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The map label for this gene is pyrR [H]

Identifier: 187927717

GI number: 187927717

Start: 661700

End: 662218

Strand: Direct

Name: pyrR [H]

Synonym: Rpic_0621

Alternate gene names: 187927717

Gene position: 661700-662218 (Clockwise)

Preceding gene: 187927716

Following gene: 187927718

Centisome position: 16.78

GC content: 67.05

Gene sequence:

>519_bases
ATGACATCGCAACAGATCGATGCCGAGGCGCTGTACCAGAGCCTCGTTGCACAACTGCGCACGCGGCTGGCCGACGGCCA
CACCTGGTCGGTGGCCGGCATTGTCAGCGGCGGCGCATGGATCGCCAAGCGGCTGGCACATGACCTTGGCCTGCCGGAAT
ACGGCGTCGTCAACGTTGCGATGCACCGCGACGACTACGCCAAGAAAGGCCTGCACGCCAAGGCGCAGCCGACCACGCTG
CCGTTCGATGTGAACGAGCGCCGCATCCTGCTGGTAGACGACGTGCTGGCCAGCGGCCGCACCATCCGCGCGGCCATCAA
CGAGCTGTTCGACTACGGGCGTCCGGCGGCGGTGGAGCTTGCCGTGTTGGTCGACCGCGGTGAACGCCAGTTGCCTGTGG
CCCCGGATTACATCGGTGAACGCATCACGCTGCCCGCCGACGAATCGCTCGTGCTGAGCGAAGCCAGCGAAGGCGCTGGC
GCGCGCTTCACCTTCACGCGCGAGCCCAAGGGCGCCTGA

Upstream 100 bases:

>100_bases
GCTATTCGTCGATCGCCGCACAGGATGCCGGTGCCTCCGACGATGTGCTCGACGCAGAAGCCGCGCGCATCATCCTCCAA
CAGTTTTTCGACGAACACGC

Downstream 100 bases:

>100_bases
CTTCAAGCGCGCACCGCACCTGCCTTGATCTGACCTGACCTGTACCGACCTCGTCGCCTTTCGTTTCTCCATGCCCAAGA
CTTTTGCCAACCCGCAGCTC

Product: bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase

Products: NA

Alternate protein names: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase; UPRTase [H]

Number of amino acids: Translated: 172; Mature: 171

Protein sequence:

>172_residues
MTSQQIDAEALYQSLVAQLRTRLADGHTWSVAGIVSGGAWIAKRLAHDLGLPEYGVVNVAMHRDDYAKKGLHAKAQPTTL
PFDVNERRILLVDDVLASGRTIRAAINELFDYGRPAAVELAVLVDRGERQLPVAPDYIGERITLPADESLVLSEASEGAG
ARFTFTREPKGA

Sequences:

>Translated_172_residues
MTSQQIDAEALYQSLVAQLRTRLADGHTWSVAGIVSGGAWIAKRLAHDLGLPEYGVVNVAMHRDDYAKKGLHAKAQPTTL
PFDVNERRILLVDDVLASGRTIRAAINELFDYGRPAAVELAVLVDRGERQLPVAPDYIGERITLPADESLVLSEASEGAG
ARFTFTREPKGA
>Mature_171_residues
TSQQIDAEALYQSLVAQLRTRLADGHTWSVAGIVSGGAWIAKRLAHDLGLPEYGVVNVAMHRDDYAKKGLHAKAQPTTLP
FDVNERRILLVDDVLASGRTIRAAINELFDYGRPAAVELAVLVDRGERQLPVAPDYIGERITLPADESLVLSEASEGAGA
RFTFTREPKGA

Specific function: Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant [H]

COG id: COG2065

COG function: function code F; Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000836
- InterPro:   IPR023050 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.9 [H]

Molecular weight: Translated: 18677; Mature: 18546

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSQQIDAEALYQSLVAQLRTRLADGHTWSVAGIVSGGAWIAKRLAHDLGLPEYGVVNVA
CCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHCCCCCCCEEEEE
MHRDDYAKKGLHAKAQPTTLPFDVNERRILLVDDVLASGRTIRAAINELFDYGRPAAVEL
ECCCHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHCCCHHHHHHHHHHHCCCCCCEEE
AVLVDRGERQLPVAPDYIGERITLPADESLVLSEASEGAGARFTFTREPKGA
EEEEECCCCCCCCCHHHCCCEEECCCCCCEEEECCCCCCCCEEEEECCCCCC
>Mature Secondary Structure 
TSQQIDAEALYQSLVAQLRTRLADGHTWSVAGIVSGGAWIAKRLAHDLGLPEYGVVNVA
CCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHHHHHHHHHCCCCCCCEEEEE
MHRDDYAKKGLHAKAQPTTLPFDVNERRILLVDDVLASGRTIRAAINELFDYGRPAAVEL
ECCCHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHCCCHHHHHHHHHHHCCCCCCEEE
AVLVDRGERQLPVAPDYIGERITLPADESLVLSEASEGAGARFTFTREPKGA
EEEEECCCCCCCCCHHHCCCEEECCCCCCEEEECCCCCCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]