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The map label for this gene is norA [H]

Identifier: 187928797

GI number: 187928797

Start: 1807866

End: 1809173

Strand: Direct

Name: norA [H]

Synonym: Rpic_1714

Alternate gene names: 187928797

Gene position: 1807866-1809173 (Clockwise)

Preceding gene: 187928796

Following gene: 187928799

Centisome position: 45.86

GC content: 63.23

Gene sequence:

>1308_bases
ATGCTTAATCAATCGTCCGCCACTCCCGCACCCCTCGATGCGCGGGCCGTCAGGCCAGCGTTGGTCGTGCTGCTTGCTCT
GGTATTTGTTGTCTCTCTCGGCTATGGAGTCGGGCTGCCGTTGCTGCAGTTGTATCTGGCGCAGTACCTGCCTGGTGCGA
CGCGGCAAACGCTGGCGTGGCACGTTGGCATGCTGGGAGGAATCTACACGCTCGCGCTGTTCATCTTTGCGCCGTGGTGG
GGCCGCCAGTCGGATCATCGTGGGCGGGCGGCGGCGCTGACTACCGGCTTCGCTATGTTTGTGCTGGGAACCGCGATGGT
CGCGCTAATACCCAGTCTCATGGCGATCTATGGCGGTCGATTGATCGCCGGGGCGGGGGCAGCGGCTATCGTGCCCGGTG
CCCAGGCCTATGTGACCGACATCAGCAATACCGAGGACAGGAGTCGGCGCTTTGTGCTGATCGGTAGTGCATCGTTCGTT
GGCTTTCTCGCGGGCCCCGCGTTCGGTAGTTGGCTTGCCGGGCCGCTGATGGGCATGCCTGCAGGCCAGATGCCCAGTAT
GGTCAACTGGCCCGCGTTGGTGGTCGCATCGGTCGGACTGCCACTTCTGTTGGCGGTTCGCCGCTGCCTGAGCACGACCA
AGCCGATCTTGCTCGACAGCGGCTCGGTGCAGATGACCCGGCAGCGCAAGCGCTTCGTTGCTGTATCGATGCTGTTAGCC
CTGCTGGCGTCCTTTGCCGCAGGTACCTTCGAAGTCGGCTTCAGCCTGTTTGGTGGCCAGACACTGCGCCTACCCAACTC
GATGATTGCGGTGATGTTTGTCACGTGCAGCCTGGCGATGCTCGCCGCGCAGGCTTTGCTGCTGCTTCCGGCAGTGCGCA
AGCATATCGACCATCGCTGGGTTGCCGGCGCATTTGCCGGCTCAGCGGTGGCACTGGGCTTTGCCGCACTGGTGCCCGAT
GCCGCCGCGCTTGGGCTGCTAATCGCCGTGGTGGCTACCGGCGTCGGCATGATTGGACCGGTGCTGTCTTATGAGTTGCT
GGAAGGTGACCGTAGTTTCGCTGGGTCGCTGTTGGCAAGGCAGGCAGCCGCAGGCAACCTGGGGCAGGCACTAGGTTCGG
TGAGTGCCGGTACCCTGTTTGGATGGAATACGTTCGCTCCATTTTGGGCAGCGGCGGCTGTGTTGCTGCTTGGTAGTGTG
GCTGCACTGCGTTGGTGGGGCGCGGCGCGGCAGGCTGAACGTCAGCCAGAGCAGCGCAGCTTTCAAGCAGAAGGAGAAAG
GCAGACGAGGGAAGGGCGGGGCGCATGA

Upstream 100 bases:

>100_bases
AAGCGAACCCGGCTGACTGGAATCCGACGCGCAAGCGCGGCGACGGTCCACAACGGCGTGACCGCTCCGGTGGCCGCTCA
CGGCGCGGGCTGAAGGCATC

Downstream 100 bases:

>100_bases
ACAACAATGAAAATTCCTCGTGCTATGTGCGCGCATTGTGCTTTTGAGGCCGCTTTCCAATGGCAGCGCACCGAACCGGC
AATTCGTGGATGGTGTAACA

Product: major facilitator superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLNQSSATPAPLDARAVRPALVVLLALVFVVSLGYGVGLPLLQLYLAQYLPGATRQTLAWHVGMLGGIYTLALFIFAPWW
GRQSDHRGRAAALTTGFAMFVLGTAMVALIPSLMAIYGGRLIAGAGAAAIVPGAQAYVTDISNTEDRSRRFVLIGSASFV
GFLAGPAFGSWLAGPLMGMPAGQMPSMVNWPALVVASVGLPLLLAVRRCLSTTKPILLDSGSVQMTRQRKRFVAVSMLLA
LLASFAAGTFEVGFSLFGGQTLRLPNSMIAVMFVTCSLAMLAAQALLLLPAVRKHIDHRWVAGAFAGSAVALGFAALVPD
AAALGLLIAVVATGVGMIGPVLSYELLEGDRSFAGSLLARQAAAGNLGQALGSVSAGTLFGWNTFAPFWAAAAVLLLGSV
AALRWWGAARQAERQPEQRSFQAEGERQTREGRGA

