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The map label for this gene is fabF [H]

Identifier: 187928014

GI number: 187928014

Start: 972518

End: 973750

Strand: Direct

Name: fabF [H]

Synonym: Rpic_0919

Alternate gene names: 187928014

Gene position: 972518-973750 (Clockwise)

Preceding gene: 187928013

Following gene: 187928015

Centisome position: 24.67

GC content: 62.45

Gene sequence:

>1233_bases
GTGAGCCGTCGTCGCGTAGTCGTAACCGGCCTGGGGCTGGTCTCTCCAGTAGGGAACTCGGTCGCCGAGGGGTGGGCCAA
TCTGGTCGCCGGCAAGTCCGGGATCGCTACCATCACCAAATTCGATCCGTCGAACCTGGCCGTGCATTTCGCGGGCGAGG
TGAAGGGTTTCAACGCAGAGGATTACATCCCTGCGAAGGAAGCCCGCAACATGGATACCTTCATCCACTATGGCATCGCT
GCTGGCGTCCAAGCGTTGAAGGACAGCGGGCTGGAAGTGACCGAAGCCAATGCCGAGCGCATCGGTGTGCTGGTCGGCTC
CGGTATCGGCGGTCTGCCGATGATCGAAGATACGCACCAGACCTACGTCGATCGTGGCCCGCGCCGGATTTCGCCGTTCT
TTGTGCCGGGTTCGATCATCAACATGATCTCCGGCCATCTGAGCATCATGTTCGGTTTGAAGGGGCCGAACCTGGCGGCC
GTCACGGCTTGCACGACCGGTCTGCACAGCATTGGTCTGGCTGCGCGCCTGATCCAGGCCGGCGATGCTGACGCGATGGT
TGCCGGCGGTGCCGAATCGACCGTGTCGCCGCTGGGCATCGGCGGCTTTGCCGCAGCCCGCGCGCTGTCCACGCGCAATG
AGGATCCGGCCACTGCGTCGCGCCCCTGGGACAAAGACCGCGACGGCTTTGTGCTGGGCGAAGGTGCTGGCGTGATGGTG
CTGGAAGAGTACGAGTCGGCCAAGGCGCGCGGTGCCACGATCTACGCGGAAATCGCTGGCTTCGGCATGAGCGGCGACGC
CTTCCACATGACAGCGCCGAACATGGACGGCCCGCGTCGTTGCATGCTGAACGCACTGCGCGACGCAGGCATGAATGCGG
ATCAAGTCCATTATCTGAACGCGCACGGTACGTCTACGCCGCTGGGCGACAAGAACGAATCCGAAGCCATCAAGGCGGCT
TTCGGCGATCATGCCAGCAAGGTTGTCGTGAATTCCACCAAGTCCATGACCGGACACTTGCTGGGCGGCGCGGGCGGGCT
GGAATCGGTGTTCACGGTGCTGGCGCTGCACCATCAGGTATCGCCGCCGACCATCAACATCTTCAACCAGGATCCCGAGT
GCGATCTCGATTACTGCGCCAACACCGCGCGTGACATGAAGATCGACGTGGCCGTGAAAAACAACTTCGGCTTCGGTGGG
ACGAACGGTACGCTGGTGTTCAAGCGCCCGTAA

Upstream 100 bases:

>100_bases
TCTTGACATCGCGGGCCACAGAAGGGGCGGTTGTCCGGTTTGACCGGGTGGCGCGTTTTCTGTGGCCTTTGTCGCTGATA
CAGAGTTGCAGGAAAGCATA

Downstream 100 bases:

>100_bases
GGCGGAGCGGCTCGTAGCCTCACGGCGCGAGCGGCTTCGTTGTTGCCTTGGTCGTCCAGAATATTGTTTTCCCAGCGTCG
TACCGGCGGTTGTGCGCGAT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSRRRVVVTGLGLVSPVGNSVAEGWANLVAGKSGIATITKFDPSNLAVHFAGEVKGFNAEDYIPAKEARNMDTFIHYGIA
AGVQALKDSGLEVTEANAERIGVLVGSGIGGLPMIEDTHQTYVDRGPRRISPFFVPGSIINMISGHLSIMFGLKGPNLAA
VTACTTGLHSIGLAARLIQAGDADAMVAGGAESTVSPLGIGGFAAARALSTRNEDPATASRPWDKDRDGFVLGEGAGVMV
LEEYESAKARGATIYAEIAGFGMSGDAFHMTAPNMDGPRRCMLNALRDAGMNADQVHYLNAHGTSTPLGDKNESEAIKAA
FGDHASKVVVNSTKSMTGHLLGGAGGLESVFTVLALHHQVSPPTINIFNQDPECDLDYCANTARDMKIDVAVKNNFGFGG
TNGTLVFKRP

Sequences:

