKLPDNAKPADKEAAKKKAEEVLAEVRKNPASFAELAKKYSG
DPGSAAQGGELGFLGKGATVPPFENALFALKQPGDISDVVQSDFGFHIIKLEEVKGGGVQPLEAVKPELERELRTQLANK
KYSELADAFSNTVEDQSDSLKPVADKLKLQIQTTDNVTRTPSPAQSGSPIGNDKVLKALFADDVIKNHRNTAAIQVGPTT
LVAARAAEYRPATVKKLADVREQVKAKVIAEQAAALAKKAGEEKLAAVKQSNSADGFGAAQTVSRQQAQGTPPAALTAIL
RADATKLPTTIGVDLGPQGYALYRINKVLPPANVDETRRAADAQQLAQAAGQTEFNAYYEALKARSKVKINSSAVDSSKP
ANTAED

Sequences:

>Translated_646_residues
MLDFVRTHRRLMFLVLLILVFPSFVFFGVQSYSSFMDSSHDAAKVDGKVISTNEVDARVREQTERLRQMLGAQYDPRQFE
GPQMRRDVLDGIIQQRVLANEVVRANLTISNEKIRDTILQIPAVAALRKPDGSFDQEAYVRLLSAQNMTPEQLEGNLRFE
LSQQQIPQSIVSSAFVPKSLVERLIQVRDQQREVQTLLFKPADYAAKVNADDKAIQAYYDAHQQEFSVPEQVKAEYVVFS
GEEMMKQIPVTPEQIKEYYDQNAARFKTQEERRAAHILIKLPDNAKPADKEAAKKKAEEVLAEVRKNPASFAELAKKYSG
DPGSAAQGGELGFLGKGATVPPFENALFALKQPGDISDVVQSDFGFHIIKLEEVKGGGVQPLEAVKPELERELRTQLANK
KYSELADAFSNTVEDQSDSLKPVADKLKLQIQTTDNVTRTPSPAQSGSPIGNDKVLKALFADDVIKNHRNTAAIQVGPTT
LVAARAAEYRPATVKKLADVREQVKAKVIAEQAAALAKKAGEEKLAAVKQSNSADGFGAAQTVSRQQAQGTPPAALTAIL
RADATKLPTTIGVDLGPQGYALYRINKVLPPANVDETRRAADAQQLAQAAGQTEFNAYYEALKARSKVKINSSAVDSSKP
ANTAED
>Mature_646_residues
MLDFVRTHRRLMFLVLLILVFPSFVFFGVQSYSSFMDSSHDAAKVDGKVISTNEVDARVREQTERLRQMLGAQYDPRQFE
GPQMRRDVLDGIIQQRVLANEVVRANLTISNEKIRDTILQIPAVAALRKPDGSFDQEAYVRLLSAQNMTPEQLEGNLRFE
LSQQQIPQSIVSSAFVPKSLVERLIQVRDQQREVQTLLFKPADYAAKVNADDKAIQAYYDAHQQEFSVPEQVKAEYVVFS
GEEMMKQIPVTPEQIKEYYDQNAARFKTQEERRAAHILIKLPDNAKPADKEAAKKKAEEVLAEVRKNPASFAELAKKYSG
DPGSAAQGGELGFLGKGATVPPFENALFALKQPGDISDVVQSDFGFHIIKLEEVKGGGVQPLEAVKPELERELRTQLANK
KYSELADAFSNTVEDQSDSLKPVADKLKLQIQTTDNVTRTPSPAQSGSPIGNDKVLKALFADDVIKNHRNTAAIQVGPTT
LVAARAAEYRPATVKKLADVREQVKAKVIAEQAAALAKKAGEEKLAAVKQSNSADGFGAAQTVSRQQAQGTPPAALTAIL
RADATKLPTTIGVDLGPQGYALYRINKVLPPANVDETRRAADAQQLAQAAGQTEFNAYYEALKARSKVKINSSAVDSSKP
ANTAED

Specific function: PPIases accelerate the folding of proteins. Seems to be involved in the folding of outer membrane proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Escherichia coli, GI1786645, Length=649, Percent_Identity=27.4268104776579, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI1786238, Length=139, Percent_Identity=36.6906474820144, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 70944; Mature: 70944

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDFVRTHRRLMFLVLLILVFPSFVFFGVQSYSSFMDSSHDAAKVDGKVISTNEVDARVR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEECCHHHHHHH
EQTERLRQMLGAQYDPRQFEGPQMRRDVLDGIIQQRVLANEVVRANLTISNEKIRDTILQ
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEECHHHHHHHHHH
IPAVAALRKPDGSFDQEAYVRLLSAQNMTPEQLEGNLRFELSQQQIPQSIVSSAFVPKSL
HHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCEEEECHHHHHHHHHHHHCCCHHH
VERLIQVRDQQREVQTLLFKPADYAAKVNADDKAIQAYYDAHQQEFSVPEQVKAEYVVFS
HHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCHHHCCCEEEEC
GEEMMKQIPVTPEQIKEYYDQNAARFKTQEERRAAHILIKLPDNAKPADKEAAKKKAEEV
CHHHHHHCCCCHHHHHHHHHCHHHHHCCHHHHCEEEEEEECCCCCCCCHHHHHHHHHHHH
LAEVRKNPASFAELAKKYSGDPGSAAQGGELGFLGKGATVPPFENALFALKQPGDISDVV
HHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHCCCCCHHHHH
QSDFGFHIIKLEEVKGGGVQPLEAVKPELERELRTQLANKKYSELADAFSNTVEDQSDSL
HCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCH
KPVADKLKLQIQTTDNVTRTPSPAQSGSPIGNDKVLKALFADDVIKNHRNTAAIQVGPTT
HHHHHHHEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCHH
LVAARAAEYRPATVKKLADVREQVKAKVIAEQAAALAKKAGEEKLAAVKQSNSADGFGAA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHH
QTVSRQQAQGTPPAALTAILRADATKLPTTIGVDLGPQGYALYRINKVLPPANVDETRRA
HHHHHHHHCCCCHHHHHHHHHHCCHHCCCEEECCCCCCCEEEEEEHHCCCCCCCHHHHHH
ADAQQLAQAAGQTEFNAYYEALKARSKVKINSSAVDSSKPANTAED
HHHHHHHHHHCCCHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLDFVRTHRRLMFLVLLILVFPSFVFFGVQSYSSFMDSSHDAAKVDGKVISTNEVDARVR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCEEEECCHHHHHHH
EQTERLRQMLGAQYDPRQFEGPQMRRDVLDGIIQQRVLANEVVRANLTISNEKIRDTILQ
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCEEECHHHHHHHHHH
IPAVAALRKPDGSFDQEAYVRLLSAQNMTPEQLEGNLRFELSQQQIPQSIVSSAFVPKSL
HHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHCCCCEEEECHHHHHHHHHHHHCCCHHH
VERLIQVRDQQREVQTLLFKPADYAAKVNADDKAIQAYYDAHQQEFSVPEQVKAEYVVFS
HHHHHHHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHCCCCHHHCCCEEEEC
GEEMMKQIPVTPEQIKEYYDQNAARFKTQEERRAAHILIKLPDNAKPADKEAAKKKAEEV
CHHHHHHCCCCHHHHHHHHHCHHHHHCCHHHHCEEEEEEECCCCCCCCHHHHHHHHHHHH
LAEVRKNPASFAELAKKYSGDPGSAAQGGELGFLGKGATVPPFENALFALKQPGDISDVV
HHHHHCCHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHCCCCCHHHHH
QSDFGFHIIKLEEVKGGGVQPLEAVKPELERELRTQLANKKYSELADAFSNTVEDQSDSL
HCCCCEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCH
KPVADKLKLQIQTTDNVTRTPSPAQSGSPIGNDKVLKALFADDVIKNHRNTAAIQVGPTT
HHHHHHHEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCHH
LVAARAAEYRPATVKKLADVREQVKAKVIAEQAAALAKKAGEEKLAAVKQSNSADGFGAA
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHH
QTVSRQQAQGTPPAALTAILRADATKLPTTIGVDLGPQGYALYRINKVLPPANVDETRRA
HHHHHHHHCCCCHHHHHHHHHHCCHHCCCEEECCCCCCCEEEEEEHHCCCCCCCHHHHHH
ADAQQLAQAAGQTEFNAYYEALKARSKVKINSSAVDSSKPANTAED
HHHHHHHHHHCCCHHHHHHHHHHHHCCEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]