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The map label for this gene is lysN [H]

Identifier: 187927941

GI number: 187927941

Start: 898463

End: 899653

Strand: Reverse

Name: lysN [H]

Synonym: Rpic_0846

Alternate gene names: 187927941

Gene position: 899653-898463 (Counterclockwise)

Preceding gene: 187927942

Following gene: 187927940

Centisome position: 22.82

GC content: 65.58

Gene sequence:

>1191_bases
ATGGACCACACCGCCTGTACCTTCTCCAGCCGCGCTCAGAAACTGACCAGCTCGGCGATCCGGGAAATCCTCAAGATCAC
CGAACGTCCTGAGGTCATTTCGTTTGCCGGTGGCCTGCCCGCCCCGGTCACCTTCCCGGTCGAAGCGATTCAGGCGGCGT
GCGCCCGCATGTTTGCAGACAACCCGCAGGCTTCGCTGCAGTACACCCCCACCGAAGGCCTGTCGGTGCTGCGCGAGTGG
ATTGCCCAGCGTCATGGCACCACCGCCTCGCGCGTGCTGATCACCACGGGTTCGCAGCAGGGGCTGGACCTGCTCGGCAA
GATCTTCATCGACCCGCAAAGCAAGGTGCTGGTCGAAACCCCGACATACCTCGGCGCGCTGCAGGCGTTCTCGCTGTTCG
AGCCGACCTATACGTCCATCGCCACCGACGACAAGGGCCTGCTGCCCGACGCGCTCACGCCGGAACTGGCTGCCGGGGCG
CGCTTCTTCTACACGATCCCGAACTTCCAGAACCCGACCGGCCGCCGCCTGCCGCTGGACCGCCGCCAGGCCCTGGTGGC
CCGCGCGAAGGAACTCGGCGTGCTGCTCGTTGAAGACGATCCGTACGGCGAACTGAGCTACACCGGCGACGCCCTGCCCT
CGCTGCGCTCGCTCAATCCGGACGGCGTGGTCTACATGGGCTCGTTCTCGAAGATCCTGGCACCGGGCATGCGCCTGGGC
TACATCATCGCGCCCGAACACATCCACTTCAAACTCGTGCAGGCCAAGCAGGCATCGGATCTGCACACGCCGAGCTTCAC
GCAGCGTGTGGCGTACGAGGTGCTGAAGACCGGGCTGCTCGATACGCACATCCCGAGCATCCGAAACCTCTACGGCAAGC
AATGCGAAGCGATGCTCGACTCGCTCACGCGCCATATGCCGGCCGGCGTGCACTGGAACCGTCCGGAAGGCGGCATGTTC
ATCTGGGTGGAAGTGCCGGAAGGCATCGACACGATGGCGCTGCTGGAGAAGGCCGTCGCGCGCAACGTGGCGTTCGTGCC
GGGCGCGCCGTTCTATGCCAATGCGCCGCGCCGCAACACACTCCGCCTCGCGTTCGTGACAGTGGCACCGGAGCGTATCG
AGCAAGGCATTGCCGTGCTGGGCGAGTTGATGCGCGCGGAAATCGCGGCGCTCACGCCCAAGGCCGCCTAA

Upstream 100 bases:

>100_bases
CGGCCCAATGTTGGACGGGCCGCTTGCCTGCTATTCTCATCGTTTTGCCCACCCACGGCGCCTGCTCACGAGGTGGGCGC
CGCAACACTAGGACCACACC

Downstream 100 bases:

>100_bases
ATTACCTAACTAACCACTCCATCCATTCAAGAAAGGAGCCGTCGTCGATGCTGCGGATCTGGGGAAGACTCTCTTCGGTC
AACGTTCAGAAGGTCGTCTG

Product: putative GntR family transcriptional regulator

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MDHTACTFSSRAQKLTSSAIREILKITERPEVISFAGGLPAPVTFPVEAIQAACARMFADNPQASLQYTPTEGLSVLREW
IAQRHGTTASRVLITTGSQQGLDLLGKIFIDPQSKVLVETPTYLGALQAFSLFEPTYTSIATDDKGLLPDALTPELAAGA
RFFYTIPNFQNPTGRRLPLDRRQALVARAKELGVLLVEDDPYGELSYTGDALPSLRSLNPDGVVYMGSFSKILAPGMRLG
YIIAPEHIHFKLVQAKQASDLHTPSFTQRVAYEVLKTGLLDTHIPSIRNLYGKQCEAMLDSLTRHMPAGVHWNRPEGGMF
IWVEVPEGIDTMALLEKAVARNVAFVPGAPFYANAPRRNTLRLAFVTVAPERIEQGIAVLGELMRAEIAALTPKAA

Sequences:

>Translated_396_residues
MDHTACTFSSRAQKLTSSAIREILKITERPEVISFAGGLPAPVTFPVEAIQAACARMFADNPQASLQYTPTEGLSVLREW
IAQRHGTTASRVLITTGSQQGLDLLGKIFIDPQSKVLVETPTYLGALQAFSLFEPTYTSIATDDKGLLPDALTPELAAGA
RFFYTIPNFQNPTGRRLPLDRRQALVARAKELGVLLVEDDPYGELSYTGDALPSLRSLNPDGVVYMGSFSKILAPGMRLG
YIIAPEHIHFKLVQAKQASDLHTPSFTQRVAYEVLKTGLLDTHIPSIRNLYGKQCEAMLDSLTRHMPAGVHWNRPEGGMF
IWVEVPEGIDTMALLEKAVARNVAFVPGAPFYANAPRRNTLRLAFVTVAPERIEQGIAVLGELMRAEIAALTPKAA
>Mature_396_residues
MDHTACTFSSRAQKLTSSAIREILKITERPEVISFAGGLPAPVTFPVEAIQAACARMFADNPQASLQYTPTEGLSVLREW
IAQRHGTTASRVLITTGSQQGLDLLGKIFIDPQSKVLVETPTYLGALQAFSLFEPTYTSIATDDKGLLPDALTPELAAGA
RFFYTIPNFQNPTGRRLPLDRRQALVARAKELGVLLVEDDPYGELSYTGDALPSLRSLNPDGVVYMGSFSKILAPGMRLG
YIIAPEHIHFKLVQAKQASDLHTPSFTQRVAYEVLKTGLLDTHIPSIRNLYGKQCEAMLDSLTRHMPAGVHWNRPEGGMF
IWVEVPEGIDTMALLEKAVARNVAFVPGAPFYANAPRRNTLRLAFVTVAPERIEQGIAVLGELMRAEIAALTPKAA

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=411, Percent_Identity=29.9270072992701, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI33469970, Length=411, Percent_Identity=29.9270072992701, Blast_Score=189, Evalue=3e-48,
Organism=Escherichia coli, GI1787710, Length=382, Percent_Identity=30.3664921465969, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1790797, Length=337, Percent_Identity=29.9703264094956, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI48994949, Length=418, Percent_Identity=26.555023923445, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788722, Length=378, Percent_Identity=25.1322751322751, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321000, Length=434, Percent_Identity=26.036866359447, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI21356535, Length=395, Percent_Identity=25.8227848101266, Blast_Score=104, Evalue=8e-23,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 43268; Mature: 43268

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHTACTFSSRAQKLTSSAIREILKITERPEVISFAGGLPAPVTFPVEAIQAACARMFAD
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCC
NPQASLQYTPTEGLSVLREWIAQRHGTTASRVLITTGSQQGLDLLGKIFIDPQSKVLVET
CCCCCEEECCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHEECCCCCEEEEC
PTYLGALQAFSLFEPTYTSIATDDKGLLPDALTPELAAGARFFYTIPNFQNPTGRRLPLD
CHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCHHHHCCCEEEEECCCCCCCCCCCCCHH
RRQALVARAKELGVLLVEDDPYGELSYTGDALPSLRSLNPDGVVYMGSFSKILAPGMRLG
HHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCHHHCCCCCCEEEECCCHHHHCCCCCEE
YIIAPEHIHFKLVQAKQASDLHTPSFTQRVAYEVLKTGLLDTHIPSIRNLYGKQCEAMLD
EEECCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHH
SLTRHMPAGVHWNRPEGGMFIWVEVPEGIDTMALLEKAVARNVAFVPGAPFYANAPRRNT
HHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCEEECCCCCCCCCCCCCCE
LRLAFVTVAPERIEQGIAVLGELMRAEIAALTPKAA
EEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDHTACTFSSRAQKLTSSAIREILKITERPEVISFAGGLPAPVTFPVEAIQAACARMFAD
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCC
NPQASLQYTPTEGLSVLREWIAQRHGTTASRVLITTGSQQGLDLLGKIFIDPQSKVLVET
CCCCCEEECCHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHEECCCCCEEEEC
PTYLGALQAFSLFEPTYTSIATDDKGLLPDALTPELAAGARFFYTIPNFQNPTGRRLPLD
CHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCHHHHCCCEEEEECCCCCCCCCCCCCHH
RRQALVARAKELGVLLVEDDPYGELSYTGDALPSLRSLNPDGVVYMGSFSKILAPGMRLG
HHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCCHHHCCCCCCEEEECCCHHHHCCCCCEE
YIIAPEHIHFKLVQAKQASDLHTPSFTQRVAYEVLKTGLLDTHIPSIRNLYGKQCEAMLD
EEECCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHHH
SLTRHMPAGVHWNRPEGGMFIWVEVPEGIDTMALLEKAVARNVAFVPGAPFYANAPRRNT
HHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCEEECCCCCCCCCCCCCCE
LRLAFVTVAPERIEQGIAVLGELMRAEIAALTPKAA
EEEEEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA