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The map label for this gene is hemN [H]

Identifier: 187736591

GI number: 187736591

Start: 2574808

End: 2575917

Strand: Direct

Name: hemN [H]

Synonym: Amuc_2113

Alternate gene names: 187736591

Gene position: 2574808-2575917 (Clockwise)

Preceding gene: 187736590

Following gene: 187736594

Centisome position: 96.65

GC content: 58.83

Gene sequence:

>1110_bases
GTGCACCTCTACGTCCACATTCCTTTCTGCCACCGTATTTGCCCGTACTGCGCTTTCTTCAAGCACACGCCGGCCTCCAC
GGACATGAAATCATTCATCCGTGCTCTGGGCAGGGAGGCGGAATCCCGCGCAGCCGCTCTGGCCACAAACCGCGGAGGGG
AAACGGCTACGCTTTATTTTGGCGGGGGTACTCCCTCCATGCTCTCGGACACGCATCTGGGGCATTTTATGGAAACCCTG
GATCGTCTCGTGCCCGTGGACAAACTGGACGAATTCTCCTTTGAGGCCAACCCCGCCACCTTTACGGAAAAAAAAGTGCG
CTTTTGGCGCAGCCTGGGCATGACACGTGTCTCCCTGGGCGTGCAGTCCCTGGATTCCGGCATCCTGCATCTGCTGGGGC
GCGAACATACCCCGGCCCAGGCTCTGCACTCCGTGGAAATGCTGAAAAATGCGGGAATGCCCCATATCAACATGGATCTC
ATGTTCGCCATTCCGGGGCAAACCCTCTCCATATGGGAAGCCACCCTGAAGGAAGCTGTCCGCGCCGGAACGGACCATAT
CTCCGCCTACAACCTCACCTATGAAGAAGACACGGAATTCTTCCGGAGCCTGCTGAGGGGAGAGAAAAGGCAGGATCCGG
ACGAAGACGCCGCCTTTTTTGAACTGGCGGAACACATGCTGGAGGCGGCAGGCTTGCGCCACTATGAAACCTCCAACTAC
GCCCGGGAGGGCTGCATCTCCCCCCACAACATGGCCTACTGGAAGGGAGAGGACTATGTGGGCATAGGGCCTGGCGCGGT
CAGCACCATCAACGGCATACGGTACTCCAACACGCGGGATACGGACGCCTACATACGCAGCACGCTGGAAAACGGCCTCC
CCCTTTCCGAACAGGAACCCGTCACCGAGGAAGACTACCGCTTGGAACGCATTGCCCTGATGCTCCGGACGGATGAAGGA
TTGCCGCTGAAATACATTCTGCCGGAATCCCGTCCTCTGCTGGAACAATACCGGGAACTGGGCTTGGCGGACATTTCCCC
GGAACAAAGGTTCATCCTGAAAGGCCGCGGACGCCTGCTCGTGGACGCCATCGCAGCGGAACTGTGCTGA

Upstream 100 bases:

>100_bases
GAAAGAGGCTTCCGACAGAATTCTGGAGCTTTCCCAGGACAAGAAAGGCGATGGGAATGGGTCCTCCGGACGCCGCCGGA
GACGCTGATTCCCCGCTTCC

Downstream 100 bases:

>100_bases
CGGATAGTTTTTCCGCCTCAGAGATCAGCAGTCTGCGGAATCCGGTGCGAACCGGACACTGGAATAAGCGGGCATGGGCT
ACTTTGTTCCCTGATTTTCA

Product: oxygen-independent coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 369; Mature: 369

Protein sequence:

>369_residues
MHLYVHIPFCHRICPYCAFFKHTPASTDMKSFIRALGREAESRAAALATNRGGETATLYFGGGTPSMLSDTHLGHFMETL
DRLVPVDKLDEFSFEANPATFTEKKVRFWRSLGMTRVSLGVQSLDSGILHLLGREHTPAQALHSVEMLKNAGMPHINMDL
MFAIPGQTLSIWEATLKEAVRAGTDHISAYNLTYEEDTEFFRSLLRGEKRQDPDEDAAFFELAEHMLEAAGLRHYETSNY
AREGCISPHNMAYWKGEDYVGIGPGAVSTINGIRYSNTRDTDAYIRSTLENGLPLSEQEPVTEEDYRLERIALMLRTDEG
LPLKYILPESRPLLEQYRELGLADISPEQRFILKGRGRLLVDAIAAELC

Sequences:

>Translated_369_residues
MHLYVHIPFCHRICPYCAFFKHTPASTDMKSFIRALGREAESRAAALATNRGGETATLYFGGGTPSMLSDTHLGHFMETL
DRLVPVDKLDEFSFEANPATFTEKKVRFWRSLGMTRVSLGVQSLDSGILHLLGREHTPAQALHSVEMLKNAGMPHINMDL
MFAIPGQTLSIWEATLKEAVRAGTDHISAYNLTYEEDTEFFRSLLRGEKRQDPDEDAAFFELAEHMLEAAGLRHYETSNY
AREGCISPHNMAYWKGEDYVGIGPGAVSTINGIRYSNTRDTDAYIRSTLENGLPLSEQEPVTEEDYRLERIALMLRTDEG
LPLKYILPESRPLLEQYRELGLADISPEQRFILKGRGRLLVDAIAAELC
>Mature_369_residues
MHLYVHIPFCHRICPYCAFFKHTPASTDMKSFIRALGREAESRAAALATNRGGETATLYFGGGTPSMLSDTHLGHFMETL
DRLVPVDKLDEFSFEANPATFTEKKVRFWRSLGMTRVSLGVQSLDSGILHLLGREHTPAQALHSVEMLKNAGMPHINMDL
MFAIPGQTLSIWEATLKEAVRAGTDHISAYNLTYEEDTEFFRSLLRGEKRQDPDEDAAFFELAEHMLEAAGLRHYETSNY
AREGCISPHNMAYWKGEDYVGIGPGAVSTINGIRYSNTRDTDAYIRSTLENGLPLSEQEPVTEEDYRLERIALMLRTDEG
LPLKYILPESRPLLEQYRELGLADISPEQRFILKGRGRLLVDAIAAELC

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=265, Percent_Identity=33.2075471698113, Blast_Score=165, Evalue=8e-41,
Organism=Escherichia coli, GI1789325, Length=330, Percent_Identity=32.1212121212121, Blast_Score=162, Evalue=2e-41,
Organism=Escherichia coli, GI87082341, Length=391, Percent_Identity=24.2966751918159, Blast_Score=107, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004559
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 41537; Mature: 41537

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLYVHIPFCHRICPYCAFFKHTPASTDMKSFIRALGREAESRAAALATNRGGETATLYF
CEEEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEE
GGGTPSMLSDTHLGHFMETLDRLVPVDKLDEFSFEANPATFTEKKVRFWRSLGMTRVSLG
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHH
VQSLDSGILHLLGREHTPAQALHSVEMLKNAGMPHINMDLMFAIPGQTLSIWEATLKEAV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEECEEEEEEECCCHHHHHHHHHHHHH
RAGTDHISAYNLTYEEDTEFFRSLLRGEKRQDPDEDAAFFELAEHMLEAAGLRHYETSNY
HCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCH
AREGCISPHNMAYWKGEDYVGIGPGAVSTINGIRYSNTRDTDAYIRSTLENGLPLSEQEP
HHHCCCCCCCCEEECCCCEEECCCCHHHHHCCCEECCCCCHHHHHHHHHHCCCCCCCCCC
VTEEDYRLERIALMLRTDEGLPLKYILPESRPLLEQYRELGLADISPEQRFILKGRGRLL
CCHHHHHHHHHHEEEECCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCHH
VDAIAAELC
HHHHHHHCC
>Mature Secondary Structure
MHLYVHIPFCHRICPYCAFFKHTPASTDMKSFIRALGREAESRAAALATNRGGETATLYF
CEEEEEECHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCEEEEEE
GGGTPSMLSDTHLGHFMETLDRLVPVDKLDEFSFEANPATFTEKKVRFWRSLGMTRVSLG
CCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHHH
VQSLDSGILHLLGREHTPAQALHSVEMLKNAGMPHINMDLMFAIPGQTLSIWEATLKEAV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEECEEEEEEECCCHHHHHHHHHHHHH
RAGTDHISAYNLTYEEDTEFFRSLLRGEKRQDPDEDAAFFELAEHMLEAAGLRHYETSNY
HCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCH
AREGCISPHNMAYWKGEDYVGIGPGAVSTINGIRYSNTRDTDAYIRSTLENGLPLSEQEP
HHHCCCCCCCCEEECCCCEEECCCCHHHHHCCCEECCCCCHHHHHHHHHHCCCCCCCCCC
VTEEDYRLERIALMLRTDEGLPLKYILPESRPLLEQYRELGLADISPEQRFILKGRGRLL
CCHHHHHHHHHHEEEECCCCCCEEEECCCCCHHHHHHHHCCCCCCCCCCEEEECCCCCHH
VDAIAAELC
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8757728; 8969508; 9384377; 1339421 [H]