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The map label for this gene is moeA [H]

Identifier: 187927997

GI number: 187927997

Start: 955378

End: 956658

Strand: Reverse

Name: moeA [H]

Synonym: Rpic_0902

Alternate gene names: 187927997

Gene position: 956658-955378 (Counterclockwise)

Preceding gene: 187927998

Following gene: 187927996

Centisome position: 24.26

GC content: 66.43

Gene sequence:

>1281_bases
ATGACCACCCTCGCCTCCGTCGTTTCGTGCCTGTCCGATTACGATCCGAACGCCCTGCCCGTCGCGCAAGCGCAAGCCAT
CATGCGCGACTTCGTGCAGCCCGTAAGCGGCGTTGCCCGCGTGCCCATCCGCAGCGCGCTCGATCGCGTGCTGGCCGAAG
ACGTGCTGTCGTCCATCGACGTGCCTTCGCACGACAACTCGGCGATGGACGGCTTTGCCTTTGCCAGTGCAGAACTTGCA
GGCCATGCAGGCGAAATCTCCTTGCGCGTGATCGGCACGGCGTATGCGGGTATCGCCTTTGACGGCGTGCCCAGCGCAGG
CGAAGCCGTGCGCGTGATGACCGGTGCCGTCATGCCGGCCGGCTGCGATACGGTCATCCCACAGGAATTCACGCAAGGCG
AAGCCGACACCGTTCGCTTTGCCCGCGACGCCGTGCGCGCAGGCGACAACCGACGTCTGCGTGGAGAAGACCTCGCGCGA
GGCAGCGCCGCGCTGTCCGCAGGCCGAACGCTGCGCCCTGCCGATATCGGTTTGCTGGCCTCGCTCGGCATCGCCGAAGT
GTCGGTGCGCCGCAAGCTGCGCGTGGCGTTCTTCTCGACCGGCGACGAGTTGCGCTCCATTGGCGAACCGCTTGACGCCG
GCTGCGTGTACGACTCCAACCGCTACACGTTACACGGCATGCTTTCGCGCCTGGGTGTTGAACTGCTCGACATGGGCGTC
GTGCGCGACGACCCGGCGGCGCTCGAAGCCGCCTTCCGCACCGCCGCCGAAAACGCCGATGCGATCATCACTTCAGGTGG
TGTCTCCGTCGGCGAAGCAGACTTCACCAAACAGATGATGGCCAAGCTGGGCGACGTGACGTTCTGGAAGATCGCCATGC
GCCCGGGCCGGCCGATGGCGTTCGGGCGCATCGCGTCAAATGGCCGCAGCGCCTTCCTTTTTGGCTTGCCGGGCAACCCG
GTGGCGGTGATGGTGACGTTCTATCACTTCGTGCGCGGTGCGCTGCTGCGCATGATGGGCGCCACCGACGCCGGCGCACC
GTTGGTGCCGGCCGTGAGCGCCGCCCAGATCCGCAAGCGCCCGGGGCGCACGGAATATCAGCGCGCGATCGCTGCCCTGA
ATGATCGCGGCCAGCTCGAAGTCCGCTTGACCGGCCAGCAAGGATCGGGCGTCCTGCGTTCCATGAGCGAAGCAAATTGC
TTCGTCGTGCTCGCCCACGAACAGGGCCAGGTCAACGCCGGCGACGCCGTGCAGGTACTGCTGTTCGACGGCCTCGTCTG
A

Upstream 100 bases:

>100_bases
ACGACAGCACCGCCTTCGCCAACATCAACACGCTGGAAGAACTGCACCAGCTGGCCGAGCGCCGCTAGAGCGCCAACGCC
ACCGATCCCTCATCGACGTC

Downstream 100 bases:

>100_bases
GCGGCGTGGCGGCAGCGGCTCTTGCGCTGGCTGCAACACCGCATGCTGTCGGTTTTTTGCGTCACCTCCGGGCTGCGGGT
ATCGGCGCATCGGTCGATTC

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTTLASVVSCLSDYDPNALPVAQAQAIMRDFVQPVSGVARVPIRSALDRVLAEDVLSSIDVPSHDNSAMDGFAFASAELA
GHAGEISLRVIGTAYAGIAFDGVPSAGEAVRVMTGAVMPAGCDTVIPQEFTQGEADTVRFARDAVRAGDNRRLRGEDLAR
GSAALSAGRTLRPADIGLLASLGIAEVSVRRKLRVAFFSTGDELRSIGEPLDAGCVYDSNRYTLHGMLSRLGVELLDMGV
VRDDPAALEAAFRTAAENADAIITSGGVSVGEADFTKQMMAKLGDVTFWKIAMRPGRPMAFGRIASNGRSAFLFGLPGNP
VAVMVTFYHFVRGALLRMMGATDAGAPLVPAVSAAQIRKRPGRTEYQRAIAALNDRGQLEVRLTGQQGSGVLRSMSEANC
FVVLAHEQGQVNAGDAVQVLLFDGLV

Sequences:

>Translated_426_residues
MTTLASVVSCLSDYDPNALPVAQAQAIMRDFVQPVSGVARVPIRSALDRVLAEDVLSSIDVPSHDNSAMDGFAFASAELA
GHAGEISLRVIGTAYAGIAFDGVPSAGEAVRVMTGAVMPAGCDTVIPQEFTQGEADTVRFARDAVRAGDNRRLRGEDLAR
GSAALSAGRTLRPADIGLLASLGIAEVSVRRKLRVAFFSTGDELRSIGEPLDAGCVYDSNRYTLHGMLSRLGVELLDMGV
VRDDPAALEAAFRTAAENADAIITSGGVSVGEADFTKQMMAKLGDVTFWKIAMRPGRPMAFGRIASNGRSAFLFGLPGNP
VAVMVTFYHFVRGALLRMMGATDAGAPLVPAVSAAQIRKRPGRTEYQRAIAALNDRGQLEVRLTGQQGSGVLRSMSEANC
FVVLAHEQGQVNAGDAVQVLLFDGLV
>Mature_425_residues
TTLASVVSCLSDYDPNALPVAQAQAIMRDFVQPVSGVARVPIRSALDRVLAEDVLSSIDVPSHDNSAMDGFAFASAELAG
HAGEISLRVIGTAYAGIAFDGVPSAGEAVRVMTGAVMPAGCDTVIPQEFTQGEADTVRFARDAVRAGDNRRLRGEDLARG
SAALSAGRTLRPADIGLLASLGIAEVSVRRKLRVAFFSTGDELRSIGEPLDAGCVYDSNRYTLHGMLSRLGVELLDMGVV
RDDPAALEAAFRTAAENADAIITSGGVSVGEADFTKQMMAKLGDVTFWKIAMRPGRPMAFGRIASNGRSAFLFGLPGNPV
AVMVTFYHFVRGALLRMMGATDAGAPLVPAVSAAQIRKRPGRTEYQRAIAALNDRGQLEVRLTGQQGSGVLRSMSEANCF
VVLAHEQGQVNAGDAVQVLLFDGLV

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=403, Percent_Identity=34.2431761786601, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI66932975, Length=403, Percent_Identity=34.2431761786601, Blast_Score=196, Evalue=4e-50,
Organism=Escherichia coli, GI1787049, Length=384, Percent_Identity=45.8333333333333, Blast_Score=341, Evalue=5e-95,
Organism=Caenorhabditis elegans, GI25147659, Length=335, Percent_Identity=33.134328358209, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17562606, Length=225, Percent_Identity=32.4444444444444, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI17136978, Length=413, Percent_Identity=28.5714285714286, Blast_Score=120, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24638841, Length=413, Percent_Identity=28.5714285714286, Blast_Score=120, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44856; Mature: 44725

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLASVVSCLSDYDPNALPVAQAQAIMRDFVQPVSGVARVPIRSALDRVLAEDVLSSID
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
VPSHDNSAMDGFAFASAELAGHAGEISLRVIGTAYAGIAFDGVPSAGEAVRVMTGAVMPA
CCCCCCCCCCCHHHHHHHHCCCCCEEEEEEEEEHCCCEEECCCCCCCCHHHHHHCCCCCC
GCDTVIPQEFTQGEADTVRFARDAVRAGDNRRLRGEDLARGSAALSAGRTLRPADIGLLA
CCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHCCCCCCCCHHHHHH
SLGIAEVSVRRKLRVAFFSTGDELRSIGEPLDAGCVYDSNRYTLHGMLSRLGVELLDMGV
HCCHHHHHHHHHEEEEEECCCHHHHHHCCCCCCCEEECCCCEEHHHHHHHHHHHHHHHCC
VRDDPAALEAAFRTAAENADAIITSGGVSVGEADFTKQMMAKLGDVTFWKIAMRPGRPMA
CCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCE
FGRIASNGRSAFLFGLPGNPVAVMVTFYHFVRGALLRMMGATDAGAPLVPAVSAAQIRKR
EHHECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCC
PGRTEYQRAIAALNDRGQLEVRLTGQQGSGVLRSMSEANCFVVLAHEQGQVNAGDAVQVL
CCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCEEEE
LFDGLV
EECCCC
>Mature Secondary Structure 
TTLASVVSCLSDYDPNALPVAQAQAIMRDFVQPVSGVARVPIRSALDRVLAEDVLSSID
CHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
VPSHDNSAMDGFAFASAELAGHAGEISLRVIGTAYAGIAFDGVPSAGEAVRVMTGAVMPA
CCCCCCCCCCCHHHHHHHHCCCCCEEEEEEEEEHCCCEEECCCCCCCCHHHHHHCCCCCC
GCDTVIPQEFTQGEADTVRFARDAVRAGDNRRLRGEDLARGSAALSAGRTLRPADIGLLA
CCCCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCCCHHHHCCHHHHHCCCCCCCCHHHHHH
SLGIAEVSVRRKLRVAFFSTGDELRSIGEPLDAGCVYDSNRYTLHGMLSRLGVELLDMGV
HCCHHHHHHHHHEEEEEECCCHHHHHHCCCCCCCEEECCCCEEHHHHHHHHHHHHHHHCC
VRDDPAALEAAFRTAAENADAIITSGGVSVGEADFTKQMMAKLGDVTFWKIAMRPGRPMA
CCCCHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCCE
FGRIASNGRSAFLFGLPGNPVAVMVTFYHFVRGALLRMMGATDAGAPLVPAVSAAQIRKR
EHHECCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCC
PGRTEYQRAIAALNDRGQLEVRLTGQQGSGVLRSMSEANCFVVLAHEQGQVNAGDAVQVL
CCCHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHCCCCEEEEEEECCCCCCCCCCEEEE
LFDGLV
EECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]