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The map label for this gene is murC [H]

Identifier: 187918670

GI number: 187918670

Start: 877209

End: 878669

Strand: Direct

Name: murC [H]

Synonym: BH0817

Alternate gene names: 187918670

Gene position: 877209-878669 (Clockwise)

Preceding gene: 187918669

Following gene: 187918671

Centisome position: 95.11

GC content: 27.65

Gene sequence:

>1461_bases
TTGATGTTATCATACATAGATTTTATGATCAAAAATGTAATTTGGAAAAAAAAGATGAATGTTGACTTGGATAATATAAG
TAATGTCTTTTTGGTAGGCATTAAGGGCTCTGGACTTTGTTCACTTGCGTGTTTTTTAAATGATAAGGGGTATTTTGTAG
AAGGGGTCGATGTTCCTTTAAAATTTCATACGGAAGATATATTAAAGAGTAATAATATAACTTATTATGAGAATATTGAT
GAATTTTCACTCAAAGTTCATAATAAATCTTATGATGTTTTAATATATTCACCAGCTTATGATAAGGATAATTTATCTGT
TTTGCTAGAAGCATGTGAACTTGGAATTCCTATTTTATCTTATCCTGAGGTTCTTGGTAAGATTTCTAAAAAATATTATA
GTATCGGAGTTGCAGGCTCTCATGGCAAAACTACCACAGCGGCATTCTTAGGTATGCTATTTAATAGTCTAGGATTGCAG
CCTAATGTAATATTAGGTGCTAGTGTTAAAGATTTTAAAAATAAATCTAGTCTTGTCGGTCAGGGTAATATATTTATTGC
AGAGACTTGTGAGTATAGGAATCACTTTTTACATTTTTCTCCGGATATGATTGTTTTAAGTAATATTGATTATGAACATG
TTGATTTTTTTGAAAATTATGAAGCAGTTTTAAATGTTTTCTTAAAGTATATTAATAATTTAAAGCAAAATGGGATATTA
ATAATAAATGCTGATGAAGTTAATTTGCTTAAAATTACAAATAAAATCTTAAGAAAAGATATTAAAGTCTTTAGTGTTGG
ATTTAATTCTCTGGCTGATTTTAAAATTGAACATTTTGAGGTGATAGACGAGTTTTTAAAGTTTGATTTTTTAGGGGGTA
TTGATATTAGACTGAGGACCCCTTTGATTCATAATGTTTTAAATTTTGCATCAGCACTTTTAGCTTTAAAGCTATTTTTA
GAGGAACATAAAAAATTAGTTTGGAGTTTTGATGAGAGAATAAAGATAGTAGCCAAAGAGTATATGGGCATTAAAAGAAG
GATGGAATTTATCATGGAAAAAGATGGAGTTATATATCTTGATGACTATGCTCATCATCCAAAGGAAATTGAAAGTACTC
TTTTGGGACTTAAGAATTTTTATAAGGATAGGCGTATTATTTTAGATTTTATGCCACATACCTTTACAAGGACACAAGTT
CTTTTTGATGAGTTTGTTAAAGTTTTAAGCAATGTTGATGTATTGATTTTGCATAATATATATCTTTCAGTTAGAGAAAA
TTTTGATCCGAATAAACTCTCTAGAGAATTGTTTTTAGCTCTTAAAGATTTAAATCAGAATGTTTATTTTTTTAAAGAAG
TAGTTGATTCTGTTGATTTTATAAGGGGTTTATTAAAGAGAAATGATTTATTTGTTACAATGGGAGCTGGTAATAATTTT
ATTTTACATGATTTTTTATAA

Upstream 100 bases:

>100_bases
GATATTCCACTTAAGAATGATTTACTTAATGGTGCGGAAATGCTTAGGAATTATATTATTGAAAACGTACTAAAATATAC
GGTAATTAATATATCTGGTA

Downstream 100 bases:

>100_bases
AGGTATTTTGAATGAAAAGTATGACTGGATTTTTTCACTTGGAAAAAGTTATTTCAAATTATATGTTTAGTGTTAATTTG
AAGTCTTATAATGGTAGATT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MMLSYIDFMIKNVIWKKKMNVDLDNISNVFLVGIKGSGLCSLACFLNDKGYFVEGVDVPLKFHTEDILKSNNITYYENID
EFSLKVHNKSYDVLIYSPAYDKDNLSVLLEACELGIPILSYPEVLGKISKKYYSIGVAGSHGKTTTAAFLGMLFNSLGLQ
PNVILGASVKDFKNKSSLVGQGNIFIAETCEYRNHFLHFSPDMIVLSNIDYEHVDFFENYEAVLNVFLKYINNLKQNGIL
IINADEVNLLKITNKILRKDIKVFSVGFNSLADFKIEHFEVIDEFLKFDFLGGIDIRLRTPLIHNVLNFASALLALKLFL
EEHKKLVWSFDERIKIVAKEYMGIKRRMEFIMEKDGVIYLDDYAHHPKEIESTLLGLKNFYKDRRIILDFMPHTFTRTQV
LFDEFVKVLSNVDVLILHNIYLSVRENFDPNKLSRELFLALKDLNQNVYFFKEVVDSVDFIRGLLKRNDLFVTMGAGNNF
ILHDFL

Sequences:

