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The map label for this gene is moaA [H]

Identifier: 187927999

GI number: 187927999

Start: 957326

End: 958447

Strand: Reverse

Name: moaA [H]

Synonym: Rpic_0904

Alternate gene names: 187927999

Gene position: 958447-957326 (Counterclockwise)

Preceding gene: 187928000

Following gene: 187927998

Centisome position: 24.31

GC content: 64.53

Gene sequence:

>1122_bases
ATGACCGAAACCGTCATCCCCCTCTACGATCTGCGTGATGGCCAGCACCATCGCGCCACGGTGCCCGCCGTGCCCAATGT
GCTTGTCCCGGCAGAGGGCAGGCTGACGGACACGCGCGGCCGCCGGCTGCACGATCTGCGCGTCTCGGTGACAGACCGCT
GCAACTTCCGCTGCGTCTACTGCATGCCGAAGGACGTGTTCGACAAGGATTACCGCTTCCTGCGGCATTCCGAGCTGCTG
TCGTTCGAAGAGATCGAGCGCATGGCGCGGCTGTTTATCGAGCACGGCGTCGAGAAGATCCGCCTGACCGGCGGCGAGCC
GCTGCTGCGCAAAGACATCGAACGTCTGGTCGAAATGCTCGCGCGCCTCACCACCGCCGAAGGCAAGCCGCTAGACCTCA
CGCTCACGACCAACGGCGCCCTGCTCGCTCGCAAGGCGCAATCGCTGAAAGATGCGGGCCTCACTCGCGTGACCGTCAGC
CTCGACGGCATCGACGATGCGACTTTCCGCCGCATGAACGATGTCGATTTTGCGGTGGGCGAAGTGCTGCACGGCATTGA
AGTCGCGCAGAACGCCGGACTGGCGCCGATCAAGGTCAACATGGTCGTCAAGAAAGGCGACAACGAAGACCAGATCGTGC
CGATGGCGCGCCACTTCCGCGGCAGCGGCATCATCGTGCGCTTTATCGAATACATGGATGTGGGCACGACCAACCATTGG
GACATGCGCTCCGTCGTGCCGTCGGCCGAGGTGATCAAGCGCCTTTCGCCCGAGTTTGCGCTCGAGCCGGTGTCGGCGAA
TTACAGCGGCGAAACGGCCGAGCGCTGGCGCTACGTCGACGGCGCTGGCGAGGTCGGCGTGATCTCGAGCGTGACCCAGG
CGTTCTGCCACGATTGCACGCGCGCGCGGTTGTCGACCGAAGGCAAGCTGTATCTCTGCCTGTTCGCCACCGAAGGCTTC
GACCTGCGCGCGTTATTGCGCGGCGGCGCGACCGATCTGGAACTCTCCAACGCGATCCGCACGGTCTGGCAAGGCCGCGC
CGATCGCTACTCCGAATTGCGTGCCAGCGGCAAGGCCCAGCCAGCCGGCCGGCGCATCGAAATGTCCTACATCGGCGGCT
GA

Upstream 100 bases:

>100_bases
ATGAAACCCCACCGCTCGCGCGGAACAGGGGCTGCGCTACACTCGAACCTGTATCGAGTGCAACACTCCCGCTTCGTGGA
TTGACGCACCGCACCACACC

Downstream 100 bases:

>100_bases
ATCCGCCAGCGTTCAACCACATGATTCCGACATCCGACATTACCGGCCTGATCCTGGCCGGCGGCCGGGGCAGCCGCATG
GGCGGCGTTGACAAAGGCCT

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MTETVIPLYDLRDGQHHRATVPAVPNVLVPAEGRLTDTRGRRLHDLRVSVTDRCNFRCVYCMPKDVFDKDYRFLRHSELL
SFEEIERMARLFIEHGVEKIRLTGGEPLLRKDIERLVEMLARLTTAEGKPLDLTLTTNGALLARKAQSLKDAGLTRVTVS
LDGIDDATFRRMNDVDFAVGEVLHGIEVAQNAGLAPIKVNMVVKKGDNEDQIVPMARHFRGSGIIVRFIEYMDVGTTNHW
DMRSVVPSAEVIKRLSPEFALEPVSANYSGETAERWRYVDGAGEVGVISSVTQAFCHDCTRARLSTEGKLYLCLFATEGF
DLRALLRGGATDLELSNAIRTVWQGRADRYSELRASGKAQPAGRRIEMSYIGG

Sequences:

>Translated_373_residues
MTETVIPLYDLRDGQHHRATVPAVPNVLVPAEGRLTDTRGRRLHDLRVSVTDRCNFRCVYCMPKDVFDKDYRFLRHSELL
SFEEIERMARLFIEHGVEKIRLTGGEPLLRKDIERLVEMLARLTTAEGKPLDLTLTTNGALLARKAQSLKDAGLTRVTVS
LDGIDDATFRRMNDVDFAVGEVLHGIEVAQNAGLAPIKVNMVVKKGDNEDQIVPMARHFRGSGIIVRFIEYMDVGTTNHW
DMRSVVPSAEVIKRLSPEFALEPVSANYSGETAERWRYVDGAGEVGVISSVTQAFCHDCTRARLSTEGKLYLCLFATEGF
DLRALLRGGATDLELSNAIRTVWQGRADRYSELRASGKAQPAGRRIEMSYIGG
>Mature_372_residues
TETVIPLYDLRDGQHHRATVPAVPNVLVPAEGRLTDTRGRRLHDLRVSVTDRCNFRCVYCMPKDVFDKDYRFLRHSELLS
FEEIERMARLFIEHGVEKIRLTGGEPLLRKDIERLVEMLARLTTAEGKPLDLTLTTNGALLARKAQSLKDAGLTRVTVSL
DGIDDATFRRMNDVDFAVGEVLHGIEVAQNAGLAPIKVNMVVKKGDNEDQIVPMARHFRGSGIIVRFIEYMDVGTTNHWD
MRSVVPSAEVIKRLSPEFALEPVSANYSGETAERWRYVDGAGEVGVISSVTQAFCHDCTRARLSTEGKLYLCLFATEGFD
LRALLRGGATDLELSNAIRTVWQGRADRYSELRASGKAQPAGRRIEMSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=312, Percent_Identity=37.8205128205128, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI22027536, Length=312, Percent_Identity=37.8205128205128, Blast_Score=189, Evalue=3e-48,
Organism=Escherichia coli, GI1786999, Length=344, Percent_Identity=32.2674418604651, Blast_Score=161, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI32566331, Length=322, Percent_Identity=33.2298136645963, Blast_Score=178, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17561210, Length=312, Percent_Identity=33.0128205128205, Blast_Score=177, Evalue=6e-45,
Organism=Caenorhabditis elegans, GI32566329, Length=312, Percent_Identity=33.0128205128205, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI28574490, Length=296, Percent_Identity=36.8243243243243, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI28574488, Length=296, Percent_Identity=36.8243243243243, Blast_Score=172, Evalue=4e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 41694; Mature: 41563

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETVIPLYDLRDGQHHRATVPAVPNVLVPAEGRLTDTRGRRLHDLRVSVTDRCNFRCVY
CCCCEEEEEECCCCCCCCEECCCCCCEEECCCCCEECCCCCEEEEEEEEEECCCCEEEEE
CMPKDVFDKDYRFLRHSELLSFEEIERMARLFIEHGVEKIRLTGGEPLLRKDIERLVEML
ECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHH
ARLTTAEGKPLDLTLTTNGALLARKAQSLKDAGLTRVTVSLDGIDDATFRRMNDVDFAVG
HHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHCCCCHHHHH
EVLHGIEVAQNAGLAPIKVNMVVKKGDNEDQIVPMARHFRGSGIIVRFIEYMDVGTTNHW
HHHHHHHHHHCCCCCEEEEEEEEECCCCCCCEEHHHHHCCCCCHHHHEEHHHCCCCCCCC
DMRSVVPSAEVIKRLSPEFALEPVSANYSGETAERWRYVDGAGEVGVISSVTQAFCHDCT
CHHHHCCHHHHHHHCCCCCEECCCCCCCCCCCHHHEEEECCCCCCHHHHHHHHHHHHHHH
RARLSTEGKLYLCLFATEGFDLRALLRGGATDLELSNAIRTVWQGRADRYSELRASGKAQ
HHHCCCCCCEEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCC
PAGRRIEMSYIGG
CCCCEEEEEECCC
>Mature Secondary Structure 
TETVIPLYDLRDGQHHRATVPAVPNVLVPAEGRLTDTRGRRLHDLRVSVTDRCNFRCVY
CCCEEEEEECCCCCCCCEECCCCCCEEECCCCCEECCCCCEEEEEEEEEECCCCEEEEE
CMPKDVFDKDYRFLRHSELLSFEEIERMARLFIEHGVEKIRLTGGEPLLRKDIERLVEML
ECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHH
ARLTTAEGKPLDLTLTTNGALLARKAQSLKDAGLTRVTVSLDGIDDATFRRMNDVDFAVG
HHHHCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHCCCCHHHHH
EVLHGIEVAQNAGLAPIKVNMVVKKGDNEDQIVPMARHFRGSGIIVRFIEYMDVGTTNHW
HHHHHHHHHHCCCCCEEEEEEEEECCCCCCCEEHHHHHCCCCCHHHHEEHHHCCCCCCCC
DMRSVVPSAEVIKRLSPEFALEPVSANYSGETAERWRYVDGAGEVGVISSVTQAFCHDCT
CHHHHCCHHHHHHHCCCCCEECCCCCCCCCCCHHHEEEECCCCCCHHHHHHHHHHHHHHH
RARLSTEGKLYLCLFATEGFDLRALLRGGATDLELSNAIRTVWQGRADRYSELRASGKAQ
HHHCCCCCCEEEEEEECCCCCHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHHHHHCCCCC
PAGRRIEMSYIGG
CCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]