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The map label for this gene is holB [H]

Identifier: 187735118

GI number: 187735118

Start: 719360

End: 720328

Strand: Direct

Name: holB [H]

Synonym: Amuc_0612

Alternate gene names: 187735118

Gene position: 719360-720328 (Clockwise)

Preceding gene: 187735113

Following gene: 187735121

Centisome position: 27.0

GC content: 60.78

Gene sequence:

>969_bases
ATGGCATTTACGGCATCCCAAGCGTTCGACCTGCTGCGCACCGCCTTCTCCCGCAACCGGCTTCCCCATGCCCTGCTCAT
CGTGGGAGACGAGCACCAGGGAGCCTCCCGCCTGATCCTGCAACTGCTGGAGCTGATAAACGGCATCCGGGCAGACCATC
TGGACAGTGTAAGGGACGAGTATTGCCGGCTGGTGCGCCCCAAGTCCAAGTCGCGCCGCATCCTGCGGGATGATATCCGC
GCCGTGGAACCCTTTTTGCAACAGCGCGCGGCGGAGGGGAAATGGAAGATAGCCGTGTTCATGGATGCGGAGCGGATGAA
TGACGAGGCCGCCAACGCTTTCCTGAAAACCCTGGAGGAACCGCCCGGCCAGTGTCTGCTCATTTTGTCCACCTCCCAGC
CGGACCAGCTTCTCCAGACAATTATTTCCCGCTGCGTGCGCGTCAATCTGCTGCAATCCGGAGAATTCAGGCTCACTCCT
ATTCAGGAGGCCCTGCTCCCGCACTGGCTGGAGACCTGCCGCAATCTGAATAATGACCTGGCCGCTCTGGCCTTCCGCAG
CAGGTTCATGGACGTCATGGCGGAGGCCAAGGCCGCCATCACCAAAAACCTGAACCAGGCTCTGAAAGATGAAGCCAGGG
AAGCAGCCCAGGGTACGGACGCCTCCGACTGGGAGGCCCGCAATAAGGACGCGAACGCCGCCCAGATAGAGACGGAATAT
CTGGAACAGCGCAATCAGGCCCTGGAACTGCTCATCAGCTGGTTTGGCCAGGCAGCCCTGATTGCCTCCGGAGCCCCGGA
AGTCGCTCCGATTCATCCGGAGGTGCGCACGCTGGCCGCCCAGATGCCCGTGAACGAATTGCTGAAACGCATGGAGGCCC
TCAACAGGCTCCGTGATGATTTGAATTTCAATATTCACGAAGCCCTGGCCCTGGATGTCCACCTGCTGGCGGCCGTCGGG
TCCTGCTGA

Upstream 100 bases:

>100_bases
TCATTTTGTTCCATAACCGGCCCCCTTAGTACATGAAATATCCGACATATACCAATCTTTTCTGTTGCCCTGACGCAACG
AAATGTTTTCATAGGAGCAT

Downstream 100 bases:

>100_bases
CGAACAACCCCGCCTGTTACCGTCGGGCCGCGCACGGCATTGGAAAAGGCGCAGAAGGTCTCTATTTTTCCCTTTCCTTC
CGGAGCAGGGGCGCCATGAT

Product: DNA polymerase III delta' subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MAFTASQAFDLLRTAFSRNRLPHALLIVGDEHQGASRLILQLLELINGIRADHLDSVRDEYCRLVRPKSKSRRILRDDIR
AVEPFLQQRAAEGKWKIAVFMDAERMNDEAANAFLKTLEEPPGQCLLILSTSQPDQLLQTIISRCVRVNLLQSGEFRLTP
IQEALLPHWLETCRNLNNDLAALAFRSRFMDVMAEAKAAITKNLNQALKDEAREAAQGTDASDWEARNKDANAAQIETEY
LEQRNQALELLISWFGQAALIASGAPEVAPIHPEVRTLAAQMPVNELLKRMEALNRLRDDLNFNIHEALALDVHLLAAVG
SC

Sequences:

>Translated_322_residues
MAFTASQAFDLLRTAFSRNRLPHALLIVGDEHQGASRLILQLLELINGIRADHLDSVRDEYCRLVRPKSKSRRILRDDIR
AVEPFLQQRAAEGKWKIAVFMDAERMNDEAANAFLKTLEEPPGQCLLILSTSQPDQLLQTIISRCVRVNLLQSGEFRLTP
IQEALLPHWLETCRNLNNDLAALAFRSRFMDVMAEAKAAITKNLNQALKDEAREAAQGTDASDWEARNKDANAAQIETEY
LEQRNQALELLISWFGQAALIASGAPEVAPIHPEVRTLAAQMPVNELLKRMEALNRLRDDLNFNIHEALALDVHLLAAVG
SC
>Mature_321_residues
AFTASQAFDLLRTAFSRNRLPHALLIVGDEHQGASRLILQLLELINGIRADHLDSVRDEYCRLVRPKSKSRRILRDDIRA
VEPFLQQRAAEGKWKIAVFMDAERMNDEAANAFLKTLEEPPGQCLLILSTSQPDQLLQTIISRCVRVNLLQSGEFRLTPI
QEALLPHWLETCRNLNNDLAALAFRSRFMDVMAEAKAAITKNLNQALKDEAREAAQGTDASDWEARNKDANAAQIETEYL
EQRNQALELLISWFGQAALIASGAPEVAPIHPEVRTLAAQMPVNELLKRMEALNRLRDDLNFNIHEALALDVHLLAAVGS
C

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG0470

COG function: function code L; ATPase involved in DNA replication

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004622 [H]

Pfam domain/function: NA

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 36146; Mature: 36015

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFTASQAFDLLRTAFSRNRLPHALLIVGDEHQGASRLILQLLELINGIRADHLDSVRDE
CCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHH
YCRLVRPKSKSRRILRDDIRAVEPFLQQRAAEGKWKIAVFMDAERMNDEAANAFLKTLEE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHCCHHHHHHHHHHHCC
PPGQCLLILSTSQPDQLLQTIISRCVRVNLLQSGEFRLTPIQEALLPHWLETCRNLNNDL
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHCCCHHH
AALAFRSRFMDVMAEAKAAITKNLNQALKDEAREAAQGTDASDWEARNKDANAAQIETEY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
LEQRNQALELLISWFGQAALIASGAPEVAPIHPEVRTLAAQMPVNELLKRMEALNRLRDD
HHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LNFNIHEALALDVHLLAAVGSC
CCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AFTASQAFDLLRTAFSRNRLPHALLIVGDEHQGASRLILQLLELINGIRADHLDSVRDE
CCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCHHHHHHHHHH
YCRLVRPKSKSRRILRDDIRAVEPFLQQRAAEGKWKIAVFMDAERMNDEAANAFLKTLEE
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECHHHCCHHHHHHHHHHHCC
PPGQCLLILSTSQPDQLLQTIISRCVRVNLLQSGEFRLTPIQEALLPHWLETCRNLNNDL
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHHHHHHHHHHCCCHHH
AALAFRSRFMDVMAEAKAAITKNLNQALKDEAREAAQGTDASDWEARNKDANAAQIETEY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHH
LEQRNQALELLISWFGQAALIASGAPEVAPIHPEVRTLAAQMPVNELLKRMEALNRLRDD
HHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHH
LNFNIHEALALDVHLLAAVGSC
CCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377 [H]