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The map label for this gene is fabH

Identifier: 187928010

GI number: 187928010

Start: 969272

End: 970252

Strand: Direct

Name: fabH

Synonym: Rpic_0915

Alternate gene names: 187928010

Gene position: 969272-970252 (Clockwise)

Preceding gene: 187928009

Following gene: 187928011

Centisome position: 24.58

GC content: 64.53

Gene sequence:

>981_bases
ATGACACGTTTCGCAAGGATCATCGGTACGGGCAGCTACCTGCCGCCCAAGCGGGTCACCAATGACGAACTGGCGGCCCA
GTTGGCCGAGAAGGGTATCGAGACGAGCGACGAATGGATCGTCTCGCGCAGCGGCATTCGGGCGCGTCATTTCGCCGAGC
CGGATGTCACGTGCAGCGACCTCGCCGTAAGGGCGGCCGAGCGCGCGATCGAAGCCGCCGGCATCGATCGCTCCGAACTC
GACCTGATCCTGGTGGCGACGTCCACGCCGGATTTCGTGTTCCCGAGCACGGCGTGCCTGGTGCAGCAAAAGCTCGGCAT
CACCAACGGGTGCGCCGCGTTCGACGTGCAGGCCGTGTGTTCCGGCTTCGTCTACGCGCTGGCAACCGCCGACAAATTTA
TCCGCTCGGGTGCCTATCGCAACGTGCTGGTGATTGGCTCCGAGGTCTTCTCGCGCATCATCGATTTCAGCGATCGCACC
ACTTGTGTCCTGTTTGGCGATGGCGCTGGCGCCGTGGTGCTGCAGGCTTCTGACGAGCCGGGCATCCTGTCGACTGCGCT
CCATGCTGACGGCAGCCACGCCAACATCCTGTGCGTGCCGGGCAACGTGGCCGCGGGTGCAATCCAGGGCAGCGCCTTCC
TGTACATGGATGGTCAGGCTGTCTTCAAGCTGGCCGTCACGGTGCTCGACAAGGTTGCCCGTGAAGCACTGGCAGCGGCG
GAACTCGATGCCTCGCAAGTCGACTGGTTGATCCCGCACCAGGCGAACATCCGCATCATGCAGGGCACGACCAAGAAGCT
GGGCCTCTCGAACGAGCGCCTGATCGTGACCGTCGATGAGCATGGCAACACGTCGGCTGCCTCGATTCCCCTGGCGCTCG
ATGTTGCTGTGCGCGACGGTCGCATCCAGCGCGGCCAGCATGTGATGCTCGAGGGCGTGGGCGGCGGCTTCACATGGGGC
GCCGCGCTGCTGCGCTTCTGA

Upstream 100 bases:

>100_bases
CACCATGACGCAGCGGGCGCTGCGCCGGTCTCCACTTCCGCTCCGGCCGCCGACGCTGCTTGAACGCGTCGCCTCCGAGT
CAGATTTCACCCCACCGCAC

Downstream 100 bases:

>100_bases
TTGACGAATTTCCAGAACGAACAATACGAGCCATGACATTCGCTTTCGTCTTCCCCGGCCAGGGTTCGCAATCGGTCGGC
ATGCTCAATGCGTTTGCCGA

Product: 3-oxoacyl-(acyl carrier protein) synthase III

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase III; Beta-ketoacyl-ACP synthase III; KAS III

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MTRFARIIGTGSYLPPKRVTNDELAAQLAEKGIETSDEWIVSRSGIRARHFAEPDVTCSDLAVRAAERAIEAAGIDRSEL
DLILVATSTPDFVFPSTACLVQQKLGITNGCAAFDVQAVCSGFVYALATADKFIRSGAYRNVLVIGSEVFSRIIDFSDRT
TCVLFGDGAGAVVLQASDEPGILSTALHADGSHANILCVPGNVAAGAIQGSAFLYMDGQAVFKLAVTVLDKVAREALAAA
ELDASQVDWLIPHQANIRIMQGTTKKLGLSNERLIVTVDEHGNTSAASIPLALDVAVRDGRIQRGQHVMLEGVGGGFTWG
AALLRF

Sequences:

>Translated_326_residues
MTRFARIIGTGSYLPPKRVTNDELAAQLAEKGIETSDEWIVSRSGIRARHFAEPDVTCSDLAVRAAERAIEAAGIDRSEL
DLILVATSTPDFVFPSTACLVQQKLGITNGCAAFDVQAVCSGFVYALATADKFIRSGAYRNVLVIGSEVFSRIIDFSDRT
TCVLFGDGAGAVVLQASDEPGILSTALHADGSHANILCVPGNVAAGAIQGSAFLYMDGQAVFKLAVTVLDKVAREALAAA
ELDASQVDWLIPHQANIRIMQGTTKKLGLSNERLIVTVDEHGNTSAASIPLALDVAVRDGRIQRGQHVMLEGVGGGFTWG
AALLRF
>Mature_325_residues
TRFARIIGTGSYLPPKRVTNDELAAQLAEKGIETSDEWIVSRSGIRARHFAEPDVTCSDLAVRAAERAIEAAGIDRSELD
LILVATSTPDFVFPSTACLVQQKLGITNGCAAFDVQAVCSGFVYALATADKFIRSGAYRNVLVIGSEVFSRIIDFSDRTT
CVLFGDGAGAVVLQASDEPGILSTALHADGSHANILCVPGNVAAGAIQGSAFLYMDGQAVFKLAVTVLDKVAREALAAAE
LDASQVDWLIPHQANIRIMQGTTKKLGLSNERLIVTVDEHGNTSAASIPLALDVAVRDGRIQRGQHVMLEGVGGGFTWGA
ALLRF

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the

COG id: COG0332

COG function: function code I; 3-oxoacyl-[acyl-carrier-protein] synthase III

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabH family

Homologues:

Organism=Escherichia coli, GI1787333, Length=323, Percent_Identity=56.0371517027864, Blast_Score=362, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): FABH_RALPJ (B2U968)

Other databases:

- EMBL:   CP001068
- RefSeq:   YP_001898497.1
- GeneID:   6288548
- GenomeReviews:   CP001068_GR
- KEGG:   rpi:Rpic_0915
- HOGENOM:   HBG649927
- OMA:   ATTTPDM
- ProtClustDB:   PRK09352
- GO:   GO:0005737
- HAMAP:   MF_01815
- InterPro:   IPR013751
- InterPro:   IPR013747
- InterPro:   IPR004655
- InterPro:   IPR016039
- InterPro:   IPR016038
- Gene3D:   G3DSA:3.40.47.10
- TIGRFAMs:   TIGR00747

Pfam domain/function: PF08545 ACP_syn_III; PF08541 ACP_syn_III_C; SSF53901 Thiolase-like

EC number: =2.3.1.180

Molecular weight: Translated: 34517; Mature: 34385

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: NA

Important sites: ACT_SITE 120-120 ACT_SITE 253-253 ACT_SITE 283-283

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRFARIIGTGSYLPPKRVTNDELAAQLAEKGIETSDEWIVSRSGIRARHFAEPDVTCSD
CCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCCCCCHHH
LAVRAAERAIEAAGIDRSELDLILVATSTPDFVFPSTACLVQQKLGITNGCAAFDVQAVC
HHHHHHHHHHHHCCCCHHHCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHEEHHHHH
SGFVYALATADKFIRSGAYRNVLVIGSEVFSRIIDFSDRTTCVLFGDGAGAVVLQASDEP
HHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCC
GILSTALHADGSHANILCVPGNVAAGAIQGSAFLYMDGQAVFKLAVTVLDKVAREALAAA
CEEEEEEECCCCCCEEEEECCCCEECEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
ELDASQVDWLIPHQANIRIMQGTTKKLGLSNERLIVTVDEHGNTSAASIPLALDVAVRDG
HCCCCCCCEECCCCCCEEEEECCCHHCCCCCCEEEEEECCCCCCCCEECEEEEEEEEECC
RIQRGQHVMLEGVGGGFTWGAALLRF
CCCCCCEEEEEECCCCHHHHHHHHCC
>Mature Secondary Structure 
TRFARIIGTGSYLPPKRVTNDELAAQLAEKGIETSDEWIVSRSGIRARHFAEPDVTCSD
CCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCCCCCHHH
LAVRAAERAIEAAGIDRSELDLILVATSTPDFVFPSTACLVQQKLGITNGCAAFDVQAVC
HHHHHHHHHHHHCCCCHHHCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCHHEEHHHHH
SGFVYALATADKFIRSGAYRNVLVIGSEVFSRIIDFSDRTTCVLFGDGAGAVVLQASDEP
HHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCC
GILSTALHADGSHANILCVPGNVAAGAIQGSAFLYMDGQAVFKLAVTVLDKVAREALAAA
CEEEEEEECCCCCCEEEEECCCCEECEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHH
ELDASQVDWLIPHQANIRIMQGTTKKLGLSNERLIVTVDEHGNTSAASIPLALDVAVRDG
HCCCCCCCEECCCCCCEEEEECCCHHCCCCCCEEEEEECCCCCCCCEECEEEEEEEEECC
RIQRGQHVMLEGVGGGFTWGAALLRF
CCCCCCEEEEEECCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA