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The map label for this gene is ffh [H]

Identifier: 187736626

GI number: 187736626

Start: 2616861

End: 2618300

Strand: Reverse

Name: ffh [H]

Synonym: Amuc_2149

Alternate gene names: 187736626

Gene position: 2618300-2616861 (Counterclockwise)

Preceding gene: 187736638

Following gene: 187736625

Centisome position: 98.28

GC content: 61.94

Gene sequence:

>1440_bases
ATGTTTTCACTTTTAGCAGATAAACTGGATAACACGTTCCGGAGGCTGCGCGGCCTGGGCAAAATTTCCGAGAAAAATAT
TGCAGACGCCCTGCGCGACATCCGGCTGGCTTTGCTGGAGGCGGACGTGGAGTTTGGCGTGGCCCGGGAATTCATCGGCC
GCGTGAAGGAACGGGCGATGGGGCAGGAAGTGCTCAAATCCATCAAGCCCGGAGAGCAAATCGTCAAAATTTTCCGTGAT
GAAATCGCCGCCCTGCTGGGCGGGGACGCCGTGGGGCTGGATCTGACGGACCCTGCCAGAATCATGGTGGTGGGGCTGAA
CGGCGCCGGCAAGACCACGACCAGCGCGAAGCTGGCCCTCCGCCTGAAGAACGAGGGGCGCCGCCCCCTGCTGGTGGCCT
GCGACCTGGTGCGTCCCGCCGCCGTGGACCAGCTGGCGACGCTGGCGGAACAAATAGGAGTGCCCGTTTATAAGCCCGCA
CCAGGCAGCAGGGACGTGGTGGCCGTGGCGCGCGAGGCTCTGGAATGGGCCCGGACCCAGAACGGAACCGTCATGATTTT
TGACACGGCGGGCCGTCAGGAAGTGGATGAAGCCCTGATAGACGAGCTGCGCCAGCTGCACGCCTTCCTTTCGCCGAGGG
AAACGCTCCTGGTGGCGGATGCCGCCACGGGACAGCAGGCCGTGAATGTGGCCCAGACCTTTGACCGTGCCGTGAACGTG
ACGGGCATCGTCCTGACCAAGCTGGACGGCGATGCCCGCGGGGGCGCGGCTCTTTCCATGCGTTCCGTAACGGGCAAGCC
CATCAAATTTTCCGGTGAGGGGGAAAAGCTGGATCAGTTCGGCCCCTTCGTCCCCGGCCGCATGGCGGATCGCATTCTGG
GCATGGGCGACATTGTCGGGCTGGTGGAGCATGCCGCCGCCCGCATTGACGAAGAGCAGGCTGCCAAATCCATGGACCGC
ATGATGTCCGGCCAATTTGATTTCAACGACTTTCTGGACCAGATGAAGATGATGCAGAACCTGGGACCGCTGGAAGGACT
GCTGGGCCTGCTCCCCGGCTTCGGCAAAATCAAAAAACAGCTTCCGGAAGGCGCCCTGGACCCCAAGCGGATGAAGCACA
TGGAAGCCATTGTGCTCTCCATGACGGCAAAGGAAAGGAGCAATCCCAACCTGTTGAATCCGTCCCGCCGCCGCCGTATT
GCCGCGGGCTGCGGCCGTCCTCTGATGGAGGTGAACAAGCTGATCAAGAATTTTTCCGAAATGCGCAAGATGATGTCCGG
CAAGGGCAAAATGGGCGCCATGATGAAGCAGATGGCTTCCATGAAAGGGAAGGGGGGCAAGATGCCCGGCCTTCCCGGCA
TGGGCGGAGGGTTGGGCGGCCTGAAGGGCCTGGGTGGATTGGGGGGCGGCCTTGGTGGCCTTTTTGGCGGACGCAGGTGA

Upstream 100 bases:

>100_bases
TGGGGCGAAGCCCCCGGCAAGTCAAGCATCATGTCCCATGCAGGGCGAGCTTGTTGACGGGAAGGGGGAAATGTGGCACA
GTCTGGCGCATCATACGATT

Downstream 100 bases:

>100_bases
ATGTAAAAAAGGACGGAATCCGGCAGGCGCGGCTGAATATGGCCGCGCCTTTGCCTTCCGGGACACAGGGGTCTGAGGGA
AAGCTCCTTCCATTGAAAGA

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 479; Mature: 479

Protein sequence:

>479_residues
MFSLLADKLDNTFRRLRGLGKISEKNIADALRDIRLALLEADVEFGVAREFIGRVKERAMGQEVLKSIKPGEQIVKIFRD
EIAALLGGDAVGLDLTDPARIMVVGLNGAGKTTTSAKLALRLKNEGRRPLLVACDLVRPAAVDQLATLAEQIGVPVYKPA
PGSRDVVAVAREALEWARTQNGTVMIFDTAGRQEVDEALIDELRQLHAFLSPRETLLVADAATGQQAVNVAQTFDRAVNV
TGIVLTKLDGDARGGAALSMRSVTGKPIKFSGEGEKLDQFGPFVPGRMADRILGMGDIVGLVEHAAARIDEEQAAKSMDR
MMSGQFDFNDFLDQMKMMQNLGPLEGLLGLLPGFGKIKKQLPEGALDPKRMKHMEAIVLSMTAKERSNPNLLNPSRRRRI
AAGCGRPLMEVNKLIKNFSEMRKMMSGKGKMGAMMKQMASMKGKGGKMPGLPGMGGGLGGLKGLGGLGGGLGGLFGGRR

Sequences:

>Translated_479_residues
MFSLLADKLDNTFRRLRGLGKISEKNIADALRDIRLALLEADVEFGVAREFIGRVKERAMGQEVLKSIKPGEQIVKIFRD
EIAALLGGDAVGLDLTDPARIMVVGLNGAGKTTTSAKLALRLKNEGRRPLLVACDLVRPAAVDQLATLAEQIGVPVYKPA
PGSRDVVAVAREALEWARTQNGTVMIFDTAGRQEVDEALIDELRQLHAFLSPRETLLVADAATGQQAVNVAQTFDRAVNV
TGIVLTKLDGDARGGAALSMRSVTGKPIKFSGEGEKLDQFGPFVPGRMADRILGMGDIVGLVEHAAARIDEEQAAKSMDR
MMSGQFDFNDFLDQMKMMQNLGPLEGLLGLLPGFGKIKKQLPEGALDPKRMKHMEAIVLSMTAKERSNPNLLNPSRRRRI
AAGCGRPLMEVNKLIKNFSEMRKMMSGKGKMGAMMKQMASMKGKGGKMPGLPGMGGGLGGLKGLGGLGGGLGGLFGGRR
>Mature_479_residues
MFSLLADKLDNTFRRLRGLGKISEKNIADALRDIRLALLEADVEFGVAREFIGRVKERAMGQEVLKSIKPGEQIVKIFRD
EIAALLGGDAVGLDLTDPARIMVVGLNGAGKTTTSAKLALRLKNEGRRPLLVACDLVRPAAVDQLATLAEQIGVPVYKPA
PGSRDVVAVAREALEWARTQNGTVMIFDTAGRQEVDEALIDELRQLHAFLSPRETLLVADAATGQQAVNVAQTFDRAVNV
TGIVLTKLDGDARGGAALSMRSVTGKPIKFSGEGEKLDQFGPFVPGRMADRILGMGDIVGLVEHAAARIDEEQAAKSMDR
MMSGQFDFNDFLDQMKMMQNLGPLEGLLGLLPGFGKIKKQLPEGALDPKRMKHMEAIVLSMTAKERSNPNLLNPSRRRRI
AAGCGRPLMEVNKLIKNFSEMRKMMSGKGKMGAMMKQMASMKGKGGKMPGLPGMGGGLGGLKGLGGLGGGLGGLFGGRR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=505, Percent_Identity=29.5049504950495, Blast_Score=209, Evalue=6e-54,
Organism=Homo sapiens, GI226371618, Length=400, Percent_Identity=31.25, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI89061728, Length=151, Percent_Identity=37.0860927152318, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI23308697, Length=289, Percent_Identity=29.0657439446367, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI295424842, Length=289, Percent_Identity=29.0657439446367, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=48.2435597189695, Blast_Score=397, Evalue=1e-112,
Organism=Escherichia coli, GI1789874, Length=251, Percent_Identity=35.0597609561753, Blast_Score=132, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17539958, Length=492, Percent_Identity=30.0813008130081, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI193206261, Length=219, Percent_Identity=34.703196347032, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325345, Length=451, Percent_Identity=29.2682926829268, Blast_Score=196, Evalue=9e-51,
Organism=Saccharomyces cerevisiae, GI6320498, Length=207, Percent_Identity=29.951690821256, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17647949, Length=490, Percent_Identity=28.9795918367347, Blast_Score=175, Evalue=6e-44,
Organism=Drosophila melanogaster, GI24641198, Length=256, Percent_Identity=30.46875, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 51384; Mature: 51384

Theoretical pI: Translated: 10.50; Mature: 10.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
5.6 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFSLLADKLDNTFRRLRGLGKISEKNIADALRDIRLALLEADVEFGVAREFIGRVKERAM
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVLKSIKPGEQIVKIFRDEIAALLGGDAVGLDLTDPARIMVVGLNGAGKTTTSAKLAL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEEEECCCCCCCCCHHEEE
RLKNEGRRPLLVACDLVRPAAVDQLATLAEQIGVPVYKPAPGSRDVVAVAREALEWARTQ
EECCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
NGTVMIFDTAGRQEVDEALIDELRQLHAFLSPRETLLVADAATGQQAVNVAQTFDRAVNV
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCC
TGIVLTKLDGDARGGAALSMRSVTGKPIKFSGEGEKLDQFGPFVPGRMADRILGMGDIVG
EEEEEEECCCCCCCCCEEEECCCCCCCEEECCCCCCHHHCCCCCCCHHHHHHHCHHHHHH
LVEHAAARIDEEQAAKSMDRMMSGQFDFNDFLDQMKMMQNLGPLEGLLGLLPGFGKIKKQ
HHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHH
LPEGALDPKRMKHMEAIVLSMTAKERSNPNLLNPSRRRRIAAGCGRPLMEVNKLIKNFSE
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
MRKMMSGKGKMGAMMKQMASMKGKGGKMPGLPGMGGGLGGLKGLGGLGGGLGGLFGGRR
HHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHCCCCC
>Mature Secondary Structure
MFSLLADKLDNTFRRLRGLGKISEKNIADALRDIRLALLEADVEFGVAREFIGRVKERAM
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GQEVLKSIKPGEQIVKIFRDEIAALLGGDAVGLDLTDPARIMVVGLNGAGKTTTSAKLAL
HHHHHHHCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEEEECCCCCCCCCHHEEE
RLKNEGRRPLLVACDLVRPAAVDQLATLAEQIGVPVYKPAPGSRDVVAVAREALEWARTQ
EECCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCC
NGTVMIFDTAGRQEVDEALIDELRQLHAFLSPRETLLVADAATGQQAVNVAQTFDRAVNV
CCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCCC
TGIVLTKLDGDARGGAALSMRSVTGKPIKFSGEGEKLDQFGPFVPGRMADRILGMGDIVG
EEEEEEECCCCCCCCCEEEECCCCCCCEEECCCCCCHHHCCCCCCCHHHHHHHCHHHHHH
LVEHAAARIDEEQAAKSMDRMMSGQFDFNDFLDQMKMMQNLGPLEGLLGLLPGFGKIKKQ
HHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHH
LPEGALDPKRMKHMEAIVLSMTAKERSNPNLLNPSRRRRIAAGCGRPLMEVNKLIKNFSE
CCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHH
MRKMMSGKGKMGAMMKQMASMKGKGGKMPGLPGMGGGLGGLKGLGGLGGGLGGLFGGRR
HHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12397186; 8763945 [H]