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The map label for this gene is engA

Identifier: 187928156

GI number: 187928156

Start: 1129872

End: 1131215

Strand: Direct

Name: engA

Synonym: Rpic_1063

Alternate gene names: 187928156

Gene position: 1129872-1131215 (Clockwise)

Preceding gene: 187928155

Following gene: 187928157

Centisome position: 28.66

GC content: 61.61

Gene sequence:

>1344_bases
ATGAAACCAGTCATTGCCCTTGTAGGGCGGCCGAATGTCGGCAAATCGACCCTCTTCAATCGTCTGACCCGCTCGCGTGA
CGCGTTGGTCGCGGATATTCCTGGCCTGACGCGCGATCGCCACTACGGCGAAGGCCGCGTGGGCGACCGTCCGTTCATCG
CCATCGATACCGGCGGCTTCGAACCCGTTGCCAAGGAAGGCATCGTGGCTGAGATGGCCAAGCAGACGCGCCAGGCCGTG
GTTGAAGCCGATGTCGTGATCTTCATCGTCGATGGACGCCTGGGACTGGCGCCGCAGGATCGCGTGATCGCCGATTACCT
GCGCAAAACCGGGCGCCGCATCCTCCTCGCCGTCAACAAGGCCGAGGGCATGCGCTACACCGCCGTCGCCAGCGATTTCT
ACGAGCTTGGTCTGGGCGATCCGGCTGCCATTTCGGCCGCGCACGGCGACGGAGTCAATGATTTGGTGGCGGAGGCGCTC
GACCTGGCATTTGCCGAGCGCCCCGAGCTTGCCGAGGCAGCCGACGCGCACGACCACGGTACCCGTATCGCCATCGTTGG
CCGTCCGAACGTGGGCAAGTCGACGCTGGTGAACGCGCTGATCGGCGAAGAGCGCGTGATTGCGTTCGATATGCCCGGCA
CCACGCGCGACGCCATCTACGTGGATTTCGAACGTAACGGCAAGCCTTACACGCTTATCGATACGGCAGGCTTGCGCAAG
CGCGGCAAGGTGTTTGAAGCAATCGAGAAGTTCTCGGTGGTGAAGACGCTGCAGTCGATTGCCGACGCCAACGTGGTTGT
GCTGATCCTCGATGCGCAGCAGGACATTTCTGATCAGGACGCGCATATCGCCGGCTTCATCGTCGAATCCGGCCGCGCGC
TGGTAATCGGTGTGAACAAGTGGGATGGCCTGACCGGGCATGCCCGCGATCGCATCAAGCACGATATGGAGCGCAAGCTG
CAGTTCCTGTCGTTTGCCAACGTGCATTACATCTCCGCCAAGGAACGTACGGGCATTGGTGCGCTGATGAAGTCCGTGGA
CGCCGCTTATGCTGCCGCCATGGTCAAGCTGCCGACGCCCAAGCTCACGCGTGTGCTGATGGAGGCGGTCGAGTATCAGC
AGCCGCGACGCGCAGGCGTTTCACGCCCTAAGCTGCGCTACGCGCACCAGGGCGGTTCCAACCCGCCGATCGTGGTGATT
CACGGCAATGCATTGTCGAATATTCCTGAAACCTATCGCCGCTTCCTGGAAGGGCGTTTCCGCGAGGCCTTCCAACTGAA
GGGCACACCGCTGCGGATCGAATTTCGTACGAACAAAAACCCGTACGCCCAATCGAACGATTGA

Upstream 100 bases:

>100_bases
GTCTTGCATCTGCGTCATCAGGCATTCAGCCGTGCAGATGCCAACCGCAGTTGCAGCAACCAGAATTTGCCGTGGCGCCA
TTCGCGTACGGCACACAAGC

Downstream 100 bases:

>100_bases
GCAGCGCGCGGGCGGTGCTCGTCGGCAGGGGCGTGTGACGCGGGGGCATTCGAACGGGGGATCACCAAAAAGGCCGAGCC
AATTCATATGGCGGGGTCAT

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MKPVIALVGRPNVGKSTLFNRLTRSRDALVADIPGLTRDRHYGEGRVGDRPFIAIDTGGFEPVAKEGIVAEMAKQTRQAV
VEADVVIFIVDGRLGLAPQDRVIADYLRKTGRRILLAVNKAEGMRYTAVASDFYELGLGDPAAISAAHGDGVNDLVAEAL
DLAFAERPELAEAADAHDHGTRIAIVGRPNVGKSTLVNALIGEERVIAFDMPGTTRDAIYVDFERNGKPYTLIDTAGLRK
RGKVFEAIEKFSVVKTLQSIADANVVVLILDAQQDISDQDAHIAGFIVESGRALVIGVNKWDGLTGHARDRIKHDMERKL
QFLSFANVHYISAKERTGIGALMKSVDAAYAAAMVKLPTPKLTRVLMEAVEYQQPRRAGVSRPKLRYAHQGGSNPPIVVI
HGNALSNIPETYRRFLEGRFREAFQLKGTPLRIEFRTNKNPYAQSND

Sequences:

>Translated_447_residues
MKPVIALVGRPNVGKSTLFNRLTRSRDALVADIPGLTRDRHYGEGRVGDRPFIAIDTGGFEPVAKEGIVAEMAKQTRQAV
VEADVVIFIVDGRLGLAPQDRVIADYLRKTGRRILLAVNKAEGMRYTAVASDFYELGLGDPAAISAAHGDGVNDLVAEAL
DLAFAERPELAEAADAHDHGTRIAIVGRPNVGKSTLVNALIGEERVIAFDMPGTTRDAIYVDFERNGKPYTLIDTAGLRK
RGKVFEAIEKFSVVKTLQSIADANVVVLILDAQQDISDQDAHIAGFIVESGRALVIGVNKWDGLTGHARDRIKHDMERKL
QFLSFANVHYISAKERTGIGALMKSVDAAYAAAMVKLPTPKLTRVLMEAVEYQQPRRAGVSRPKLRYAHQGGSNPPIVVI
HGNALSNIPETYRRFLEGRFREAFQLKGTPLRIEFRTNKNPYAQSND
>Mature_447_residues
MKPVIALVGRPNVGKSTLFNRLTRSRDALVADIPGLTRDRHYGEGRVGDRPFIAIDTGGFEPVAKEGIVAEMAKQTRQAV
VEADVVIFIVDGRLGLAPQDRVIADYLRKTGRRILLAVNKAEGMRYTAVASDFYELGLGDPAAISAAHGDGVNDLVAEAL
DLAFAERPELAEAADAHDHGTRIAIVGRPNVGKSTLVNALIGEERVIAFDMPGTTRDAIYVDFERNGKPYTLIDTAGLRK
RGKVFEAIEKFSVVKTLQSIADANVVVLILDAQQDISDQDAHIAGFIVESGRALVIGVNKWDGLTGHARDRIKHDMERKL
QFLSFANVHYISAKERTGIGALMKSVDAAYAAAMVKLPTPKLTRVLMEAVEYQQPRRAGVSRPKLRYAHQGGSNPPIVVI
HGNALSNIPETYRRFLEGRFREAFQLKGTPLRIEFRTNKNPYAQSND

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=472, Percent_Identity=50.4237288135593, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI2367268, Length=120, Percent_Identity=37.5, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788919, Length=161, Percent_Identity=32.2981366459627, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323665, Length=186, Percent_Identity=27.4193548387097, Blast_Score=74, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_RALPJ (B2U9V3)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001898643.1
- GeneID:   6288143
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_1063
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- ProtClustDB:   PRK00093
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00326
- SMART:   SM00382
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 48969; Mature: 48969

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVIALVGRPNVGKSTLFNRLTRSRDALVADIPGLTRDRHYGEGRVGDRPFIAIDTGGF
CCCEEEEECCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEECCCC
EPVAKEGIVAEMAKQTRQAVVEADVVIFIVDGRLGLAPQDRVIADYLRKTGRRILLAVNK
CHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEEEC
AEGMRYTAVASDFYELGLGDPAAISAAHGDGVNDLVAEALDLAFAERPELAEAADAHDHG
CCCCEEEEEHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCC
TRIAIVGRPNVGKSTLVNALIGEERVIAFDMPGTTRDAIYVDFERNGKPYTLIDTAGLRK
CEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCCCEEEEECCCCCH
RGKVFEAIEKFSVVKTLQSIADANVVVLILDAQQDISDQDAHIAGFIVESGRALVIGVNK
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEEEECCCEEEEEECC
WDGLTGHARDRIKHDMERKLQFLSFANVHYISAKERTGIGALMKSVDAAYAAAMVKLPTP
CCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHEECCCH
KLTRVLMEAVEYQQPRRAGVSRPKLRYAHQGGSNPPIVVIHGNALSNIPETYRRFLEGRF
HHHHHHHHHHHHCCHHHCCCCCCCCHHHHCCCCCCCEEEEECCHHHCCHHHHHHHHHHHH
REAFQLKGTPLRIEFRTNKNPYAQSND
HHHHHCCCCEEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MKPVIALVGRPNVGKSTLFNRLTRSRDALVADIPGLTRDRHYGEGRVGDRPFIAIDTGGF
CCCEEEEECCCCCCHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCCEEEEECCCC
EPVAKEGIVAEMAKQTRQAVVEADVVIFIVDGRLGLAPQDRVIADYLRKTGRRILLAVNK
CHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEEEC
AEGMRYTAVASDFYELGLGDPAAISAAHGDGVNDLVAEALDLAFAERPELAEAADAHDHG
CCCCEEEEEHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCCC
TRIAIVGRPNVGKSTLVNALIGEERVIAFDMPGTTRDAIYVDFERNGKPYTLIDTAGLRK
CEEEEEECCCCCHHHHHHHHHCCCEEEEEECCCCCCCEEEEEEECCCCCEEEEECCCCCH
RGKVFEAIEKFSVVKTLQSIADANVVVLILDAQQDISDQDAHIAGFIVESGRALVIGVNK
HHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCEEEEEEEECCCEEEEEECC
WDGLTGHARDRIKHDMERKLQFLSFANVHYISAKERTGIGALMKSVDAAYAAAMVKLPTP
CCCCCCHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHHHHHEECCCH
KLTRVLMEAVEYQQPRRAGVSRPKLRYAHQGGSNPPIVVIHGNALSNIPETYRRFLEGRF
HHHHHHHHHHHHCCHHHCCCCCCCCHHHHCCCCCCCEEEEECCHHHCCHHHHHHHHHHHH
REAFQLKGTPLRIEFRTNKNPYAQSND
HHHHHCCCCEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA