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The map label for this gene is parC [H]

Identifier: 187927926

GI number: 187927926

Start: 877083

End: 879425

Strand: Direct

Name: parC [H]

Synonym: Rpic_0831

Alternate gene names: 187927926

Gene position: 877083-879425 (Clockwise)

Preceding gene: 187927925

Following gene: 187927927

Centisome position: 22.25

GC content: 65.09

Gene sequence:

>2343_bases
ATGGAACAACAAGACATCCTCTTCGACCCCAGCGAGCCGGCCGAAGCGCTCACGCTTGGCGCCTATGCTGAGCGCGCTTA
CCTCGACTACGCCATCAGCGTGGTCAAGGGCCGCGCACTGCCCGAGGTGGCCGATGGCCAGAAGCCGGTGCAGCGCCGCA
TCCTGTTCGCGATGCACGAGATGGGCCTGCGCTCCGATGCCAAGCCTGTCAAATCGGCGCGCGTGGTCGGCGACGTGCTG
GGCAAATTCCACCCGCATGGCGATCAATCCGCCTACGACGCACTCGTGCGCCTGGCGCAGGATTTCTCGCTGCGTTACCC
GCTGATCGACGGGCAGGGCAACTTCGGCTCGCGCGACGGCGACGGTGCGGCGGCGATGCGCTATACCGAAGCGCGCCTCA
CGCCCATTTCGCGTCTGCTGCTCGAAGAGCTGGACCAGGGCACCGTCGATTTCATCCCGAACTACGACGGCTCGATGGAA
GAGCCGAAGCTGCTGCCAGCGCGCTTGCCGTTCGTGCTGCTCAACGGCGCATCGGGCATTGCGGTCGGGATGGCCACGGA
GATCCCGTCGCACAACCTGCGCGAAGTGGCGGCCGCCACCGTGGCGCTCATCCGCGACGACAAGCTCACCAGCACCGACC
TGATGCAGTACATGCCGGGGCCGGACTTTCCGGGCGGCGGGCAGATCATCTCGTCGGCGGCCGACATTGCGCAGGTGTAT
GAAAGCGGTCGCGGCAGCCTGAAGGTGCGTGCGCGCTGGAAGATCGAAGAACTCGCGCGCGGCCAGTGGCAGCTCGTGGT
GAACGAATTGCCGCCGAACACCTCGTCGCAGAAGGTGCTGGAAGAGATTGAAGAGCTGACGAACCCGAAGGTGCGCACGG
GCAAGAAGTCGCTGTCGCCGGATCAGCTCACCATGAAGCAGACCATGCTGGGCCTGCTTGATGCCGTGCGCGACGAATCC
GGCAAGGACGCTCCGGTGCGCCTCGTGTTCGAGCCCAAGAGCAAGAACATCGACCAGCAGGAATTTGCCAATGCATTGCT
GGCCCACACATCGCTGGAGTCGGGTGCGGCCATCAACCTGGTGATGATCGGCACGGATGGCCGTCCGCGCCAGAAGGGCC
TGGCAGAGATCCTGCGAGAGTGGATCGTCTACCGCTTCGCCACGGTCACGCGTCGCACGCGCCATCGTCTGGGCAAGGTG
GAAGACCGTATCCACATCCTCGAAGGGCGGCAGTTGGTTCTGCTGCGCATCGAAGACGTGATCCGCATCATCCGTGAGAG
CGAAGACCCGAAGGCCGCGCTGATCCAGGTCTTCAACCTGAGCGATCGCCAGGCCGAAGACATTCTGGAAATCCGCCTGC
GTCAGCTTGCTCGCCTGGAAGCGATCAAGATCGAGCAGGAGCTGAAGAACCTGCGCGAAGAGCAGGGCGAGCTGGACGTG
CTGCTGAAGTCCGAGACCATGATGCGCCGTCGCATCATCAAGGAGATCGAGACCGACGCGAAGCAATACGGTGACGACCG
CCGCACCTTCATCCAGGAAGAGCGCCGCGCCGCAGCCGAAGTGAAGGTCGTTGATGAACCCGTCACGGTGATCGTTTCGC
AGAAGGGCTGGGTGCGTACGCGCCAGGGCCATGGCCACGACGCCACGCAATTCACCTTCAAGGCAGGCGACACGCTCTAC
GACACGTTTGAATGCCGGACCACCGATGCGCTGTTGATCTTCGGCACGCGCGACGACAAGGGCACGGGCCGGGTCTATTC
CGTGGCCGTGGCGAACCTGCCCGGCGGCCGTGGCGACGGCGTGCCGCTGACGACGCTGATCGAACTCGCGCCGGGTACGC
ACATCGCCCACACGTTCGCAGGCCATGCCGAACAGAATCTGGTGATTTCCACGCGCGGCGGCAACGGCTTCCTGGCCAAG
GTGGGTGACATGGTCGGCCGCCAGAAGGCTGGCAAGGCGTTCCTGACGCTGGATGAGGGCGACCAGCCCAACAAGCCAGC
GCCGGTGCCGGCTGACGCCTATGGCGTGGCGTGCCTGTCCGAAGGCGGCCGCATGCTGCTCTTCCAGATCAGCGAGTTGA
AGACGCTCGCCAGCGGTGGTCGTGGCGTGATCCTGATGGAACTGGAGAAGAACGAAGCGCTGCTTCAGGCAGTGGCCTTC
GGTGCAGCGGGCTTCGTGCTCTCGGGCACCGGCCCGCGCGGCGGCAAGGCGGTCGAGCAGACCATGACGACCCGCGCGCA
AGAGCCGTACGCCGGCAAGCGCGCACGCAAGGGCAAGACGCTCGAGCCCAAGCTGCGCGACCCGAAGCTCTCGTTGCCCA
AGCCCGCGCCGGACGCCGCCTGA

Upstream 100 bases:

>100_bases
CTCGTATTGGACCCGGCCACCGGCGTGGCCACGAACGTACCTCAACATTGATCCTGGCGGCGCCGCAACGTTGAAGCGCG
CCGCTTTCGCTTGAGTCTCC

Downstream 100 bases:

>100_bases
ACCCATGAGCGATCCGAGCGCCGCACCTGACGCCAACGCCGCAGCAAACGCAAACATTCCGTCCTGCAGCAAGCTCTTCA
CCGAGTTTGCGCGGATGGGC

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 780; Mature: 780

Protein sequence:

>780_residues
MEQQDILFDPSEPAEALTLGAYAERAYLDYAISVVKGRALPEVADGQKPVQRRILFAMHEMGLRSDAKPVKSARVVGDVL
GKFHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPISRLLLEELDQGTVDFIPNYDGSME
EPKLLPARLPFVLLNGASGIAVGMATEIPSHNLREVAAATVALIRDDKLTSTDLMQYMPGPDFPGGGQIISSAADIAQVY
ESGRGSLKVRARWKIEELARGQWQLVVNELPPNTSSQKVLEEIEELTNPKVRTGKKSLSPDQLTMKQTMLGLLDAVRDES
GKDAPVRLVFEPKSKNIDQQEFANALLAHTSLESGAAINLVMIGTDGRPRQKGLAEILREWIVYRFATVTRRTRHRLGKV
EDRIHILEGRQLVLLRIEDVIRIIRESEDPKAALIQVFNLSDRQAEDILEIRLRQLARLEAIKIEQELKNLREEQGELDV
LLKSETMMRRRIIKEIETDAKQYGDDRRTFIQEERRAAAEVKVVDEPVTVIVSQKGWVRTRQGHGHDATQFTFKAGDTLY
DTFECRTTDALLIFGTRDDKGTGRVYSVAVANLPGGRGDGVPLTTLIELAPGTHIAHTFAGHAEQNLVISTRGGNGFLAK
VGDMVGRQKAGKAFLTLDEGDQPNKPAPVPADAYGVACLSEGGRMLLFQISELKTLASGGRGVILMELEKNEALLQAVAF
GAAGFVLSGTGPRGGKAVEQTMTTRAQEPYAGKRARKGKTLEPKLRDPKLSLPKPAPDAA

Sequences:

>Translated_780_residues
MEQQDILFDPSEPAEALTLGAYAERAYLDYAISVVKGRALPEVADGQKPVQRRILFAMHEMGLRSDAKPVKSARVVGDVL
GKFHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPISRLLLEELDQGTVDFIPNYDGSME
EPKLLPARLPFVLLNGASGIAVGMATEIPSHNLREVAAATVALIRDDKLTSTDLMQYMPGPDFPGGGQIISSAADIAQVY
ESGRGSLKVRARWKIEELARGQWQLVVNELPPNTSSQKVLEEIEELTNPKVRTGKKSLSPDQLTMKQTMLGLLDAVRDES
GKDAPVRLVFEPKSKNIDQQEFANALLAHTSLESGAAINLVMIGTDGRPRQKGLAEILREWIVYRFATVTRRTRHRLGKV
EDRIHILEGRQLVLLRIEDVIRIIRESEDPKAALIQVFNLSDRQAEDILEIRLRQLARLEAIKIEQELKNLREEQGELDV
LLKSETMMRRRIIKEIETDAKQYGDDRRTFIQEERRAAAEVKVVDEPVTVIVSQKGWVRTRQGHGHDATQFTFKAGDTLY
DTFECRTTDALLIFGTRDDKGTGRVYSVAVANLPGGRGDGVPLTTLIELAPGTHIAHTFAGHAEQNLVISTRGGNGFLAK
VGDMVGRQKAGKAFLTLDEGDQPNKPAPVPADAYGVACLSEGGRMLLFQISELKTLASGGRGVILMELEKNEALLQAVAF
GAAGFVLSGTGPRGGKAVEQTMTTRAQEPYAGKRARKGKTLEPKLRDPKLSLPKPAPDAA
>Mature_780_residues
MEQQDILFDPSEPAEALTLGAYAERAYLDYAISVVKGRALPEVADGQKPVQRRILFAMHEMGLRSDAKPVKSARVVGDVL
GKFHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPISRLLLEELDQGTVDFIPNYDGSME
EPKLLPARLPFVLLNGASGIAVGMATEIPSHNLREVAAATVALIRDDKLTSTDLMQYMPGPDFPGGGQIISSAADIAQVY
ESGRGSLKVRARWKIEELARGQWQLVVNELPPNTSSQKVLEEIEELTNPKVRTGKKSLSPDQLTMKQTMLGLLDAVRDES
GKDAPVRLVFEPKSKNIDQQEFANALLAHTSLESGAAINLVMIGTDGRPRQKGLAEILREWIVYRFATVTRRTRHRLGKV
EDRIHILEGRQLVLLRIEDVIRIIRESEDPKAALIQVFNLSDRQAEDILEIRLRQLARLEAIKIEQELKNLREEQGELDV
LLKSETMMRRRIIKEIETDAKQYGDDRRTFIQEERRAAAEVKVVDEPVTVIVSQKGWVRTRQGHGHDATQFTFKAGDTLY
DTFECRTTDALLIFGTRDDKGTGRVYSVAVANLPGGRGDGVPLTTLIELAPGTHIAHTFAGHAEQNLVISTRGGNGFLAK
VGDMVGRQKAGKAFLTLDEGDQPNKPAPVPADAYGVACLSEGGRMLLFQISELKTLASGGRGVILMELEKNEALLQAVAF
GAAGFVLSGTGPRGGKAVEQTMTTRAQEPYAGKRARKGKTLEPKLRDPKLSLPKPAPDAA

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=254, Percent_Identity=29.9212598425197, Blast_Score=96, Evalue=9e-20,
Organism=Homo sapiens, GI19913406, Length=167, Percent_Identity=35.3293413173653, Blast_Score=95, Evalue=3e-19,
Organism=Escherichia coli, GI1789396, Length=707, Percent_Identity=45.2616690240453, Blast_Score=597, Evalue=1e-171,
Organism=Escherichia coli, GI1788562, Length=792, Percent_Identity=34.8484848484849, Blast_Score=386, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17535065, Length=173, Percent_Identity=36.4161849710983, Blast_Score=99, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI212645657, Length=187, Percent_Identity=32.620320855615, Blast_Score=89, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI212645845, Length=389, Percent_Identity=25.9640102827763, Blast_Score=89, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115534553, Length=169, Percent_Identity=33.7278106508876, Blast_Score=87, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324241, Length=176, Percent_Identity=34.0909090909091, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17136538, Length=173, Percent_Identity=34.1040462427746, Blast_Score=95, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 85661; Mature: 85661

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQQDILFDPSEPAEALTLGAYAERAYLDYAISVVKGRALPEVADGQKPVQRRILFAMHE
CCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
MGLRSDAKPVKSARVVGDVLGKFHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDG
HCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEECCEECCCCCCCCCCC
DGAAAMRYTEARLTPISRLLLEELDQGTVDFIPNYDGSMEEPKLLPARLPFVLLNGASGI
CCHHHEEEHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCCE
AVGMATEIPSHNLREVAAATVALIRDDKLTSTDLMQYMPGPDFPGGGQIISSAADIAQVY
EEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
ESGRGSLKVRARWKIEELARGQWQLVVNELPPNTSSQKVLEEIEELTNPKVRTGKKSLSP
HCCCCCEEEEEEECHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEECCCCCCCC
DQLTMKQTMLGLLDAVRDESGKDAPVRLVFEPKSKNIDQQEFANALLAHTSLESGAAINL
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEE
VMIGTDGRPRQKGLAEILREWIVYRFATVTRRTRHRLGKVEDRIHILEGRQLVLLRIEDV
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEECCCEEEEEEHHHH
IRIIRESEDPKAALIQVFNLSDRQAEDILEIRLRQLARLEAIKIEQELKNLREEQGELDV
HHHHHCCCCCHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
LLKSETMMRRRIIKEIETDAKQYGDDRRTFIQEERRAAAEVKVVDEPVTVIVSQKGWVRT
EECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCEEE
RQGHGHDATQFTFKAGDTLYDTFECRTTDALLIFGTRDDKGTGRVYSVAVANLPGGRGDG
CCCCCCCCCEEEEECCCCEEEEEEECCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCCC
VPLTTLIELAPGTHIAHTFAGHAEQNLVISTRGGNGFLAKVGDMVGRQKAGKAFLTLDEG
CCHHHHEECCCCCHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCC
DQPNKPAPVPADAYGVACLSEGGRMLLFQISELKTLASGGRGVILMELEKNEALLQAVAF
CCCCCCCCCCCCHHHHHHHCCCCCEEEEEHHHHHHHHCCCCEEEEEEECCCHHHHHHHHH
GAAGFVLSGTGPRGGKAVEQTMTTRAQEPYAGKRARKGKTLEPKLRDPKLSLPKPAPDAA
CCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MEQQDILFDPSEPAEALTLGAYAERAYLDYAISVVKGRALPEVADGQKPVQRRILFAMHE
CCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
MGLRSDAKPVKSARVVGDVLGKFHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDG
HCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEECCEECCCCCCCCCCC
DGAAAMRYTEARLTPISRLLLEELDQGTVDFIPNYDGSMEEPKLLPARLPFVLLNGASGI
CCHHHEEEHHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECCCCE
AVGMATEIPSHNLREVAAATVALIRDDKLTSTDLMQYMPGPDFPGGGQIISSAADIAQVY
EEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
ESGRGSLKVRARWKIEELARGQWQLVVNELPPNTSSQKVLEEIEELTNPKVRTGKKSLSP
HCCCCCEEEEEEECHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEECCCCCCCC
DQLTMKQTMLGLLDAVRDESGKDAPVRLVFEPKSKNIDQQEFANALLAHTSLESGAAINL
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCEEEE
VMIGTDGRPRQKGLAEILREWIVYRFATVTRRTRHRLGKVEDRIHILEGRQLVLLRIEDV
EEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEEEECCCEEEEEEHHHH
IRIIRESEDPKAALIQVFNLSDRQAEDILEIRLRQLARLEAIKIEQELKNLREEQGELDV
HHHHHCCCCCHHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
LLKSETMMRRRIIKEIETDAKQYGDDRRTFIQEERRAAAEVKVVDEPVTVIVSQKGWVRT
EECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCCEEEEEECCCCEEE
RQGHGHDATQFTFKAGDTLYDTFECRTTDALLIFGTRDDKGTGRVYSVAVANLPGGRGDG
CCCCCCCCCEEEEECCCCEEEEEEECCCCEEEEEECCCCCCCCCEEEEEEEECCCCCCCC
VPLTTLIELAPGTHIAHTFAGHAEQNLVISTRGGNGFLAKVGDMVGRQKAGKAFLTLDEG
CCHHHHEECCCCCHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHHHHCCCEEEEECCC
DQPNKPAPVPADAYGVACLSEGGRMLLFQISELKTLASGGRGVILMELEKNEALLQAVAF
CCCCCCCCCCCCHHHHHHHCCCCCEEEEEHHHHHHHHCCCCEEEEEEECCCHHHHHHHHH
GAAGFVLSGTGPRGGKAVEQTMTTRAQEPYAGKRARKGKTLEPKLRDPKLSLPKPAPDAA
CCCCEEEECCCCCCCHHHHHHHHHHCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7830580 [H]