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The map label for this gene is dapA2 [H]

Identifier: 187927705

GI number: 187927705

Start: 644579

End: 645487

Strand: Direct

Name: dapA2 [H]

Synonym: Rpic_0609

Alternate gene names: 187927705

Gene position: 644579-645487 (Clockwise)

Preceding gene: 187927696

Following gene: 187927707

Centisome position: 16.35

GC content: 64.47

Gene sequence:

>909_bases
GTGCTTGAAAATTCATCCACCAATTTGTCCACCAACGAACGTCCGTCGTATGCGGGCATCTGGGTGCCCATCGTGACGCC
GTTTGCCGATGACGCGGCGCGATCGGTCGACTACGGCGCGCTGTATACATTAGTGATGCGGTATCGCGCGCTTGGCGCCG
CCGGTTTCGTAGCGTGTGGCAGCACTGGCGAAGCGGCAGCGCTGACCGATCAGGAACAGGCCGACGTGCTCGATACGGTA
CGTGCCGCCGCCGACGGCTTGCCCGTGGTGATGGGCGTCTCGGGCAGCGCTCTCGCGTCCGTACGCGAGCGGATGCTGCG
CCTCGCCGAACATCGGCCGGCAGCGTTTCTGATTCCGGCGCCTTCCTACATTCGCCCGTCGCAGCGCGGGATCATCGAGT
ACTTCACTGCATTGGCCGATGCTTCGCCCGTGCCGGTGCTGCTGTACGACATTCCGTATCGCACCGGCGCACACATCGAC
ACCGAAACGCTGCTCGCGCTGGCGGCGCATCCCAACATCCACGGCATCAAGGATTGCGGCGGCGACGCGGACAAGACGCA
GCGCCTGATCGCCGACGGGCGGTTGCAGGTGCTGGCCGGGGAAGATGCGCAGGTGTTCGGCACGCTGTGCGCCGGCGGTG
TCGGGGCGATTATTGCTGCCGCGCATGTCCGCACGGAGCTGTTTGTCGAGATGGCAAGGGCGGTGCAGGAGCAGCGGTTG
AACGATGCACGACGGTTGCATCATGCGCTGGCACCGGTGATTCGGTTGCTGTTTGCTGAGACGAATCCGGGGCCCTTGAA
GGCTTGGCTTGCGGCTGAGGGGCTGATTCGGAATGTGTTGCGGGCGCCGATGATGATGGCTTCTGAGGGGTTGGGGCGGG
AGTTGGTGGGGGTGGTTGGGCGGGTTTGA

Upstream 100 bases:

>100_bases
TTGGACACGGTTGCCTCTCTCCCGCATCTCGCGGGGCCGCATTCCCGAAGCGCTTCTGACGGTTCTTTGACCGGTCGTTG
ATTCGTCCAGGAGTGTTGTC

Downstream 100 bases:

>100_bases
GTTTTTTTTTGTTGGTGGTCCATCCCCTTTTCGTACCCTGCCGGGCACGACCTACTTTTCTTTGTCTTGCCAAAGAAAAG
TAGGCAAAAGAAAAGCGCGC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS 2 [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MLENSSTNLSTNERPSYAGIWVPIVTPFADDAARSVDYGALYTLVMRYRALGAAGFVACGSTGEAAALTDQEQADVLDTV
RAAADGLPVVMGVSGSALASVRERMLRLAEHRPAAFLIPAPSYIRPSQRGIIEYFTALADASPVPVLLYDIPYRTGAHID
TETLLALAAHPNIHGIKDCGGDADKTQRLIADGRLQVLAGEDAQVFGTLCAGGVGAIIAAAHVRTELFVEMARAVQEQRL
NDARRLHHALAPVIRLLFAETNPGPLKAWLAAEGLIRNVLRAPMMMASEGLGRELVGVVGRV

Sequences:

>Translated_302_residues
MLENSSTNLSTNERPSYAGIWVPIVTPFADDAARSVDYGALYTLVMRYRALGAAGFVACGSTGEAAALTDQEQADVLDTV
RAAADGLPVVMGVSGSALASVRERMLRLAEHRPAAFLIPAPSYIRPSQRGIIEYFTALADASPVPVLLYDIPYRTGAHID
TETLLALAAHPNIHGIKDCGGDADKTQRLIADGRLQVLAGEDAQVFGTLCAGGVGAIIAAAHVRTELFVEMARAVQEQRL
NDARRLHHALAPVIRLLFAETNPGPLKAWLAAEGLIRNVLRAPMMMASEGLGRELVGVVGRV
>Mature_302_residues
MLENSSTNLSTNERPSYAGIWVPIVTPFADDAARSVDYGALYTLVMRYRALGAAGFVACGSTGEAAALTDQEQADVLDTV
RAAADGLPVVMGVSGSALASVRERMLRLAEHRPAAFLIPAPSYIRPSQRGIIEYFTALADASPVPVLLYDIPYRTGAHID
TETLLALAAHPNIHGIKDCGGDADKTQRLIADGRLQVLAGEDAQVFGTLCAGGVGAIIAAAHVRTELFVEMARAVQEQRL
NDARRLHHALAPVIRLLFAETNPGPLKAWLAAEGLIRNVLRAPMMMASEGLGRELVGVVGRV

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=240, Percent_Identity=33.75, Blast_Score=119, Evalue=2e-27,
Organism=Escherichia coli, GI1788823, Length=286, Percent_Identity=33.9160839160839, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1786463, Length=259, Percent_Identity=27.7992277992278, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI87082415, Length=246, Percent_Identity=26.8292682926829, Blast_Score=75, Evalue=7e-15,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 32101; Mature: 32101

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLENSSTNLSTNERPSYAGIWVPIVTPFADDAARSVDYGALYTLVMRYRALGAAGFVACG
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHCCCHHEEEC
STGEAAALTDQEQADVLDTVRAAADGLPVVMGVSGSALASVRERMLRLAEHRPAAFLIPA
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCCEEEECC
PSYIRPSQRGIIEYFTALADASPVPVLLYDIPYRTGAHIDTETLLALAAHPNIHGIKDCG
CHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHCC
GDADKTQRLIADGRLQVLAGEDAQVFGTLCAGGVGAIIAAAHVRTELFVEMARAVQEQRL
CCHHHHHHHHHCCCEEEEECCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NDARRLHHALAPVIRLLFAETNPGPLKAWLAAEGLIRNVLRAPMMMASEGLGRELVGVVG
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHC
RV
CC
>Mature Secondary Structure
MLENSSTNLSTNERPSYAGIWVPIVTPFADDAARSVDYGALYTLVMRYRALGAAGFVACG
CCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHCCHHHHHHHHHHHHHHCCCHHEEEC
STGEAAALTDQEQADVLDTVRAAADGLPVVMGVSGSALASVRERMLRLAEHRPAAFLIPA
CCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHCCCCEEEECC
PSYIRPSQRGIIEYFTALADASPVPVLLYDIPYRTGAHIDTETLLALAAHPNIHGIKDCG
CHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCHHHCC
GDADKTQRLIADGRLQVLAGEDAQVFGTLCAGGVGAIIAAAHVRTELFVEMARAVQEQRL
CCHHHHHHHHHCCCEEEEECCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NDARRLHHALAPVIRLLFAETNPGPLKAWLAAEGLIRNVLRAPMMMASEGLGRELVGVVG
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHC
RV
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11466286 [H]