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The map label for this gene is bvgS [H]

Identifier: 187927855

GI number: 187927855

Start: 799291

End: 801747

Strand: Direct

Name: bvgS [H]

Synonym: Rpic_0759

Alternate gene names: 187927855

Gene position: 799291-801747 (Clockwise)

Preceding gene: 187927854

Following gene: 187927857

Centisome position: 20.27

GC content: 63.17

Gene sequence:

>2457_bases
ATGGGGACGGGGGGAGATGTGAGCAATGTAGCCGCGGCGGTCCGCGCGCTGATCTTAGGCTTCTGGCTCGGCTTGATGTC
CGGCGGCAGCAATGCGGCCCCAACTTCGCTGTTCACCCCCGAAGAGGATGCTTGGATCGCCGCGCATCCGATCGTGCGCA
CCTGCGTGGATGCGCACTGGCGTCCGTTCGAGTTTGTCAAAGCCGGCAAGGTGGTCGGCATGGTTCCATCGTTCCTCGAT
GCGGTTGCCCATGTGAGTGGGCTGCGTTTCGACTATGTGGACGGTGCGTGCTGGAACGGCTCGCTGGCTGCACTGAAGCT
CGGGCAGGTGGACATGCTCCCCGACTGGAGCAAGGACGAAGCCGTGGCACCCTACCGGGACGGTTACATCGCGAGCACGC
CGTACTATGTCGGGACAATCGCAATCGTTACGGCGGAACAGGAAAACCTGTTCGCCAGTTTCTCGCAATTGTCCGGCAAG
CGGCTTGCGATCAAGGGCGGCGGTGGTCTTGAACTGGCCATCCGCCGCAGCTCCGTCCCCGTGAAGTTGGTAACGTTTCA
AAACGAGTCCGACGCGTTGCAGGCGGTTGTGGACGGCGATGCCGACGCCGCACTCGGAACAGACGCTTCGATCGTTCCGC
AACTGCACCGGCAGTTCAAGGGCCAACTGTTCCTTTCGGGCAGCCTCTGGGACCGGCCCTATGCGTTGACGATGGTCACG
CGCGGTGACAACCCCGTGCTCGCGTCGATTCTCGATAAATCGCTGACCGCCATTTCGGCGTCGGAGGCCGACGCTATCCG
GCAGCGGTGGCAGGAAACGACCGACTACGGCGCGCCGTCGCTGGCGTCGATCCTGCATTACCGCTGGCGCCAGGTCGCTC
TCGTTGCGATCATTGTTCTGGCGTTTGCGGTGTTGGCCTATGTGCTATGGCGTGCGCGTGTGGCCGCCGTTCGCAGTGAG
CGTGAAAAGGCGATGTTCCTCGCATTCATCAGCCACGAAATCCGGACGCCGATGCACACGATTCTTGCGTCGCTGGAACT
GTTGCAGCGCTCGCAATTGACCGGCCAGCAAGCCAGTCGTGCGGATGCCGCTGTCTCGGCGTCGGAAACGCTCTTGGCCC
TGCTTGACGATGTCCTGGAATACTCCCGTCTCGAATCTCGCAGCGTGACACTCGTGCTTCAGCCTACGGCGATCGGGCCG
TGGGCCGAGCAGGCTCTGGACATGGTCCGTTGGCGCTCCGATGAGAAAAAGCTGGCGTTGTCGCTCGATCTTGCCTGCGC
GCCGGATTTCAGCGTGGACATCGATGCCATGCGCGTGCGGCAGATCGTTTTGAACCTGTTGGTGAACGCGATCAAATTCA
CCACGGTCGGCAAGGTTGTCCTCCGCGTCGACTATCTGCCCGGAAAGCGGCGCGGCAGCGGAACGCTCGTGCTCGAGGTC
AGAGACACGGGCATGGGCATTCCGCCCGAGCGCCAGCGGAACATTTTCGAACCGTATGCACGCGTGGAAAGCCCGGGCAA
TCGCGGTGCCAGCGGAACAGGGCTGGGCTTGTCGATCTGCCACGAACTCGTGGAGTTGATGGGAGGCGTGATCACCGTCA
GCAGCAGCCCCGAGGTCGGCACGGTGTTCACTGTCATGTTGCCGGCACGGGAGGCGCGCGCAGCGATGGCGTTGCCAAAG
GCTGCGGCAGCAGCGGGGGCGTCTGCGCCCCACGCAATATCGCCTCCTCGGGCGGCAAAGGCGCCGTCGCCGGAATCGGA
GGAGGGGCCGCTGGTCTTGGTGGTCGATGACCACGAGGCGGTGCAGCACGCGATCCAGCACCAGCTGGACGCACTGGCCT
GTCGGTCTGCCATTGCCGGCACAGGCGAGGCCGCGCTCGAACAGTTTGCGTCAGCGTCGTTTGACATGGTGCTGCTCGAT
TGCAACCTGCCAGGCATCGACGGATATACCGTCGCGCAACGCATGCGCGAAATCGAGCGCCAGCGCGCAGGCGAGCGTAC
ACCGATTGTCGCCATCTCCGCCGCGACAGACGACGCGCACCGTATTCGGTGCTTCGACAGCGGCATGGACGGTGTTCTGG
GCAAGCCATTGCGCCTTGCCGCATTGCGGGAGCTGATCGAACTGTGGTGCGCCCACGGCGATTCCGCCCGCAACGCGGAG
CCTATGGAGCACGACCTGGCGCCGTCGTCGGACGTGCTCGCGATTTATCGACAGACCATGAAGACCGATCTTGAGATGCT
TAGCCAGGGCATCGCACGTCGGGATATCGAGCAGGCACGTCGAGCCGCTCATCGAATTTCCGGCGCTGCGGCCGTTGTGG
AAGATTTGCCGACGCGCAACTTGGCCAGAGAACTGGAACGACGTCTTTCGGACTCGTTCAGCGACATCAATGCGGAGATC
CAGGCGCTCCTCGTTGCACTCCAATCCTTGCACGGAGCAGAGGCCCCCGACGCCTGA

Upstream 100 bases:

>100_bases
AGGTCGTTTCCGGCCATCCGGCTCGGGACTGAATTAAGCTTCTGAATTGGCGCGATCAGCAACATCGCGAACCCGACGCG
CCGAGGCAATCGATTCCGAT

Downstream 100 bases:

>100_bases
TTCATTCGCTCAGGGCCCCGTGTCGGCCTGATCGCGCTCCGCCGGCATACGCGCTGTCGACCCCACCTGCGGCGGCCTGC
GCCTCGTGTTGTCCCAATCC

Product: multi-sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 818; Mature: 817

Protein sequence:

>818_residues
MGTGGDVSNVAAAVRALILGFWLGLMSGGSNAAPTSLFTPEEDAWIAAHPIVRTCVDAHWRPFEFVKAGKVVGMVPSFLD
AVAHVSGLRFDYVDGACWNGSLAALKLGQVDMLPDWSKDEAVAPYRDGYIASTPYYVGTIAIVTAEQENLFASFSQLSGK
RLAIKGGGGLELAIRRSSVPVKLVTFQNESDALQAVVDGDADAALGTDASIVPQLHRQFKGQLFLSGSLWDRPYALTMVT
RGDNPVLASILDKSLTAISASEADAIRQRWQETTDYGAPSLASILHYRWRQVALVAIIVLAFAVLAYVLWRARVAAVRSE
REKAMFLAFISHEIRTPMHTILASLELLQRSQLTGQQASRADAAVSASETLLALLDDVLEYSRLESRSVTLVLQPTAIGP
WAEQALDMVRWRSDEKKLALSLDLACAPDFSVDIDAMRVRQIVLNLLVNAIKFTTVGKVVLRVDYLPGKRRGSGTLVLEV
RDTGMGIPPERQRNIFEPYARVESPGNRGASGTGLGLSICHELVELMGGVITVSSSPEVGTVFTVMLPAREARAAMALPK
AAAAAGASAPHAISPPRAAKAPSPESEEGPLVLVVDDHEAVQHAIQHQLDALACRSAIAGTGEAALEQFASASFDMVLLD
CNLPGIDGYTVAQRMREIERQRAGERTPIVAISAATDDAHRIRCFDSGMDGVLGKPLRLAALRELIELWCAHGDSARNAE
PMEHDLAPSSDVLAIYRQTMKTDLEMLSQGIARRDIEQARRAAHRISGAAAVVEDLPTRNLARELERRLSDSFSDINAEI
QALLVALQSLHGAEAPDA

Sequences:

>Translated_818_residues
MGTGGDVSNVAAAVRALILGFWLGLMSGGSNAAPTSLFTPEEDAWIAAHPIVRTCVDAHWRPFEFVKAGKVVGMVPSFLD
AVAHVSGLRFDYVDGACWNGSLAALKLGQVDMLPDWSKDEAVAPYRDGYIASTPYYVGTIAIVTAEQENLFASFSQLSGK
RLAIKGGGGLELAIRRSSVPVKLVTFQNESDALQAVVDGDADAALGTDASIVPQLHRQFKGQLFLSGSLWDRPYALTMVT
RGDNPVLASILDKSLTAISASEADAIRQRWQETTDYGAPSLASILHYRWRQVALVAIIVLAFAVLAYVLWRARVAAVRSE
REKAMFLAFISHEIRTPMHTILASLELLQRSQLTGQQASRADAAVSASETLLALLDDVLEYSRLESRSVTLVLQPTAIGP
WAEQALDMVRWRSDEKKLALSLDLACAPDFSVDIDAMRVRQIVLNLLVNAIKFTTVGKVVLRVDYLPGKRRGSGTLVLEV
RDTGMGIPPERQRNIFEPYARVESPGNRGASGTGLGLSICHELVELMGGVITVSSSPEVGTVFTVMLPAREARAAMALPK
AAAAAGASAPHAISPPRAAKAPSPESEEGPLVLVVDDHEAVQHAIQHQLDALACRSAIAGTGEAALEQFASASFDMVLLD
CNLPGIDGYTVAQRMREIERQRAGERTPIVAISAATDDAHRIRCFDSGMDGVLGKPLRLAALRELIELWCAHGDSARNAE
PMEHDLAPSSDVLAIYRQTMKTDLEMLSQGIARRDIEQARRAAHRISGAAAVVEDLPTRNLARELERRLSDSFSDINAEI
QALLVALQSLHGAEAPDA
>Mature_817_residues
GTGGDVSNVAAAVRALILGFWLGLMSGGSNAAPTSLFTPEEDAWIAAHPIVRTCVDAHWRPFEFVKAGKVVGMVPSFLDA
VAHVSGLRFDYVDGACWNGSLAALKLGQVDMLPDWSKDEAVAPYRDGYIASTPYYVGTIAIVTAEQENLFASFSQLSGKR
LAIKGGGGLELAIRRSSVPVKLVTFQNESDALQAVVDGDADAALGTDASIVPQLHRQFKGQLFLSGSLWDRPYALTMVTR
GDNPVLASILDKSLTAISASEADAIRQRWQETTDYGAPSLASILHYRWRQVALVAIIVLAFAVLAYVLWRARVAAVRSER
EKAMFLAFISHEIRTPMHTILASLELLQRSQLTGQQASRADAAVSASETLLALLDDVLEYSRLESRSVTLVLQPTAIGPW
AEQALDMVRWRSDEKKLALSLDLACAPDFSVDIDAMRVRQIVLNLLVNAIKFTTVGKVVLRVDYLPGKRRGSGTLVLEVR
DTGMGIPPERQRNIFEPYARVESPGNRGASGTGLGLSICHELVELMGGVITVSSSPEVGTVFTVMLPAREARAAMALPKA
AAAAGASAPHAISPPRAAKAPSPESEEGPLVLVVDDHEAVQHAIQHQLDALACRSAIAGTGEAALEQFASASFDMVLLDC
NLPGIDGYTVAQRMREIERQRAGERTPIVAISAATDDAHRIRCFDSGMDGVLGKPLRLAALRELIELWCAHGDSARNAEP
MEHDLAPSSDVLAIYRQTMKTDLEMLSQGIARRDIEQARRAAHRISGAAAVVEDLPTRNLARELERRLSDSFSDINAEIQ
ALLVALQSLHGAEAPDA

Specific function: Member of the two-component regulatory system BvgS/BvgA. Phosphorylates BvgA via a four-step phosphorelay in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=484, Percent_Identity=28.7190082644628, Blast_Score=181, Evalue=2e-46,
Organism=Escherichia coli, GI1788713, Length=512, Percent_Identity=27.734375, Blast_Score=172, Evalue=8e-44,
Organism=Escherichia coli, GI87081816, Length=475, Percent_Identity=28.6315789473684, Blast_Score=160, Evalue=3e-40,
Organism=Escherichia coli, GI145693157, Length=294, Percent_Identity=34.0136054421769, Blast_Score=149, Evalue=9e-37,
Organism=Escherichia coli, GI1789149, Length=235, Percent_Identity=34.468085106383, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI1786912, Length=248, Percent_Identity=28.6290322580645, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1788393, Length=234, Percent_Identity=30.7692307692308, Blast_Score=89, Evalue=1e-18,
Organism=Escherichia coli, GI1787894, Length=232, Percent_Identity=30.1724137931034, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1790436, Length=280, Percent_Identity=27.1428571428571, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=247, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1788549, Length=226, Percent_Identity=23.4513274336283, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1790346, Length=224, Percent_Identity=24.5535714285714, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1786600, Length=227, Percent_Identity=25.1101321585903, Blast_Score=68, Evalue=3e-12,
Organism=Escherichia coli, GI1788279, Length=249, Percent_Identity=23.2931726907631, Blast_Score=63, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=86, Percent_Identity=39.5348837209302, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR001638
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00989 PAS; PF00072 Response_reg; PF00497 SBP_bac_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 88087; Mature: 87955

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTGGDVSNVAAAVRALILGFWLGLMSGGSNAAPTSLFTPEEDAWIAAHPIVRTCVDAHW
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCC
RPFEFVKAGKVVGMVPSFLDAVAHVSGLRFDYVDGACWNGSLAALKLGQVDMLPDWSKDE
CCHHHHHHCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCCCCCCCCCCC
AVAPYRDGYIASTPYYVGTIAIVTAEQENLFASFSQLSGKRLAIKGGGGLELAIRRSSVP
CCCCCCCCEEECCCEEEEEEEEEEECHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCC
VKLVTFQNESDALQAVVDGDADAALGTDASIVPQLHRQFKGQLFLSGSLWDRPYALTMVT
EEEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEE
RGDNPVLASILDKSLTAISASEADAIRQRWQETTDYGAPSLASILHYRWRQVALVAIIVL
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AFAVLAYVLWRARVAAVRSEREKAMFLAFISHEIRTPMHTILASLELLQRSQLTGQQASR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHH
ADAAVSASETLLALLDDVLEYSRLESRSVTLVLQPTAIGPWAEQALDMVRWRSDEKKLAL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEE
SLDLACAPDFSVDIDAMRVRQIVLNLLVNAIKFTTVGKVVLRVDYLPGKRRGSGTLVLEV
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCEEEEEE
RDTGMGIPPERQRNIFEPYARVESPGNRGASGTGLGLSICHELVELMGGVITVSSSPEVG
ECCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCC
TVFTVMLPAREARAAMALPKAAAAAGASAPHAISPPRAAKAPSPESEEGPLVLVVDDHEA
EEEEEEECCHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHH
VQHAIQHQLDALACRSAIAGTGEAALEQFASASFDMVLLDCNLPGIDGYTVAQRMREIER
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
QRAGERTPIVAISAATDDAHRIRCFDSGMDGVLGKPLRLAALRELIELWCAHGDSARNAE
HHCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
PMEHDLAPSSDVLAIYRQTMKTDLEMLSQGIARRDIEQARRAAHRISGAAAVVEDLPTRN
CCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LARELERRLSDSFSDINAEIQALLVALQSLHGAEAPDA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GTGGDVSNVAAAVRALILGFWLGLMSGGSNAAPTSLFTPEEDAWIAAHPIVRTCVDAHW
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCC
RPFEFVKAGKVVGMVPSFLDAVAHVSGLRFDYVDGACWNGSLAALKLGQVDMLPDWSKDE
CCHHHHHHCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCEEEEEECCCCCCCCCCCCC
AVAPYRDGYIASTPYYVGTIAIVTAEQENLFASFSQLSGKRLAIKGGGGLELAIRRSSVP
CCCCCCCCEEECCCEEEEEEEEEEECHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCC
VKLVTFQNESDALQAVVDGDADAALGTDASIVPQLHRQFKGQLFLSGSLWDRPYALTMVT
EEEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEEEEE
RGDNPVLASILDKSLTAISASEADAIRQRWQETTDYGAPSLASILHYRWRQVALVAIIVL
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
AFAVLAYVLWRARVAAVRSEREKAMFLAFISHEIRTPMHTILASLELLQRSQLTGQQASR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCHHHH
ADAAVSASETLLALLDDVLEYSRLESRSVTLVLQPTAIGPWAEQALDMVRWRSDEKKLAL
HHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEE
SLDLACAPDFSVDIDAMRVRQIVLNLLVNAIKFTTVGKVVLRVDYLPGKRRGSGTLVLEV
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCCCCEEEEEE
RDTGMGIPPERQRNIFEPYARVESPGNRGASGTGLGLSICHELVELMGGVITVSSSPEVG
ECCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCEEEECCCCCCC
TVFTVMLPAREARAAMALPKAAAAAGASAPHAISPPRAAKAPSPESEEGPLVLVVDDHEA
EEEEEEECCHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHH
VQHAIQHQLDALACRSAIAGTGEAALEQFASASFDMVLLDCNLPGIDGYTVAQRMREIER
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHH
QRAGERTPIVAISAATDDAHRIRCFDSGMDGVLGKPLRLAALRELIELWCAHGDSARNAE
HHCCCCCCEEEEEECCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
PMEHDLAPSSDVLAIYRQTMKTDLEMLSQGIARRDIEQARRAAHRISGAAAVVEDLPTRN
CCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LARELERRLSDSFSDINAEIQALLVALQSLHGAEAPDA
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1791760; 12910271 [H]