Sequences:

>Translated_435_residues
MLNQSSATPAPLDARAVRPALVVLLALVFVVSLGYGVGLPLLQLYLAQYLPGATRQTLAWHVGMLGGIYTLALFIFAPWW
GRQSDHRGRAAALTTGFAMFVLGTAMVALIPSLMAIYGGRLIAGAGAAAIVPGAQAYVTDISNTEDRSRRFVLIGSASFV
GFLAGPAFGSWLAGPLMGMPAGQMPSMVNWPALVVASVGLPLLLAVRRCLSTTKPILLDSGSVQMTRQRKRFVAVSMLLA
LLASFAAGTFEVGFSLFGGQTLRLPNSMIAVMFVTCSLAMLAAQALLLLPAVRKHIDHRWVAGAFAGSAVALGFAALVPD
AAALGLLIAVVATGVGMIGPVLSYELLEGDRSFAGSLLARQAAAGNLGQALGSVSAGTLFGWNTFAPFWAAAAVLLLGSV
AALRWWGAARQAERQPEQRSFQAEGERQTREGRGA
>Mature_435_residues
MLNQSSATPAPLDARAVRPALVVLLALVFVVSLGYGVGLPLLQLYLAQYLPGATRQTLAWHVGMLGGIYTLALFIFAPWW
GRQSDHRGRAAALTTGFAMFVLGTAMVALIPSLMAIYGGRLIAGAGAAAIVPGAQAYVTDISNTEDRSRRFVLIGSASFV
GFLAGPAFGSWLAGPLMGMPAGQMPSMVNWPALVVASVGLPLLLAVRRCLSTTKPILLDSGSVQMTRQRKRFVAVSMLLA
LLASFAAGTFEVGFSLFGGQTLRLPNSMIAVMFVTCSLAMLAAQALLLLPAVRKHIDHRWVAGAFAGSAVALGFAALVPD
AAALGLLIAVVATGVGMIGPVLSYELLEGDRSFAGSLLARQAAAGNLGQALGSVSAGTLFGWNTFAPFWAAAAVLLLGSV
AALRWWGAARQAERQPEQRSFQAEGERQTREGRGA

Specific function: Involved in quinolone resistance. May constitute a membrane-associated active efflux pump of hydrophilic quinolones [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45409; Mature: 45409

Theoretical pI: Translated: 11.22; Mature: 11.22

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNQSSATPAPLDARAVRPALVVLLALVFVVSLGYGVGLPLLQLYLAQYLPGATRQTLAW
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHH
HVGMLGGIYTLALFIFAPWWGRQSDHRGRAAALTTGFAMFVLGTAMVALIPSLMAIYGGR
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LIAGAGAAAIVPGAQAYVTDISNTEDRSRRFVLIGSASFVGFLAGPAFGSWLAGPLMGMP
EEECCCCHHCCCCCHHEEECCCCCCCCCCEEEEEECCHHHHHHHCHHHHHHHHHHHCCCC
AGQMPSMVNWPALVVASVGLPLLLAVRRCLSTTKPILLDSGSVQMTRQRKRFVAVSMLLA
CCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHH
LLASFAAGTFEVGFSLFGGQTLRLPNSMIAVMFVTCSLAMLAAQALLLLPAVRKHIDHRW
HHHHHCCCHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAGAFAGSAVALGFAALVPDAAALGLLIAVVATGVGMIGPVLSYELLEGDRSFAGSLLAR
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
QAAAGNLGQALGSVSAGTLFGWNTFAPFWAAAAVLLLGSVAALRWWGAARQAERQPEQRS
HHHCCHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
FQAEGERQTREGRGA
HHCCCHHHHHCCCCC
>Mature Secondary Structure
MLNQSSATPAPLDARAVRPALVVLLALVFVVSLGYGVGLPLLQLYLAQYLPGATRQTLAW
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHH
HVGMLGGIYTLALFIFAPWWGRQSDHRGRAAALTTGFAMFVLGTAMVALIPSLMAIYGGR
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LIAGAGAAAIVPGAQAYVTDISNTEDRSRRFVLIGSASFVGFLAGPAFGSWLAGPLMGMP
EEECCCCHHCCCCCHHEEECCCCCCCCCCEEEEEECCHHHHHHHCHHHHHHHHHHHCCCC
AGQMPSMVNWPALVVASVGLPLLLAVRRCLSTTKPILLDSGSVQMTRQRKRFVAVSMLLA
CCCCCCCCCCHHHHHHHCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHH
LLASFAAGTFEVGFSLFGGQTLRLPNSMIAVMFVTCSLAMLAAQALLLLPAVRKHIDHRW
HHHHHCCCHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VAGAFAGSAVALGFAALVPDAAALGLLIAVVATGVGMIGPVLSYELLEGDRSFAGSLLAR
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
QAAAGNLGQALGSVSAGTLFGWNTFAPFWAAAAVLLLGSVAALRWWGAARQAERQPEQRS
HHHCCHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
FQAEGERQTREGRGA
HHCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA