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The map label for this gene is hisC

Identifier: 187736616

GI number: 187736616

Start: 2605768

End: 2606859

Strand: Reverse

Name: hisC

Synonym: Amuc_2138

Alternate gene names: 187736616

Gene position: 2606859-2605768 (Counterclockwise)

Preceding gene: 187736617

Following gene: 187736615

Centisome position: 97.85

GC content: 58.88

Gene sequence:

>1092_bases
ATGAGTATTGAGAGTTTCGCAAATCAGCATGTGCTGGAGTTGGTGGCTTATCAGCCGGGCAAGCCGATTGAGGAGACGGC
CCGGGAACTGGGCCTGAATCCCCATGATATTGTGAAACTGGCGTCTAATGAAAATCCTCTGGGGCCGTCCCCGAAGGCGG
TGGAGGCGATTGCCCGTGCGGCTGCCGGCGTGAACATTTATCCGGACGGAGCGGCTTTCCGCCTGCGTTCCGCTATTGCG
GAGTTCTGCGGCGTGGAGTTCGGCCAGACGGTAGTGGGCACGGGCAGCAGCGAAGTGATTGAACTGATCTGCCATGCCCT
GCTGAATCCCCGTGCGGAGGTGGTGGCCGCCAAACACGCCTTTTCCATGTACCCTATCATGTCCAAGCTGTTTGGCGCCG
CGTACGTGGAAGTGCCCAACAAGGAGGACTGGACGCATGACCTGGACGGCTTCCTGGCCGCTATTACGGAGAATACGCGC
GTCGTGTTCATTACGAATCCCACCAATCCCGTAGGCACCGTAGTGGGACAGCAGGAAATAGACGATTTCATGGCGAAGGT
CCCGGAACATGTGCTGGTGGTCTTTGACGAGGCGTACCGGGAGTTTTCCGACAATCCTCCGGATACCCTCAAATTTGTGC
GAGAAGGCCGCAACGTGGTTGTTCTGCGCACCTTCTCCAAGGCTTACGGCCTGGCGGGGCTGCGCGTGGGCTACGGCATT
GCGCCGGAACCGGTTTGCAGCATGCTGCACAAGGCGCGTGCTCCGTTCAACCTGCATGTTCTGGCCCAGGAGGCCGCCCT
GGCCGCCCTGGAGGACCGGGAGCATGTGCGCCGCACTGTGGAGAATAATAAGGAAGGCATGCGTTTTTATGAGCAGGCTT
TCCGGGAAATGGGCCTGGAATGGATTCCCAGCCAGGGCAACTTTATCCTGGTGAAAGTGGGCCGGGGCAAGCAGGTGTTC
CAGGATATGCTTGCCAGGGGAGTCATCGTCCGCGCGCAGGACGGTTACGGCCTGCCGGAATGGATACGCATCAGCATAGG
CACTCCTGCGGAGAACGCCCGCTGCATTGAGGTATTGAAAGAGGTTCTTTAA

Upstream 100 bases:

>100_bases
GCCAGCGCAGATTCTCTAAACGGCTGTCATCTTCCCAGGGGCCGGCCGGATGGAAATCCGTATTGCCAGAAACGGGGAAT
GGCGGTAACATTCCGCCGCT

Downstream 100 bases:

>100_bases
ACAGTTTTTCCGTTTTTCGTGTCTCACCCTGCATGATGATCTCCCCGGAACAGTATATTGACGGTCTGGAATGGCGTTAC
GCCTGCAAAAAATTTGATCC

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSIESFANQHVLELVAYQPGKPIEETARELGLNPHDIVKLASNENPLGPSPKAVEAIARAAAGVNIYPDGAAFRLRSAIA
EFCGVEFGQTVVGTGSSEVIELICHALLNPRAEVVAAKHAFSMYPIMSKLFGAAYVEVPNKEDWTHDLDGFLAAITENTR
VVFITNPTNPVGTVVGQQEIDDFMAKVPEHVLVVFDEAYREFSDNPPDTLKFVREGRNVVVLRTFSKAYGLAGLRVGYGI
APEPVCSMLHKARAPFNLHVLAQEAALAALEDREHVRRTVENNKEGMRFYEQAFREMGLEWIPSQGNFILVKVGRGKQVF
QDMLARGVIVRAQDGYGLPEWIRISIGTPAENARCIEVLKEVL

Sequences:

>Translated_363_residues
MSIESFANQHVLELVAYQPGKPIEETARELGLNPHDIVKLASNENPLGPSPKAVEAIARAAAGVNIYPDGAAFRLRSAIA
EFCGVEFGQTVVGTGSSEVIELICHALLNPRAEVVAAKHAFSMYPIMSKLFGAAYVEVPNKEDWTHDLDGFLAAITENTR
VVFITNPTNPVGTVVGQQEIDDFMAKVPEHVLVVFDEAYREFSDNPPDTLKFVREGRNVVVLRTFSKAYGLAGLRVGYGI
APEPVCSMLHKARAPFNLHVLAQEAALAALEDREHVRRTVENNKEGMRFYEQAFREMGLEWIPSQGNFILVKVGRGKQVF
QDMLARGVIVRAQDGYGLPEWIRISIGTPAENARCIEVLKEVL
>Mature_362_residues
SIESFANQHVLELVAYQPGKPIEETARELGLNPHDIVKLASNENPLGPSPKAVEAIARAAAGVNIYPDGAAFRLRSAIAE
FCGVEFGQTVVGTGSSEVIELICHALLNPRAEVVAAKHAFSMYPIMSKLFGAAYVEVPNKEDWTHDLDGFLAAITENTRV
VFITNPTNPVGTVVGQQEIDDFMAKVPEHVLVVFDEAYREFSDNPPDTLKFVREGRNVVVLRTFSKAYGLAGLRVGYGIA
PEPVCSMLHKARAPFNLHVLAQEAALAALEDREHVRRTVENNKEGMRFYEQAFREMGLEWIPSQGNFILVKVGRGKQVFQ
DMLARGVIVRAQDGYGLPEWIRISIGTPAENARCIEVLKEVL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=371, Percent_Identity=29.1105121293801, Blast_Score=133, Evalue=1e-32,
Organism=Escherichia coli, GI1788627, Length=308, Percent_Identity=25.974025974026, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1786816, Length=271, Percent_Identity=25.830258302583, Blast_Score=65, Evalue=8e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=361, Percent_Identity=26.0387811634349, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6322401, Length=253, Percent_Identity=26.8774703557312, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_AKKM8 (B2UPR9)

Other databases:

- EMBL:   CP001071
- RefSeq:   YP_001878728.1
- ProteinModelPortal:   B2UPR9
- SMR:   B2UPR9
- GeneID:   6273705
- GenomeReviews:   CP001071_GR
- KEGG:   amu:Amuc_2138
- HOGENOM:   HBG646350
- OMA:   KLIYIAN
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39996; Mature: 39865

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIESFANQHVLELVAYQPGKPIEETARELGLNPHDIVKLASNENPLGPSPKAVEAIARA
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHEEECCCCCCCCCCHHHHHHHHHH
AAGVNIYPDGAAFRLRSAIAEFCGVEFGQTVVGTGSSEVIELICHALLNPRAEVVAAKHA
HCCCEECCCCHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHHHH
FSMYPIMSKLFGAAYVEVPNKEDWTHDLDGFLAAITENTRVVFITNPTNPVGTVVGQQEI
HHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHEECCCEEEEEECCCCCHHHHCCHHHH
DDFMAKVPEHVLVVFDEAYREFSDNPPDTLKFVREGRNVVVLRTFSKAYGLAGLRVGYGI
HHHHHHCCHHEEEEEHHHHHHHCCCCHHHHHHHHCCCCEEEEEECHHHHCCCHHHCCCCC
APEPVCSMLHKARAPFNLHVLAQEAALAALEDREHVRRTVENNKEGMRFYEQAFREMGLE
CCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCE
WIPSQGNFILVKVGRGKQVFQDMLARGVIVRAQDGYGLPEWIRISIGTPAENARCIEVLK
EECCCCCEEEEEECCCHHHHHHHHHCCEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHH
EVL
HHC
>Mature Secondary Structure 
SIESFANQHVLELVAYQPGKPIEETARELGLNPHDIVKLASNENPLGPSPKAVEAIARA
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHHEEECCCCCCCCCCHHHHHHHHHH
AAGVNIYPDGAAFRLRSAIAEFCGVEFGQTVVGTGSSEVIELICHALLNPRAEVVAAKHA
HCCCEECCCCHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHCCCHHHHHHHHHH
FSMYPIMSKLFGAAYVEVPNKEDWTHDLDGFLAAITENTRVVFITNPTNPVGTVVGQQEI
HHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHEECCCEEEEEECCCCCHHHHCCHHHH
DDFMAKVPEHVLVVFDEAYREFSDNPPDTLKFVREGRNVVVLRTFSKAYGLAGLRVGYGI
HHHHHHCCHHEEEEEHHHHHHHCCCCHHHHHHHHCCCCEEEEEECHHHHCCCHHHCCCCC
APEPVCSMLHKARAPFNLHVLAQEAALAALEDREHVRRTVENNKEGMRFYEQAFREMGLE
CCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCE
WIPSQGNFILVKVGRGKQVFQDMLARGVIVRAQDGYGLPEWIRISIGTPAENARCIEVLK
EECCCCCEEEEEECCCHHHHHHHHHCCEEEEECCCCCCCCEEEEEECCCCCCHHHHHHHH
EVL
HHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA