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The map label for this gene is livM [H]

Identifier: 187928538

GI number: 187928538

Start: 1542557

End: 1543891

Strand: Reverse

Name: livM [H]

Synonym: Rpic_1452

Alternate gene names: 187928538

Gene position: 1543891-1542557 (Counterclockwise)

Preceding gene: 187928539

Following gene: 187928537

Centisome position: 39.16

GC content: 63.75

Gene sequence:

>1335_bases
ATGGAACGCACCATGCACCAACAAGCGCAACAACAAGCCGCGCTGCCGGCCAACGATCGAGCGCGGACGATGAAGTTCAA
GCCTGTCAATCTTGCCCGCTGGATGCTCTGGGGCACCACTGCGCTGGTGATGATCGTGCTGCCGCTCATCTGGCCGCAGG
GTTTTGCCATCACGCTGCTTTCGCAGATGGGCATCATGATCATCTTCGCGCTGTCGTACAACATGCTGCTGGGGCAGTCC
GGCATGCTGTCGTTCGGGCACGCGGTGTATGCCGGCCTGGGCGCCTTCATGGCCGTGCACCTGCTCAACAAGATCGGCGC
CGTGCAGGCGCTGGGCATCGGCGGGCCGCTCGCCGTTGCGCTGTTGCCGATTGCCGGCGGCCTGGGCGGTGCGCTATTCG
GCGTGATCTTCGGCTACGTCACCACCAAGAAGTCCGGCACGACGTTCGCCATGATCACGCTGGGTATCGGCGAGATGGTG
TTTGCCAGCGCGTTGATGTTTCCGGACTTCTTTGGCGGCGAGGGCGGTGTCTCCACGAACCGCAGCATCGGCGATGCCCT
GGCCGGCATCACCTTCGGCCCGGCACGCCAGGTGTATTACCTGATCGCCGCGTGGTGCCTGATTTCAATGGCGCTGATGT
ACGCCTGGACGCAGACGCCGCTGGGCCGCATCGCCAACGCGGTGCGCGACAACCCTGAGCGCGTGGAGTTCATCGGCTAC
AACACGCAGCGCGTGCGCTTCCTGGTAGTAATTCTGTCGGCGTTCTTCGCTGGCATTGCCGGCGCGCTGTCGTGCATCAA
CTTTGAGATCGTGACGGCCGAGAACGTGTCGGCAGTGCGCTCGGGCTCCGTGCTGCTGGCGGCGTTCATTGGCGGCATGG
GCAGCTTCTTCGGGCCGATCATCGGCGCGGTGCTCACGGTGTTCTTCACCGTGGCGCTGTCGGGCATCACCAAGGCGTGG
CTGCTGTACCTGGGGTTGTTCTTTGTGCTGATGGTCATGTACGCGCCGGGTGGCATCGCCAGCCTCTTGGTCATACATCT
GCCGATCCTGCGACGCGGCAAGCTGAAGACGCTCCTGCCAGCTTACGGTTTGGCGATTGTGCCGGCGGTCATCCTGCTGG
TCGCGTTGATTTCCACCGTGGAAATGATCTACGCCGTGCAGGACGACGCCTCGGGTGGCGTGGCCACGCTGTTCGGCCTG
TCTGTCGAACCGAATACCCTCAAGCCATGGATTGTCACCGCCGCGCTGTGGCTGGTGGGCGCCTTCGGCCTGCGTGCTGC
AGCGGGCAAGCTGCGCGCCGCTTGGGACAACGCATTGCAGGAGCCGCAACCATGA

Upstream 100 bases:

>100_bases
CCTGACGATTGCGCAAGTCGCACCGGTGCTGCCGTATCTGCTGCTGGTGCTGATGCTGATCTTCCGCCCGCGTGGGCTGA
TGGGTACGCGGGAGAGCTAA

Downstream 100 bases:

>100_bases
GCCAACTGACATCCGGGCCGACCGCCGCGCTCGAGTTGCGCGACGTTCGCAAGCGCTTTGGCGCGACCGAAATCATTCGA
GGGGTCAACCTCACCATCGG

Product: inner-membrane translocator

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MERTMHQQAQQQAALPANDRARTMKFKPVNLARWMLWGTTALVMIVLPLIWPQGFAITLLSQMGIMIIFALSYNMLLGQS
GMLSFGHAVYAGLGAFMAVHLLNKIGAVQALGIGGPLAVALLPIAGGLGGALFGVIFGYVTTKKSGTTFAMITLGIGEMV
FASALMFPDFFGGEGGVSTNRSIGDALAGITFGPARQVYYLIAAWCLISMALMYAWTQTPLGRIANAVRDNPERVEFIGY
NTQRVRFLVVILSAFFAGIAGALSCINFEIVTAENVSAVRSGSVLLAAFIGGMGSFFGPIIGAVLTVFFTVALSGITKAW
LLYLGLFFVLMVMYAPGGIASLLVIHLPILRRGKLKTLLPAYGLAIVPAVILLVALISTVEMIYAVQDDASGGVATLFGL
SVEPNTLKPWIVTAALWLVGAFGLRAAAGKLRAAWDNALQEPQP

Sequences:

>Translated_444_residues
MERTMHQQAQQQAALPANDRARTMKFKPVNLARWMLWGTTALVMIVLPLIWPQGFAITLLSQMGIMIIFALSYNMLLGQS
GMLSFGHAVYAGLGAFMAVHLLNKIGAVQALGIGGPLAVALLPIAGGLGGALFGVIFGYVTTKKSGTTFAMITLGIGEMV
FASALMFPDFFGGEGGVSTNRSIGDALAGITFGPARQVYYLIAAWCLISMALMYAWTQTPLGRIANAVRDNPERVEFIGY
NTQRVRFLVVILSAFFAGIAGALSCINFEIVTAENVSAVRSGSVLLAAFIGGMGSFFGPIIGAVLTVFFTVALSGITKAW
LLYLGLFFVLMVMYAPGGIASLLVIHLPILRRGKLKTLLPAYGLAIVPAVILLVALISTVEMIYAVQDDASGGVATLFGL
SVEPNTLKPWIVTAALWLVGAFGLRAAAGKLRAAWDNALQEPQP
>Mature_444_residues
MERTMHQQAQQQAALPANDRARTMKFKPVNLARWMLWGTTALVMIVLPLIWPQGFAITLLSQMGIMIIFALSYNMLLGQS
GMLSFGHAVYAGLGAFMAVHLLNKIGAVQALGIGGPLAVALLPIAGGLGGALFGVIFGYVTTKKSGTTFAMITLGIGEMV
FASALMFPDFFGGEGGVSTNRSIGDALAGITFGPARQVYYLIAAWCLISMALMYAWTQTPLGRIANAVRDNPERVEFIGY
NTQRVRFLVVILSAFFAGIAGALSCINFEIVTAENVSAVRSGSVLLAAFIGGMGSFFGPIIGAVLTVFFTVALSGITKAW
LLYLGLFFVLMVMYAPGGIASLLVIHLPILRRGKLKTLLPAYGLAIVPAVILLVALISTVEMIYAVQDDASGGVATLFGL
SVEPNTLKPWIVTAALWLVGAFGLRAAAGKLRAAWDNALQEPQP

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=296, Percent_Identity=29.3918918918919, Blast_Score=81, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 47103; Mature: 47103

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERTMHQQAQQQAALPANDRARTMKFKPVNLARWMLWGTTALVMIVLPLIWPQGFAITLL
CCCHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
SQMGIMIIFALSYNMLLGQSGMLSFGHAVYAGLGAFMAVHLLNKIGAVQALGIGGPLAVA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCHHHHH
LLPIAGGLGGALFGVIFGYVTTKKSGTTFAMITLGIGEMVFASALMFPDFFGGEGGVSTN
HHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCC
RSIGDALAGITFGPARQVYYLIAAWCLISMALMYAWTQTPLGRIANAVRDNPERVEFIGY
CHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEECC
NTQRVRFLVVILSAFFAGIAGALSCINFEIVTAENVSAVRSGSVLLAAFIGGMGSFFGPI
CHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHH
IGAVLTVFFTVALSGITKAWLLYLGLFFVLMVMYAPGGIASLLVIHLPILRRGKLKTLLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHH
AYGLAIVPAVILLVALISTVEMIYAVQDDASGGVATLFGLSVEPNTLKPWIVTAALWLVG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
AFGLRAAAGKLRAAWDNALQEPQP
HHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MERTMHQQAQQQAALPANDRARTMKFKPVNLARWMLWGTTALVMIVLPLIWPQGFAITLL
CCCHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
SQMGIMIIFALSYNMLLGQSGMLSFGHAVYAGLGAFMAVHLLNKIGAVQALGIGGPLAVA
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHEECCCCHHHHH
LLPIAGGLGGALFGVIFGYVTTKKSGTTFAMITLGIGEMVFASALMFPDFFGGEGGVSTN
HHHHHCCHHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCC
RSIGDALAGITFGPARQVYYLIAAWCLISMALMYAWTQTPLGRIANAVRDNPERVEFIGY
CHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEEEECC
NTQRVRFLVVILSAFFAGIAGALSCINFEIVTAENVSAVRSGSVLLAAFIGGMGSFFGPI
CHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHH
IGAVLTVFFTVALSGITKAWLLYLGLFFVLMVMYAPGGIASLLVIHLPILRRGKLKTLLP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCHHHHHH
AYGLAIVPAVILLVALISTVEMIYAVQDDASGGVATLFGLSVEPNTLKPWIVTAALWLVG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHH
AFGLRAAAGKLRAAWDNALQEPQP
HHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]