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The map label for this gene is glyA [H]

Identifier: 187927774

GI number: 187927774

Start: 716948

End: 718195

Strand: Reverse

Name: glyA [H]

Synonym: Rpic_0678

Alternate gene names: 187927774

Gene position: 718195-716948 (Counterclockwise)

Preceding gene: 187927793

Following gene: 187927773

Centisome position: 18.22

GC content: 62.58

Gene sequence:

>1248_bases
ATGTTCGAACGCAGCCGCTATACGATCGACCAGATCGATCCCGAAATCTTTGCCGCCATCCAGAAGGAAAATCAGCGTCA
GGAAGACCACATCGAGCTGATTGCCTCTGAGAACTACACCTCCCCGGCCGTGATGGCCGCGCAGGGCTCGCAACTGACCA
ACAAGTACGCCGAGGGCTACCCCGGCAAGCGTTACTACGGCGGTTGCGAATACGTGGACGTGGTGGAACAGCTCGCCATC
GATCGCGTGAAGCAGCTCTTTGGGGCCGAAGCTGCCAACGTGCAGCCGAACTCGGGCTCGCAGGCCAACCAGGGCGTGTT
CTTCGCCGTGCTCAAGCCGGGCGACACGATCATGGGGATGAGCCTGGCCGAAGGCGGCCACCTGACCCACGGCATGGCGC
TCAACATGAGCGGCAAGTGGTTCAACGTTGTCAGCTACGGCCTGAACGCTCAGGAAGACATCGACTACGACGCGCTCGAA
GCCCTGGCGCAAGAGAAGAAGCCGAAGCTGATCATTGCCGGCGCATCGGCATTTGCGCTGCGCATCGATTTCGAACGCAT
CGGCAAGATCGCCAAGTCGATTGGTGCGTACTTCATGGTGGACATGGCCCACTACGCGGGCCTGATCGCTGCCGGTGTGT
ACCCGAACCCGGTGCCGCACGCCGACTTCGTCACGACGACCACGCACAAGAGCCTGCGCGGCCCGCGCGGCGGCGTGATC
CTGATGAAGGCCGAACACGAGAAGGCCATCAACTCGGCGATCTTCCCGGGCATCCAGGGCGGCCCGCTGATGCACGTGAT
TGCCGGCAAGGCGGTGGCGTTCAAGGAAGCACTGTCGCCCGAGTTCAAGGCTTACCAGGAACAGGTGGTGAAGAACGCTG
CAGCCATGGCCGAAACGCTGATGGCCCGCGGCCTGCGTATCGTCTCCGGCCGCACCGAAAGCCACGTGATGCTGGTCGAC
CTGCGCGCCAAGAAGATCACCGGCAAGGAAGCCGAAAAGGTGCTGGGTGATGCACACATCACGGTCAACAAGAACGCCAT
TCCGAATGACCCGGAAAAGCCGTTCGTGACCTCGGGCGTGCGCCTGGGCTCGCCTGCCATGACCACGCGTGGCTTCAAGG
AAGCCGAGGCCGTGAAGGTCGCCCACCTGATTGCCGATGTGCTGGACAACCCGCACGACGAGGCCAACATCGCCGCCGTG
CGCGCCAAGGTGGCTGAGCTGACCAAGCAGTTCCCGGTCTACGGCTGA

Upstream 100 bases:

>100_bases
TCGGCTAACGCCGAGCGCAGTCGTTCAAGCCGCGCGCATGTTTCCCCACGCCTCGCCCGATCTCTGCCATTTCCGTTTCG
TTTCAGACCAGACACTCGCC

Downstream 100 bases:

>100_bases
GGCATCCGCCGATGGCCGGATCTTCCGGCCACGTAGTACCCTGCCGCGATGCGCCCCGAATTGAATGAGGGGCCATCGCG
GCGTTGTTCTTTTAGCGCAG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT 1; Serine methylase 1 [H]

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MFERSRYTIDQIDPEIFAAIQKENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAVLKPGDTIMGMSLAEGGHLTHGMALNMSGKWFNVVSYGLNAQEDIDYDALE
ALAQEKKPKLIIAGASAFALRIDFERIGKIAKSIGAYFMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEHEKAINSAIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQEQVVKNAAAMAETLMARGLRIVSGRTESHVMLVD
LRAKKITGKEAEKVLGDAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFKEAEAVKVAHLIADVLDNPHDEANIAAV
RAKVAELTKQFPVYG

Sequences:

>Translated_415_residues
MFERSRYTIDQIDPEIFAAIQKENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAVLKPGDTIMGMSLAEGGHLTHGMALNMSGKWFNVVSYGLNAQEDIDYDALE
ALAQEKKPKLIIAGASAFALRIDFERIGKIAKSIGAYFMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEHEKAINSAIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQEQVVKNAAAMAETLMARGLRIVSGRTESHVMLVD
LRAKKITGKEAEKVLGDAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFKEAEAVKVAHLIADVLDNPHDEANIAAV
RAKVAELTKQFPVYG
>Mature_415_residues
MFERSRYTIDQIDPEIFAAIQKENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGYPGKRYYGGCEYVDVVEQLAI
DRVKQLFGAEAANVQPNSGSQANQGVFFAVLKPGDTIMGMSLAEGGHLTHGMALNMSGKWFNVVSYGLNAQEDIDYDALE
ALAQEKKPKLIIAGASAFALRIDFERIGKIAKSIGAYFMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
LMKAEHEKAINSAIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQEQVVKNAAAMAETLMARGLRIVSGRTESHVMLVD
LRAKKITGKEAEKVLGDAHITVNKNAIPNDPEKPFVTSGVRLGSPAMTTRGFKEAEAVKVAHLIADVLDNPHDEANIAAV
RAKVAELTKQFPVYG

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=454, Percent_Identity=41.8502202643172, Blast_Score=344, Evalue=9e-95,
Organism=Homo sapiens, GI261862352, Length=454, Percent_Identity=41.8502202643172, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI261862350, Length=454, Percent_Identity=41.8502202643172, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI261862348, Length=454, Percent_Identity=41.8502202643172, Blast_Score=343, Evalue=1e-94,
Organism=Homo sapiens, GI261862346, Length=453, Percent_Identity=41.280353200883, Blast_Score=335, Evalue=5e-92,
Organism=Homo sapiens, GI22547186, Length=424, Percent_Identity=44.811320754717, Blast_Score=327, Evalue=1e-89,
Organism=Homo sapiens, GI22547189, Length=409, Percent_Identity=42.7872860635697, Blast_Score=293, Evalue=2e-79,
Organism=Escherichia coli, GI1788902, Length=414, Percent_Identity=63.5265700483092, Blast_Score=530, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI25144732, Length=415, Percent_Identity=45.5421686746988, Blast_Score=353, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI25144729, Length=415, Percent_Identity=45.5421686746988, Blast_Score=352, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6319739, Length=401, Percent_Identity=45.3865336658354, Blast_Score=349, Evalue=4e-97,
Organism=Saccharomyces cerevisiae, GI6323087, Length=427, Percent_Identity=43.7939110070258, Blast_Score=335, Evalue=6e-93,
Organism=Drosophila melanogaster, GI24640005, Length=452, Percent_Identity=42.9203539823009, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221329721, Length=452, Percent_Identity=42.9203539823009, Blast_Score=363, Evalue=1e-101,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 44914; Mature: 44914

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFERSRYTIDQIDPEIFAAIQKENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCCCCCCHHHCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCHHHHHHHCCC
PGKRYYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAVLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAEGGHLTHGMALNMSGKWFNVVSYGLNAQEDIDYDALEALAQEKKPKLIIAGASAFAL
EECCCCCEECCEEEECCCCEEEHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCEEEE
RIDFERIGKIAKSIGAYFMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKAEHEKAINSAIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQEQVVKNAAAMAETL
EEECCHHHHHHHHHCCCCCCCCEEEEHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
MARGLRIVSGRTESHVMLVDLRAKKITGKEAEKVLGDAHITVNKNAIPNDPEKPFVTSGV
HHCCEEEECCCCCCEEEEEEECCHHCCCHHHHHHHCCCEEEEECCCCCCCCCCCCEECCE
RLGSPAMTTRGFKEAEAVKVAHLIADVLDNPHDEANIAAVRAKVAELTKQFPVYG
ECCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFERSRYTIDQIDPEIFAAIQKENQRQEDHIELIASENYTSPAVMAAQGSQLTNKYAEGY
CCCCCCCCHHHCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCEEEEECCCHHHHHHHCCC
PGKRYYGGCEYVDVVEQLAIDRVKQLFGAEAANVQPNSGSQANQGVFFAVLKPGDTIMGM
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEE
SLAEGGHLTHGMALNMSGKWFNVVSYGLNAQEDIDYDALEALAQEKKPKLIIAGASAFAL
EECCCCCEECCEEEECCCCEEEHHCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCCEEEE
RIDFERIGKIAKSIGAYFMVDMAHYAGLIAAGVYPNPVPHADFVTTTTHKSLRGPRGGVI
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEECCHHHHCCCCCCEE
LMKAEHEKAINSAIFPGIQGGPLMHVIAGKAVAFKEALSPEFKAYQEQVVKNAAAMAETL
EEECCHHHHHHHHHCCCCCCCCEEEEHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
MARGLRIVSGRTESHVMLVDLRAKKITGKEAEKVLGDAHITVNKNAIPNDPEKPFVTSGV
HHCCEEEECCCCCCEEEEEEECCHHCCCHHHHHHHCCCEEEEECCCCCCCCCCCCEECCE
RLGSPAMTTRGFKEAEAVKVAHLIADVLDNPHDEANIAAVRAKVAELTKQFPVYG
ECCCCCHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA