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The map label for this gene is kdsA

Identifier: 187928063

GI number: 187928063

Start: 1028873

End: 1029727

Strand: Direct

Name: kdsA

Synonym: Rpic_0970

Alternate gene names: 187928063

Gene position: 1028873-1029727 (Clockwise)

Preceding gene: 187928062

Following gene: 187928064

Centisome position: 26.1

GC content: 62.57

Gene sequence:

>855_bases
ATGAAACTCTGCGATTTCGAAGTCGGCCTCGACAAACCGTTCTTCCTGATTGCCGGCACCTGCGTGATCGAATCCGAGCA
GATGGCGATCGACACCGCCGGTACGCTCAAGGAGATCACGGGTGCGTTGGGCATTCCGTTCATCTACAAGTCGTCGTTCG
ACAAGGCGAACCGCTCGTCGGACGCTTCGTTCCGCGGTCTGGGCATGGAAGAGGGGCTGCGCATTCTGTCGGAGGTCCGT
CGCCAGGTGGGCGTGCCGGTGCTGACCGACATCCACGAGATCGACGAGATCAAGCCGGTGGCCGAAGTCGTGGACGTGCT
CCAGACGCCGGCGTTCCTGTGCCGCCAGACCGATTTCATCCGCGCCTGCGCGCAGAGCGGCAAGCCCGTCAACATCAAGA
AGGGCCAGTTCCTCGCACCGCACGACATGAAGAATGTCATCGACAAGGCGCGTCACGCTGCCCGCGATGCCGGTCTGCCG
GAAGACAACTTCATGGCCTGCGAGCGCGGCGCCTCGTTCGGTTACAACAACCTGGTGTCGGACATGCGCTCGCTGGCGAT
CATGCGCGAGACGGGGGCGCCGGTGGTGTTCGACGCCACGCATTCGGTGCAATTGCCGGGCGGCCAGGGCACCAGTTCGG
GCGGCCAGCGGGAGTTCGTGCCGGTGCTGGCTCGTGCCGCGATCGCTGTGGGGGTTGCAGGTGTCTTCATGGAAACGCAC
CCCGATCCCGCATGCGCAAAATCAGATGGCCCGAATGCTGTGCCGCTGCGGCGCATGAAAGACTTGCTGTCAGTACTGAA
AGAACTGGATGCGCTCACCAAGCGCAGCGGTTTCCTGGAAAATCAGTTCGACTGA

Upstream 100 bases:

>100_bases
TGACGGCCACCCGCTGTTCAAAGCCTACGTGGAAGCCGCGCTGGCACATCAGCAGAACACGCAACGCGCTGCCGCCTGAG
CGCCGGCACACGGGAACATC

Downstream 100 bases:

>100_bases
TTTCCCCCGATGACCGGCGGCTCTACCAGCCGCCGCTGTCGTTTTCGGTTCAGCCCAGTTCAGTTTTCGTTTCGGCATCC
GGAGAGAGACACATGGCCGC

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MKLCDFEVGLDKPFFLIAGTCVIESEQMAIDTAGTLKEITGALGIPFIYKSSFDKANRSSDASFRGLGMEEGLRILSEVR
RQVGVPVLTDIHEIDEIKPVAEVVDVLQTPAFLCRQTDFIRACAQSGKPVNIKKGQFLAPHDMKNVIDKARHAARDAGLP
EDNFMACERGASFGYNNLVSDMRSLAIMRETGAPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAAIAVGVAGVFMETH
PDPACAKSDGPNAVPLRRMKDLLSVLKELDALTKRSGFLENQFD

Sequences:

>Translated_284_residues
MKLCDFEVGLDKPFFLIAGTCVIESEQMAIDTAGTLKEITGALGIPFIYKSSFDKANRSSDASFRGLGMEEGLRILSEVR
RQVGVPVLTDIHEIDEIKPVAEVVDVLQTPAFLCRQTDFIRACAQSGKPVNIKKGQFLAPHDMKNVIDKARHAARDAGLP
EDNFMACERGASFGYNNLVSDMRSLAIMRETGAPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAAIAVGVAGVFMETH
PDPACAKSDGPNAVPLRRMKDLLSVLKELDALTKRSGFLENQFD
>Mature_284_residues
MKLCDFEVGLDKPFFLIAGTCVIESEQMAIDTAGTLKEITGALGIPFIYKSSFDKANRSSDASFRGLGMEEGLRILSEVR
RQVGVPVLTDIHEIDEIKPVAEVVDVLQTPAFLCRQTDFIRACAQSGKPVNIKKGQFLAPHDMKNVIDKARHAARDAGLP
EDNFMACERGASFGYNNLVSDMRSLAIMRETGAPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAAIAVGVAGVFMETH
PDPACAKSDGPNAVPLRRMKDLLSVLKELDALTKRSGFLENQFD

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family

Homologues:

Organism=Escherichia coli, GI1787466, Length=282, Percent_Identity=45.3900709219858, Blast_Score=256, Evalue=1e-69,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): KDSA_RALPJ (B2U9C1)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001898550.1
- ProteinModelPortal:   B2U9C1
- SMR:   B2U9C1
- GeneID:   6286623
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_0970
- HOGENOM:   HBG575990
- OMA:   PDPSKAM
- ProtClustDB:   PRK05198
- GO:   GO:0005737
- HAMAP:   MF_00056
- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR21057:SF2
- TIGRFAMs:   TIGR01362

Pfam domain/function: PF00793 DAHP_synth_1

EC number: =2.5.1.55

Molecular weight: Translated: 30728; Mature: 30728

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLCDFEVGLDKPFFLIAGTCVIESEQMAIDTAGTLKEITGALGIPFIYKSSFDKANRSS
CCCCCCCCCCCCCEEEEECCCEECCCHHHHCCHHHHHHHHHHHCCCHHHHCCCCCCCCCC
DASFRGLGMEEGLRILSEVRRQVGVPVLTDIHEIDEIKPVAEVVDVLQTPAFLCRQTDFI
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
RACAQSGKPVNIKKGQFLAPHDMKNVIDKARHAARDAGLPEDNFMACERGASFGYNNLVS
HHHHHCCCCCEECCCCEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHH
DMRSLAIMRETGAPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAAIAVGVAGVFMETH
HHHHHHHHHHCCCCEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PDPACAKSDGPNAVPLRRMKDLLSVLKELDALTKRSGFLENQFD
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MKLCDFEVGLDKPFFLIAGTCVIESEQMAIDTAGTLKEITGALGIPFIYKSSFDKANRSS
CCCCCCCCCCCCCEEEEECCCEECCCHHHHCCHHHHHHHHHHHCCCHHHHCCCCCCCCCC
DASFRGLGMEEGLRILSEVRRQVGVPVLTDIHEIDEIKPVAEVVDVLQTPAFLCRQTDFI
CCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
RACAQSGKPVNIKKGQFLAPHDMKNVIDKARHAARDAGLPEDNFMACERGASFGYNNLVS
HHHHHCCCCCEECCCCEECCHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCHHHHHH
DMRSLAIMRETGAPVVFDATHSVQLPGGQGTSSGGQREFVPVLARAAIAVGVAGVFMETH
HHHHHHHHHHCCCCEEEECCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
PDPACAKSDGPNAVPLRRMKDLLSVLKELDALTKRSGFLENQFD
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA