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The map label for this gene is panF [H]

Identifier: 187918667

GI number: 187918667

Start: 873963

End: 875384

Strand: Direct

Name: panF [H]

Synonym: BH0814

Alternate gene names: 187918667

Gene position: 873963-875384 (Clockwise)

Preceding gene: 187918702

Following gene: 187918668

Centisome position: 94.76

GC content: 26.58

Gene sequence:

>1422_bases
ATGACTAGAGGATTTTTTGTATTTTTTATCTTTTTGATTTTATATTGCGCTTTTGGTTTTTTTGCTAGAAAAAAAAGGGC
GAGATCGTTATTTTTACATAATTATTTTCTTGCAAATCAGGGTCTAAATTTTGTCGTAATGGCATTAGTAGTTGCTTCTA
GCTATATTAGTGCTAGTAGTTTTATTTCAGGGCCTTCAGCTGTTTATAGATATGGATTATCTTTCATATTCTTAGCAGTT
ATTCAAATTCCTACAAGTTTAATTTCATTTGTCATTGTTGGTGAGAAATTAAATTTGGAAGCAAAAAAAATTAATGCAAT
TAATATTATTGATTATATTGGATATAGATATCTCAGTCGCTCTTTAGTTCTAGTTAGTAGTTTTATAATCATTTTTTTTT
CTTTGTTTTTAATCTCAGCTCAGCTTATGGGAGGTGCTAAACTTTTAGAAGTTTTTTTTCAAATCGGTTATACTGATGCT
CTTATTTTTTTCTCTCTATTTGTTTTTTTATATGTTTGTTTGGGTGGGTTTAAGATGATAGCATATATGGATTTCATTCA
AGGCATTTTGATGATCGTAGCGTCTGTACTATTATTTTCAAGACTAGTTGATTTGGGAGGTGGAATTAGTAATCTCTTTA
ATATGGCTCGGTTGAATCTTAAAGATGATTTATTTTTGCCATCAAACTTAGATTTGAAAATTGGATATATAATTTCTTTT
TGGATATTAATAGGAATTGGAGTATTGGGGCTGCCACAATTTGTTAATAATTTTATAGCATTTAAAGATGTGAAATCTAT
GAGATTTTCTCTTCCCATTGTTACTTTTGTAATAGGGTTTTTAGTTGTTATTATGCATTTAATAGGTTTTTTTTCCCTTG
TTATTTTTTCCAAATTTGAACCAAATGATAAATTTATTTTAAATGTAGCATTAGAGGTATTAAATCCTAAAATATTTATA
TTATTTTTTGTAGGACTCTTATCAGCGATAATGTCTACAATAGATTCAGGTCTTCTATTGCTGTCTTCTATTTGGGTAAA
AGCAATAATGTCTTTAAATAAGAGTCTTGTTGGTAAGATTGGAATTAATAGAATTACTATTATTTCTAATGTTTGTTTTA
TGTCAATAATCGTTTTTTTATCTTTAAATCCACCTGATTTTTTGTTTTTTTTAAATATTTTTGCAATTGGGGCCTTGGAA
GTTTCATTCTTTTCTATTATTGTTTTTGGGCTTTATTTTAATTTTGTAAGTAAAATATCAGCTTTTATTTCTCAGTTTTT
GGGACTTTTAAGTTATTTGATCATAATTTTTTATGGTGAAGTAAGTAGTTATTATTTTCATCCTATTGTTCCTTCACTTT
TTATATCTATATCTTCATTTTTGATAGTTAATCTTTTTTGTCAAAGATGTAGTAAAATTTAG

Upstream 100 bases:

>100_bases
ATTACTATTTTTAATATTCCTCTTTGGTTTTTTTTATCATGTATCTTTTTCTCTATTTTCAGTTTGTTATTAGTATGTAT
TTTTGTGATTTTTTTTAAAA

Downstream 100 bases:

>100_bases
TTGTATGTTGTCTTTAAATGATAAGAGTGTTGGTAAATATAGAGTTATCGATGTTCTAAAGAATGACAATGGTAAAAGAC
TTGATGCAGTGTTAATAAAG

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 473; Mature: 472

Protein sequence:

>473_residues
MTRGFFVFFIFLILYCAFGFFARKKRARSLFLHNYFLANQGLNFVVMALVVASSYISASSFISGPSAVYRYGLSFIFLAV
IQIPTSLISFVIVGEKLNLEAKKINAINIIDYIGYRYLSRSLVLVSSFIIIFFSLFLISAQLMGGAKLLEVFFQIGYTDA
LIFFSLFVFLYVCLGGFKMIAYMDFIQGILMIVASVLLFSRLVDLGGGISNLFNMARLNLKDDLFLPSNLDLKIGYIISF
WILIGIGVLGLPQFVNNFIAFKDVKSMRFSLPIVTFVIGFLVVIMHLIGFFSLVIFSKFEPNDKFILNVALEVLNPKIFI
LFFVGLLSAIMSTIDSGLLLLSSIWVKAIMSLNKSLVGKIGINRITIISNVCFMSIIVFLSLNPPDFLFFLNIFAIGALE
VSFFSIIVFGLYFNFVSKISAFISQFLGLLSYLIIIFYGEVSSYYFHPIVPSLFISISSFLIVNLFCQRCSKI

Sequences:

>Translated_473_residues
MTRGFFVFFIFLILYCAFGFFARKKRARSLFLHNYFLANQGLNFVVMALVVASSYISASSFISGPSAVYRYGLSFIFLAV
IQIPTSLISFVIVGEKLNLEAKKINAINIIDYIGYRYLSRSLVLVSSFIIIFFSLFLISAQLMGGAKLLEVFFQIGYTDA
LIFFSLFVFLYVCLGGFKMIAYMDFIQGILMIVASVLLFSRLVDLGGGISNLFNMARLNLKDDLFLPSNLDLKIGYIISF
WILIGIGVLGLPQFVNNFIAFKDVKSMRFSLPIVTFVIGFLVVIMHLIGFFSLVIFSKFEPNDKFILNVALEVLNPKIFI
LFFVGLLSAIMSTIDSGLLLLSSIWVKAIMSLNKSLVGKIGINRITIISNVCFMSIIVFLSLNPPDFLFFLNIFAIGALE
VSFFSIIVFGLYFNFVSKISAFISQFLGLLSYLIIIFYGEVSSYYFHPIVPSLFISISSFLIVNLFCQRCSKI
>Mature_472_residues
TRGFFVFFIFLILYCAFGFFARKKRARSLFLHNYFLANQGLNFVVMALVVASSYISASSFISGPSAVYRYGLSFIFLAVI
QIPTSLISFVIVGEKLNLEAKKINAINIIDYIGYRYLSRSLVLVSSFIIIFFSLFLISAQLMGGAKLLEVFFQIGYTDAL
IFFSLFVFLYVCLGGFKMIAYMDFIQGILMIVASVLLFSRLVDLGGGISNLFNMARLNLKDDLFLPSNLDLKIGYIISFW
ILIGIGVLGLPQFVNNFIAFKDVKSMRFSLPIVTFVIGFLVVIMHLIGFFSLVIFSKFEPNDKFILNVALEVLNPKIFIL
FFVGLLSAIMSTIDSGLLLLSSIWVKAIMSLNKSLVGKIGINRITIISNVCFMSIIVFLSLNPPDFLFFLNIFAIGALEV
SFFSIIVFGLYFNFVSKISAFISQFLGLLSYLIIIFYGEVSSYYFHPIVPSLFISISSFLIVNLFCQRCSKI

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=500, Percent_Identity=25.8, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI87082237, Length=467, Percent_Identity=31.2633832976445, Blast_Score=233, Evalue=2e-62,
Organism=Escherichia coli, GI1787251, Length=434, Percent_Identity=22.3502304147465, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1790503, Length=459, Percent_Identity=22.6579520697168, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 53217; Mature: 53086

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS00879 ODR_DC_2_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TRGFFVFFIFLILYCAFGFFARKKRARSLFLHNYFLANQGLNFVVMALVVASSYISASS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]