>Translated_486_residues
MMLSYIDFMIKNVIWKKKMNVDLDNISNVFLVGIKGSGLCSLACFLNDKGYFVEGVDVPLKFHTEDILKSNNITYYENID
EFSLKVHNKSYDVLIYSPAYDKDNLSVLLEACELGIPILSYPEVLGKISKKYYSIGVAGSHGKTTTAAFLGMLFNSLGLQ
PNVILGASVKDFKNKSSLVGQGNIFIAETCEYRNHFLHFSPDMIVLSNIDYEHVDFFENYEAVLNVFLKYINNLKQNGIL
IINADEVNLLKITNKILRKDIKVFSVGFNSLADFKIEHFEVIDEFLKFDFLGGIDIRLRTPLIHNVLNFASALLALKLFL
EEHKKLVWSFDERIKIVAKEYMGIKRRMEFIMEKDGVIYLDDYAHHPKEIESTLLGLKNFYKDRRIILDFMPHTFTRTQV
LFDEFVKVLSNVDVLILHNIYLSVRENFDPNKLSRELFLALKDLNQNVYFFKEVVDSVDFIRGLLKRNDLFVTMGAGNNF
ILHDFL
>Mature_486_residues
MMLSYIDFMIKNVIWKKKMNVDLDNISNVFLVGIKGSGLCSLACFLNDKGYFVEGVDVPLKFHTEDILKSNNITYYENID
EFSLKVHNKSYDVLIYSPAYDKDNLSVLLEACELGIPILSYPEVLGKISKKYYSIGVAGSHGKTTTAAFLGMLFNSLGLQ
PNVILGASVKDFKNKSSLVGQGNIFIAETCEYRNHFLHFSPDMIVLSNIDYEHVDFFENYEAVLNVFLKYINNLKQNGIL
IINADEVNLLKITNKILRKDIKVFSVGFNSLADFKIEHFEVIDEFLKFDFLGGIDIRLRTPLIHNVLNFASALLALKLFL
EEHKKLVWSFDERIKIVAKEYMGIKRRMEFIMEKDGVIYLDDYAHHPKEIESTLLGLKNFYKDRRIILDFMPHTFTRTQV
LFDEFVKVLSNVDVLILHNIYLSVRENFDPNKLSRELFLALKDLNQNVYFFKEVVDSVDFIRGLLKRNDLFVTMGAGNNF
ILHDFL

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=448, Percent_Identity=27.4553571428571, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI1790680, Length=470, Percent_Identity=22.3404255319149, Blast_Score=106, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 56081; Mature: 56081

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMLSYIDFMIKNVIWKKKMNVDLDNISNVFLVGIKGSGLCSLACFLNDKGYFVEGVDVPL
CCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCEEECCCCCE
KFHTEDILKSNNITYYENIDEFSLKVHNKSYDVLIYSPAYDKDNLSVLLEACELGIPILS
EECHHHHHHCCCEEEEECCCEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCC
YPEVLGKISKKYYSIGVAGSHGKTTTAAFLGMLFNSLGLQPNVILGASVKDFKNKSSLVG
CHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCHHHHCCCCCCCC
QGNIFIAETCEYRNHFLHFSPDMIVLSNIDYEHVDFFENYEAVLNVFLKYINNLKQNGIL
CCCEEEEEECHHCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IINADEVNLLKITNKILRKDIKVFSVGFNSLADFKIEHFEVIDEFLKFDFLGGIDIRLRT
EEECCCEEHHHHHHHHHHHHHHEEEECCCCHHCCCHHHHHHHHHHHHHHCCCCCEEEEEC
PLIHNVLNFASALLALKLFLEEHKKLVWSFDERIKIVAKEYMGIKRRMEFIMEKDGVIYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
DDYAHHPKEIESTLLGLKNFYKDRRIILDFMPHTFTRTQVLFDEFVKVLSNVDVLILHNI
CCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEHH
YLSVRENFDPNKLSRELFLALKDLNQNVYFFKEVVDSVDFIRGLLKRNDLFVTMGAGNNF
HHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCE
ILHDFL
EEECCC
>Mature Secondary Structure
MMLSYIDFMIKNVIWKKKMNVDLDNISNVFLVGIKGSGLCSLACFLNDKGYFVEGVDVPL
CCHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCEEEEEEECCCCCEEECCCCCE
KFHTEDILKSNNITYYENIDEFSLKVHNKSYDVLIYSPAYDKDNLSVLLEACELGIPILS
EECHHHHHHCCCEEEEECCCEEEEEEECCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCC
YPEVLGKISKKYYSIGVAGSHGKTTTAAFLGMLFNSLGLQPNVILGASVKDFKNKSSLVG
CHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEECCHHHHCCCCCCCC
QGNIFIAETCEYRNHFLHFSPDMIVLSNIDYEHVDFFENYEAVLNVFLKYINNLKQNGIL
CCCEEEEEECHHCCCEEEECCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
IINADEVNLLKITNKILRKDIKVFSVGFNSLADFKIEHFEVIDEFLKFDFLGGIDIRLRT
EEECCCEEHHHHHHHHHHHHHHEEEECCCCHHCCCHHHHHHHHHHHHHHCCCCCEEEEEC
PLIHNVLNFASALLALKLFLEEHKKLVWSFDERIKIVAKEYMGIKRRMEFIMEKDGVIYL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
DDYAHHPKEIESTLLGLKNFYKDRRIILDFMPHTFTRTQVLFDEFVKVLSNVDVLILHNI
CCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEHH
YLSVRENFDPNKLSRELFLALKDLNQNVYFFKEVVDSVDFIRGLLKRNDLFVTMGAGNNF
HHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCE
ILHDFL
EEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA