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The map label for this gene is norM [H]

Identifier: 187928116

GI number: 187928116

Start: 1083524

End: 1084870

Strand: Reverse

Name: norM [H]

Synonym: Rpic_1023

Alternate gene names: 187928116

Gene position: 1084870-1083524 (Counterclockwise)

Preceding gene: 187928117

Following gene: 187928114

Centisome position: 27.52

GC content: 62.58

Gene sequence:

>1347_bases
ATGTTTGTCGCCGACGTCCGCCGCATTACCGCACTGGCTTGGCCGGTGCTGATCGGCCAGTTGGCGGTCATCGCTTTCGG
CGTACTCGATACGGCGATGGCTGGCCGCGCGACTGCAGCAGACCTCGCGGCCATCGGACTCGGCGGGTCGATCTACGTGA
CGGTGTACATCAGCCTGATGGGTGTGCTGCAAGCGCTCTCGCCCATCGCCGGCCAACTGTATGGCGCGCAAAGGCACAGC
GAGATCGGCGAAGAAGTGCGCCAGGCTGTCTGGCTCGGGCTGGTGCTCGCGGCTATCGGCATGCTGATCCTGTGGTTCCC
TGCGCCGCTACTGCAACTGGCGGATGCGACACCGGAACTCACCGAGAAAGCCACCGCCTATTTGCGGTATGAAGCACTCG
CATTGCCTGCTGCGCTCGGCTTCCGGATCTACTCTGCGTTGAACAACGCGCTGTCGCGCCCAGTGATGGTGACGGTGCTG
CAGCTCGCCGGCCTCGCCATCAAATTTCCGCTCAACGCACTGTTTCTGTACGGCGGCATGGGCGTCCCCGCGATGGGTGG
CCCGGGCTGTGCACTCGCCTCGATGATTATCAGCTGGCTATGGTTTGTGGCTGCGGCCGCCATCCTGATGCGCAATCCAG
CGTACAAGCCGCTTGCGATTTTCACGCACTACTCGCCACCCAATCGCGCGCGGCTGTGGGCACTCGTACTCCTGGGTGTG
CCGATGGGCTTCACCTACCTGATCGAGATCACATCGTTCACGTTGATGGCGATCTTCATCGCGCGTCTCGGTACGGTGGT
CTTGGCAGGGCATCAGATTGCCGCCAACCTCGGGGCAGTGGCCTACATGGTGCCGCTGTCCTTGTCGATCGCGACGTCGA
CGCTGGCTGCGCAGTCGATCGGCGCGCGCGATCGCGTTGCGGCCCGACGCATCTCGCTGAACGGCATCAAATTGGCGGTG
ATGTGCGCGATCATCGTTTGCGCGGCCGTGCTGTTCTTGCGTCGCGAGCTGGTCAGCCTCTACACGCACGATGCTACTGT
CCTGGCGATTGCGGTGCCGCTGCTGCCTTTCATCGCCTTCTATCAGATGTTCGATGCGCTGCAGGTCATGACTGCATTCA
TCCTGCGCGCATACAAGATCGCGCTCATCCCGACCGTCATCTACGCCTTATCGCTGTGGGGCGTGGGTCTGGGCGGCGGC
TACGTGCTCGGATTTGGACTACTGGGCGAGTTTGCGACGCCTCTGCGTGGCGCAGCCGGCTTCTGGGCGGCCAATGCGCT
CAGTTTGATGGTGGCCGGCGCGTTGCTGGTCAGCTATTTCAATCGAGTTAGCCGTGCGCCCGATTAA

Upstream 100 bases:

>100_bases
TACCGCCTGACCGAGGCGGCCACCGCCACACATCCGCCGCCCGCGCCGGCCACCACACGCCGGCGCAAGCTGCGCCAATA
ACGCTCTCGGTCGTACCCAC

Downstream 100 bases:

>100_bases
AGAAAGCCATTCGCCGCCGCTTTAAAACGACGTCAATCTGGAATGACTAGAATTGAATAGAAAGCGCAAAAGAAAAAACC
CGCTGCAAGCAGCGGGTTTT

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MFVADVRRITALAWPVLIGQLAVIAFGVLDTAMAGRATAADLAAIGLGGSIYVTVYISLMGVLQALSPIAGQLYGAQRHS
EIGEEVRQAVWLGLVLAAIGMLILWFPAPLLQLADATPELTEKATAYLRYEALALPAALGFRIYSALNNALSRPVMVTVL
QLAGLAIKFPLNALFLYGGMGVPAMGGPGCALASMIISWLWFVAAAAILMRNPAYKPLAIFTHYSPPNRARLWALVLLGV
PMGFTYLIEITSFTLMAIFIARLGTVVLAGHQIAANLGAVAYMVPLSLSIATSTLAAQSIGARDRVAARRISLNGIKLAV
MCAIIVCAAVLFLRRELVSLYTHDATVLAIAVPLLPFIAFYQMFDALQVMTAFILRAYKIALIPTVIYALSLWGVGLGGG
YVLGFGLLGEFATPLRGAAGFWAANALSLMVAGALLVSYFNRVSRAPD

Sequences:

>Translated_448_residues
MFVADVRRITALAWPVLIGQLAVIAFGVLDTAMAGRATAADLAAIGLGGSIYVTVYISLMGVLQALSPIAGQLYGAQRHS
EIGEEVRQAVWLGLVLAAIGMLILWFPAPLLQLADATPELTEKATAYLRYEALALPAALGFRIYSALNNALSRPVMVTVL
QLAGLAIKFPLNALFLYGGMGVPAMGGPGCALASMIISWLWFVAAAAILMRNPAYKPLAIFTHYSPPNRARLWALVLLGV
PMGFTYLIEITSFTLMAIFIARLGTVVLAGHQIAANLGAVAYMVPLSLSIATSTLAAQSIGARDRVAARRISLNGIKLAV
MCAIIVCAAVLFLRRELVSLYTHDATVLAIAVPLLPFIAFYQMFDALQVMTAFILRAYKIALIPTVIYALSLWGVGLGGG
YVLGFGLLGEFATPLRGAAGFWAANALSLMVAGALLVSYFNRVSRAPD
>Mature_448_residues
MFVADVRRITALAWPVLIGQLAVIAFGVLDTAMAGRATAADLAAIGLGGSIYVTVYISLMGVLQALSPIAGQLYGAQRHS
EIGEEVRQAVWLGLVLAAIGMLILWFPAPLLQLADATPELTEKATAYLRYEALALPAALGFRIYSALNNALSRPVMVTVL
QLAGLAIKFPLNALFLYGGMGVPAMGGPGCALASMIISWLWFVAAAAILMRNPAYKPLAIFTHYSPPNRARLWALVLLGV
PMGFTYLIEITSFTLMAIFIARLGTVVLAGHQIAANLGAVAYMVPLSLSIATSTLAAQSIGARDRVAARRISLNGIKLAV
MCAIIVCAAVLFLRRELVSLYTHDATVLAIAVPLLPFIAFYQMFDALQVMTAFILRAYKIALIPTVIYALSLWGVGLGGG
YVLGFGLLGEFATPLRGAAGFWAANALSLMVAGALLVSYFNRVSRAPD

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=433, Percent_Identity=22.4018475750577, Blast_Score=73, Evalue=7e-13,
Organism=Escherichia coli, GI48994890, Length=448, Percent_Identity=30.1339285714286, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI226510954, Length=411, Percent_Identity=23.3576642335766, Blast_Score=63, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321821, Length=352, Percent_Identity=27.2727272727273, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6320545, Length=404, Percent_Identity=23.7623762376238, Blast_Score=82, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 47519; Mature: 47519

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVADVRRITALAWPVLIGQLAVIAFGVLDTAMAGRATAADLAAIGLGGSIYVTVYISLM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHH
GVLQALSPIAGQLYGAQRHSEIGEEVRQAVWLGLVLAAIGMLILWFPAPLLQLADATPEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
TEKATAYLRYEALALPAALGFRIYSALNNALSRPVMVTVLQLAGLAIKFPLNALFLYGGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHCCCHHHHHHCCCC
GVPAMGGPGCALASMIISWLWFVAAAAILMRNPAYKPLAIFTHYSPPNRARLWALVLLGV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHC
PMGFTYLIEITSFTLMAIFIARLGTVVLAGHQIAANLGAVAYMVPLSLSIATSTLAAQSI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GARDRVAARRISLNGIKLAVMCAIIVCAAVLFLRRELVSLYTHDATVLAIAVPLLPFIAF
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
YQMFDALQVMTAFILRAYKIALIPTVIYALSLWGVGLGGGYVLGFGLLGEFATPLRGAAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCH
FWAANALSLMVAGALLVSYFNRVSRAPD
HHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFVADVRRITALAWPVLIGQLAVIAFGVLDTAMAGRATAADLAAIGLGGSIYVTVYISLM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHHHHHHHHH
GVLQALSPIAGQLYGAQRHSEIGEEVRQAVWLGLVLAAIGMLILWFPAPLLQLADATPEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
TEKATAYLRYEALALPAALGFRIYSALNNALSRPVMVTVLQLAGLAIKFPLNALFLYGGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCHHHCCCHHHHHHCCCC
GVPAMGGPGCALASMIISWLWFVAAAAILMRNPAYKPLAIFTHYSPPNRARLWALVLLGV
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHC
PMGFTYLIEITSFTLMAIFIARLGTVVLAGHQIAANLGAVAYMVPLSLSIATSTLAAQSI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GARDRVAARRISLNGIKLAVMCAIIVCAAVLFLRRELVSLYTHDATVLAIAVPLLPFIAF
CCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
YQMFDALQVMTAFILRAYKIALIPTVIYALSLWGVGLGGGYVLGFGLLGEFATPLRGAAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCH
FWAANALSLMVAGALLVSYFNRVSRAPD
HHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA