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The map label for this gene is apt [H]

Identifier: 187918630

GI number: 187918630

Start: 829601

End: 830143

Strand: Direct

Name: apt [H]

Synonym: BH0777

Alternate gene names: 187918630

Gene position: 829601-830143 (Clockwise)

Preceding gene: 187918629

Following gene: 187918631

Centisome position: 89.95

GC content: 32.6

Gene sequence:

>543_bases
GTGGAAATATCAATGAAAGATAAAACGGAATATTATGATAAGTTTATTATGAGAGTGCCTAACTTTCCAAAGGAAGGTAT
ACTTTTTTATGATATTACTAATGTTTTGCTCCAAGCAGAAGCATATAAATCTTTAATGGAAGATGCTCATGCTTTTTATG
CATCAAGAAAAATTGATTGCATTGCTGCTATTGAATCAAGAGGGTATCTTATTGGTTCGCCTTTGGCTTTAAAAATGGGT
TTACCTCTTTTACTAATTCGAAAAGCAGGTAAGCTCCCAAGGCAAGTATTAAGAGAGGAGTATGAGCTTGAATATGGATT
TAGCAGTATTGAAATACATAAAGATGATGTTAAACAACATTCAAATATTTTGTTAGTTGATGACATTTTAGCTACCGGAG
GCACTCTAAAAGCAGCTGCTATGTTACTTAAAAAGGCGGGTGGAGTAGTATCTGATATATTTTGTTTCATTGAACTTGTA
AAGATGAATGGTAGAGATATTTTACGGGAGTATAGTTTGAATTCTCTTGTTAGGTATTTTTGA

Upstream 100 bases:

>100_bases
GGACAAGAGCTAAAGAAGATGAGATTCCAAAGCTAGATGTAGAAGGCATAGTACCAAATCCGCCTGTGGCAGAGGAATAA
AGAAGGATAAATATTAATTT

Downstream 100 bases:

>100_bases
TAATTTATTTAATAAATAATTTATGTTATTAATTAAGCTTGAATAATTGACTTTAAATTTTATTGAATTTATAATATTTA
GCTGAACATTGAGAGGTGAT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MEISMKDKTEYYDKFIMRVPNFPKEGILFYDITNVLLQAEAYKSLMEDAHAFYASRKIDCIAAIESRGYLIGSPLALKMG
LPLLLIRKAGKLPRQVLREEYELEYGFSSIEIHKDDVKQHSNILLVDDILATGGTLKAAAMLLKKAGGVVSDIFCFIELV
KMNGRDILREYSLNSLVRYF

Sequences:

>Translated_180_residues
MEISMKDKTEYYDKFIMRVPNFPKEGILFYDITNVLLQAEAYKSLMEDAHAFYASRKIDCIAAIESRGYLIGSPLALKMG
LPLLLIRKAGKLPRQVLREEYELEYGFSSIEIHKDDVKQHSNILLVDDILATGGTLKAAAMLLKKAGGVVSDIFCFIELV
KMNGRDILREYSLNSLVRYF
>Mature_180_residues
MEISMKDKTEYYDKFIMRVPNFPKEGILFYDITNVLLQAEAYKSLMEDAHAFYASRKIDCIAAIESRGYLIGSPLALKMG
LPLLLIRKAGKLPRQVLREEYELEYGFSSIEIHKDDVKQHSNILLVDDILATGGTLKAAAMLLKKAGGVVSDIFCFIELV
KMNGRDILREYSLNSLVRYF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis [H]

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4502171, Length=174, Percent_Identity=37.9310344827586, Blast_Score=117, Evalue=5e-27,
Organism=Homo sapiens, GI71773201, Length=128, Percent_Identity=39.84375, Blast_Score=94, Evalue=5e-20,
Organism=Escherichia coli, GI1786675, Length=166, Percent_Identity=38.5542168674699, Blast_Score=128, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17509087, Length=170, Percent_Identity=38.8235294117647, Blast_Score=125, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=122, Percent_Identity=41.8032786885246, Blast_Score=91, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6320649, Length=134, Percent_Identity=34.3283582089552, Blast_Score=62, Evalue=5e-11,
Organism=Drosophila melanogaster, GI17136334, Length=180, Percent_Identity=40.5555555555556, Blast_Score=122, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005764
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.4.2.7 [H]

Molecular weight: Translated: 20480; Mature: 20480

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEISMKDKTEYYDKFIMRVPNFPKEGILFYDITNVLLQAEAYKSLMEDAHAFYASRKIDC
CCCCCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
IAAIESRGYLIGSPLALKMGLPLLLIRKAGKLPRQVLREEYELEYGFSSIEIHKDDVKQH
EEECCCCCEEECCCHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHC
SNILLVDDILATGGTLKAAAMLLKKAGGVVSDIFCFIELVKMNGRDILREYSLNSLVRYF
CCEEEEHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEISMKDKTEYYDKFIMRVPNFPKEGILFYDITNVLLQAEAYKSLMEDAHAFYASRKIDC
CCCCCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
IAAIESRGYLIGSPLALKMGLPLLLIRKAGKLPRQVLREEYELEYGFSSIEIHKDDVKQH
EEECCCCCEEECCCHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEEHHHHHHC
SNILLVDDILATGGTLKAAAMLLKKAGGVVSDIFCFIELVKMNGRDILREYSLNSLVRYF
CCEEEEHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA