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The map label for this gene is ilvA [H]

Identifier: 187927914

GI number: 187927914

Start: 862169

End: 863170

Strand: Direct

Name: ilvA [H]

Synonym: Rpic_0819

Alternate gene names: 187927914

Gene position: 862169-863170 (Clockwise)

Preceding gene: 187927911

Following gene: 187927916

Centisome position: 21.87

GC content: 65.37

Gene sequence:

>1002_bases
ATGTCGCCCATAGCTACCTCCGCATCGCTGGACCGTGCCGCTGAATTGCGCCATCTGCGCGCTGCGGCCAGCGTCGTTCA
TGCGGTGATTCCACCGACCCCGCAGTACTGCTGGCCGGTGCTCTCGCAAGCCATGGGCACGGCGGTGTGCGTGAAGCATG
AGAACCACACGGAAGTGGGCGCGTTCAAGGTGCGCGGCGGGCTGACTTATCTGCATGCCTTGCGCCAACGTGAGCCGCAG
GTGCGTGGTGTGATAGCGGCGACGCGCGGCAATCATGGCCAGTCGATTGCATGGGCGGCGCGTCGTAACGGTATCGCTGT
CAACATCGTCGTGCCGCATGGCAACAGCGTGGAGAAGAACGCCGCCATACGCGCGCTCGGCGCAGAGCTCATCGAAGCGG
GCGATGACTTCCAGGCCAGCCGCGAGGCGGCCGATCAACTGGCCGCTGAACGTCGCTTGCACTTCGTGCCCTCGTATCAC
GATGACCTGGTCGTCGGCGTAGCAAGCTACTGGCTGGAGTTCCTCGAGGCCACGCCGCTGGATGTTGTCTATGTGCCGAT
CGGCATGGGTTCGGGAATTTGCGCGGCGGTGCGGGCGCGCGATGCGCTGGGGCTGTCGACGCGCATTGTCGGCGTCGTGT
CAGCACATGCGCGATGCTATGAGCAATCTTTCGCAAGCGGGACCGTGGTGTCGGCGCCGGTATCGACGCTGCTGGCTGAC
GGGCTTGCATGTCGCACACCGGATGCGAAGGCGCTGGAGGTGATCCGCGCTGGCGTCGACCACATCATTGCGGTGACGGA
TGACGAGGTGGCAGAGGCTATTCGCCTGTATTTCTCCACCACCCACAACGTGGCCGAAGGCGCTGCCGCCGCAGCCCTGG
CGGGGGCATGGCAGCAGCGCGAGCGGATTGCCGGCCAGCGTATCGGCCTGCCGCTGACCGGTGGCAACATTGATCGCGCC
AAGCTGGCGCGCGTGCTCGCCGGTCAGCCAATCCTGGCTTAG

Upstream 100 bases:

>100_bases
GAACGGCTGGACTGACAAAGCGCAGAATTGTCGATGTGCCAGGGGCGGCAGGGCGGGCAGGATGGCCTCATCGCTTCAAA
TTGTCTGCCGGAGAATGATC

Downstream 100 bases:

>100_bases
GCGGGTTGTTGGCGGCGACGCTGCACCAGCCAGCCGCCACCCAGCACGATCAGGAGCACCAGCACATACACCGCCCACTT
GAACGGCGGCTGTGCAGCAA

Product: hypothetical protein

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 333; Mature: 332

Protein sequence:

>333_residues
MSPIATSASLDRAAELRHLRAAASVVHAVIPPTPQYCWPVLSQAMGTAVCVKHENHTEVGAFKVRGGLTYLHALRQREPQ
VRGVIAATRGNHGQSIAWAARRNGIAVNIVVPHGNSVEKNAAIRALGAELIEAGDDFQASREAADQLAAERRLHFVPSYH
DDLVVGVASYWLEFLEATPLDVVYVPIGMGSGICAAVRARDALGLSTRIVGVVSAHARCYEQSFASGTVVSAPVSTLLAD
GLACRTPDAKALEVIRAGVDHIIAVTDDEVAEAIRLYFSTTHNVAEGAAAAALAGAWQQRERIAGQRIGLPLTGGNIDRA
KLARVLAGQPILA

Sequences:

>Translated_333_residues
MSPIATSASLDRAAELRHLRAAASVVHAVIPPTPQYCWPVLSQAMGTAVCVKHENHTEVGAFKVRGGLTYLHALRQREPQ
VRGVIAATRGNHGQSIAWAARRNGIAVNIVVPHGNSVEKNAAIRALGAELIEAGDDFQASREAADQLAAERRLHFVPSYH
DDLVVGVASYWLEFLEATPLDVVYVPIGMGSGICAAVRARDALGLSTRIVGVVSAHARCYEQSFASGTVVSAPVSTLLAD
GLACRTPDAKALEVIRAGVDHIIAVTDDEVAEAIRLYFSTTHNVAEGAAAAALAGAWQQRERIAGQRIGLPLTGGNIDRA
KLARVLAGQPILA
>Mature_332_residues
SPIATSASLDRAAELRHLRAAASVVHAVIPPTPQYCWPVLSQAMGTAVCVKHENHTEVGAFKVRGGLTYLHALRQREPQV
RGVIAATRGNHGQSIAWAARRNGIAVNIVVPHGNSVEKNAAIRALGAELIEAGDDFQASREAADQLAAERRLHFVPSYHD
DLVVGVASYWLEFLEATPLDVVYVPIGMGSGICAAVRARDALGLSTRIVGVVSAHARCYEQSFASGTVVSAPVSTLLADG
LACRTPDAKALEVIRAGVDHIIAVTDDEVAEAIRLYFSTTHNVAEGAAAAALAGAWQQRERIAGQRIGLPLTGGNIDRAK
LARVLAGQPILA

Specific function: Catalyzes the formation of alpha-ketobutyrate from threonine in a two-step reaction. The first step is a dehydration of threonine, followed by rehydration and liberation of ammonia [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=296, Percent_Identity=27.3648648648649, Blast_Score=99, Evalue=4e-21,
Organism=Escherichia coli, GI1790207, Length=290, Percent_Identity=28.2758620689655, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1789505, Length=289, Percent_Identity=29.0657439446367, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI71991565, Length=318, Percent_Identity=27.9874213836478, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17537387, Length=289, Percent_Identity=30.1038062283737, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17508781, Length=281, Percent_Identity=27.7580071174377, Blast_Score=85, Evalue=6e-17,
Organism=Saccharomyces cerevisiae, GI6322631, Length=310, Percent_Identity=30.3225806451613, Blast_Score=139, Evalue=9e-34,
Organism=Saccharomyces cerevisiae, GI6320930, Length=277, Percent_Identity=28.5198555956679, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21355833, Length=288, Percent_Identity=28.4722222222222, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005787
- InterPro:   IPR001721 [H]

Pfam domain/function: PF00291 PALP; PF00585 Thr_dehydrat_C [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 35168; Mature: 35037

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPIATSASLDRAAELRHLRAAASVVHAVIPPTPQYCWPVLSQAMGTAVCVKHENHTEVG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCCCC
AFKVRGGLTYLHALRQREPQVRGVIAATRGNHGQSIAWAARRNGIAVNIVVPHGNSVEKN
EEEECCCHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCHH
AAIRALGAELIEAGDDFQASREAADQLAAERRLHFVPSYHDDLVVGVASYWLEFLEATPL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCCCC
DVVYVPIGMGSGICAAVRARDALGLSTRIVGVVSAHARCYEQSFASGTVVSAPVSTLLAD
EEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHC
GLACRTPDAKALEVIRAGVDHIIAVTDDEVAEAIRLYFSTTHNVAEGAAAAALAGAWQQR
CCCCCCCCHHHHHHHHHCHHHEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ERIAGQRIGLPLTGGNIDRAKLARVLAGQPILA
HHHHHHHCCCEECCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SPIATSASLDRAAELRHLRAAASVVHAVIPPTPQYCWPVLSQAMGTAVCVKHENHTEVG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCEEEEECCCCCCCC
AFKVRGGLTYLHALRQREPQVRGVIAATRGNHGQSIAWAARRNGIAVNIVVPHGNSVEKN
EEEECCCHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEECCCCEEEEEEECCCCCCCHH
AAIRALGAELIEAGDDFQASREAADQLAAERRLHFVPSYHDDLVVGVASYWLEFLEATPL
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHCCCC
DVVYVPIGMGSGICAAVRARDALGLSTRIVGVVSAHARCYEQSFASGTVVSAPVSTLLAD
EEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHC
GLACRTPDAKALEVIRAGVDHIIAVTDDEVAEAIRLYFSTTHNVAEGAAAAALAGAWQQR
CCCCCCCCHHHHHHHHHCHHHEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
ERIAGQRIGLPLTGGNIDRAKLARVLAGQPILA
HHHHHHHCCCEECCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]