| Definition | Ralstonia pickettii 12J chromosome chromosome 1, complete sequence. |
|---|---|
| Accession | NC_010682 |
| Length | 3,942,557 |
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The map label for this gene is gyrA [H]
Identifier: 187927867
GI number: 187927867
Start: 815029
End: 817698
Strand: Direct
Name: gyrA [H]
Synonym: Rpic_0771
Alternate gene names: 187927867
Gene position: 815029-817698 (Clockwise)
Preceding gene: 187927865
Following gene: 187927868
Centisome position: 20.67
GC content: 61.95
Gene sequence:
>2670_bases ATGGATCAATTCGCCAAAGAGACACTCCCGGTATCGCTCGAAGAAGAAATGCGCAGCTCGTATCTCGCTTACGCCATGAG CGTAATCGTGGGCCGCGCGCTTCCAGATGTGCGGGATGGTCTCAAGCCGGTGCATCGCCGTGCGCTTTACTCGATGCACG AGCTGAACAACGACTGGAATCGCCCCTATAAGAAGTCTGCCCGTATTGTCGGGGATGTGATCGGTAAGTATCACCCCCAC GGCGACACTGCTGTATACGACACCATCGTGCGGATGGCGCAGAACTTCTCGCTGCGCTACATGCTGGTCGACGGCCAAGG CAACTTCGGCTCCGTCGATGGCGACAACGCCGCGGCGATGCGTTACACCGAAATCCGCCTGTCGAAGATTGCCCACGAAC TGCTGGCCGACCTCGACAAGGAAACCGTCAATTTTGAGCCGAACTACGACGGTTCCGAAACTGAACCGTCCGTTCTGCCG GCCCGCATCCCCAACTTGCTGATCAACGGTTCGTCCGGGATCGCGGTGGGTATGGCGACGAACATTCCGCCGCATAACCT GAATGAAGTCGTCGATGGCTGCCTCCACTTGCTGCGCAATCCGGAAGCGACGGTCGACGAGCTGATCGAGCTGATCCCGG CGCCGGACTTCCCAACGGCAGGCATCATCTACGGCATTTCGGGTGTCCGCGAGGGCTATCGCACCGGCCGCGGCCGTGTG GTGATGCGCGCCAAGACGCACTTCGAGGATATCGACCGCGGCCAGCGCCAGGCGATCATCGTCGACGAGCTGCCGTATCA GGTTAACAAGCGCACGCTGCTCGAGCGCATCGCCGAGCTGGTCACCGAAAAGCGCATCGAAGGCATTTCCGACATTCGCG ATGAGTCGGACAAGTCCGGCATGCGCGTGGTGATCGAACTCAAGCGCGGCGAGGTGCCAGAGGTCGTGCTCAACAACCTC TATAAGAATACGCAGCTGCAGGACACGTTCGGTATGAACATGGTCGCGCTTGTCGACGGCCAGCCACGCCTGCTGAACCT GCGCCAGATGCTTGAGTGCTTCCTGCTGCACCGCCGCGAGGTGGTGACGCGTCGCACGGTATTCGACCTGCGCAAGGCAC GCGAGCGCGGCCACATCCTTGAAGGTCTGGCTGTTGCACTGGCCAACATCGACGAATTCATCGCCATCATCAAGGCTGCG CCGACCCCGCCGGTTGCCAAGGCTGAGCTGATGAACCGCAGTTGGGATTCGGGCCTCGTGCGCGACATGCTCGTTCGCGC CGAGAGCGAAACCTCCGGCGGTGGCGCCGCGTATCGTCCGGAAGGTCTGCTGCCGGTGTTTGGTATGCAGGGCGACGGCT TGTACAGGCTGTCGGATACGCAAGCGCAGGAAATTCTGCAGATGCGCCTGCAACGCCTCACCGGGCTGGAGCAGGACAAG ATCGTCCAGGAATACCGCGAAGTGATGGCGCAGATCGCCGATCTGTTGGACATCCTGGCTAGGCCGGAGCGCATTACCGC CATCATCGTCGAGGAACTCACCGCGATCCGCGCTGAGTTTGGCGATGAGCGTCGCTCGCAGATTGAGCACAATGCCACCG AGTTGGATACAGAAGACCTCATTACGCCGCAGGATCTGGTGGTGACGCTGTCCCACAGCGGCTACATGAAGAGTCAGCCG ATTTCCGAATACCGGGCGCAAAAGCGTGGCGGCCGCGGCAAGCAAGCTGCGGCGACGAAGGAAGACGATTGGATCGACAC GCTATTCGTCGCCAACACGCACGATTACATTCTCTGCTTCTCGAACCGCGGCCGTCTGTATTGGCTGAAGGTGTGGGAGG TGCCTCAGGGCAGCCGTAACTCGCGCGGGCGCCCGATCGTCAATATGTTCCCGCTGTCGCCGGGCGAGAAGATCAACGTG ATCCTGCCGGTGAAGCAGTTCGACGAGCAGCACTTCGTGTTCATGGCGACCTCCAAGGGGACGGTCAAGAAGACGGCGCT GACGGAATTCTCGAACCCACGCAAGGCCGGCATCATCGCGGTCGATCTGGACGAGGGCGACTTCCTGATCGGCGCGGACA TTACCGACGGCCAGCACGACGTCATGTTGTTCTCCGACGCAGGCAAGGCGGTGCGCTTCGATGAAAACGACGTGCGCCCG ATGGGTCGCCAGGCACGCGGCGTTCGCGGTATGAACCTGGAAGAGACGCAGCAAGTGATTGCCATGCTGGTGGCGCCCGC GGAAACCGAGGGCGAGGGCGCTCAGTCGGTCGCCGGTAGCGTGCTGACCGCCACCGAGAACGGCTACGGTAAGCGCACAC CGATCTCGGAGTACACCCGGCACGGCCGCGGCACGAAGGGCATGATCGCCATCCAGACCTCCGAGCGTAACGGCAAGGTC GTGGCCGCCGCGCTGGTGGCGCCTGAAGACGAAATCATGCTGATCACGACGGGCGGGGTGCTGATCCGCACGCGCGTGGA TGAGATCCGTGAAATGGGTCGCGCCACGCAGGGCGTCACGCTCATCTCGGTGGGTGAGGGCAACAAGCTGTCCGGGCTGC AACGGGTGATGGAGTCCGACGCTGAAGGCGCGGAGAGTATCGAGGGCGCTGATGCGGCGGACGCCGCCCCGGATGCCGAT GCACAGGCGGATGACAGCAGCGAGACATAA
Upstream 100 bases:
>100_bases GGGGGCTTGCGGCATGGTAAAATGTTCTGTTATTCGCGCAACCGCAGCGTCCTGCAGTGCGCATTGCTGTGCTCACTAGG GACCTCCCACCGTTCGCCCA
Downstream 100 bases:
>100_bases TTAGAAACATCTTTTGCTTGCCGTTGGGCGCAGTTCTGTCATGATGCCGGACCTGTGCGCGGCAAGGGCCTGGAACTTTT GCATCACACGCCCGGCCTAA
Product: DNA gyrase subunit A
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 889; Mature: 889
Protein sequence:
>889_residues MDQFAKETLPVSLEEEMRSSYLAYAMSVIVGRALPDVRDGLKPVHRRALYSMHELNNDWNRPYKKSARIVGDVIGKYHPH GDTAVYDTIVRMAQNFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRLSKIAHELLADLDKETVNFEPNYDGSETEPSVLP ARIPNLLINGSSGIAVGMATNIPPHNLNEVVDGCLHLLRNPEATVDELIELIPAPDFPTAGIIYGISGVREGYRTGRGRV VMRAKTHFEDIDRGQRQAIIVDELPYQVNKRTLLERIAELVTEKRIEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL YKNTQLQDTFGMNMVALVDGQPRLLNLRQMLECFLLHRREVVTRRTVFDLRKARERGHILEGLAVALANIDEFIAIIKAA PTPPVAKAELMNRSWDSGLVRDMLVRAESETSGGGAAYRPEGLLPVFGMQGDGLYRLSDTQAQEILQMRLQRLTGLEQDK IVQEYREVMAQIADLLDILARPERITAIIVEELTAIRAEFGDERRSQIEHNATELDTEDLITPQDLVVTLSHSGYMKSQP ISEYRAQKRGGRGKQAAATKEDDWIDTLFVANTHDYILCFSNRGRLYWLKVWEVPQGSRNSRGRPIVNMFPLSPGEKINV ILPVKQFDEQHFVFMATSKGTVKKTALTEFSNPRKAGIIAVDLDEGDFLIGADITDGQHDVMLFSDAGKAVRFDENDVRP MGRQARGVRGMNLEETQQVIAMLVAPAETEGEGAQSVAGSVLTATENGYGKRTPISEYTRHGRGTKGMIAIQTSERNGKV VAAALVAPEDEIMLITTGGVLIRTRVDEIREMGRATQGVTLISVGEGNKLSGLQRVMESDAEGAESIEGADAADAAPDAD AQADDSSET
Sequences:
>Translated_889_residues MDQFAKETLPVSLEEEMRSSYLAYAMSVIVGRALPDVRDGLKPVHRRALYSMHELNNDWNRPYKKSARIVGDVIGKYHPH GDTAVYDTIVRMAQNFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRLSKIAHELLADLDKETVNFEPNYDGSETEPSVLP ARIPNLLINGSSGIAVGMATNIPPHNLNEVVDGCLHLLRNPEATVDELIELIPAPDFPTAGIIYGISGVREGYRTGRGRV VMRAKTHFEDIDRGQRQAIIVDELPYQVNKRTLLERIAELVTEKRIEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL YKNTQLQDTFGMNMVALVDGQPRLLNLRQMLECFLLHRREVVTRRTVFDLRKARERGHILEGLAVALANIDEFIAIIKAA PTPPVAKAELMNRSWDSGLVRDMLVRAESETSGGGAAYRPEGLLPVFGMQGDGLYRLSDTQAQEILQMRLQRLTGLEQDK IVQEYREVMAQIADLLDILARPERITAIIVEELTAIRAEFGDERRSQIEHNATELDTEDLITPQDLVVTLSHSGYMKSQP ISEYRAQKRGGRGKQAAATKEDDWIDTLFVANTHDYILCFSNRGRLYWLKVWEVPQGSRNSRGRPIVNMFPLSPGEKINV ILPVKQFDEQHFVFMATSKGTVKKTALTEFSNPRKAGIIAVDLDEGDFLIGADITDGQHDVMLFSDAGKAVRFDENDVRP MGRQARGVRGMNLEETQQVIAMLVAPAETEGEGAQSVAGSVLTATENGYGKRTPISEYTRHGRGTKGMIAIQTSERNGKV VAAALVAPEDEIMLITTGGVLIRTRVDEIREMGRATQGVTLISVGEGNKLSGLQRVMESDAEGAESIEGADAADAAPDAD AQADDSSET >Mature_889_residues MDQFAKETLPVSLEEEMRSSYLAYAMSVIVGRALPDVRDGLKPVHRRALYSMHELNNDWNRPYKKSARIVGDVIGKYHPH GDTAVYDTIVRMAQNFSLRYMLVDGQGNFGSVDGDNAAAMRYTEIRLSKIAHELLADLDKETVNFEPNYDGSETEPSVLP ARIPNLLINGSSGIAVGMATNIPPHNLNEVVDGCLHLLRNPEATVDELIELIPAPDFPTAGIIYGISGVREGYRTGRGRV VMRAKTHFEDIDRGQRQAIIVDELPYQVNKRTLLERIAELVTEKRIEGISDIRDESDKSGMRVVIELKRGEVPEVVLNNL YKNTQLQDTFGMNMVALVDGQPRLLNLRQMLECFLLHRREVVTRRTVFDLRKARERGHILEGLAVALANIDEFIAIIKAA PTPPVAKAELMNRSWDSGLVRDMLVRAESETSGGGAAYRPEGLLPVFGMQGDGLYRLSDTQAQEILQMRLQRLTGLEQDK IVQEYREVMAQIADLLDILARPERITAIIVEELTAIRAEFGDERRSQIEHNATELDTEDLITPQDLVVTLSHSGYMKSQP ISEYRAQKRGGRGKQAAATKEDDWIDTLFVANTHDYILCFSNRGRLYWLKVWEVPQGSRNSRGRPIVNMFPLSPGEKINV ILPVKQFDEQHFVFMATSKGTVKKTALTEFSNPRKAGIIAVDLDEGDFLIGADITDGQHDVMLFSDAGKAVRFDENDVRP MGRQARGVRGMNLEETQQVIAMLVAPAETEGEGAQSVAGSVLTATENGYGKRTPISEYTRHGRGTKGMIAIQTSERNGKV VAAALVAPEDEIMLITTGGVLIRTRVDEIREMGRATQGVTLISVGEGNKLSGLQRVMESDAEGAESIEGADAADAAPDAD AQADDSSET
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Homo sapiens, GI19913406, Length=407, Percent_Identity=27.027027027027, Blast_Score=96, Evalue=1e-19, Organism=Homo sapiens, GI19913408, Length=320, Percent_Identity=26.5625, Blast_Score=93, Evalue=1e-18, Organism=Escherichia coli, GI1788562, Length=892, Percent_Identity=59.5291479820628, Blast_Score=1060, Evalue=0.0, Organism=Escherichia coli, GI1789396, Length=739, Percent_Identity=35.8592692828146, Blast_Score=395, Evalue=1e-111, Organism=Caenorhabditis elegans, GI212645845, Length=190, Percent_Identity=32.6315789473684, Blast_Score=75, Evalue=1e-13, Organism=Caenorhabditis elegans, GI17535065, Length=325, Percent_Identity=25.2307692307692, Blast_Score=75, Evalue=2e-13, Organism=Caenorhabditis elegans, GI212645657, Length=352, Percent_Identity=24.1477272727273, Blast_Score=74, Evalue=5e-13, Organism=Saccharomyces cerevisiae, GI6324241, Length=347, Percent_Identity=26.8011527377522, Blast_Score=84, Evalue=1e-16, Organism=Drosophila melanogaster, GI17136538, Length=352, Percent_Identity=24.7159090909091, Blast_Score=82, Evalue=1e-15,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR005743 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013757 - InterPro: IPR013760 [H]
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 98432; Mature: 98432
Theoretical pI: Translated: 4.97; Mature: 4.97
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 3.3 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 3.3 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDQFAKETLPVSLEEEMRSSYLAYAMSVIVGRALPDVRDGLKPVHRRALYSMHELNNDWN CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC RPYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQNFSLRYMLVDGQGNFGSVDGDNAAAM CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE RYTEIRLSKIAHELLADLDKETVNFEPNYDGSETEPSVLPARIPNLLINGSSGIAVGMAT EHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCHHHCCCEEEECCCCEEEEEEC NIPPHNLNEVVDGCLHLLRNPEATVDELIELIPAPDFPTAGIIYGISGVREGYRTGRGRV CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHCCCCEE VMRAKTHFEDIDRGQRQAIIVDELPYQVNKRTLLERIAELVTEKRIEGISDIRDESDKSG EEEEHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC MRVVIELKRGEVPEVVLNNLYKNTQLQDTFGMNMVALVDGQPRLLNLRQMLECFLLHRRE CEEEEEECCCCCHHHHHHHHHCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHH VVTRRTVFDLRKARERGHILEGLAVALANIDEFIAIIKAAPTPPVAKAELMNRSWDSGLV HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHH RDMLVRAESETSGGGAAYRPEGLLPVFGMQGDGLYRLSDTQAQEILQMRLQRLTGLEQDK HHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCHHHHHHHHHHHHHHCCCCHHH IVQEYREVMAQIADLLDILARPERITAIIVEELTAIRAEFGDERRSQIEHNATELDTEDL HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHCCHHHC ITPQDLVVTLSHSGYMKSQPISEYRAQKRGGRGKQAAATKEDDWIDTLFVANTHDYILCF CCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEE SNRGRLYWLKVWEVPQGSRNSRGRPIVNMFPLSPGEKINVILPVKQFDEQHFVFMATSKG CCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHCCCCEEEEEEECCC TVKKTALTEFSNPRKAGIIAVDLDEGDFLIGADITDGQHDVMLFSDAGKAVRFDENDVRP CCHHHHHHHCCCCCCCCEEEEEECCCCEEEECCCCCCCCCEEEEECCCCEEECCCCCCCC MGRQARGVRGMNLEETQQVIAMLVAPAETEGEGAQSVAGSVLTATENGYGKRTPISEYTR CCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHCCEEEECCCCCCCCCCHHHHHH HGRGTKGMIAIQTSERNGKVVAAALVAPEDEIMLITTGGVLIRTRVDEIREMGRATQGVT CCCCCCCEEEEEECCCCCCEEEEEEECCCCCEEEEEECCEEEEEHHHHHHHHCCHHCCEE LISVGEGNKLSGLQRVMESDAEGAESIEGADAADAAPDADAQADDSSET EEEECCCCCHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCC >Mature Secondary Structure MDQFAKETLPVSLEEEMRSSYLAYAMSVIVGRALPDVRDGLKPVHRRALYSMHELNNDWN CCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCC RPYKKSARIVGDVIGKYHPHGDTAVYDTIVRMAQNFSLRYMLVDGQGNFGSVDGDNAAAM CCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCEE RYTEIRLSKIAHELLADLDKETVNFEPNYDGSETEPSVLPARIPNLLINGSSGIAVGMAT EHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCCCCCCCCHHHCCCEEEECCCCEEEEEEC NIPPHNLNEVVDGCLHLLRNPEATVDELIELIPAPDFPTAGIIYGISGVREGYRTGRGRV CCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHCCCCEE VMRAKTHFEDIDRGQRQAIIVDELPYQVNKRTLLERIAELVTEKRIEGISDIRDESDKSG EEEEHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC MRVVIELKRGEVPEVVLNNLYKNTQLQDTFGMNMVALVDGQPRLLNLRQMLECFLLHRRE CEEEEEECCCCCHHHHHHHHHCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHH VVTRRTVFDLRKARERGHILEGLAVALANIDEFIAIIKAAPTPPVAKAELMNRSWDSGLV HHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCHHH RDMLVRAESETSGGGAAYRPEGLLPVFGMQGDGLYRLSDTQAQEILQMRLQRLTGLEQDK HHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCEEEECCHHHHHHHHHHHHHHCCCCHHH IVQEYREVMAQIADLLDILARPERITAIIVEELTAIRAEFGDERRSQIEHNATELDTEDL HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCHHCCHHHC ITPQDLVVTLSHSGYMKSQPISEYRAQKRGGRGKQAAATKEDDWIDTLFVANTHDYILCF CCCCCEEEEEECCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEE SNRGRLYWLKVWEVPQGSRNSRGRPIVNMFPLSPGEKINVILPVKQFDEQHFVFMATSKG CCCCCEEEEEEEECCCCCCCCCCCCEEEEECCCCCCEEEEEEEHHHCCCCEEEEEEECCC TVKKTALTEFSNPRKAGIIAVDLDEGDFLIGADITDGQHDVMLFSDAGKAVRFDENDVRP CCHHHHHHHCCCCCCCCEEEEEECCCCEEEECCCCCCCCCEEEEECCCCEEECCCCCCCC MGRQARGVRGMNLEETQQVIAMLVAPAETEGEGAQSVAGSVLTATENGYGKRTPISEYTR CCHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHCCEEEECCCCCCCCCCHHHHHH HGRGTKGMIAIQTSERNGKVVAAALVAPEDEIMLITTGGVLIRTRVDEIREMGRATQGVT CCCCCCCEEEEEECCCCCCEEEEEEECCCCCEEEEEECCEEEEEHHHHHHHHCCHHCCEE LISVGEGNKLSGLQRVMESDAEGAESIEGADAADAAPDADAQADDSSET EEEECCCCCHHHHHHHHHCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 11677609; 8849216 [H]