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The map label for this gene is menB [H]

Identifier: 187734859

GI number: 187734859

Start: 415130

End: 415954

Strand: Direct

Name: menB [H]

Synonym: Amuc_0351

Alternate gene names: 187734859

Gene position: 415130-415954 (Clockwise)

Preceding gene: 187734851

Following gene: 187734860

Centisome position: 15.58

GC content: 61.09

Gene sequence:

>825_bases
ATGAGCGCACAATGGATCACCGCCAAGGAATACACGGACATCAAGTATGAAACAACGGACAACGGCAGCATCGCAAAAAT
CACGATCAACCGCCCCCACGTCCGCAATGCGTTCCGTCCCCTGACCGTGCATGAAATGCTCAACGCCCTGAACGCCGCTC
ATGAAGACCCCAAGGTGGGCGTGGTCATCCTGACCGGGGAAGGCCCGGACGCTTTCTGCTCCGGAGGCGACCAGAAAGTG
CGCGGAAATGCCGGCTACATCGGTGAAGACGGCGTGCCGCGCCTGAACATTCTGGACGTGCAGCGCACCATCCGCACCAT
GCCCAAGCCCGTCGTCGCCATGGTGGCCGGATACGCCATCGGCGGAGGTCACGTCCTCCACGTCGTCTGTGACCTCACCA
TTGCCGCGGACAACGCCAAATTCGGACAGACAGGGCCCAAAGTGGGCTCTTTTGACGGAGGCCTCGGCTCCTCCTACCTG
GCGCGCATTGTGGGCCAGAAAAAAGCGCGGGAAATCTGGTACCTGTGCAGGCAGTACGATGCCCGGCAGGCGCTGGACAT
GGGCCTGGTCAATACCGTGGTTCCCCTGGAGGACCTGGAGGAGGAAACGCTCTCCTGGTGCCGCCAGATGCTCCGCCACA
GCCCTCTGGCCCTGCGCTGCCTGAAGGCATCCCTGAACGCCGACTGCGACGGGCAGATGGGCCTGCTGGACCTGGCCGGC
AACGCCACCCTGCTCTATTATATGAGCGAGGAAGCGAAGGAAGGCAAAAACGCCTTCGTTGAAAAACGCGCTCCGGATTT
TTCCAAATTCCCCAGACTTCCGTAA

Upstream 100 bases:

>100_bases
CGGCCGCAGCACCGCCCCATCCCCCGCAGGTTCCGGACATACCCGGAAGGCGGCGCATTTTAGGCTTCCCATTGCCGGGC
GCCTTATTAAAGTAATCCGT

Downstream 100 bases:

>100_bases
CCTCCCCCTCCTCCGCACCATGGCACCCAGCTCCGACAATGAAGGCGCCCCCCGGAACGGCACCGCCGGCAGGGAATCCC
TGCGCGACCTGCCGGAACAT

Product: naphthoate synthase

Products: NA

Alternate protein names: DHNA-CoA synthase [H]

Number of amino acids: Translated: 274; Mature: 273

Protein sequence:

>274_residues
MSAQWITAKEYTDIKYETTDNGSIAKITINRPHVRNAFRPLTVHEMLNALNAAHEDPKVGVVILTGEGPDAFCSGGDQKV
RGNAGYIGEDGVPRLNILDVQRTIRTMPKPVVAMVAGYAIGGGHVLHVVCDLTIAADNAKFGQTGPKVGSFDGGLGSSYL
ARIVGQKKAREIWYLCRQYDARQALDMGLVNTVVPLEDLEEETLSWCRQMLRHSPLALRCLKASLNADCDGQMGLLDLAG
NATLLYYMSEEAKEGKNAFVEKRAPDFSKFPRLP

Sequences:

>Translated_274_residues
MSAQWITAKEYTDIKYETTDNGSIAKITINRPHVRNAFRPLTVHEMLNALNAAHEDPKVGVVILTGEGPDAFCSGGDQKV
RGNAGYIGEDGVPRLNILDVQRTIRTMPKPVVAMVAGYAIGGGHVLHVVCDLTIAADNAKFGQTGPKVGSFDGGLGSSYL
ARIVGQKKAREIWYLCRQYDARQALDMGLVNTVVPLEDLEEETLSWCRQMLRHSPLALRCLKASLNADCDGQMGLLDLAG
NATLLYYMSEEAKEGKNAFVEKRAPDFSKFPRLP
>Mature_273_residues
SAQWITAKEYTDIKYETTDNGSIAKITINRPHVRNAFRPLTVHEMLNALNAAHEDPKVGVVILTGEGPDAFCSGGDQKVR
GNAGYIGEDGVPRLNILDVQRTIRTMPKPVVAMVAGYAIGGGHVLHVVCDLTIAADNAKFGQTGPKVGSFDGGLGSSYLA
RIVGQKKAREIWYLCRQYDARQALDMGLVNTVVPLEDLEEETLSWCRQMLRHSPLALRCLKASLNADCDGQMGLLDLAGN
ATLLYYMSEEAKEGKNAFVEKRAPDFSKFPRLP

Specific function: Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA) [H]

COG id: COG0447

COG function: function code H; Dihydroxynaphthoic acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=250, Percent_Identity=33.2, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4502327, Length=263, Percent_Identity=30.4182509505703, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI31542718, Length=249, Percent_Identity=29.3172690763052, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI45643119, Length=208, Percent_Identity=29.3269230769231, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI260275230, Length=208, Percent_Identity=29.3269230769231, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI260274832, Length=208, Percent_Identity=29.3269230769231, Blast_Score=79, Evalue=6e-15,
Organism=Homo sapiens, GI213417737, Length=225, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=4e-14,
Organism=Homo sapiens, GI157694516, Length=225, Percent_Identity=26.6666666666667, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI4757966, Length=222, Percent_Identity=27.4774774774775, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI51538581, Length=222, Percent_Identity=27.4774774774775, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI25453481, Length=222, Percent_Identity=27.4774774774775, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI51538573, Length=222, Percent_Identity=27.4774774774775, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI70995211, Length=237, Percent_Identity=29.1139240506329, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1788597, Length=273, Percent_Identity=72.8937728937729, Blast_Score=412, Evalue=1e-116,
Organism=Escherichia coli, GI1787659, Length=245, Percent_Identity=33.469387755102, Blast_Score=118, Evalue=5e-28,
Organism=Escherichia coli, GI221142681, Length=256, Percent_Identity=32.8125, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI87082183, Length=251, Percent_Identity=28.6852589641434, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787660, Length=251, Percent_Identity=29.8804780876494, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788682, Length=201, Percent_Identity=27.363184079602, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25145438, Length=255, Percent_Identity=30.1960784313725, Blast_Score=107, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17540714, Length=214, Percent_Identity=31.3084112149533, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17554946, Length=270, Percent_Identity=28.1481481481481, Blast_Score=104, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17560910, Length=206, Percent_Identity=27.6699029126214, Blast_Score=80, Evalue=9e-16,
Organism=Caenorhabditis elegans, GI17535521, Length=215, Percent_Identity=26.046511627907, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17536985, Length=221, Percent_Identity=25.7918552036199, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17549921, Length=198, Percent_Identity=26.2626262626263, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17534483, Length=235, Percent_Identity=27.6595744680851, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17540306, Length=267, Percent_Identity=27.7153558052434, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI20129971, Length=259, Percent_Identity=32.046332046332, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653477, Length=259, Percent_Identity=32.046332046332, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI24653139, Length=269, Percent_Identity=28.2527881040892, Blast_Score=98, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21357171, Length=182, Percent_Identity=30.2197802197802, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19922422, Length=249, Percent_Identity=25.3012048192771, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376
- InterPro:   IPR010198 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.3.36 [H]

Molecular weight: Translated: 29952; Mature: 29820

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQWITAKEYTDIKYETTDNGSIAKITINRPHVRNAFRPLTVHEMLNALNAAHEDPKVG
CCCCEEECCCCCCEEEEECCCCCEEEEEECCCHHHHHCCCCHHHHHHHHHHHCCCCCCEE
VVILTGEGPDAFCSGGDQKVRGNAGYIGEDGVPRLNILDVQRTIRTMPKPVVAMVAGYAI
EEEEECCCCCHHHCCCCCEECCCCCEECCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHCC
GGGHVLHVVCDLTIAADNAKFGQTGPKVGSFDGGLGSSYLARIVGQKKAREIWYLCRQYD
CCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ARQALDMGLVNTVVPLEDLEEETLSWCRQMLRHSPLALRCLKASLNADCDGQMGLLDLAG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEECC
NATLLYYMSEEAKEGKNAFVEKRAPDFSKFPRLP
CEEEEEEECCHHHCHHHHHHHCCCCCHHHCCCCC
>Mature Secondary Structure 
SAQWITAKEYTDIKYETTDNGSIAKITINRPHVRNAFRPLTVHEMLNALNAAHEDPKVG
CCCEEECCCCCCEEEEECCCCCEEEEEECCCHHHHHCCCCHHHHHHHHHHHCCCCCCEE
VVILTGEGPDAFCSGGDQKVRGNAGYIGEDGVPRLNILDVQRTIRTMPKPVVAMVAGYAI
EEEEECCCCCHHHCCCCCEECCCCCEECCCCCCCEEEHHHHHHHHHCCHHHHHHHHHHCC
GGGHVLHVVCDLTIAADNAKFGQTGPKVGSFDGGLGSSYLARIVGQKKAREIWYLCRQYD
CCCCEEEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ARQALDMGLVNTVVPLEDLEEETLSWCRQMLRHSPLALRCLKASLNADCDGQMGLLDLAG
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCEEEEECC
NATLLYYMSEEAKEGKNAFVEKRAPDFSKFPRLP
CEEEEEEECCHHHCHHHHHHHCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]