Click here to switch to the map view.

The map label for this gene is aceA [H]

Identifier: 187928321

GI number: 187928321

Start: 1319775

End: 1321079

Strand: Direct

Name: aceA [H]

Synonym: Rpic_1232

Alternate gene names: 187928321

Gene position: 1319775-1321079 (Clockwise)

Preceding gene: 187928320

Following gene: 187928324

Centisome position: 33.48

GC content: 60.92

Gene sequence:

>1305_bases
ATGTCACGCGAACTCGAAGTGCAAAAGCTGCAGAAGGAATGGGATACCAACCCGCGTTGGAAGGGCATCAAGCGTGGTTA
CACCGCTGAAGATGTCGTGCGCCTGCGTGGTTCGCTGCAGATCGAACATACGCTGGCCAAGCGTGGTGCCGAAAAGCTGT
GGAACCTGATCAACAACGAACCCTTCGTCAACGCCCTGGGCGCACTGACGGGCAACCAGGCCATGCAGCAGGTCAAGGCC
GGATTGAAGGCGATCTATCTGTCGGGCTGGCAGGTTGCGGGCGATGCCAACAGCAACGGCGAGATGTATCCGGACCAGTC
GCTGTACTCGGTGGACTCGGTGCCCAAGGTCGTGAAGAAGATCAACAACACCTTCCAGCGCGCTGACCAAATCCAATGGT
CGGAAGGCAAGGACGACATCGACTTCTTCGCCCCGATCGTGGCGGACGCAGAAGCCGGTTTCGGCGGCGTGCTGAACGCG
TTCGAACTGATGAAGGCCATGATCGAGGCTGGAGCCGCGGGCGTGCACTTTGAAGACCAGTTGGCCGCCGTGAAGAAGTG
CGGCCACATGGGCGGCAAGGTTCTGGTGCCGACCCGTGAAGCCGTGAGCAAGCTCGTCGCCGCGCGTCTGGCTGCCGACG
TGATGGGCGTGCCGACCGTGCTGATCGCCCGCACCGACGCAGAGGCGGCGGACCTGTTGACTACCGATGTGGACGAGAAC
GACAAGCCGTTCTGCACCGGCGAGCGCACCGTCGAAGGCTTCTACCGCACCAAGCCCGGTCTGCAGCAGGCCATCTCGCG
CGGTCTGGCCTACGCAGAAGTGGCTGACCTCGTGTGGTGCGAAACCGGCAAGCCGGATCTGGAATACGCCAAGAAGTTTG
CGGAAGCCATTCACGCCAAGTTCCCGGGCAAGATGCTGGCCTACAACTGCTCGCCGTCGTTCAACTGGAAGAAGAACCTG
GACGACGTCACGATCGCCCGATTCCAGAAGGAGCTTGGCGCAATGGGCTACAAGTTCCAGTTCATCACGCTGGCCGGTTT
CCACGCCCTGAACTACTCGATGTTCAACCTGGCCTACGGCTATGCCCGCAACCAGATGAGCGCTTTCGTGGAGCTGCAAG
AGGCCGAATTCAAGGCGGCGGAAAAGGGCTTCACCGCGGTGAAGCACCAGCGCGAAGTCGGCACGGGCTACTTCGATGCC
GTGACGCAGACCATCGAACGCGAGGCGTCGACCACGGCGCTCAAGGGCTCGACGGAAGACGAACAATTCTTCGAAGAAAC
GGCGCAAGCCAAGAAGGTTGCCTGA

Upstream 100 bases:

>100_bases
TTGAGCCAACCAGCAGCGCCCCAAGAAGGCGCCAGCGGCTCAAGGCGCAGAGTGAGATACCGGTTTTTATTTGATGGATG
CGATCAAACAGGAGAGTGCG

Downstream 100 bases:

>100_bases
GGCTGCCGACGCATCCGGCACCTAGGTATCCGGGCCGGCCGTGCTGACCACACGCCGGCCTCTCGAACCGCGCTTCCTCA
ACGGCGCGGTTTTTTTTTCG

Product: isocitrate lyase

Products: NA

Alternate protein names: ICL; Isocitrase; Isocitratase [H]

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSRELEVQKLQKEWDTNPRWKGIKRGYTAEDVVRLRGSLQIEHTLAKRGAEKLWNLINNEPFVNALGALTGNQAMQQVKA
GLKAIYLSGWQVAGDANSNGEMYPDQSLYSVDSVPKVVKKINNTFQRADQIQWSEGKDDIDFFAPIVADAEAGFGGVLNA
FELMKAMIEAGAAGVHFEDQLAAVKKCGHMGGKVLVPTREAVSKLVAARLAADVMGVPTVLIARTDAEAADLLTTDVDEN
DKPFCTGERTVEGFYRTKPGLQQAISRGLAYAEVADLVWCETGKPDLEYAKKFAEAIHAKFPGKMLAYNCSPSFNWKKNL
DDVTIARFQKELGAMGYKFQFITLAGFHALNYSMFNLAYGYARNQMSAFVELQEAEFKAAEKGFTAVKHQREVGTGYFDA
VTQTIEREASTTALKGSTEDEQFFEETAQAKKVA

Sequences:

>Translated_434_residues
MSRELEVQKLQKEWDTNPRWKGIKRGYTAEDVVRLRGSLQIEHTLAKRGAEKLWNLINNEPFVNALGALTGNQAMQQVKA
GLKAIYLSGWQVAGDANSNGEMYPDQSLYSVDSVPKVVKKINNTFQRADQIQWSEGKDDIDFFAPIVADAEAGFGGVLNA
FELMKAMIEAGAAGVHFEDQLAAVKKCGHMGGKVLVPTREAVSKLVAARLAADVMGVPTVLIARTDAEAADLLTTDVDEN
DKPFCTGERTVEGFYRTKPGLQQAISRGLAYAEVADLVWCETGKPDLEYAKKFAEAIHAKFPGKMLAYNCSPSFNWKKNL
DDVTIARFQKELGAMGYKFQFITLAGFHALNYSMFNLAYGYARNQMSAFVELQEAEFKAAEKGFTAVKHQREVGTGYFDA
VTQTIEREASTTALKGSTEDEQFFEETAQAKKVA
>Mature_433_residues
SRELEVQKLQKEWDTNPRWKGIKRGYTAEDVVRLRGSLQIEHTLAKRGAEKLWNLINNEPFVNALGALTGNQAMQQVKAG
LKAIYLSGWQVAGDANSNGEMYPDQSLYSVDSVPKVVKKINNTFQRADQIQWSEGKDDIDFFAPIVADAEAGFGGVLNAF
ELMKAMIEAGAAGVHFEDQLAAVKKCGHMGGKVLVPTREAVSKLVAARLAADVMGVPTVLIARTDAEAADLLTTDVDEND
KPFCTGERTVEGFYRTKPGLQQAISRGLAYAEVADLVWCETGKPDLEYAKKFAEAIHAKFPGKMLAYNCSPSFNWKKNLD
DVTIARFQKELGAMGYKFQFITLAGFHALNYSMFNLAYGYARNQMSAFVELQEAEFKAAEKGFTAVKHQREVGTGYFDAV
TQTIEREASTTALKGSTEDEQFFEETAQAKKVA

Specific function: Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle. May be involved in the assimilation of one-carbon compounds via the isocitrate lyase- positive serine pathway [H]

COG id: COG2224

COG function: function code C; Isocitrate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family [H]

Homologues:

Organism=Escherichia coli, GI1790445, Length=433, Percent_Identity=67.2055427251732, Blast_Score=598, Evalue=1e-172,
Organism=Escherichia coli, GI1786525, Length=261, Percent_Identity=28.735632183908, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17561814, Length=413, Percent_Identity=62.227602905569, Blast_Score=531, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI71982926, Length=413, Percent_Identity=62.227602905569, Blast_Score=531, Evalue=1e-151,
Organism=Saccharomyces cerevisiae, GI6320908, Length=289, Percent_Identity=36.3321799307958, Blast_Score=173, Evalue=4e-44,
Organism=Saccharomyces cerevisiae, GI6325263, Length=249, Percent_Identity=36.144578313253, Blast_Score=154, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006254
- InterPro:   IPR000918
- InterPro:   IPR018523
- InterPro:   IPR015813 [H]

Pfam domain/function: PF00463 ICL [H]

EC number: =4.1.3.1 [H]

Molecular weight: Translated: 47911; Mature: 47780

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: PS00161 ISOCITRATE_LYASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRELEVQKLQKEWDTNPRWKGIKRGYTAEDVVRLRGSLQIEHTLAKRGAEKLWNLINNE
CCCCHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
PFVNALGALTGNQAMQQVKAGLKAIYLSGWQVAGDANSNGEMYPDQSLYSVDSVPKVVKK
CHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
INNTFQRADQIQWSEGKDDIDFFAPIVADAEAGFGGVLNAFELMKAMIEAGAAGVHFEDQ
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
LAAVKKCGHMGGKVLVPTREAVSKLVAARLAADVMGVPTVLIARTDAEAADLLTTDVDEN
HHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCCCC
DKPFCTGERTVEGFYRTKPGLQQAISRGLAYAEVADLVWCETGKPDLEYAKKFAEAIHAK
CCCCCCCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHEECCCCCCHHHHHHHHHHHHHC
FPGKMLAYNCSPSFNWKKNLDDVTIARFQKELGAMGYKFQFITLAGFHALNYSMFNLAYG
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHH
YARNQMSAFVELQEAEFKAAEKGFTAVKHQREVGTGYFDAVTQTIEREASTTALKGSTED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCH
EQFFEETAQAKKVA
HHHHHHHHHHHCCC
>Mature Secondary Structure 
SRELEVQKLQKEWDTNPRWKGIKRGYTAEDVVRLRGSLQIEHTLAKRGAEKLWNLINNE
CCCHHHHHHHHHHCCCCCCCCHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCC
PFVNALGALTGNQAMQQVKAGLKAIYLSGWQVAGDANSNGEMYPDQSLYSVDSVPKVVKK
CHHHHHHHHHHHHHHHHHHHHHHEEEECCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHH
INNTFQRADQIQWSEGKDDIDFFAPIVADAEAGFGGVLNAFELMKAMIEAGAAGVHFEDQ
HHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHH
LAAVKKCGHMGGKVLVPTREAVSKLVAARLAADVMGVPTVLIARTDAEAADLLTTDVDEN
HHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHCCCCCCC
DKPFCTGERTVEGFYRTKPGLQQAISRGLAYAEVADLVWCETGKPDLEYAKKFAEAIHAK
CCCCCCCCHHHHHHHHCCCHHHHHHHCCCHHHHHHHHHEECCCCCCHHHHHHHHHHHHHC
FPGKMLAYNCSPSFNWKKNLDDVTIARFQKELGAMGYKFQFITLAGFHALNYSMFNLAYG
CCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHH
YARNQMSAFVELQEAEFKAAEKGFTAVKHQREVGTGYFDAVTQTIEREASTTALKGSTED
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCH
EQFFEETAQAKKVA
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]