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The map label for this gene is hisI [H]

Identifier: 187735117

GI number: 187735117

Start: 718782

End: 719273

Strand: Reverse

Name: hisI [H]

Synonym: Amuc_0611

Alternate gene names: 187735117

Gene position: 719273-718782 (Counterclockwise)

Preceding gene: 187735119

Following gene: 187735116

Centisome position: 27.0

GC content: 57.32

Gene sequence:

>492_bases
ATGGAACAAAATGACATCTCATCCCGGATTGTCTTTGCCGACCGCGGCAAGGTGAATGTGGAAAAAGGCGTGGAATTCGC
CCCCAAATTTGACCAGAACGGCCTGATTCCGGCCCTCGCCATGGATCATATTACCCATGAACCGCTGATGCTGGCCTATA
TGAATGCGGAATCCCTGCGCATGACCATGGAACTGGGGGAAGCCGTCTACTATTCCCGCAGCCGTCAGGAAATCTGGCAT
AAGGGCGCTACCAGCGGCCATGTGCAAAAAGTAAAGCAAATCCTGGTTGACTGTGACCAGGATGCCCTGATTGTGCTGGT
GGACCAGTGCGGCGCCGGAGCCTGCCACACCGGGCACCACTCCTGCTTTTACCGTTCCGTTCCGTTCGGCGATGAACTGA
AAGCCCAGCCCCAGGGGGGGGGCGTCACGCTGCGTGAAGCGGACGGAGGCGTCGTTTTTGATGCCGAAGCCGTGTACGGC
AAGGGCCATTAA

Upstream 100 bases:

>100_bases
GCCGTAAATGCCATATGCTCCTATGAAAACATTTCGTTGCGTCAGGGCAACAGAAAAGATTGGTATATGTCGGATATTTC
ATGTACTAAGGGGGCCGGTT

Downstream 100 bases:

>100_bases
CTCTTTTTGCGCGTCAATCTGCGTTCGCCGGATTGACGCGCCCTCTTTTTCTGCTGTAAAATCATGAATGTGAAAAAACT
GTTTCTCATGATGGCTGCCG

Product: Phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MEQNDISSRIVFADRGKVNVEKGVEFAPKFDQNGLIPALAMDHITHEPLMLAYMNAESLRMTMELGEAVYYSRSRQEIWH
KGATSGHVQKVKQILVDCDQDALIVLVDQCGAGACHTGHHSCFYRSVPFGDELKAQPQGGGVTLREADGGVVFDAEAVYG
KGH

Sequences:

>Translated_163_residues
MEQNDISSRIVFADRGKVNVEKGVEFAPKFDQNGLIPALAMDHITHEPLMLAYMNAESLRMTMELGEAVYYSRSRQEIWH
KGATSGHVQKVKQILVDCDQDALIVLVDQCGAGACHTGHHSCFYRSVPFGDELKAQPQGGGVTLREADGGVVFDAEAVYG
KGH
>Mature_163_residues
MEQNDISSRIVFADRGKVNVEKGVEFAPKFDQNGLIPALAMDHITHEPLMLAYMNAESLRMTMELGEAVYYSRSRQEIWH
KGATSGHVQKVKQILVDCDQDALIVLVDQCGAGACHTGHHSCFYRSVPFGDELKAQPQGGGVTLREADGGVVFDAEAVYG
KGH

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=91, Percent_Identity=43.956043956044, Blast_Score=87, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6319819, Length=91, Percent_Identity=47.2527472527472, Blast_Score=83, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 17862; Mature: 17862

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQNDISSRIVFADRGKVNVEKGVEFAPKFDQNGLIPALAMDHITHEPLMLAYMNAESLR
CCCCCCCCEEEEECCCEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEECHHHHH
MTMELGEAVYYSRSRQEIWHKGATSGHVQKVKQILVDCDQDALIVLVDQCGAGACHTGHH
HHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCC
SCFYRSVPFGDELKAQPQGGGVTLREADGGVVFDAEAVYGKGH
CEEEECCCCCCCCCCCCCCCCEEEEECCCCEEEECCEECCCCC
>Mature Secondary Structure
MEQNDISSRIVFADRGKVNVEKGVEFAPKFDQNGLIPALAMDHITHEPLMLAYMNAESLR
CCCCCCCCEEEEECCCEEECCCCCCCCCCCCCCCCCHHHHHHHCCCCCEEEEEECHHHHH
MTMELGEAVYYSRSRQEIWHKGATSGHVQKVKQILVDCDQDALIVLVDQCGAGACHTGHH
HHHHHHHHHHHCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCC
SCFYRSVPFGDELKAQPQGGGVTLREADGGVVFDAEAVYGKGH
CEEEECCCCCCCCCCCCCCCCEEEEECCCCEEEECCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA