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The map label for this gene is cbl [H]

Identifier: 187928313

GI number: 187928313

Start: 1312507

End: 1313466

Strand: Direct

Name: cbl [H]

Synonym: Rpic_1224

Alternate gene names: 187928313

Gene position: 1312507-1313466 (Clockwise)

Preceding gene: 187928312

Following gene: 187928314

Centisome position: 33.29

GC content: 65.62

Gene sequence:

>960_bases
ATGAACTTCCAACAACTGCGTTCCATCCGTGAGGCGGTGCGCCGCCAGTTCAACCTGACTGAAGTCGCCAACGCGCTGTA
CACGTCGCAGCCCGGCGTGTCGCGCCAGATTCGCGAGCTGGAGGATGAACTGGGCGTGGAGATTTTCGAGCGCTATGGCA
AGCGCCTGACGGGCCTGACCGAGCCGGGCCGCGAGATCGTCCGCATTGTCGAGCGGTTGTTGCTGGAAGCGGAAAACCTG
CGCCAGGCCGGCGAGGAATTCTCGGGCCGACAATCCGGCCGCCTGACCGTGGCGACGACGCACACGCAAGCGCGCTATGC
GCTGCCCAAGGTGGTGCAGTCGTTCCGCAAGGAGTATCCGCACGTCACGCTGGCGCTGCAGGAAGCGTCGCCTTCGCACA
TCGTCGAGCTGTTGCTGACAGGGCAGGCCGATATCGGCATCGCCACCGAGGCGGTGGCCAACGAGCCGGGGCTGACGTCG
TTCGAGGCGTACCGCTGGCGCCACGTGCTGGTGGTCAGCCCGGACCATCCGCTGACCAAGAACCCGCTTCCCACGCTCGA
AGACGTGGCGCAGTATCCGCTCATCACGTACGACGCGGGCTTCACGGGCCGACGCAACATCGACGCGGCATTTGGCAGCG
CCGGCCTGCATCCCGAGATCGTGCTGACCGCCATGGACGCCGACGTGATCAAGACCTATGTGGCGCTGGACGTGGGCGTG
GGCATCATCGCGTCGATGGCGTATGACGGGCGCAAGGACGACAACCTTGTCTGCATCGGCGCGGACCATCTGTTCGAGCC
GAATACCACGCGTGTGGCGGTGCGCCGTGGCGCGTACCTGCGTGGCTATGCGCATGATTTCATCGGGATGTTCGCGCCGC
ATCTGTCGCGCGAAACGGTTGCCGAGGCGGTGGCTTCCACGGTGGTGACGCAATCCGCGCGGGAGGCGCTGGCGGCGTAA

Upstream 100 bases:

>100_bases
CGCGCGATCCGCGTGTTCGCGCAAGGCAATGCACGGCCCGTCGCGCAAGCCGCCGTGTAACACGCCGCTCCGACGACAAC
CAATACGAGAGGACACGAGC

Downstream 100 bases:

>100_bases
TCGTCCCGCGCTCGGAGCCGGCTGCGCGCCGTTCATCCGTCCAATCGCACCATTCGTCGCATACGCATGGCGCCTGCCCA
GGCGCCATTCCTATACTGCG

Product: transcriptional regulator CysB-like protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MNFQQLRSIREAVRRQFNLTEVANALYTSQPGVSRQIRELEDELGVEIFERYGKRLTGLTEPGREIVRIVERLLLEAENL
RQAGEEFSGRQSGRLTVATTHTQARYALPKVVQSFRKEYPHVTLALQEASPSHIVELLLTGQADIGIATEAVANEPGLTS
FEAYRWRHVLVVSPDHPLTKNPLPTLEDVAQYPLITYDAGFTGRRNIDAAFGSAGLHPEIVLTAMDADVIKTYVALDVGV
GIIASMAYDGRKDDNLVCIGADHLFEPNTTRVAVRRGAYLRGYAHDFIGMFAPHLSRETVAEAVASTVVTQSAREALAA

Sequences:

>Translated_319_residues
MNFQQLRSIREAVRRQFNLTEVANALYTSQPGVSRQIRELEDELGVEIFERYGKRLTGLTEPGREIVRIVERLLLEAENL
RQAGEEFSGRQSGRLTVATTHTQARYALPKVVQSFRKEYPHVTLALQEASPSHIVELLLTGQADIGIATEAVANEPGLTS
FEAYRWRHVLVVSPDHPLTKNPLPTLEDVAQYPLITYDAGFTGRRNIDAAFGSAGLHPEIVLTAMDADVIKTYVALDVGV
GIIASMAYDGRKDDNLVCIGADHLFEPNTTRVAVRRGAYLRGYAHDFIGMFAPHLSRETVAEAVASTVVTQSAREALAA
>Mature_319_residues
MNFQQLRSIREAVRRQFNLTEVANALYTSQPGVSRQIRELEDELGVEIFERYGKRLTGLTEPGREIVRIVERLLLEAENL
RQAGEEFSGRQSGRLTVATTHTQARYALPKVVQSFRKEYPHVTLALQEASPSHIVELLLTGQADIGIATEAVANEPGLTS
FEAYRWRHVLVVSPDHPLTKNPLPTLEDVAQYPLITYDAGFTGRRNIDAAFGSAGLHPEIVLTAMDADVIKTYVALDVGV
GIIASMAYDGRKDDNLVCIGADHLFEPNTTRVAVRRGAYLRGYAHDFIGMFAPHLSRETVAEAVASTVVTQSAREALAA

Specific function: May be an accessory regulatory protein within the cys regulon [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788296, Length=307, Percent_Identity=51.1400651465798, Blast_Score=318, Evalue=4e-88,
Organism=Escherichia coli, GI1787530, Length=305, Percent_Identity=49.5081967213115, Blast_Score=307, Evalue=7e-85,
Organism=Escherichia coli, GI157672245, Length=213, Percent_Identity=34.2723004694836, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790399, Length=287, Percent_Identity=25.0871080139373, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789204, Length=235, Percent_Identity=26.8085106382979, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788887, Length=243, Percent_Identity=27.9835390946502, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790208, Length=254, Percent_Identity=28.3464566929134, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI87082132, Length=225, Percent_Identity=27.1111111111111, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788481, Length=250, Percent_Identity=27.2, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI2367136, Length=233, Percent_Identity=24.0343347639485, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI145693105, Length=185, Percent_Identity=27.5675675675676, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87081904, Length=208, Percent_Identity=30.2884615384615, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787879, Length=253, Percent_Identity=25.6916996047431, Blast_Score=62, Evalue=5e-11,
Organism=Escherichia coli, GI1789173, Length=191, Percent_Identity=29.8429319371728, Blast_Score=62, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 35211; Mature: 35211

Theoretical pI: Translated: 6.06; Mature: 6.06

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFQQLRSIREAVRRQFNLTEVANALYTSQPGVSRQIRELEDELGVEIFERYGKRLTGLT
CCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCC
EPGREIVRIVERLLLEAENLRQAGEEFSGRQSGRLTVATTHTQARYALPKVVQSFRKEYP
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCC
HVTLALQEASPSHIVELLLTGQADIGIATEAVANEPGLTSFEAYRWRHVLVVSPDHPLTK
EEEEEEECCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHCCEEEEEEECCCCCCCC
NPLPTLEDVAQYPLITYDAGFTGRRNIDAAFGSAGLHPEIVLTAMDADVIKTYVALDVGV
CCCCCHHHHHHCCEEEECCCCCCCCCCCHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHH
GIIASMAYDGRKDDNLVCIGADHLFEPNTTRVAVRRGAYLRGYAHDFIGMFAPHLSRETV
HHHHHHHCCCCCCCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCHHHH
AEAVASTVVTQSAREALAA
HHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFQQLRSIREAVRRQFNLTEVANALYTSQPGVSRQIRELEDELGVEIFERYGKRLTGLT
CCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHCHHHHHHHHHHHCCCC
EPGREIVRIVERLLLEAENLRQAGEEFSGRQSGRLTVATTHTQARYALPKVVQSFRKEYP
CCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCC
HVTLALQEASPSHIVELLLTGQADIGIATEAVANEPGLTSFEAYRWRHVLVVSPDHPLTK
EEEEEEECCCHHHHHHHHHCCCCCCCCHHHHHCCCCCCCCHHHCCEEEEEEECCCCCCCC
NPLPTLEDVAQYPLITYDAGFTGRRNIDAAFGSAGLHPEIVLTAMDADVIKTYVALDVGV
CCCCCHHHHHHCCEEEECCCCCCCCCCCHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHH
GIIASMAYDGRKDDNLVCIGADHLFEPNTTRVAVRRGAYLRGYAHDFIGMFAPHLSRETV
HHHHHHHCCCCCCCCEEEEECCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHCCCHHHH
AEAVASTVVTQSAREALAA
HHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8529872; 9097040; 9278503 [H]