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The map label for this gene is msrA [H]

Identifier: 187927810

GI number: 187927810

Start: 748766

End: 749326

Strand: Direct

Name: msrA [H]

Synonym: Rpic_0714

Alternate gene names: 187927810

Gene position: 748766-749326 (Clockwise)

Preceding gene: 187927808

Following gene: 187927814

Centisome position: 18.99

GC content: 61.68

Gene sequence:

>561_bases
ATGACTGAACAACGCGCCCTTGAAACCGCCGTCCTGGGTGGAGGCTGCTTCTGGTGCCTTGAAGCGGTGTTCCAGCAGGT
GCAAGGCGTGCACAGCGTGGTGTCCGGCTATGCCGGCGGCCATGTCGATCGCCCGAGTTACCGTGCCGTTTGCAATGGCA
ACACTGGTCATGCCGAAGTGGTGGCCGTGAAGTTCGACCCGGCTGTGATCCCATATCGCGAGATTCTCGACATCTTCTTC
GCCATTCACGACCCGACCACCGTAGATCGCCAGGGCAACGATGTCGGCCCGCAATACCGTTCGGCTATCTTTGCGCAAAC
GCCCGAGCAATTGGCGACGGCGCGCACGGCCATTGCCGAACTCGGCGCCAGCGATATTTTTGAAGCGCCCATCGTGACGG
AACTGGTGGATGCCGCTGACGGCAAGGTGACCTTCTGGCGGGCGGAAGACGAGCACCAGAACTACTTCCGCGACCACCCG
GCCCAGGGCTACTGCGCGTTCGTCATCTCGCCCAAGGTGGCGAAATTCCGCAAGCAGTTCGCACACCGCTTGCAGGGCTA
G

Upstream 100 bases:

>100_bases
TAGGGCTTTGCGTGATTCTGCGGCCACATGGTGGTGCCTGTGTCAGGATTGAAGCCTTCGGCCGACCAATGGCAGCCCAA
TCAATTGCAGGAGAATCCGA

Downstream 100 bases:

>100_bases
AAGAGGGCGCCGAGGCTACGCTGCGTCTGCCGGCAAGCGCGCGGCAATGGCCTCGGCCAGCTTGATGCACGACAACGGGG
ATGATCCTTCTGCCTTGTTG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 186; Mature: 185

Protein sequence:

>186_residues
MTEQRALETAVLGGGCFWCLEAVFQQVQGVHSVVSGYAGGHVDRPSYRAVCNGNTGHAEVVAVKFDPAVIPYREILDIFF
AIHDPTTVDRQGNDVGPQYRSAIFAQTPEQLATARTAIAELGASDIFEAPIVTELVDAADGKVTFWRAEDEHQNYFRDHP
AQGYCAFVISPKVAKFRKQFAHRLQG

Sequences:

>Translated_186_residues
MTEQRALETAVLGGGCFWCLEAVFQQVQGVHSVVSGYAGGHVDRPSYRAVCNGNTGHAEVVAVKFDPAVIPYREILDIFF
AIHDPTTVDRQGNDVGPQYRSAIFAQTPEQLATARTAIAELGASDIFEAPIVTELVDAADGKVTFWRAEDEHQNYFRDHP
AQGYCAFVISPKVAKFRKQFAHRLQG
>Mature_185_residues
TEQRALETAVLGGGCFWCLEAVFQQVQGVHSVVSGYAGGHVDRPSYRAVCNGNTGHAEVVAVKFDPAVIPYREILDIFFA
IHDPTTVDRQGNDVGPQYRSAIFAQTPEQLATARTAIAELGASDIFEAPIVTELVDAADGKVTFWRAEDEHQNYFRDHPA
QGYCAFVISPKVAKFRKQFAHRLQG

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=162, Percent_Identity=40.7407407407407, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI208609995, Length=165, Percent_Identity=40, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI208609993, Length=115, Percent_Identity=40, Blast_Score=82, Evalue=3e-16,
Organism=Escherichia coli, GI1790665, Length=159, Percent_Identity=45.9119496855346, Blast_Score=144, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6320881, Length=162, Percent_Identity=37.037037037037, Blast_Score=93, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24664627, Length=170, Percent_Identity=32.3529411764706, Blast_Score=80, Evalue=6e-16,
Organism=Drosophila melanogaster, GI45553131, Length=166, Percent_Identity=31.9277108433735, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664631, Length=170, Percent_Identity=31.1764705882353, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20455; Mature: 20324

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEQRALETAVLGGGCFWCLEAVFQQVQGVHSVVSGYAGGHVDRPSYRAVCNGNTGHAEV
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEEE
VAVKFDPAVIPYREILDIFFAIHDPTTVDRQGNDVGPQYRSAIFAQTPEQLATARTAIAE
EEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHH
LGASDIFEAPIVTELVDAADGKVTFWRAEDEHQNYFRDHPAQGYCAFVISPKVAKFRKQF
HCHHHHHCCHHHHHHHHCCCCCEEEEECCCHHHHHHHCCCCCCEEEEEECHHHHHHHHHH
AHRLQG
HHHHCC
>Mature Secondary Structure 
TEQRALETAVLGGGCFWCLEAVFQQVQGVHSVVSGYAGGHVDRPSYRAVCNGNTGHAEV
CCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCEEE
VAVKFDPAVIPYREILDIFFAIHDPTTVDRQGNDVGPQYRSAIFAQTPEQLATARTAIAE
EEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHH
LGASDIFEAPIVTELVDAADGKVTFWRAEDEHQNYFRDHPAQGYCAFVISPKVAKFRKQF
HCHHHHHCCHHHHHHHHCCCCCEEEEECCCHHHHHHHCCCCCCEEEEEECHHHHHHHHHH
AHRLQG
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]