>Translated_410_residues
MSRRRVVVTGLGLVSPVGNSVAEGWANLVAGKSGIATITKFDPSNLAVHFAGEVKGFNAEDYIPAKEARNMDTFIHYGIA
AGVQALKDSGLEVTEANAERIGVLVGSGIGGLPMIEDTHQTYVDRGPRRISPFFVPGSIINMISGHLSIMFGLKGPNLAA
VTACTTGLHSIGLAARLIQAGDADAMVAGGAESTVSPLGIGGFAAARALSTRNEDPATASRPWDKDRDGFVLGEGAGVMV
LEEYESAKARGATIYAEIAGFGMSGDAFHMTAPNMDGPRRCMLNALRDAGMNADQVHYLNAHGTSTPLGDKNESEAIKAA
FGDHASKVVVNSTKSMTGHLLGGAGGLESVFTVLALHHQVSPPTINIFNQDPECDLDYCANTARDMKIDVAVKNNFGFGG
TNGTLVFKRP
>Mature_409_residues
SRRRVVVTGLGLVSPVGNSVAEGWANLVAGKSGIATITKFDPSNLAVHFAGEVKGFNAEDYIPAKEARNMDTFIHYGIAA
GVQALKDSGLEVTEANAERIGVLVGSGIGGLPMIEDTHQTYVDRGPRRISPFFVPGSIINMISGHLSIMFGLKGPNLAAV
TACTTGLHSIGLAARLIQAGDADAMVAGGAESTVSPLGIGGFAAARALSTRNEDPATASRPWDKDRDGFVLGEGAGVMVL
EEYESAKARGATIYAEIAGFGMSGDAFHMTAPNMDGPRRCMLNALRDAGMNADQVHYLNAHGTSTPLGDKNESEAIKAAF
GDHASKVVVNSTKSMTGHLLGGAGGLESVFTVLALHHQVSPPTINIFNQDPECDLDYCANTARDMKIDVAVKNNFGFGGT
NGTLVFKRP

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=46.875, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI223972627, Length=152, Percent_Identity=49.3421052631579, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI41872631, Length=438, Percent_Identity=24.2009132420091, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1787337, Length=412, Percent_Identity=62.378640776699, Blast_Score=499, Evalue=1e-142,
Organism=Escherichia coli, GI1788663, Length=411, Percent_Identity=38.9294403892944, Blast_Score=245, Evalue=4e-66,
Organism=Caenorhabditis elegans, GI71983541, Length=412, Percent_Identity=34.9514563106796, Blast_Score=233, Evalue=9e-62,
Organism=Caenorhabditis elegans, GI71983535, Length=255, Percent_Identity=38.8235294117647, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI212642053, Length=379, Percent_Identity=25.5936675461741, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17550940, Length=415, Percent_Identity=25.3012048192771, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320904, Length=449, Percent_Identity=37.6391982182628, Blast_Score=264, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24644341, Length=415, Percent_Identity=44.578313253012, Blast_Score=328, Evalue=4e-90,
Organism=Drosophila melanogaster, GI19920632, Length=375, Percent_Identity=24.8, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI221330659, Length=375, Percent_Identity=24.8, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24581345, Length=428, Percent_Identity=22.196261682243, Blast_Score=93, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 42816; Mature: 42685

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRRVVVTGLGLVSPVGNSVAEGWANLVAGKSGIATITKFDPSNLAVHFAGEVKGFNAE
CCCCEEEEEECCHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCCC
DYIPAKEARNMDTFIHYGIAAGVQALKDSGLEVTEANAERIGVLVGSGIGGLPMIEDTHQ
CCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEECCCCCCCCCCCCHH
TYVDRGPRRISPFFVPGSIINMISGHLSIMFGLKGPNLAAVTACTTGLHSIGLAARLIQA
HHHHCCCCCCCCEECCHHHHHHHCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHC
GDADAMVAGGAESTVSPLGIGGFAAARALSTRNEDPATASRPWDKDRDGFVLGEGAGVMV
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYESAKARGATIYAEIAGFGMSGDAFHMTAPNMDGPRRCMLNALRDAGMNADQVHYLN
EECCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEE
AHGTSTPLGDKNESEAIKAAFGDHASKVVVNSTKSMTGHLLGGAGGLESVFTVLALHHQV
CCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHCC
SPPTINIFNQDPECDLDYCANTARDMKIDVAVKNNFGFGGTNGTLVFKRP
CCCEEEEECCCCCCCHHHHCCCCCCEEEEEEEECCCCCCCCCCEEEEECC
>Mature Secondary Structure 
SRRRVVVTGLGLVSPVGNSVAEGWANLVAGKSGIATITKFDPSNLAVHFAGEVKGFNAE
CCCEEEEEECCHHHHCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCCC
DYIPAKEARNMDTFIHYGIAAGVQALKDSGLEVTEANAERIGVLVGSGIGGLPMIEDTHQ
CCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEEECCCCCCCCCCCCHH
TYVDRGPRRISPFFVPGSIINMISGHLSIMFGLKGPNLAAVTACTTGLHSIGLAARLIQA
HHHHCCCCCCCCEECCHHHHHHHCCCEEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHHC
GDADAMVAGGAESTVSPLGIGGFAAARALSTRNEDPATASRPWDKDRDGFVLGEGAGVMV
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYESAKARGATIYAEIAGFGMSGDAFHMTAPNMDGPRRCMLNALRDAGMNADQVHYLN
EECCCCCCCCCCEEEEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCEEEEEE
AHGTSTPLGDKNESEAIKAAFGDHASKVVVNSTKSMTGHLLGGAGGLESVFTVLALHHQV
CCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCEEEECCCCCHHHHHHHHHHHHCC
SPPTINIFNQDPECDLDYCANTARDMKIDVAVKNNFGFGGTNGTLVFKRP
CCCEEEEECCCCCCCHHHHCCCCCCEEEEEEEECCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]