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The map label for this gene is dapA [H]

Identifier: 187928080

GI number: 187928080

Start: 1042271

End: 1043155

Strand: Direct

Name: dapA [H]

Synonym: Rpic_0987

Alternate gene names: 187928080

Gene position: 1042271-1043155 (Clockwise)

Preceding gene: 187928079

Following gene: 187928081

Centisome position: 26.44

GC content: 63.5

Gene sequence:

>885_bases
ATGATCCAGATTTCCGGCAGTCTCGTCGCCATCGTCACGCCCATGCACGAGGACGGCAGCCTTGATTTCCCGTCCCTGCG
CAAGCTCATCGACTGGCACATCGCCGAAGGCACCGACGGCATCGTGATCGTCGGAACCAGCGGCGAATCGCCGACCGTGT
CGGTGGAAGAGCACCGTGAACTAATCCGCGTGGCGGTCGAGCAGGCCAACAAGCGCATTCCCATCATTGCCGGTACCGGC
GGCAACTCCACCACCGAGGCGGTGGAGCTGACGGCCTACGCCAAGCAAGTAGGCGCTGATGCCTCCCTGCAGGTCGTGCC
GTACTACAACAAGCCGACGCAGGAAGGCATGTATCTGCACTTCCGCAAGGTGGCCGAGTCGGTGGATCTGCCGGTCATTC
TGTACAACGTGCCGGGCCGCACCGTGGCCGATATGACGGTCGAAACCATGCTGCGTCTGGCCGAAGTGCCGGGCATCATC
GGCGTGAAGGAAGCCACGGGCAACATCGACCGCGCCGCGCACCTCATCAAGGGCGCACCGGCCTCGTTCAAGATTTACAG
CGGGGATGATCCGACGGCCATCGCGCTGATGCTGCTGGGTGGCCACGGCAACATTTCCGTGACGGCCAACGTGGCGCCGC
GTGCCATGCACGAACTGTGCGTTGCCGCCATGCGCGGCGACGTGGAGACGGCTCGCCGCATCCACATGCAACTGCTGTCG
GTGCACAAGAACCTGTTCGTCGAGTCGAACCCGATTCCCGTCAAGTGGGCTCTCCAGGCCATGGGCAAGATGGAAGGTGG
CATTCGCCTGCCGTTGACGCCGCTGGCACCCCAGTATCACGAGGTTGTGCGCGCATCCCTGAAGGATGCCGGGCTGCTCT
CCTGA

Upstream 100 bases:

>100_bases
CTTACCCGTCTCTTGGCGGGTCTCAGATGTGGCGAATCCGTTCTGACGATCCGGTACAATCCGACTGTTTACGTTCACGC
TTTTGTCTGCTTTCGAAACC

Downstream 100 bases:

>100_bases
TTGTTTCAAGGCGCTTCTCAGGCCCTTAAGCCATCGTTCTCATCTGAAGGATCGCAAGTCAATGAAACTGCACCAAACCC
GTCGCGGGGCTGTGGCGACG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MIQISGSLVAIVTPMHEDGSLDFPSLRKLIDWHIAEGTDGIVIVGTSGESPTVSVEEHRELIRVAVEQANKRIPIIAGTG
GNSTTEAVELTAYAKQVGADASLQVVPYYNKPTQEGMYLHFRKVAESVDLPVILYNVPGRTVADMTVETMLRLAEVPGII
GVKEATGNIDRAAHLIKGAPASFKIYSGDDPTAIALMLLGGHGNISVTANVAPRAMHELCVAAMRGDVETARRIHMQLLS
VHKNLFVESNPIPVKWALQAMGKMEGGIRLPLTPLAPQYHEVVRASLKDAGLLS

Sequences:

>Translated_294_residues
MIQISGSLVAIVTPMHEDGSLDFPSLRKLIDWHIAEGTDGIVIVGTSGESPTVSVEEHRELIRVAVEQANKRIPIIAGTG
GNSTTEAVELTAYAKQVGADASLQVVPYYNKPTQEGMYLHFRKVAESVDLPVILYNVPGRTVADMTVETMLRLAEVPGII
GVKEATGNIDRAAHLIKGAPASFKIYSGDDPTAIALMLLGGHGNISVTANVAPRAMHELCVAAMRGDVETARRIHMQLLS
VHKNLFVESNPIPVKWALQAMGKMEGGIRLPLTPLAPQYHEVVRASLKDAGLLS
>Mature_294_residues
MIQISGSLVAIVTPMHEDGSLDFPSLRKLIDWHIAEGTDGIVIVGTSGESPTVSVEEHRELIRVAVEQANKRIPIIAGTG
GNSTTEAVELTAYAKQVGADASLQVVPYYNKPTQEGMYLHFRKVAESVDLPVILYNVPGRTVADMTVETMLRLAEVPGII
GVKEATGNIDRAAHLIKGAPASFKIYSGDDPTAIALMLLGGHGNISVTANVAPRAMHELCVAAMRGDVETARRIHMQLLS
VHKNLFVESNPIPVKWALQAMGKMEGGIRLPLTPLAPQYHEVVRASLKDAGLLS

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=295, Percent_Identity=27.1186440677966, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI13540533, Length=304, Percent_Identity=25, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=51.2027491408935, Blast_Score=295, Evalue=2e-81,
Organism=Escherichia coli, GI1786463, Length=245, Percent_Identity=36.734693877551, Blast_Score=154, Evalue=8e-39,
Organism=Escherichia coli, GI87082415, Length=270, Percent_Identity=34.0740740740741, Blast_Score=151, Evalue=5e-38,
Organism=Escherichia coli, GI1789620, Length=239, Percent_Identity=29.2887029288703, Blast_Score=129, Evalue=2e-31,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31550; Mature: 31550

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQISGSLVAIVTPMHEDGSLDFPSLRKLIDWHIAEGTDGIVIVGTSGESPTVSVEEHRE
CEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEHHHHHH
LIRVAVEQANKRIPIIAGTGGNSTTEAVELTAYAKQVGADASLQVVPYYNKPTQEGMYLH
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHH
FRKVAESVDLPVILYNVPGRTVADMTVETMLRLAEVPGIIGVKEATGNIDRAAHLIKGAP
HHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCC
ASFKIYSGDDPTAIALMLLGGHGNISVTANVAPRAMHELCVAAMRGDVETARRIHMQLLS
CEEEEECCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VHKNLFVESNPIPVKWALQAMGKMEGGIRLPLTPLAPQYHEVVRASLKDAGLLS
HHHHHEECCCCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MIQISGSLVAIVTPMHEDGSLDFPSLRKLIDWHIAEGTDGIVIVGTSGESPTVSVEEHRE
CEEECCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCEEEHHHHHH
LIRVAVEQANKRIPIIAGTGGNSTTEAVELTAYAKQVGADASLQVVPYYNKPTQEGMYLH
HHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHH
FRKVAESVDLPVILYNVPGRTVADMTVETMLRLAEVPGIIGVKEATGNIDRAAHLIKGAP
HHHHHHHCCCCEEEEECCCCEEHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHCCCC
ASFKIYSGDDPTAIALMLLGGHGNISVTANVAPRAMHELCVAAMRGDVETARRIHMQLLS
CEEEEECCCCCCEEEEEEECCCCCEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHH
VHKNLFVESNPIPVKWALQAMGKMEGGIRLPLTPLAPQYHEVVRASLKDAGLLS
HHHHHEECCCCCCHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]