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The map label for this gene is zitB [H]

Identifier: 187927666

GI number: 187927666

Start: 603805

End: 605109

Strand: Direct

Name: zitB [H]

Synonym: Rpic_0570

Alternate gene names: 187927666

Gene position: 603805-605109 (Clockwise)

Preceding gene: 187927665

Following gene: 187927667

Centisome position: 15.32

GC content: 63.14

Gene sequence:

>1305_bases
ATGAGCAATTTCTACGACACGCCGTTCCACGCCAGCCACGACCACGTGTTCCTGGGCGAGGGACATGAAAAGAACGAGCG
CAAAACCTGGGCCGTGATCGTGCTATGCACCCTCATGATGGCCGCCGAGATCATCGGCGGAAGCGTGTTTGGCTCGCTGG
CACTGGTGGCCGATGGGCTGCATATGTCGACGCACGCGGGCGCCATGCTGATCGCTGCGCTGGCTTACACCTATGCGCGA
CGTCATGCGAACGACCCGCGTTTCGTGTTCGGCACAGGCAAGCTTGGTGATCTAGCCGGCTTCACCAGCGCCATCATCCT
GGCGATGGTTGCACTGTTGATCGGCTACGAAGCGGTGGTGCGATTCTTCTCGCCGGTGCCGATCCACTTTAGTGAGGCGA
TCCCGATTGCGGTCGTCGGTCTGCTGGTGAATATCGCAAGCGCCTGGCTGCTGAGCGGTGGCGACCACGGTGGTCACAGC
CATGGCCACAGTCATCACCATGGTCACGCCCACGGACACGATCACGGCGCAGCCGGACTTGGCGACACGCATCCGCATGG
CAGGGAAGTGCAGCACATCGAGGCGCCCGGGGGCGTGTTCGCACTGTCGATCTTCGAAGACGGCGTACCGCCAGTGTTCC
GGTTAGCTGGAGAAACCGCTCCGCTGCCGGGCGATGTGGCGACGGTAACCACCATTCGGCCGGACGGGAGCCGCCAGGAA
TTCCTGCTGGTCCGCAAGGCAAACTATCTGGAATCCACCACCGAGATTCCGGAACCACATGCCTTCACTGCCGTACTCGG
CATCGGCGGCCAGGAATACAGCGTGGCCTTCGACGAGCATGACCACGATCACGCCGACGGTCACGGGGCACACCATCGCG
ACCACAACATGCGCGCGGCCTATGTGCACGTTCTGGCGGATGCCGCCGTCTCTGTGCTGGCCATTATCGGTCTGCTGCTC
GCCAGAACATTTGGCTGGCTCTGGATGGACCCCCTTGCAGGCGTCGTCGGTGCGGTGGTCATCGCCAACTGGGCGTACGG
ATTGATGCGCGACACCGGCGGCATTCTGGTCGACGTGACGCCGGACAAGCATATCGGCAGGCGCATCAAGACGGCGCTGG
AGTCCGATGGCGACACGCTGCTCGACCTGCACGTATGGCGCATCGGCCCTGGCCACCTGGGCGCGGTGGTCTCGGTGAGC
ACAGGCCAGGCGCATCGCGGGCCGCAGTTTTATCACCAACGGTTGCGGCGACTCCAGGCACTGTCGCATATCACCGTGGA
AGTTCACGCGTCGCCGGGCAAATAG

Upstream 100 bases:

>100_bases
ACCCACCTGACCGAGGTGGATGACGAACACGAGCACGCCGACGGCAGCGCCAAAGAGCAGCTGATCGAGGTCGTGCATAG
CTATTTCAGGTGAGCCGGCT

Downstream 100 bases:

>100_bases
CCTATTGGTCGACTCGGACATTTGCTCCGCATCACCAGCATGGGGCGCGGCACCCTGCCATGCGTGCCGCATCTGCCCGA
CCACAACAAAACACATTCGC

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MSNFYDTPFHASHDHVFLGEGHEKNERKTWAVIVLCTLMMAAEIIGGSVFGSLALVADGLHMSTHAGAMLIAALAYTYAR
RHANDPRFVFGTGKLGDLAGFTSAIILAMVALLIGYEAVVRFFSPVPIHFSEAIPIAVVGLLVNIASAWLLSGGDHGGHS
HGHSHHHGHAHGHDHGAAGLGDTHPHGREVQHIEAPGGVFALSIFEDGVPPVFRLAGETAPLPGDVATVTTIRPDGSRQE
FLLVRKANYLESTTEIPEPHAFTAVLGIGGQEYSVAFDEHDHDHADGHGAHHRDHNMRAAYVHVLADAAVSVLAIIGLLL
ARTFGWLWMDPLAGVVGAVVIANWAYGLMRDTGGILVDVTPDKHIGRRIKTALESDGDTLLDLHVWRIGPGHLGAVVSVS
TGQAHRGPQFYHQRLRRLQALSHITVEVHASPGK

Sequences:

>Translated_434_residues
MSNFYDTPFHASHDHVFLGEGHEKNERKTWAVIVLCTLMMAAEIIGGSVFGSLALVADGLHMSTHAGAMLIAALAYTYAR
RHANDPRFVFGTGKLGDLAGFTSAIILAMVALLIGYEAVVRFFSPVPIHFSEAIPIAVVGLLVNIASAWLLSGGDHGGHS
HGHSHHHGHAHGHDHGAAGLGDTHPHGREVQHIEAPGGVFALSIFEDGVPPVFRLAGETAPLPGDVATVTTIRPDGSRQE
FLLVRKANYLESTTEIPEPHAFTAVLGIGGQEYSVAFDEHDHDHADGHGAHHRDHNMRAAYVHVLADAAVSVLAIIGLLL
ARTFGWLWMDPLAGVVGAVVIANWAYGLMRDTGGILVDVTPDKHIGRRIKTALESDGDTLLDLHVWRIGPGHLGAVVSVS
TGQAHRGPQFYHQRLRRLQALSHITVEVHASPGK
>Mature_433_residues
SNFYDTPFHASHDHVFLGEGHEKNERKTWAVIVLCTLMMAAEIIGGSVFGSLALVADGLHMSTHAGAMLIAALAYTYARR
HANDPRFVFGTGKLGDLAGFTSAIILAMVALLIGYEAVVRFFSPVPIHFSEAIPIAVVGLLVNIASAWLLSGGDHGGHSH
GHSHHHGHAHGHDHGAAGLGDTHPHGREVQHIEAPGGVFALSIFEDGVPPVFRLAGETAPLPGDVATVTTIRPDGSRQEF
LLVRKANYLESTTEIPEPHAFTAVLGIGGQEYSVAFDEHDHDHADGHGAHHRDHNMRAAYVHVLADAAVSVLAIIGLLLA
RTFGWLWMDPLAGVVGAVVIANWAYGLMRDTGGILVDVTPDKHIGRRIKTALESDGDTLLDLHVWRIGPGHLGAVVSVST
GQAHRGPQFYHQRLRRLQALSHITVEVHASPGK

Specific function: Involved in zinc efflux across the cytoplasmic membrane, thus reducing zinc accumulation in the cytoplasm and rendering bacteria more resistant to zinc. It may contribute to zinc homeostasis at low concentrations of zinc [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI20070323, Length=178, Percent_Identity=26.9662921348315, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786966, Length=132, Percent_Identity=40.9090909090909, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17550442, Length=401, Percent_Identity=22.1945137157107, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17550440, Length=401, Percent_Identity=22.1945137157107, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6323899, Length=375, Percent_Identity=25.8666666666667, Blast_Score=81, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6320411, Length=150, Percent_Identity=30, Blast_Score=68, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6324892, Length=392, Percent_Identity=21.9387755102041, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 46477; Mature: 46346

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNFYDTPFHASHDHVFLGEGHEKNERKTWAVIVLCTLMMAAEIIGGSVFGSLALVADGL
CCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCC
HMSTHAGAMLIAALAYTYARRHANDPRFVFGTGKLGDLAGFTSAIILAMVALLIGYEAVV
CCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RFFSPVPIHFSEAIPIAVVGLLVNIASAWLLSGGDHGGHSHGHSHHHGHAHGHDHGAAGL
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GDTHPHGREVQHIEAPGGVFALSIFEDGVPPVFRLAGETAPLPGDVATVTTIRPDGSRQE
CCCCCCCCCEEEEECCCCEEEEEECCCCCCHHHHHCCCCCCCCCCCEEEEEECCCCCCCE
FLLVRKANYLESTTEIPEPHAFTAVLGIGGQEYSVAFDEHDHDHADGHGAHHRDHNMRAA
EEEEEHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHH
YVHVLADAAVSVLAIIGLLLARTFGWLWMDPLAGVVGAVVIANWAYGLMRDTGGILVDVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
PDKHIGRRIKTALESDGDTLLDLHVWRIGPGHLGAVVSVSTGQAHRGPQFYHQRLRRLQA
CCHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
LSHITVEVHASPGK
HHEEEEEEECCCCC
>Mature Secondary Structure 
SNFYDTPFHASHDHVFLGEGHEKNERKTWAVIVLCTLMMAAEIIGGSVFGSLALVADGL
CCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHCCC
HMSTHAGAMLIAALAYTYARRHANDPRFVFGTGKLGDLAGFTSAIILAMVALLIGYEAVV
CCCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RFFSPVPIHFSEAIPIAVVGLLVNIASAWLLSGGDHGGHSHGHSHHHGHAHGHDHGAAGL
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
GDTHPHGREVQHIEAPGGVFALSIFEDGVPPVFRLAGETAPLPGDVATVTTIRPDGSRQE
CCCCCCCCCEEEEECCCCEEEEEECCCCCCHHHHHCCCCCCCCCCCEEEEEECCCCCCCE
FLLVRKANYLESTTEIPEPHAFTAVLGIGGQEYSVAFDEHDHDHADGHGAHHRDHNMRAA
EEEEEHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHH
YVHVLADAAVSVLAIIGLLLARTFGWLWMDPLAGVVGAVVIANWAYGLMRDTGGILVDVT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEC
PDKHIGRRIKTALESDGDTLLDLHVWRIGPGHLGAVVSVSTGQAHRGPQFYHQRLRRLQA
CCHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHH
LSHITVEVHASPGK
HHEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]